array:24 [
  "pii" => "S1578219012001059"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.04.009"
  "estado" => "S300"
  "fechaPublicacion" => "2012-04-01"
  "aid" => "490"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2012;103:253-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3913
    "formatos" => array:3 [
      "EPUB" => 50
      "HTML" => 3254
      "PDF" => 609
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011004273"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.06.008"
      "estado" => "S300"
      "fechaPublicacion" => "2012-04-01"
      "aid" => "490"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2012;103:253-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4730
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3512
          "PDF" => 1216
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "253"
            "paginaFinal" => "255"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 830
                "Ancho" => 998
                "Tamanyo" => 117807
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo en t&#243;rax&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Palacios Abuf&#243;n, E&#46; Acebo Mari&#241;as, J&#46; Gardeazabal Garc&#237;a, J&#46;C&#46; Garc&#237;a-Ruiz"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Palacios Abuf&#243;n"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Acebo Mari&#241;as"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Gardeazabal Garc&#237;a"
              ]
              3 => array:2 [
                "nombre" => "J&#46;C&#46;"
                "apellidos" => "Garc&#237;a-Ruiz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012001059"
          "doi" => "10.1016/j.adengl.2012.04.009"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001059?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004273?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000003/v1_201304241400/S0001731011004273/v1_201304241400/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012001060"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.010"
    "estado" => "S300"
    "fechaPublicacion" => "2012-04-01"
    "aid" => "496"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:255-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3353
      "formatos" => array:3 [
        "EPUB" => 54
        "HTML" => 2660
        "PDF" => 639
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cases and Research Letters</span>"
      "titulo" => "Short-Contact Therapy With Topical Tazarotene in Darier Disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "256"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Terapia de contacto corto con tazaroteno t&#243;pico en Darier segmentaria"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1171
              "Ancho" => 997
              "Tamanyo" => 131154
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Complete disappearance of lesions after 1 month of topical treatment with 0&#46;1&#37; tazarotene&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Sanz-S&#225;nchez, R&#46;M&#46; D&#237;az-D&#237;az, O&#46; L&#243;pez-Barrantes, R&#46; Valverde-Garrido"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Sanz-S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "D&#237;az-D&#237;az"
            ]
            2 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "L&#243;pez-Barrantes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Valverde-Garrido"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011004613"
        "doi" => "10.1016/j.ad.2011.09.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004613?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001060?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001060/v1_201304241257/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012001047"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.008"
    "estado" => "S300"
    "fechaPublicacion" => "2012-04-01"
    "aid" => "489"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:251-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4386
      "formatos" => array:3 [
        "EPUB" => 52
        "HTML" => 3453
        "PDF" => 881
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cases and Research Letters</span>"
      "titulo" => "Lupus Vulgaris Caused by <span class="elsevierStyleItalic">Mycobacterium bovis</span>"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "251"
          "paginaFinal" => "253"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lupus vulgar causado por <span class="elsevierStyleItalic">Mycobacterium bovis</span>"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 899
              "Ancho" => 999
              "Tamanyo" => 169336
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brownish erythematous plaque located on the posterior aspect of the left axilla&#44; with an atrophic center&#44; raised borders&#44; and telangiectasias&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Jaka-Moreno, M&#46; L&#243;pez-N&#250;&#241;ez, A&#46; L&#243;pez-Pesta&#241;a, A&#46; Tuneu-Valls"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jaka-Moreno"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "L&#243;pez-N&#250;&#241;ez"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "L&#243;pez-Pesta&#241;a"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu-Valls"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011004261"
        "doi" => "10.1016/j.ad.2011.03.031"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004261?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001047?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001047/v1_201304241257/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "253"
        "paginaFinal" => "255"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Palacios Abuf&#243;n, E&#46; Acebo Mari&#241;as, J&#46; Gardeazabal Garc&#237;a, J&#46;C&#46; Garc&#237;a-Ruiz"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Palacios Abuf&#243;n"
            "email" => array:1 [
              0 => "andres&#46;palacios&#46;ib&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Acebo Mari&#241;as"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Gardeazabal Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;C&#46;"
            "apellidos" => "Garc&#237;a-Ruiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Cruces&#44; Baracaldo&#44; Vizcaya&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Universitario de Cruces&#44; Baracaldo&#44; Vizcaya&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1338
            "Ancho" => 993
            "Tamanyo" => 389853
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bcl2<span class="elsevierStyleSup">&#43;</span> lymphoid infiltrate&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Follicular lymphoma &#40;FL&#41; constitutes approximately 30&#37; of all non-Hodgkin lymphomas in Western countries&#46; Clinical presentation is typically in the form of lymphadenopathy&#44; hepatomegaly&#44; splenomegaly and bone marrow infiltration&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Extranodal involvement is less frequent than in large B-cell lymphoma<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and does not appear to affect prognosis&#59; this is not the case with B-cell lymphoma&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a patient diagnosed with FL who developed skin nodules in the course of her disease&#46; The lymphoma recurred after treatment&#44; but it was exclusively limited to the skin&#44; an unusual observation in this disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 54-year-old woman who was referred to the hematology department in August 2004 for thrombocytopenia detected during a routine blood analysis &#40;platelet count 70&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#46; Monoclonal B-cell lymphocytosis in the peripheral blood and bone marrow&#44; enlarged subcentimeter abdominal lymph nodes and splenomegaly were observed during the study&#46; The diagnosis was chronic B-cell lymphoproliferative syndrome and the patient was offered splenectomy&#44; which she refused at that time&#46; At follow-up in January 2007&#44; enlarged mediastinal and retroperitoneal lymph nodes &#40;&#8804;5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#41; were observed&#44; prompting the performance of diagnostic and therapeutic splenectomy&#46; Histologic study of the spleen showed a proliferation of small lymphoid cells&#44; with a micronodular growth pattern&#44; predominantly in the germinal centers of the white pulp&#44; with infiltration of the red pulp&#46; The cells had a CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#44; IgD<span class="elsevierStyleSup">&#8722;</span> CD23<span class="elsevierStyleSup">&#8722;</span>&#44; cyclin D1<span class="elsevierStyleSup">&#8722;</span> and p53<span class="elsevierStyleSup">&#8722;</span> phenotype and a low proliferative index&#44; findings which were consistent with the diagnosis of FL&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In March 2007&#44; the patient was referred to the dermatology department due to the gradual appearance of asymptomatic subcutaneous nodular lesions on the face&#44; chest and back&#46; The nodules had an erythematous-violacious appearance&#44; were slightly raised&#44; and had diameters ranging between 8<span class="elsevierStyleHsp" style=""></span>mm and 20<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy of the lesions showed a lymphoid infiltrate composed of small monomorphous cells&#44; compatible with FL infiltration &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Reassessment of the disease at this time also demonstrated the development of lymphadenopathy&#44; for which chemotherapy was started with a rituximab-CHOP schedule &#40;cyclophosphamide&#44; vincristine&#44; adriamycin and prednisone&#41;&#46; Complete remission was achieved after 6 cycles&#44; with clearance of the subcutaneous nodules and the enlarged lymph nodes&#59; subsequently&#44; the patient was placed on maintenance therapy with rituximab administered every 3 months&#46; In December 2009&#44; the patient again presented with cutaneous lesions&#44; predominantly facial&#44; similar to those previously described&#59; biopsy reconfirmed the diagnosis of infiltration by FL&#46; The rituximab maintenance treatment ended in June 2010&#59; the skin lesions were still stable and there was no evidence of disease spread to other areas &#40;peripheral blood immunophenotyping and cervical-thoracic-abdomen CT scan were normal&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FL is characterized by an indolent course and has no standardized treatment&#59; a variety of approaches are used&#44; including simple observation&#44; radiotherapy&#44; immunotherapy&#44; polychemotherapy&#44; maintenance treatment with rituximab&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and even the application of various hematopoietic stem cell transplantation treatment modalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As in other lymphoid malignancies&#44; patients with FL can have extranodal involvement affecting the skin in up to 3&#46;8&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Extranodal involvement in FL does not generally affect overall survival&#44; unlike the case with large diffuse B-cell lymphoma&#59; these 2 diseases constitute the majority of B-cell lymphomas in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It is therefore important to rule out transformation of FL to more aggressive forms as these are associated with significantly decreased survival&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For this reason&#44; lesions should be biopsied whenever a patient experiences relapse or disease progression&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Differential diagnosis is particularly important in primary cutaneous follicular center lymphoma&#44; since it shares histologic features with FL&#46; In addition to systemic involvement&#44; Bcl2 negativity&#44; which is common in cases primarily involving the skin&#44; may be of use in differentiating the 2 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">FL usually responds well to treatment&#44; although relapses are common and usually affect the lymph nodes&#44; bone marrow or peripheral blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> What is unusual is recurrence being limited to the skin&#44; as in our patient&#46; At present&#44; and after more than 6 years of follow-up&#44; the patient&#39;s disease remains limited to the skin&#46; The persistence of cutaneous disease reflects a lack of complete control of the disease&#44; and it is therefore likely that the patient will develop systemic disease in the future&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Palacios Abuf&#243;n A&#44; et al&#46; Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;253&#8211;55&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 830
            "Ancho" => 993
            "Tamanyo" => 112437
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nodule on the chest&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1338
            "Ancho" => 993
            "Tamanyo" => 389853
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bcl2<span class="elsevierStyleSup">&#43;</span> lymphoid infiltrate&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular lymphomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "U&#46; Vitolo"
                            1 => "A&#46;J&#46;M&#46; Ferreri"
                            2 => "S&#46; Montoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.critrevonc.2008.01.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Rev Oncol Hematol"
                        "fecha" => "2008"
                        "volumen" => "66"
                        "paginaInicial" => "248"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18359244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues"
                        "serieFecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rituximab maintenance for 2 years in patients with high tumor burden follicular lymphoma responding to rituximab plus chemotherapy &#40;PRIMA&#41;&#58; a phase 3&#44; randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Salles"
                            1 => "J&#46;F&#46; Seymour"
                            2 => "F&#46; Offner"
                            3 => "A&#46; Lopez-Guillermo"
                            4 => "D&#46; Belada"
                            5 => "L&#46; Xerri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(10)62175-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2011"
                        "volumen" => "377"
                        "paginaInicial" => "42"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21176949"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathologic spectrum of cutaneous manifestations in systemic follicular lymphoma&#46; A study of 11 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Dabski"
                            1 => "P&#46; Banks"
                            2 => "R&#46;K&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "64"
                        "paginaInicial" => "1480"
                        "paginaFinal" => "1485"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2789095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reclassification of 300 primary cutaneous B-cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas&#58; comparison with previous classifications and identification of prognostic markers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Senff"
                            1 => "J&#46;J&#46; Hoefnagel"
                            2 => "P&#46;M&#46; Jansen"
                            3 => "M&#46;H&#46; Vermeer"
                            4 => "J&#46; van Baarlen"
                            5 => "W&#46;A&#46; Blokx"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2006.09.6396"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "1581"
                        "paginaFinal" => "1587"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17353548"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001059/v1_201304241257/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6169"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Cases and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000003/v1_201304241257/S1578219012001059/v1_201304241257/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001059?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letters
Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence
Linfoma folicular sistémico con afectación cutánea y recidiva únicamente cutánea
A. Palacios Abufóna,
Autor para correspondencia
andres.palacios.ib@gmail.com

Corresponding author.
, E. Acebo Mariñasa, J. Gardeazabal Garcíaa, J.C. García-Ruizb
a Servicio de Dermatología, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain
b Servicio de Hematología, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain
Leído
17669
Veces
se ha leído el artículo
2586
Total PDF
15083
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219012001059"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.04.009"
  "estado" => "S300"
  "fechaPublicacion" => "2012-04-01"
  "aid" => "490"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2012;103:253-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3913
    "formatos" => array:3 [
      "EPUB" => 50
      "HTML" => 3254
      "PDF" => 609
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011004273"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.06.008"
      "estado" => "S300"
      "fechaPublicacion" => "2012-04-01"
      "aid" => "490"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2012;103:253-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4730
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3512
          "PDF" => 1216
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "253"
            "paginaFinal" => "255"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 830
                "Ancho" => 998
                "Tamanyo" => 117807
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo en t&#243;rax&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Palacios Abuf&#243;n, E&#46; Acebo Mari&#241;as, J&#46; Gardeazabal Garc&#237;a, J&#46;C&#46; Garc&#237;a-Ruiz"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Palacios Abuf&#243;n"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Acebo Mari&#241;as"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Gardeazabal Garc&#237;a"
              ]
              3 => array:2 [
                "nombre" => "J&#46;C&#46;"
                "apellidos" => "Garc&#237;a-Ruiz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012001059"
          "doi" => "10.1016/j.adengl.2012.04.009"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001059?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004273?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000003/v1_201304241400/S0001731011004273/v1_201304241400/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012001060"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.010"
    "estado" => "S300"
    "fechaPublicacion" => "2012-04-01"
    "aid" => "496"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:255-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3353
      "formatos" => array:3 [
        "EPUB" => 54
        "HTML" => 2660
        "PDF" => 639
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cases and Research Letters</span>"
      "titulo" => "Short-Contact Therapy With Topical Tazarotene in Darier Disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "256"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Terapia de contacto corto con tazaroteno t&#243;pico en Darier segmentaria"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1171
              "Ancho" => 997
              "Tamanyo" => 131154
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Complete disappearance of lesions after 1 month of topical treatment with 0&#46;1&#37; tazarotene&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Sanz-S&#225;nchez, R&#46;M&#46; D&#237;az-D&#237;az, O&#46; L&#243;pez-Barrantes, R&#46; Valverde-Garrido"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Sanz-S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "D&#237;az-D&#237;az"
            ]
            2 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "L&#243;pez-Barrantes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Valverde-Garrido"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011004613"
        "doi" => "10.1016/j.ad.2011.09.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004613?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001060?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001060/v1_201304241257/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012001047"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.008"
    "estado" => "S300"
    "fechaPublicacion" => "2012-04-01"
    "aid" => "489"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:251-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4386
      "formatos" => array:3 [
        "EPUB" => 52
        "HTML" => 3453
        "PDF" => 881
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Cases and Research Letters</span>"
      "titulo" => "Lupus Vulgaris Caused by <span class="elsevierStyleItalic">Mycobacterium bovis</span>"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "251"
          "paginaFinal" => "253"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lupus vulgar causado por <span class="elsevierStyleItalic">Mycobacterium bovis</span>"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 899
              "Ancho" => 999
              "Tamanyo" => 169336
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brownish erythematous plaque located on the posterior aspect of the left axilla&#44; with an atrophic center&#44; raised borders&#44; and telangiectasias&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Jaka-Moreno, M&#46; L&#243;pez-N&#250;&#241;ez, A&#46; L&#243;pez-Pesta&#241;a, A&#46; Tuneu-Valls"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jaka-Moreno"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "L&#243;pez-N&#250;&#241;ez"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "L&#243;pez-Pesta&#241;a"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu-Valls"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011004261"
        "doi" => "10.1016/j.ad.2011.03.031"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011004261?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001047?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001047/v1_201304241257/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Systemic Follicular Lymphoma With Cutaneous Manifestations and Exclusively Cutaneous Recurrence"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "253"
        "paginaFinal" => "255"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Palacios Abuf&#243;n, E&#46; Acebo Mari&#241;as, J&#46; Gardeazabal Garc&#237;a, J&#46;C&#46; Garc&#237;a-Ruiz"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Palacios Abuf&#243;n"
            "email" => array:1 [
              0 => "andres&#46;palacios&#46;ib&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Acebo Mari&#241;as"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Gardeazabal Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;C&#46;"
            "apellidos" => "Garc&#237;a-Ruiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Cruces&#44; Baracaldo&#44; Vizcaya&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital Universitario de Cruces&#44; Baracaldo&#44; Vizcaya&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1338
            "Ancho" => 993
            "Tamanyo" => 389853
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bcl2<span class="elsevierStyleSup">&#43;</span> lymphoid infiltrate&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Follicular lymphoma &#40;FL&#41; constitutes approximately 30&#37; of all non-Hodgkin lymphomas in Western countries&#46; Clinical presentation is typically in the form of lymphadenopathy&#44; hepatomegaly&#44; splenomegaly and bone marrow infiltration&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Extranodal involvement is less frequent than in large B-cell lymphoma<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and does not appear to affect prognosis&#59; this is not the case with B-cell lymphoma&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a patient diagnosed with FL who developed skin nodules in the course of her disease&#46; The lymphoma recurred after treatment&#44; but it was exclusively limited to the skin&#44; an unusual observation in this disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 54-year-old woman who was referred to the hematology department in August 2004 for thrombocytopenia detected during a routine blood analysis &#40;platelet count 70&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#46; Monoclonal B-cell lymphocytosis in the peripheral blood and bone marrow&#44; enlarged subcentimeter abdominal lymph nodes and splenomegaly were observed during the study&#46; The diagnosis was chronic B-cell lymphoproliferative syndrome and the patient was offered splenectomy&#44; which she refused at that time&#46; At follow-up in January 2007&#44; enlarged mediastinal and retroperitoneal lymph nodes &#40;&#8804;5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#41; were observed&#44; prompting the performance of diagnostic and therapeutic splenectomy&#46; Histologic study of the spleen showed a proliferation of small lymphoid cells&#44; with a micronodular growth pattern&#44; predominantly in the germinal centers of the white pulp&#44; with infiltration of the red pulp&#46; The cells had a CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#44; IgD<span class="elsevierStyleSup">&#8722;</span> CD23<span class="elsevierStyleSup">&#8722;</span>&#44; cyclin D1<span class="elsevierStyleSup">&#8722;</span> and p53<span class="elsevierStyleSup">&#8722;</span> phenotype and a low proliferative index&#44; findings which were consistent with the diagnosis of FL&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In March 2007&#44; the patient was referred to the dermatology department due to the gradual appearance of asymptomatic subcutaneous nodular lesions on the face&#44; chest and back&#46; The nodules had an erythematous-violacious appearance&#44; were slightly raised&#44; and had diameters ranging between 8<span class="elsevierStyleHsp" style=""></span>mm and 20<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy of the lesions showed a lymphoid infiltrate composed of small monomorphous cells&#44; compatible with FL infiltration &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#44; Bcl2<span class="elsevierStyleSup">&#43;</span>&#44; Bcl6<span class="elsevierStyleSup">&#43;</span>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Reassessment of the disease at this time also demonstrated the development of lymphadenopathy&#44; for which chemotherapy was started with a rituximab-CHOP schedule &#40;cyclophosphamide&#44; vincristine&#44; adriamycin and prednisone&#41;&#46; Complete remission was achieved after 6 cycles&#44; with clearance of the subcutaneous nodules and the enlarged lymph nodes&#59; subsequently&#44; the patient was placed on maintenance therapy with rituximab administered every 3 months&#46; In December 2009&#44; the patient again presented with cutaneous lesions&#44; predominantly facial&#44; similar to those previously described&#59; biopsy reconfirmed the diagnosis of infiltration by FL&#46; The rituximab maintenance treatment ended in June 2010&#59; the skin lesions were still stable and there was no evidence of disease spread to other areas &#40;peripheral blood immunophenotyping and cervical-thoracic-abdomen CT scan were normal&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FL is characterized by an indolent course and has no standardized treatment&#59; a variety of approaches are used&#44; including simple observation&#44; radiotherapy&#44; immunotherapy&#44; polychemotherapy&#44; maintenance treatment with rituximab&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and even the application of various hematopoietic stem cell transplantation treatment modalities&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As in other lymphoid malignancies&#44; patients with FL can have extranodal involvement affecting the skin in up to 3&#46;8&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Extranodal involvement in FL does not generally affect overall survival&#44; unlike the case with large diffuse B-cell lymphoma&#59; these 2 diseases constitute the majority of B-cell lymphomas in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It is therefore important to rule out transformation of FL to more aggressive forms as these are associated with significantly decreased survival&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For this reason&#44; lesions should be biopsied whenever a patient experiences relapse or disease progression&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Differential diagnosis is particularly important in primary cutaneous follicular center lymphoma&#44; since it shares histologic features with FL&#46; In addition to systemic involvement&#44; Bcl2 negativity&#44; which is common in cases primarily involving the skin&#44; may be of use in differentiating the 2 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">FL usually responds well to treatment&#44; although relapses are common and usually affect the lymph nodes&#44; bone marrow or peripheral blood&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> What is unusual is recurrence being limited to the skin&#44; as in our patient&#46; At present&#44; and after more than 6 years of follow-up&#44; the patient&#39;s disease remains limited to the skin&#46; The persistence of cutaneous disease reflects a lack of complete control of the disease&#44; and it is therefore likely that the patient will develop systemic disease in the future&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Palacios Abuf&#243;n A&#44; et al&#46; Linfoma folicular sist&#233;mico con afectaci&#243;n cut&#225;nea y recidiva &#250;nicamente cut&#225;nea&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;253&#8211;55&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 830
            "Ancho" => 993
            "Tamanyo" => 112437
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nodule on the chest&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1338
            "Ancho" => 993
            "Tamanyo" => 389853
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bcl2<span class="elsevierStyleSup">&#43;</span> lymphoid infiltrate&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular lymphomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "U&#46; Vitolo"
                            1 => "A&#46;J&#46;M&#46; Ferreri"
                            2 => "S&#46; Montoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.critrevonc.2008.01.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Rev Oncol Hematol"
                        "fecha" => "2008"
                        "volumen" => "66"
                        "paginaInicial" => "248"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18359244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues"
                        "serieFecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rituximab maintenance for 2 years in patients with high tumor burden follicular lymphoma responding to rituximab plus chemotherapy &#40;PRIMA&#41;&#58; a phase 3&#44; randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Salles"
                            1 => "J&#46;F&#46; Seymour"
                            2 => "F&#46; Offner"
                            3 => "A&#46; Lopez-Guillermo"
                            4 => "D&#46; Belada"
                            5 => "L&#46; Xerri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(10)62175-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2011"
                        "volumen" => "377"
                        "paginaInicial" => "42"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21176949"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathologic spectrum of cutaneous manifestations in systemic follicular lymphoma&#46; A study of 11 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Dabski"
                            1 => "P&#46; Banks"
                            2 => "R&#46;K&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "64"
                        "paginaInicial" => "1480"
                        "paginaFinal" => "1485"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2789095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reclassification of 300 primary cutaneous B-cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas&#58; comparison with previous classifications and identification of prognostic markers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Senff"
                            1 => "J&#46;J&#46; Hoefnagel"
                            2 => "P&#46;M&#46; Jansen"
                            3 => "M&#46;H&#46; Vermeer"
                            4 => "J&#46; van Baarlen"
                            5 => "W&#46;A&#46; Blokx"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2006.09.6396"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "1581"
                        "paginaFinal" => "1587"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17353548"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000003/v1_201304241257/S1578219012001059/v1_201304241257/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6169"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Cases and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000003/v1_201304241257/S1578219012001059/v1_201304241257/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001059?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 21 12 33
2024 Octubre 177 65 242
2024 Septiembre 152 25 177
2024 Agosto 147 58 205
2024 Julio 131 48 179
2024 Junio 115 96 211
2024 Mayo 128 46 174
2024 Abril 114 29 143
2024 Marzo 179 29 208
2024 Febrero 181 38 219
2024 Enero 462 38 500
2023 Diciembre 394 17 411
2023 Noviembre 545 24 569
2023 Octubre 679 39 718
2023 Septiembre 617 42 659
2023 Agosto 673 17 690
2023 Julio 645 35 680
2023 Junio 502 27 529
2023 Mayo 312 32 344
2023 Abril 154 19 173
2023 Marzo 134 39 173
2023 Febrero 278 22 300
2023 Enero 501 34 535
2022 Diciembre 260 49 309
2022 Noviembre 214 28 242
2022 Octubre 346 30 376
2022 Septiembre 402 61 463
2022 Agosto 238 53 291
2022 Julio 128 37 165
2022 Junio 58 35 93
2022 Mayo 154 42 196
2022 Abril 254 37 291
2022 Marzo 321 61 382
2022 Febrero 234 36 270
2022 Enero 221 45 266
2021 Diciembre 122 39 161
2021 Noviembre 183 48 231
2021 Octubre 142 50 192
2021 Septiembre 111 35 146
2021 Agosto 104 45 149
2021 Julio 107 29 136
2021 Junio 106 28 134
2021 Mayo 76 38 114
2021 Abril 181 70 251
2021 Marzo 103 27 130
2021 Febrero 96 26 122
2021 Enero 53 19 72
2020 Diciembre 62 16 78
2020 Noviembre 48 16 64
2020 Octubre 44 12 56
2020 Septiembre 32 10 42
2020 Agosto 48 23 71
2020 Julio 23 15 38
2020 Junio 37 32 69
2020 Mayo 23 17 40
2020 Abril 27 21 48
2020 Marzo 25 15 40
2020 Febrero 6 1 7
2020 Enero 4 0 4
2019 Diciembre 8 4 12
2019 Noviembre 4 0 4
2019 Octubre 0 20 20
2019 Septiembre 8 0 8
2019 Agosto 4 1 5
2019 Julio 2 3 5
2019 Junio 6 2 8
2019 Mayo 3 18 21
2019 Marzo 2 7 9
2019 Enero 2 0 2
2018 Diciembre 3 0 3
2018 Noviembre 2 0 2
2018 Octubre 2 0 2
2018 Septiembre 3 0 3
2018 Marzo 5 0 5
2018 Febrero 82 3 85
2018 Enero 84 4 88
2017 Diciembre 70 7 77
2017 Noviembre 47 3 50
2017 Octubre 63 5 68
2017 Septiembre 68 2 70
2017 Agosto 83 8 91
2017 Julio 58 4 62
2017 Junio 78 7 85
2017 Mayo 67 5 72
2017 Abril 66 5 71
2017 Marzo 51 11 62
2017 Febrero 44 11 55
2017 Enero 43 8 51
2016 Diciembre 49 7 56
2016 Noviembre 110 9 119
2016 Octubre 62 7 69
2016 Septiembre 72 19 91
2016 Agosto 60 11 71
2016 Julio 36 9 45
2016 Junio 9 15 24
2016 Mayo 6 13 19
2016 Abril 9 12 21
2016 Marzo 10 2 12
2016 Febrero 12 2 14
2016 Enero 9 0 9
2015 Diciembre 9 2 11
2015 Noviembre 42 2 44
2015 Octubre 40 0 40
2015 Septiembre 12 6 18
2015 Agosto 10 5 15
2015 Julio 97 9 106
2015 Junio 74 6 80
2015 Mayo 100 10 110
2015 Abril 81 9 90
2015 Marzo 84 6 90
2015 Febrero 114 17 131
2015 Enero 87 20 107
2014 Diciembre 86 7 93
2014 Noviembre 58 13 71
2014 Octubre 79 10 89
2014 Septiembre 69 9 78
2014 Agosto 73 12 85
2014 Julio 77 23 100
2014 Junio 103 14 117
2014 Mayo 100 17 117
2014 Abril 62 14 76
2014 Marzo 33 7 40
2014 Febrero 30 5 35
2014 Enero 25 10 35
2013 Diciembre 13 10 23
2013 Noviembre 17 10 27
2013 Octubre 16 6 22
2013 Septiembre 9 5 14
2013 Agosto 10 11 21
2013 Julio 11 19 30
2013 Junio 13 20 33
2013 Mayo 17 11 28
2013 Abril 15 8 23
2013 Marzo 21 12 33
2013 Febrero 40 7 47
2013 Enero 88 8 96
2012 Diciembre 32 5 37
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?