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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous metastasis&#44; a condition with variable clinical presentation&#44; can be the first manifestation of internal malignancy&#44; although it is rarely seen in hepatocellular carcinoma &#40;HCC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In patients with HCC&#44; the presence of cutaneous metastases is associated with a dismal prognosis&#44; an increased likelihood of metastases at other sites&#44; and a median survival of less than 5 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> This letter describes the case of a liver transplant recipient in whom multiple cutaneous metastases were the first sign of HCC recurrence&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 57-year-old man with a personal history of type 2 diabetes mellitus and liver transplant for treatment of alcoholic liver cirrhosis complicated by HCC&#46; At the patient&#39;s regular post-transplant follow-up visits at the hepatology unit&#44; good graft function was seen and there was no evidence of tumor recurrence&#46; Seven months after transplant&#44; the patient presented with rapidly growing asymptomatic lesions on the scalp and in the left supraclavicular region that had appeared several weeks earlier&#46; Physical examination revealed 3 firm&#44; erythematous-violaceous tumors with well-defined borders&#44; measuring between 1 and 2<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; in the right temporal-parietal region of the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and in the left supraclavicular region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Some of the tumors had a small central erosion and a pronounced vascular component &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathologic examination of the lesions revealed a proliferation of neoplastic cells in the dermis arranged in trabeculae&#44; alveoli&#44; and&#44; in some places&#44; pseudoglandular patterns &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The cells were cuboidal&#44; with granular cytoplasm&#44; hyperchromatic nuclei&#44; and marked cellular pleomorphism&#46; Several mitotic figures were also visible&#46; The tumor cells were positively labeled with antibodies against cytokeratin AE1&#47;AE3 and alpha-fetoprotein&#44; and with the hepatocyte antibody&#46; The morphologic and immunohistochemical findings were consistent with a diagnosis of cutaneous metastases of HCC&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Two weeks after histologic confirmation of the metastases&#44; the patient presented to the emergency department with productive cough with whitish sputum and lower chest pain on both sides&#46; The symptoms had appeared 3 days earlier&#46; A chest radiograph showed a poorly defined radiopaque area in the basal region of the right lung field &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; In view of the patient&#39;s medical history&#44; a computed tomography scan was performed&#44; confirming the presence of a large mass measuring 4&#46;3<span class="elsevierStyleHsp" style=""></span>cm in the right lower lobe&#44; and showing multiple pulmonary nodules and mediastinal lymph node involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Metastases were also observed in the liver&#44; around the kidneys&#44; and in a suprarenal gland &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#44; as well as in subcutaneous tissue and muscle tissue&#46; One month later&#44; the patient once again presented to the emergency department with disorientation and generalized tonic-clonic seizures&#46; Brain magnetic resonance imaging revealed a prominent left choroid plexus and an irregularly shaped&#44; high-uptake image consistent with a metastatic lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41;&#46; Following gradual deterioration in general health&#44; the patient died just 6 weeks after the diagnosis of cutaneous metastases&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">HCC is the most common primary malignant tumor of the liver&#44; and its incidence has increased in recent years&#46; However&#44; cutaneous metastases of HCC are very rare&#44; accounting for 0&#46;2&#37; to 2&#46;7&#37; of all cutaneous metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> These metastases are of interest in part because they can be the first manifestation of the primary tumor<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> or&#44; as in our case&#44; the first sign of disease recurrence&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cutaneous metastasis of HCC occurs most frequently in men over 50 years of age&#44; usually in the sixth decade of life&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and usually manifests as a single painless&#44; fast-growing lesion&#46; The most common location is the head &#40;usually the face&#41;&#44; followed by the chest&#44; the abdomen&#44; and the limbs&#46; The lesions can take a variety of clinical forms but are usually firm&#44; bluish-red or purple&#44; 1 to 5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; and nonulcerated&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;6</span></a> They may also be necrotic or purulent or resemble pyogenic granulomas&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Three different mechanisms<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> by which a liver tumor can produce cutaneous metastases have been described&#58; 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Cases and Research Letters
Multiple Cutaneous Metastases From Hepatocellular Carcinoma as the First Sign of Tumor Recurrence in a Transplant Patient
Metástasis cutáneas múltiples de carcinoma hepatocelular como primer signo de recidiva tumoral en paciente trasplantado
J. Alonso-González
Autor para correspondencia
julio.alonso.gonzalez@gmail.com

Corresponding author.
, D. Sánchez-Aguilar, J. Toribio
Departamento de Dermatología, Complejo Hospitalario Universitario, Facultad de Medicina, Santiago de Compostela, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous metastasis&#44; a condition with variable clinical presentation&#44; can be the first manifestation of internal malignancy&#44; although it is rarely seen in hepatocellular carcinoma &#40;HCC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In patients with HCC&#44; the presence of cutaneous metastases is associated with a dismal prognosis&#44; an increased likelihood of metastases at other sites&#44; and a median survival of less than 5 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> This letter describes the case of a liver transplant recipient in whom multiple cutaneous metastases were the first sign of HCC recurrence&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 57-year-old man with a personal history of type 2 diabetes mellitus and liver transplant for treatment of alcoholic liver cirrhosis complicated by HCC&#46; At the patient&#39;s regular post-transplant follow-up visits at the hepatology unit&#44; good graft function was seen and there was no evidence of tumor recurrence&#46; Seven months after transplant&#44; the patient presented with rapidly growing asymptomatic lesions on the scalp and in the left supraclavicular region that had appeared several weeks earlier&#46; Physical examination revealed 3 firm&#44; erythematous-violaceous tumors with well-defined borders&#44; measuring between 1 and 2<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; in the right temporal-parietal region of the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and in the left supraclavicular region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Some of the tumors had a small central erosion and a pronounced vascular component &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathologic examination of the lesions revealed a proliferation of neoplastic cells in the dermis arranged in trabeculae&#44; alveoli&#44; and&#44; in some places&#44; pseudoglandular patterns &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The cells were cuboidal&#44; with granular cytoplasm&#44; hyperchromatic nuclei&#44; and marked cellular pleomorphism&#46; Several mitotic figures were also visible&#46; The tumor cells were positively labeled with antibodies against cytokeratin AE1&#47;AE3 and alpha-fetoprotein&#44; and with the hepatocyte antibody&#46; The morphologic and immunohistochemical findings were consistent with a diagnosis of cutaneous metastases of HCC&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Two weeks after histologic confirmation of the metastases&#44; the patient presented to the emergency department with productive cough with whitish sputum and lower chest pain on both sides&#46; The symptoms had appeared 3 days earlier&#46; A chest radiograph showed a poorly defined radiopaque area in the basal region of the right lung field &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; In view of the patient&#39;s medical history&#44; a computed tomography scan was performed&#44; confirming the presence of a large mass measuring 4&#46;3<span class="elsevierStyleHsp" style=""></span>cm in the right lower lobe&#44; and showing multiple pulmonary nodules and mediastinal lymph node involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Metastases were also observed in the liver&#44; around the kidneys&#44; and in a suprarenal gland &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#44; as well as in subcutaneous tissue and muscle tissue&#46; One month later&#44; the patient once again presented to the emergency department with disorientation and generalized tonic-clonic seizures&#46; Brain magnetic resonance imaging revealed a prominent left choroid plexus and an irregularly shaped&#44; high-uptake image consistent with a metastatic lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41;&#46; Following gradual deterioration in general health&#44; the patient died just 6 weeks after the diagnosis of cutaneous metastases&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">HCC is the most common primary malignant tumor of the liver&#44; and its incidence has increased in recent years&#46; However&#44; cutaneous metastases of HCC are very rare&#44; accounting for 0&#46;2&#37; to 2&#46;7&#37; of all cutaneous metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> These metastases are of interest in part because they can be the first manifestation of the primary tumor<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> or&#44; as in our case&#44; the first sign of disease recurrence&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cutaneous metastasis of HCC occurs most frequently in men over 50 years of age&#44; usually in the sixth decade of life&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and usually manifests as a single painless&#44; fast-growing lesion&#46; The most common location is the head &#40;usually the face&#41;&#44; followed by the chest&#44; the abdomen&#44; and the limbs&#46; The lesions can take a variety of clinical forms but are usually firm&#44; bluish-red or purple&#44; 1 to 5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; and nonulcerated&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;6</span></a> They may also be necrotic or purulent or resemble pyogenic granulomas&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Three different mechanisms<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> by which a liver tumor can produce cutaneous metastases have been described&#58; continuous growth from the liver parenchyma&#44; systemic spread of disease&#44; and tumor implantation or seeding following manipulation of the lesion using various diagnostic or therapeutic methods&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Histopathologic diagnosis is possible when a hepatocellular component&#8212;bile production in part of the tumor&#44; intercellular bile canaliculi&#44; or a trabecular growth pattern&#8212;is present&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> From an immunohistochemical perspective&#44; the hepatocyte antibody has proved to be very helpful in the diagnosis of poorly differentiated tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The presence of cutaneous metastases of HCC is associated with a very poor prognosis&#44; an increased likelihood of metastases at other sites&#44; and a median survival of less than 5 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> This case highlights the fact that a dermatologist may be the first specialist to detect the recurrence of an internal malignancy when metastases have not reached sites other than the skin or have not manifested clinically&#46;</p></span>"
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ISSN: 15782190
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