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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Back covered with small psoriasis plaques on which warts had developed&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Common warts &#40;verruca vulgaris&#41; are found very frequently in children and adults &#40;prevalence&#44; 10&#37;&#41; and can sometimes prove difficult to treat&#44; particularly when multiple or recalcitrant&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a patient who developed multiple warts on psoriasis plaques&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 58-year-old man with a history of hypertension and an immunoglobulin A monoclonal gammopathy for which he was not receiving any treatment at the time&#46; He had a history of plaque psoriasis with joint involvement since the age of 15&#46; Treatment with topical corticosteroids and oral methotrexate had achieved only slight improvement in this condition&#46; He attended our clinic because of an outbreak of small erythematous-desquamative lesions distributed symmetrically across his arms and trunk on which multiple spiny whitish papules had developed&#46; The appearance of the papules was consistent with a diagnosis of viral warts &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had never previously had warts&#46; The results of the additional tests performed were normal&#44; and serology for human immunodeficiency virus and hepatitis B and C viruses was negative&#46; Skin biopsy revealed an acanthotic epidermis with papillomatosis&#44; hyperkeratosis with focal parakeratosis&#44; and no clear signs of viral cytopathic effect&#46; A chronic inflammatory infiltrate was found in the underlying dermis&#46; Genotyping for the human papillomavirus &#40;HPV&#41; performed using hybridization techniques &#40;Clinical Arrays&#44; Genomica&#41; was positive for genotypes 6 and 31&#46; The histologic diagnosis was verruca vulgaris on plaque psoriasis&#46; Methotrexate was withdrawn and the patient started treatment with acitretin 35<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46; Virtually all the warts disappeared within 1 month&#44; but the psoriasis plaques persisted&#46; These were then treated with narrowband UV-B phototherapy with excellent results &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">On reviewing the literature we found 1 report of a case of psoriasis on viral warts in a patient treated with interferon-&#945;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It has been suggested that the HPV may contain proteins that stimulate keratinocyte proliferation&#46; These proteins&#44; and others included in the viral capsid&#44; can be recognized by preactivated CD4&#43; lymphocytes and lead to the generation of specific antibodies &#40;antigenic activation&#41;&#46; The autoimmune reaction triggered in this way could lead to complement activation&#44; neutrophil chemotaxis&#44; and formation of the Munro microabscesses so characteristic of plaque psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Thus&#44; while HPV does not cause the psoriasis&#44; it may be involved in the pathogenesis of the disease&#44; particularly in the case of genotypes 5 and 36&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> and contribute to keratinocyte proliferation and the perpetuation of the autoimmune reaction&#46; Our patient tested positive for HPV 6 and 31&#44; genotypes that carry only a low oncogenic risk and are often found in common warts&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient&#44; the inverse situation occurred as the viral warts only appeared on the psoriasis plaques&#46; Some authors have suggested that the epidermal hyperproliferation characteristic of psoriasis may reactivate latent HPV infection&#44; leading to the development of warts&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Moreover&#44; HPV DNA has been identified in psoriasis plaques&#44; carcinomas&#44; and epidermodysplasia verruciformis&#44; but not in other skin diseases&#44; such as eczemas and atopic dermatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In our patient&#44; there were also other factors that could have contributed to the appearance of these warts&#44; such as the immunosuppressant therapy he received to treat his psoriasis and the monoclonal gammopathy&#46; A case was recently reported in which viral warts appeared suddenly in a patient with psoriasis being treated with the anti-tumor necrosis factor agent etanercept&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The few articles published on the topic shed little light on this complex interrelationship between cytokines&#44; psoriasis&#44; and HPV infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Finally&#44; in our review of the literature we found no reports of psoriasis with viral warts treated with acitretin&#44; the drug that achieved complete resolution of the warts in our patient&#46;</p></span>"
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Cases and Research Lelleters
Multiple Warts Appearing Exclusively on Psoriasis Plaques
Verrugas múltiples localizadas exclusivamente sobre las placas de psoriasis
L. Carnero
Autor para correspondencia
, R. González-Pérez, I. Arrue, R. Soloeta
Servicio de Dermatología, Hospital Santiago Apóstol, Vitoria, Álava, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Common warts &#40;verruca vulgaris&#41; are found very frequently in children and adults &#40;prevalence&#44; 10&#37;&#41; and can sometimes prove difficult to treat&#44; particularly when multiple or recalcitrant&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a patient who developed multiple warts on psoriasis plaques&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 58-year-old man with a history of hypertension and an immunoglobulin A monoclonal gammopathy for which he was not receiving any treatment at the time&#46; He had a history of plaque psoriasis with joint involvement since the age of 15&#46; Treatment with topical corticosteroids and oral methotrexate had achieved only slight improvement in this condition&#46; He attended our clinic because of an outbreak of small erythematous-desquamative lesions distributed symmetrically across his arms and trunk on which multiple spiny whitish papules had developed&#46; The appearance of the papules was consistent with a diagnosis of viral warts &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had never previously had warts&#46; The results of the additional tests performed were normal&#44; and serology for human immunodeficiency virus and hepatitis B and C viruses was negative&#46; Skin biopsy revealed an acanthotic epidermis with papillomatosis&#44; hyperkeratosis with focal parakeratosis&#44; and no clear signs of viral cytopathic effect&#46; A chronic inflammatory infiltrate was found in the underlying dermis&#46; Genotyping for the human papillomavirus &#40;HPV&#41; performed using hybridization techniques &#40;Clinical Arrays&#44; Genomica&#41; was positive for genotypes 6 and 31&#46; The histologic diagnosis was verruca vulgaris on plaque psoriasis&#46; Methotrexate was withdrawn and the patient started treatment with acitretin 35<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46; Virtually all the warts disappeared within 1 month&#44; but the psoriasis plaques persisted&#46; These were then treated with narrowband UV-B phototherapy with excellent results &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">On reviewing the literature we found 1 report of a case of psoriasis on viral warts in a patient treated with interferon-&#945;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It has been suggested that the HPV may contain proteins that stimulate keratinocyte proliferation&#46; These proteins&#44; and others included in the viral capsid&#44; can be recognized by preactivated CD4&#43; lymphocytes and lead to the generation of specific antibodies &#40;antigenic activation&#41;&#46; The autoimmune reaction triggered in this way could lead to complement activation&#44; neutrophil chemotaxis&#44; and formation of the Munro microabscesses so characteristic of plaque psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Thus&#44; while HPV does not cause the psoriasis&#44; it may be involved in the pathogenesis of the disease&#44; particularly in the case of genotypes 5 and 36&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> and contribute to keratinocyte proliferation and the perpetuation of the autoimmune reaction&#46; Our patient tested positive for HPV 6 and 31&#44; genotypes that carry only a low oncogenic risk and are often found in common warts&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient&#44; the inverse situation occurred as the viral warts only appeared on the psoriasis plaques&#46; Some authors have suggested that the epidermal hyperproliferation characteristic of psoriasis may reactivate latent HPV infection&#44; leading to the development of warts&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Moreover&#44; HPV DNA has been identified in psoriasis plaques&#44; carcinomas&#44; and epidermodysplasia verruciformis&#44; but not in other skin diseases&#44; such as eczemas and atopic dermatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In our patient&#44; there were also other factors that could have contributed to the appearance of these warts&#44; such as the immunosuppressant therapy he received to treat his psoriasis and the monoclonal gammopathy&#46; A case was recently reported in which viral warts appeared suddenly in a patient with psoriasis being treated with the anti-tumor necrosis factor agent etanercept&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The few articles published on the topic shed little light on this complex interrelationship between cytokines&#44; psoriasis&#44; and HPV infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Finally&#44; in our review of the literature we found no reports of psoriasis with viral warts treated with acitretin&#44; the drug that achieved complete resolution of the warts in our patient&#46;</p></span>"
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