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array:24 [ "pii" => "S1578219011000965" "issn" => "15782190" "doi" => "10.1016/j.adengl.2011.11.009" "estado" => "S300" "fechaPublicacion" => "2011-11-01" "aid" => "398" "copyright" => "Elsevier España, S.L. and AEDV" "copyrightAnyo" => "2010" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:737-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4095 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 3322 "PDF" => 735 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731011002158" "issn" => "00017310" "doi" => "10.1016/j.ad.2010.12.017" "estado" => "S300" "fechaPublicacion" => "2011-11-01" "aid" => "398" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:737-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4632 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 3685 "PDF" => 946 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Sarcoma mieloide en un área de plastia" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "737" "paginaFinal" => "739" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Myeloid Sarcoma in the Area of a Skin Flap" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 562 "Ancho" => 950 "Tamanyo" => 160429 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Detalle de la celularidad: proliferación neoplásica difusa constituida por células mononucleares de mediano tamaño, de morfología redondeada y oval, citoplasma eosinófilo y núcleo basófilo, presentando indentaciones algunos de ellos (HE x40).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. 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A propósito de dos casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 625 "Ancho" => 952 "Tamanyo" => 95027 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Case 2. Pigmented fungiform papillae of the tongue with a diffuse symmetrical pattern, predominantly affecting the lateral surfaces of the tongue in an indigenous South American woman.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Marcoval, J. Notario, S. Martín-Sala, I. Figueras" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval" ] 1 => array:2 [ "nombre" => "J." 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Respuesta terapéutica a inmunoglobulinas pre y postparto" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 970 "Ancho" => 1397 "Tamanyo" => 121273 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Papular eruption with tense blisters on the patient's abdomen. B, Condition of the patient at 6 weeks after delivery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Ruiz-Villaverde, D. Sánchez-Cano, C.L. Ramirez-Tortosa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] 1 => array:2 [ "nombre" => "D." 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García-Arpa, M. Rodríguez-Vázquez, C. Murillo Lázaro, C. Calle Primo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "García-Arpa" "email" => array:1 [ 0 => "mgarciaa73@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Rodríguez-Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Murillo Lázaro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Calle Primo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General de Ciudad Real, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General de Albacete, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital General de Ciudad Real, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Hematología, Hospital General de Ciudad Real, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sarcoma mieloide en un área de plastia" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 563 "Ancho" => 952 "Tamanyo" => 159171 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cytology: diffuse neoplastic proliferation formed of round/oval medium-sized mononuclear cells with eosinophilic cytoplasm and basophilic nuclei, several of which had indentations (hematoxylin-eosin, original magnification ×40).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Leukemia cutis, which is the infiltration of leukocytes into the skin, is rare and accounts for just 3.1% of all types of leukemia. The subtypes that most commonly affect the skin are monocytic acute myeloid leukemia (AML-M5 [French-American-British classification]) and acute myelomonocytic leukemia (AML-M4), with a respective prevalence of 33% and 13% to 18%). Myeloid sarcoma, formerly known as granulocytic sarcoma, is an extramedullary tumor composed of immature myeloid cells.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although the skin is among the organs most frequently affected by myeloid sarcoma, this tumor is still a rare variant of leukemia cutis. We report the case of a patient with myeloid sarcoma in the area of a skin flap.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient, an 86-year-old man, had been diagnosed with myelodysplastic syndrome 2 years earlier. He had consulted for 2 basal cell carcinomas, one on the left temple and the other on the right ala nasi. Both tumors were excised. The surgical defect was repaired by direct closure in the first case and with a nasolabial fold flap in the second. A few hours after surgery, the patient presented at the emergency department with diffuse hemorrhage from both surgical wounds and a large hematoma in the area of the skin flap. Laboratory tests showed a leukocyte count of 12 200/μL (upper limit of normal, 10 000/μL; neutrophils, 31.2%; lymphocytes, 21.3%; monocytes, 43.6%); a hemoglobin level of 11.7<span class="elsevierStyleHsp" style=""></span>g/dL (lower limit of normal, 13<span class="elsevierStyleHsp" style=""></span>g/dL), a platelet count of 65 000/μL (lower limit of normal, 150 000/μL), and a creatinine level of 1.5<span class="elsevierStyleHsp" style=""></span>mg/dL (upper limit of normal, 1.3<span class="elsevierStyleHsp" style=""></span>mg/dL). The other tests (coagulation studies, liver function tests, and lactate dehydrogenase) were normal. One month after surgery, a fast-growing asymptomatic nodule appeared in the area of the skin flap, accompanied by progressive infiltration of the lower part of the flap (which had healed perfectly) and ulceration (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy of the nodule and the infiltrated scar revealed a diffuse neoplastic proliferation of medium-sized, round/oval mononuclear cells with eosinophilic cytoplasm and basophilic nuclei in the dermis and adipose tissue (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Immunohistochemical staining showed diffuse positivity for myeloperoxidase (MPO), CD68, and CD43, and focal positivity for CD34, leading to a diagnosis of myeloid sarcoma (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). During this time, the patient's myelodysplastic syndrome progressed to AML-M4. Palliative treatment was initiated with thioguanine, but the patient died 3 weeks later.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Myeloid sarcoma presents as one or more tumor masses composed of immature myeloid cells. While the tumors can affect any part of the body except the bone marrow, the most common sites of involvement are bone, periosteum, skin, gums, and lymph nodes. Multifocal disease is seen in less than 10% of cases. Myeloid sarcoma can precede, coincide with, or indicate recurrence of AML. It can also indicate blastic transformation of a myelodysplastic syndrome, chronic myeloid leukemia, or other myeloproliferative disorders. It is slightly more common in men than in women (male to female ratio, 1.42:1) and in advanced ages (mean age at diagnosis, 56 years). Myeloid sarcoma of the skin presents as a solitary tumor that grows in a matter of days or weeks and typically affects the face, the scalp, or the trunk. There have also been reports of multiple and even disseminated lesions.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> The literature contains approximately 20 reports of myeloid sarcoma in leukemia cutis, arising at sites of previous skin lesions or trauma, mainly at central venous catheterization sites (11 cases)<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and puncture sites for venous and arterial sampling and bone marrow aspiration (4 cases).<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> There have also been isolated reports of myeloid sarcoma at sites of extravasation of chemotherapy agents,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> traumatic scars and excoriations,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Mantoux test injection sites,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> decubitus ulcer, Sister Mary Joseph's nodule, pyoderma gangrenosum,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> tetanus booster injection sites,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and within a basal cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> We reexamined the surgical specimens from the basal cell carcinomas removed from the patient's temple and nose but found no evidence of leukemic infiltration. Myeloid sarcoma in a patient with AML is normally a marker of recurrence and rapid disease progression. Of 4 such cases described in the literature, it was aleukemic in just 1 case<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>; in the other 3, its appearance coincided with transformation of a myelodysplastic syndrome into AML. Prognosis is generally very poor. It is noteworthy that while text books state that leukemia cutis can occur at the site of surgical scars, we found no such cases reported in the literature.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Histologic diagnosis of myeloid sarcoma requires a high level of clinical suspicion and diagnosis might be missed if there is no previous history of AML. Histologic findings include dense neoplastic infiltration of the dermis and adipose tissue, typically most intense around vessels and adnexa, without epidermotropism. The papillary dermis is usually spared (Grenz zone). Cytology varies greatly according to the origin of the tumor and the degree of cell maturation. Immunohistochemical studies are essential for diagnosis, with CD68, MPO, CD43, CD3, CD20, and chloroacetate esterase staining recommended.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The pathogenesis of leukemia cutis and myeloid sarcoma is not clear, but it appears to be influenced by both the type of leukemia and local factors. Infiltration would appear to be more common in monocytic variants because neoplastic monocytes have a greater capacity to adhere to vessel walls and invade extravascular spaces, forming skin tumors.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,8</span></a> Nevertheless, local skin trauma of any type can activate keratinocytes or fibroblasts in old lesions, releasing chemotactic factors for leukocytes and inflammatory cells that would lead to the recruitment of leukemic cells.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a> Of particular interest in the case presented is the fact that the leukemic infiltration was confined to the area of the skin flap, ie, it did not affect the surgical defect repaired by direct closure. This might be because skin flap surgery causes greater tissue damage than direct closure, and this damage, combined with the profuse hemorrhage and subsequent hematoma (related to the patient's underlying disease), would have caused greater local inflammation, which, in turn, would have promoted the recruitment of leukemic cells in a process that coincided with the transformation of myelodysplastic syndrome to AML.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: García-Arpa M, et al. Sarcoma mieloide en un área de plastia. Actas Dermosifiliogr.2011;102:737-739.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 638 "Ancho" => 851 "Tamanyo" => 113710 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nodule of firm consistency measuring 1<span class="elsevierStyleHsp" style=""></span>cm, with multiple telangiectases in the upper part of the skin flap and infiltration in the lower part of the scar.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 563 "Ancho" => 952 "Tamanyo" => 159171 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cytology: diffuse neoplastic proliferation formed of round/oval medium-sized mononuclear cells with eosinophilic cytoplasm and basophilic nuclei, several of which had indentations (hematoxylin-eosin, original magnification ×40).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 563 "Ancho" => 952 "Tamanyo" => 150520 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical staining: diffuse cytoplasmic positivity for myeloperoxidase.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myeloid Sarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.A. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 8 | 7 | 15 |
2024 Octubre | 72 | 62 | 134 |
2024 Septiembre | 95 | 30 | 125 |
2024 Agosto | 109 | 57 | 166 |
2024 Julio | 85 | 52 | 137 |
2024 Junio | 84 | 66 | 150 |
2024 Mayo | 93 | 34 | 127 |
2024 Abril | 73 | 33 | 106 |
2024 Marzo | 92 | 31 | 123 |
2024 Febrero | 82 | 43 | 125 |
2024 Enero | 75 | 38 | 113 |
2023 Diciembre | 81 | 28 | 109 |
2023 Noviembre | 90 | 27 | 117 |
2023 Octubre | 77 | 34 | 111 |
2023 Septiembre | 77 | 43 | 120 |
2023 Agosto | 72 | 27 | 99 |
2023 Julio | 97 | 35 | 132 |
2023 Junio | 93 | 35 | 128 |
2023 Mayo | 88 | 23 | 111 |
2023 Abril | 86 | 28 | 114 |
2023 Marzo | 81 | 20 | 101 |
2023 Febrero | 84 | 20 | 104 |
2023 Enero | 77 | 24 | 101 |
2022 Diciembre | 79 | 39 | 118 |
2022 Noviembre | 42 | 26 | 68 |
2022 Octubre | 34 | 22 | 56 |
2022 Septiembre | 31 | 39 | 70 |
2022 Agosto | 27 | 33 | 60 |
2022 Julio | 31 | 34 | 65 |
2022 Junio | 28 | 26 | 54 |
2022 Mayo | 80 | 46 | 126 |
2022 Abril | 110 | 47 | 157 |
2022 Marzo | 86 | 67 | 153 |
2022 Febrero | 75 | 45 | 120 |
2022 Enero | 71 | 41 | 112 |
2021 Diciembre | 54 | 47 | 101 |
2021 Noviembre | 66 | 48 | 114 |
2021 Octubre | 76 | 51 | 127 |
2021 Septiembre | 64 | 44 | 108 |
2021 Agosto | 53 | 21 | 74 |
2021 Julio | 81 | 32 | 113 |
2021 Junio | 50 | 32 | 82 |
2021 Mayo | 71 | 53 | 124 |
2021 Abril | 132 | 88 | 220 |
2021 Marzo | 102 | 30 | 132 |
2021 Febrero | 77 | 24 | 101 |
2021 Enero | 69 | 14 | 83 |
2020 Diciembre | 69 | 19 | 88 |
2020 Noviembre | 38 | 15 | 53 |
2020 Octubre | 34 | 11 | 45 |
2020 Septiembre | 41 | 17 | 58 |
2020 Agosto | 25 | 20 | 45 |
2020 Julio | 16 | 14 | 30 |
2020 Junio | 47 | 36 | 83 |
2020 Mayo | 25 | 23 | 48 |
2020 Abril | 28 | 21 | 49 |
2020 Marzo | 38 | 35 | 73 |
2020 Febrero | 6 | 5 | 11 |
2020 Enero | 0 | 1 | 1 |
2019 Diciembre | 4 | 3 | 7 |
2019 Noviembre | 0 | 5 | 5 |
2019 Octubre | 0 | 1 | 1 |
2019 Septiembre | 4 | 6 | 10 |
2019 Agosto | 0 | 8 | 8 |
2019 Julio | 0 | 11 | 11 |
2019 Junio | 2 | 10 | 12 |
2019 Mayo | 0 | 19 | 19 |
2019 Abril | 0 | 17 | 17 |
2019 Marzo | 2 | 10 | 12 |
2019 Febrero | 0 | 1 | 1 |
2019 Enero | 1 | 4 | 5 |
2018 Diciembre | 1 | 0 | 1 |
2018 Noviembre | 1 | 0 | 1 |
2018 Octubre | 3 | 0 | 3 |
2018 Septiembre | 3 | 1 | 4 |
2018 Abril | 0 | 7 | 7 |
2018 Marzo | 2 | 1 | 3 |
2018 Febrero | 59 | 3 | 62 |
2018 Enero | 69 | 11 | 80 |
2017 Diciembre | 58 | 8 | 66 |
2017 Noviembre | 48 | 6 | 54 |
2017 Octubre | 48 | 8 | 56 |
2017 Septiembre | 45 | 10 | 55 |
2017 Agosto | 57 | 10 | 67 |
2017 Julio | 46 | 4 | 50 |
2017 Junio | 63 | 11 | 74 |
2017 Mayo | 64 | 10 | 74 |
2017 Abril | 48 | 8 | 56 |
2017 Marzo | 57 | 36 | 93 |
2017 Febrero | 101 | 12 | 113 |
2017 Enero | 52 | 16 | 68 |
2016 Diciembre | 70 | 5 | 75 |
2016 Noviembre | 85 | 11 | 96 |
2016 Octubre | 130 | 21 | 151 |
2016 Septiembre | 178 | 10 | 188 |
2016 Agosto | 108 | 11 | 119 |
2016 Julio | 56 | 13 | 69 |
2016 Junio | 12 | 0 | 12 |
2016 Mayo | 6 | 16 | 22 |
2016 Abril | 6 | 2 | 8 |
2016 Marzo | 10 | 0 | 10 |
2016 Febrero | 11 | 2 | 13 |
2016 Enero | 8 | 2 | 10 |
2015 Diciembre | 14 | 0 | 14 |
2015 Noviembre | 22 | 4 | 26 |
2015 Octubre | 38 | 1 | 39 |
2015 Septiembre | 27 | 3 | 30 |
2015 Agosto | 10 | 3 | 13 |
2015 Julio | 96 | 10 | 106 |
2015 Junio | 69 | 7 | 76 |
2015 Mayo | 99 | 22 | 121 |
2015 Abril | 84 | 15 | 99 |
2015 Marzo | 56 | 7 | 63 |
2015 Febrero | 52 | 12 | 64 |
2015 Enero | 71 | 13 | 84 |
2014 Diciembre | 58 | 9 | 67 |
2014 Noviembre | 47 | 11 | 58 |
2014 Octubre | 53 | 23 | 76 |
2014 Septiembre | 55 | 13 | 68 |
2014 Agosto | 52 | 17 | 69 |
2014 Julio | 61 | 22 | 83 |
2014 Junio | 97 | 13 | 110 |
2014 Mayo | 116 | 20 | 136 |
2014 Abril | 89 | 9 | 98 |
2014 Marzo | 95 | 20 | 115 |
2014 Febrero | 76 | 10 | 86 |
2014 Enero | 54 | 12 | 66 |
2013 Diciembre | 61 | 14 | 75 |
2013 Noviembre | 50 | 12 | 62 |
2013 Octubre | 16 | 6 | 22 |
2013 Septiembre | 21 | 2 | 23 |
2013 Agosto | 16 | 5 | 21 |
2013 Julio | 18 | 13 | 31 |
2013 Junio | 13 | 12 | 25 |
2013 Mayo | 26 | 3 | 29 |
2013 Abril | 15 | 16 | 31 |
2013 Marzo | 16 | 7 | 23 |
2013 Febrero | 22 | 4 | 26 |
2013 Enero | 24 | 9 | 33 |
2012 Diciembre | 15 | 5 | 20 |