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of 19 lesions that were reclassified as malignant lesions&#46; Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found epidermal effacement in 92 &#40;43&#37;&#41; of 213 melanomas but in just 4 &#40;4&#46;2&#37;&#41; of 94 melanomas in situ or high-grade dysplastic nevi&#46; There was no effacement in 146 benign nevi &#40;114 low-grade dysplastic nevi&#44; 8 congenital nevi&#44; and 24 common nevi&#41;&#46; In other words&#44; epidermal effacement could be used&#44; with caution&#44; as a diagnostic criterion for differentiating melanoma from Spitz nevus or dysplastic nevus&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Even though epidermal effacement is a relatively common finding in melanomas &#40;found by Hantschke et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> in 86&#37; and 43&#37; of cases&#44; respectively&#41;&#44; very few studies have analyzed it&#46; Furthermore&#44; we believe that this histologic feature is unfamiliar to the majority of dermatologists&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We recently saw 2 cases of malignant melanoma with epidermal effacement&#46; The first was a superficial spreading melanoma &#40;SSM&#41;&#44; located on the right arm&#44; that had entered the vertical growth phase &#40;Breslow depth of 0&#46;95<span class="elsevierStyleHsp" style=""></span>mm and Clark level III&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The second was also a SSM in the vertical growth phase &#40;Breslow depth of 1&#46;87<span class="elsevierStyleHsp" style=""></span>mm and Clark level IV&#41; but located on the abdomen &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The tumors had been removed from a 51-year-old and a 50-year-old man&#44; respectively&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">It has been postulated that epidermal effacement is the result of an autoimmune or immunologic process as this histologic feature has also been seen in certain halo nevi &#40;pseudo-epidermal effacement&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> do not believe this to be the case as they found no association between epidermal effacement and either tumor regression or inflammatory infiltrates&#46; It might also be a physical phenomenon related to the compression caused by tumor growth<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a>&#59; this&#44; however&#44; would not explain why epidermal effacement is found in some thin melanomas &#40;with a low Breslow depth&#41; or indeed why it is not found in the vast majority of thick melanomas&#46; Epidermal effacement has also been seen in areas adjacent to melanoma ulceration as well as in association with fissures&#44; clefting&#44; and areas of dermal-epidermal separation&#44; explaining why numerous studies have suggested that this histologic feature might be a marker of subsequent progression to ulceration&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> In support of this theory&#44; we have seen epidermal effacement in several epidermotropic metastatic melanomas&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Further studies are necessary to determine whether epidermal effacement&#44; like ulceration&#44; is associated with poorer prognosis in melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Moreover&#44; epidermal effacement is observed more frequently in association with other indicators of poorer prognosis in malignant melanomas<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#58; increasing Breslow depth&#44; number of mitoses per field&#44; ulceration&#44; and vertical growth&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Until it is determined whether or not epidermal effacement&#44; like ulceration&#44; is associated with poorer prognosis&#44; we believe that it should be included in protocols for melanoma histopathology reports&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It is also interesting to note that paratumoral epidermal hyperplasia&#44; which is precisely the opposite of epidermal effacement&#44; located in zones adjacent to melanoma is associated with better prognosis in thick melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The question remains as to why epidermal effacement and ulceration occur in certain malignant melanomas independently of tumor duration&#44; Breslow depth&#44; or faster growth&#46; Epidermal effacement &#40;and therefore subsequent ulceration&#41; might be caused by the action of metalloproteases or the alteration of certain calcium-dependent adhesion molecules such as E-cadherin&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;9&#44;10</span></a></p></span>"
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Case and Research Letters
Epidermal Effacement in Malignant Melanoma
Adelgazamiento epidérmico en melanomas malignos
R. Corbalán-Véleza,
Autor para correspondencia
raulcorb@gmail.com

Corresponding author.
, I. Oviedo-Ramírezb, E. Martínez-Barbab, A. Clemente-Ruiz de Almiróna
a Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermal effacement&#44; also known as consumption of the epidermis&#44; is a histologic feature that can be seen in a number of malignant melanomas&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> It consists of the thinning or disappearance of epidermal cell layers overlying the melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Hantschke et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> found epidermal effacement in 88 &#40;86&#37;&#41; of 102 melanomas but in only 12 &#40;9&#46;6&#37;&#41; of 125 Spitz nevi&#46; They also studied 61 spitzoid lesions without a clear diagnosis using genomic hybridization techniques and found epidermal effacement in 6 &#40;14&#37;&#41; of 42 lesions that were reclassified as benign lesions and in 14 &#40;74&#37;&#41; of 19 lesions that were reclassified as malignant lesions&#46; Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found epidermal effacement in 92 &#40;43&#37;&#41; of 213 melanomas but in just 4 &#40;4&#46;2&#37;&#41; of 94 melanomas in situ or high-grade dysplastic nevi&#46; There was no effacement in 146 benign nevi &#40;114 low-grade dysplastic nevi&#44; 8 congenital nevi&#44; and 24 common nevi&#41;&#46; In other words&#44; epidermal effacement could be used&#44; with caution&#44; as a diagnostic criterion for differentiating melanoma from Spitz nevus or dysplastic nevus&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Even though epidermal effacement is a relatively common finding in melanomas &#40;found by Hantschke et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> in 86&#37; and 43&#37; of cases&#44; respectively&#41;&#44; very few studies have analyzed it&#46; Furthermore&#44; we believe that this histologic feature is unfamiliar to the majority of dermatologists&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We recently saw 2 cases of malignant melanoma with epidermal effacement&#46; The first was a superficial spreading melanoma &#40;SSM&#41;&#44; located on the right arm&#44; that had entered the vertical growth phase &#40;Breslow depth of 0&#46;95<span class="elsevierStyleHsp" style=""></span>mm and Clark level III&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The second was also a SSM in the vertical growth phase &#40;Breslow depth of 1&#46;87<span class="elsevierStyleHsp" style=""></span>mm and Clark level IV&#41; but located on the abdomen &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The tumors had been removed from a 51-year-old and a 50-year-old man&#44; respectively&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">It has been postulated that epidermal effacement is the result of an autoimmune or immunologic process as this histologic feature has also been seen in certain halo nevi &#40;pseudo-epidermal effacement&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Walters et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> do not believe this to be the case as they found no association between epidermal effacement and either tumor regression or inflammatory infiltrates&#46; It might also be a physical phenomenon related to the compression caused by tumor growth<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a>&#59; this&#44; however&#44; would not explain why epidermal effacement is found in some thin melanomas &#40;with a low Breslow depth&#41; or indeed why it is not found in the vast majority of thick melanomas&#46; Epidermal effacement has also been seen in areas adjacent to melanoma ulceration as well as in association with fissures&#44; clefting&#44; and areas of dermal-epidermal separation&#44; explaining why numerous studies have suggested that this histologic feature might be a marker of subsequent progression to ulceration&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> In support of this theory&#44; we have seen epidermal effacement in several epidermotropic metastatic melanomas&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Further studies are necessary to determine whether epidermal effacement&#44; like ulceration&#44; is associated with poorer prognosis in melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Moreover&#44; epidermal effacement is observed more frequently in association with other indicators of poorer prognosis in malignant melanomas<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#58; increasing Breslow depth&#44; number of mitoses per field&#44; ulceration&#44; and vertical growth&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Until it is determined whether or not epidermal effacement&#44; like ulceration&#44; is associated with poorer prognosis&#44; we believe that it should be included in protocols for melanoma histopathology reports&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It is also interesting to note that paratumoral epidermal hyperplasia&#44; which is precisely the opposite of epidermal effacement&#44; located in zones adjacent to melanoma is associated with better prognosis in thick melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The question remains as to why epidermal effacement and ulceration occur in certain malignant melanomas independently of tumor duration&#44; Breslow depth&#44; or faster growth&#46; Epidermal effacement &#40;and therefore subsequent ulceration&#41; might be caused by the action of metalloproteases or the alteration of certain calcium-dependent adhesion molecules such as E-cadherin&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;9&#44;10</span></a></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Corbal&#225;n-V&#233;lez R&#44; et al&#46; Adelgazamiento epid&#233;rmico en melanomas malignos&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;634-5&#46;</p>"
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ISSN: 15782190
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