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Castellanos-González, G. Petiti-Martín, C. Postigo, J.L. Rodriguez-Peralto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Castellanos-González" "email" => array:1 [ 0 => "maria.castellanos.gonzalez@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Petiti-Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Postigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.L." "apellidos" => "Rodriguez-Peralto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología y Venereología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nevus de tejido conectivo con patrón zosteriforme. Aportación de un nuevo caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 900 "Ancho" => 1750 "Tamanyo" => 186693 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaques with orange-peel skin. A, Deltoid area. B, Lower back.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Connective tissue nevus is a type of dermal hamartoma with a variable clinical presentation. This condition generally appears on the trunk or limbs as flesh-colored, yellowish, or brownish plaques with a marbled surface. Its most typical presentations include the orange-peel skin associated with tuberous sclerosis or cobblestone plaques. Connective tissue nevus is characterized by excess collagen or altered elastic fibers. Diagnosis is based on the correlation of clinical and pathological findings, and it is essential to identify variants that are potentially associated with extracutaneous manifestations. Zosteriform connective tissue nevus is an extremely rare variant, with only 5 cases reported to date.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 14-year-old girl with no past history of interest who came to our clinic with an indurated area on her right upper arm that first appeared when she was 6 months old. The lesion initially measured 1<span class="elsevierStyleHsp" style=""></span>cm and had gradually increased in size until it involved the whole deltoid area of that arm. The only concomitant symptom was difficulty raising her arms. Physical examination revealed a poorly defined indurated plaque measuring 7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>cm that extended from the deltoid area to the outer aspect of the right upper arm. The plaque was firm in consistency, had a cobblestone appearance, and was adherent to the deeper layers of the skin, with no alteration to adnexa or changes in the skin surface. She presented a second, similar plaque measuring 8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm on her lower back (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">There were no significant findings on hematoxylin-eosin staining of a biopsy specimen of the lesion on the arm with the inclusion of subcutaneous tissue; however, staining for elastic fibers revealed a conserved epidermis and marked reduction and fragmentation of elastic fibers in the reticular dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). No accompanying inflammatory infiltrate was observed. The results of imaging tests (ultrasound, magnetic resonance, and Doppler ultrasound) were normal. No significant findings were detected in the complete blood count, biochemistry with liver and kidney function tests, or coagulation studies, and the results of an assessment in the cardiology department were unremarkable. After physiotherapy, physical examination revealed reduced infiltration, even though the lesions had extended to the elbow and onto the forearm.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The term connective tissue nevus was first mentioned by Lewandowsky in 1921, although it was not accepted until the review by Gutmann<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in 1926. Connective tissue nevus is considered a hamartoma of connective tissue (collagen or elastic tissue) that takes the form of tumor-like dermal lesions. Attempts have been made to classify the lesions according to histologic criteria, clinical criteria, or both. One of the most widely accepted classifications is that of Pierard and Lapiere, which divides connective tissue nevi into 2 types—reticular and adventitial—according their clinical and histopathological presentation. Zosteriform nevus is an unusual form of reticular connective tissue nevus that is diagnosed according to its clinical distribution. It was first described by Steiner<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> in 1944. Since then, only 5 cases have been published (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>); 3 of those involved multiple lesions.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Once diagnosis is confirmed, it must be decided whether to extend the study and, if this is the case, the relevant additional tests must be selected. Several associations have been reported between familial connective tissue diseases and other diseases, principally affecting the heart.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Shagreen plaques, for example, are a major criterion for establishing a diagnosis of tuberous sclerosis. One case of connective tissue nevus associated with macrodactyly and hemihypertrophy has been reported.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> However, to date, we have been unable to find evidence of diseases associated with zosteriform connective tissue nevus. Therefore, if neither the history nor a detailed physical examination reveals findings indicative of associated diseases, it is not necessary to continue with the study. Observation alone is sufficient.</p><p id="par0030" class="elsevierStylePara elsevierViewall">As for clinical course, the lesions tend to be persistent and their prognosis depends on the presence of associated diseases. Treatment is only required in cases with major cosmetic repercussions.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, we present a new case of a rare condition that fits the description of connective tissue nevus. The lesions had a peculiar, zosteriform-type distribution. Our case is unusual in that it involved 2 areas: the deltoid area and the lower back. We wish to stress the importance of ruling out familial cases because of their frequent association with other diseases, which would necessitate a more meticulous workup.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Castellanos-González M, Petiti-Martín G, Postigo C, Rodriguez-Peralto JL. Nevus de tejido conectivo con patrón zosteriforme. Aportación de un nuevo caso. Actas Dermosifiliogr.2012;103:640-642.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 900 "Ancho" => 1750 "Tamanyo" => 186693 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaques with orange-peel skin. A, Deltoid area. B, Lower back.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 639 "Ancho" => 949 "Tamanyo" => 236698 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology with staining of elastic fibers (van Gieson, original magnification ×10). Note the significant reduction in elastic fibers.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Steiner<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Kozminsky et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Yeh et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Amjadi et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Brazelli et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 y \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single plaque \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Several plaques \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Single plaque \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Forty nodules \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Several plaques \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Site \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Right thorax and back \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dermatomes C6<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>T1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Right flank \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Right lumbar region and upper part of right buttock \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lumbosacral region and proximal right leg \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Clinical course \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Since 7 years of age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Since birth \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Since 6 years of age \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Concomitant symptoms and course \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Isolated fibroma in right axilla \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable over time with no increase in size \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Progressive growth until 19 years of age. Some lesions coalesced to form plaques. Stable since then \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pathology \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fragmented elastic fibers in the mid dermis. Trichrome staining did not reveal collagen abnormalities \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fragmented elastic fibers in the mid dermis. No collagen abnormalities \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Excess collagen. Remaining connective tissue normal. No other significant findings \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thickening and sclerosis of the collagen fibers in the superficial, mid, and deep dermis, with nodular distribution accompanied by thinning and fragmentation of the elastic fibers \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab182300.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara">These data are not specified in the corresponding article.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cases of Zosteriform Connective Tissue Nevus.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zur Frage der Bindegewebsnaevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. 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Guerci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2007.00520.x" "Revista" => array:6 [ "tituloSerie" => "Pediatric Dermatology" "fecha" => "2007" "volumen" => "24" "paginaInicial" => "557" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17958812" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrodactyly, hemihipertrophy and connective tissue nevi. A new syndrome and review of the literatura" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Temtamy" 1 => "J.G. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 14 | 12 | 26 |
2024 Octubre | 89 | 63 | 152 |
2024 Septiembre | 110 | 46 | 156 |
2024 Agosto | 128 | 65 | 193 |
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2024 Junio | 122 | 90 | 212 |
2024 Mayo | 89 | 35 | 124 |
2024 Abril | 100 | 32 | 132 |
2024 Marzo | 79 | 37 | 116 |
2024 Febrero | 88 | 33 | 121 |
2024 Enero | 74 | 41 | 115 |
2023 Diciembre | 91 | 18 | 109 |
2023 Noviembre | 96 | 40 | 136 |
2023 Octubre | 89 | 29 | 118 |
2023 Septiembre | 96 | 41 | 137 |
2023 Agosto | 85 | 24 | 109 |
2023 Julio | 108 | 33 | 141 |
2023 Junio | 61 | 22 | 83 |
2023 Mayo | 99 | 28 | 127 |
2023 Abril | 100 | 19 | 119 |
2023 Marzo | 85 | 21 | 106 |
2023 Febrero | 75 | 26 | 101 |
2023 Enero | 79 | 39 | 118 |
2022 Diciembre | 74 | 36 | 110 |
2022 Noviembre | 52 | 26 | 78 |
2022 Octubre | 60 | 22 | 82 |
2022 Septiembre | 46 | 41 | 87 |
2022 Agosto | 37 | 33 | 70 |
2022 Julio | 36 | 32 | 68 |
2022 Junio | 29 | 30 | 59 |
2022 Mayo | 71 | 38 | 109 |
2022 Abril | 84 | 46 | 130 |
2022 Marzo | 66 | 54 | 120 |
2022 Febrero | 59 | 27 | 86 |
2022 Enero | 91 | 55 | 146 |
2021 Diciembre | 58 | 43 | 101 |
2021 Noviembre | 72 | 46 | 118 |
2021 Octubre | 77 | 43 | 120 |
2021 Septiembre | 58 | 37 | 95 |
2021 Agosto | 85 | 29 | 114 |
2021 Julio | 63 | 22 | 85 |
2021 Junio | 64 | 43 | 107 |
2021 Mayo | 56 | 48 | 104 |
2021 Abril | 119 | 64 | 183 |
2021 Marzo | 67 | 46 | 113 |
2021 Febrero | 61 | 45 | 106 |
2021 Enero | 52 | 19 | 71 |
2020 Diciembre | 53 | 21 | 74 |
2020 Noviembre | 32 | 9 | 41 |
2020 Octubre | 34 | 9 | 43 |
2020 Septiembre | 30 | 11 | 41 |
2020 Agosto | 23 | 20 | 43 |
2020 Julio | 34 | 10 | 44 |
2020 Junio | 29 | 31 | 60 |
2020 Mayo | 24 | 19 | 43 |
2020 Abril | 26 | 16 | 42 |
2020 Marzo | 30 | 22 | 52 |
2020 Febrero | 4 | 2 | 6 |
2020 Enero | 4 | 3 | 7 |
2019 Diciembre | 8 | 6 | 14 |
2019 Noviembre | 3 | 2 | 5 |
2019 Octubre | 0 | 2 | 2 |
2019 Septiembre | 8 | 4 | 12 |
2019 Agosto | 4 | 2 | 6 |
2019 Julio | 4 | 1 | 5 |
2019 Junio | 6 | 1 | 7 |
2019 Mayo | 5 | 28 | 33 |
2019 Abril | 2 | 1 | 3 |
2019 Marzo | 2 | 6 | 8 |
2019 Febrero | 2 | 0 | 2 |
2019 Enero | 2 | 0 | 2 |
2018 Diciembre | 3 | 0 | 3 |
2018 Noviembre | 2 | 0 | 2 |
2018 Octubre | 5 | 0 | 5 |
2018 Septiembre | 3 | 0 | 3 |
2018 Marzo | 1 | 0 | 1 |
2018 Febrero | 56 | 7 | 63 |
2018 Enero | 54 | 4 | 58 |
2017 Diciembre | 49 | 8 | 57 |
2017 Noviembre | 47 | 4 | 51 |
2017 Octubre | 48 | 1 | 49 |
2017 Septiembre | 45 | 9 | 54 |
2017 Agosto | 52 | 7 | 59 |
2017 Julio | 31 | 7 | 38 |
2017 Junio | 59 | 10 | 69 |
2017 Mayo | 39 | 7 | 46 |
2017 Abril | 38 | 11 | 49 |
2017 Marzo | 29 | 5 | 34 |
2017 Febrero | 101 | 5 | 106 |
2017 Enero | 48 | 10 | 58 |
2016 Diciembre | 63 | 13 | 76 |
2016 Noviembre | 71 | 13 | 84 |
2016 Octubre | 126 | 20 | 146 |
2016 Septiembre | 190 | 8 | 198 |
2016 Agosto | 93 | 19 | 112 |
2016 Julio | 44 | 18 | 62 |
2016 Junio | 12 | 14 | 26 |
2016 Mayo | 5 | 16 | 21 |
2016 Abril | 3 | 1 | 4 |
2016 Marzo | 11 | 1 | 12 |
2016 Febrero | 8 | 1 | 9 |
2016 Enero | 13 | 1 | 14 |
2015 Diciembre | 10 | 1 | 11 |
2015 Noviembre | 27 | 1 | 28 |
2015 Octubre | 41 | 3 | 44 |
2015 Septiembre | 26 | 1 | 27 |
2015 Agosto | 23 | 2 | 25 |
2015 Julio | 121 | 12 | 133 |
2015 Junio | 73 | 32 | 105 |
2015 Mayo | 75 | 4 | 79 |
2015 Abril | 85 | 10 | 95 |
2015 Marzo | 83 | 6 | 89 |
2015 Febrero | 96 | 9 | 105 |
2015 Enero | 75 | 12 | 87 |
2014 Diciembre | 80 | 10 | 90 |
2014 Noviembre | 66 | 7 | 73 |
2014 Octubre | 96 | 14 | 110 |
2014 Septiembre | 78 | 17 | 95 |
2014 Agosto | 51 | 6 | 57 |
2014 Julio | 34 | 7 | 41 |
2014 Junio | 49 | 7 | 56 |
2014 Mayo | 69 | 10 | 79 |
2014 Abril | 42 | 5 | 47 |
2014 Marzo | 59 | 11 | 70 |
2014 Febrero | 42 | 6 | 48 |
2014 Enero | 60 | 11 | 71 |
2013 Diciembre | 45 | 3 | 48 |
2013 Noviembre | 46 | 17 | 63 |
2013 Octubre | 47 | 7 | 54 |
2013 Septiembre | 32 | 7 | 39 |
2013 Agosto | 30 | 15 | 45 |
2013 Julio | 17 | 9 | 26 |
2013 Junio | 11 | 16 | 27 |
2013 Mayo | 11 | 9 | 20 |
2013 Abril | 12 | 10 | 22 |
2013 Marzo | 18 | 8 | 26 |
2013 Febrero | 34 | 5 | 39 |
2013 Enero | 55 | 9 | 64 |
2012 Diciembre | 25 | 11 | 36 |
2012 Noviembre | 1 | 5 | 6 |
2012 Octubre | 0 | 5 | 5 |
2012 Septiembre | 0 | 1 | 1 |