array:24 [
  "pii" => "S1578219011000424"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.03.004"
  "estado" => "S300"
  "fechaPublicacion" => "2011-09-01"
  "aid" => "374"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Actas Dermosifiliogr. 2011;102:498-504"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3580
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 2800
      "PDF" => 734
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011001402"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2011-09-01"
      "aid" => "374"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Actas Dermosifiliogr. 2011;102:498-504"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5153
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3679
          "PDF" => 1472
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Novedades en dermatolog&#237;a</span>"
        "titulo" => "Papel de las quimiocinas en la progresi&#243;n del melanoma"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "498"
            "paginaFinal" => "504"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Role of Chemokines in Melanoma Progression"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2424
                "Ancho" => 2500
                "Tamanyo" => 275857
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Participaci&#243;n de las quimiocinas y receptores en la distribuci&#243;n selectiva de las met&#225;stasis en los pacientes con melanoma cut&#225;neo&#58; las flechas gruesas negras corresponden a interacciones bien caracterizadas quimiocinas-receptor&#46; Las flechas gruesas grises indican asociaciones potenciales no completamente caracterizadas&#46; Las flechas curvas delgadas representan la producci&#243;n aut&#243;loga de las quimiocinas &#40;ligandos&#41; por las propias c&#233;lulas tumorales con efectos autocrinos&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Monteagudo, A&#46; Pell&#237;n-Carcel&#233;n, J&#46;M&#46; Mart&#237;n, D&#46; Ramos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Monteagudo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Pell&#237;n-Carcel&#233;n"
              ]
              2 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Mart&#237;n"
              ]
              3 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ramos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219011000424"
          "doi" => "10.1016/j.adengl.2011.03.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000424?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001402?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000007/v1_201304241332/S0001731011001402/v1_201304241332/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219011000576"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.03.007"
    "estado" => "S300"
    "fechaPublicacion" => "2011-09-01"
    "aid" => "387"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2011;102:505-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3572
      "formatos" => array:3 [
        "EPUB" => 40
        "HTML" => 2399
        "PDF" => 1133
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Practical Dermatology</span>"
      "titulo" => "Psoriasis and Obesity&#58; A Review and Practical Recommendations"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "505"
          "paginaFinal" => "509"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Psoriasis y obesidad&#58; revisi&#243;n y recomendaciones pr&#225;cticas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;M&#46; Far&#237;as, V&#46; Serrano, C&#46; de la Cruz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;M&#46;"
              "apellidos" => "Far&#237;as"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Serrano"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "de la Cruz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011001712"
        "doi" => "10.1016/j.ad.2011.03.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001712?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000576?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000576/v1_201304241231/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219011000412"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.03.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-09-01"
    "aid" => "372"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2011;102:487-97"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 8107
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 6333
        "PDF" => 1732
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Connective Tissue Diseases and Psoriasis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "487"
          "paginaFinal" => "497"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Conectivopat&#237;as y psoriasis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1736
              "Ancho" => 2403
              "Tamanyo" => 196687
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Naive T helper &#40;T<span class="elsevierStyleInf">H</span>&#41; cells differentiate into 3 different subsets &#40;T<span class="elsevierStyleInf">H</span>1&#44;T<span class="elsevierStyleInf">H</span>2&#44;and T<span class="elsevierStyleInf">H</span>17&#41; depending on the cytokine stimuli they receive&#46; Transforming growth factor &#40;TGF&#41; &#946; and interleukin &#40;IL&#41; 6 are the primary mediators of differentiation into T<span class="elsevierStyleInf">H</span>17 cells&#44; while IL-23 contributes to the survival and proliferation of these cells&#46; Among the many cytokines secreted by T<span class="elsevierStyleInf">H</span>17 cells&#44; IL-21 intervenes in a positive feedback loop&#46; IFN indicates interferon&#59; TNF&#44; tumor necrosis factor&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Cuesta-Montero, I&#46; Belinch&#243;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Cuesta-Montero"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011001384"
        "doi" => "10.1016/j.ad.2011.03.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001384?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000412?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000412/v1_201304241231/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Novelties in Dermatology</span>"
    "titulo" => "Role of Chemokines in Melanoma Progression"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "498"
        "paginaFinal" => "504"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Monteagudo, A&#46; Pell&#237;n-Carcel&#233;n, J&#46;M&#46; Mart&#237;n, D&#46; Ramos"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "Monteagudo"
            "email" => array:1 [
              0 => "Carlos&#46;Monteagudo&#64;uv&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Pell&#237;n-Carcel&#233;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Patolog&#237;a&#44; Universidad de Valencia&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario-INCLIVA&#44; Universidad de Valencia&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de las quimiocinas en la progresi&#243;n del melanoma"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2424
            "Ancho" => 2500
            "Tamanyo" => 262194
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Involvement of chemokines and their receptors in selective metastasis in patients with cutaneous melanoma&#46; Black arrows indicate well-characterized interactions between chemokines and their receptors&#59; gray arrows indicate potential associations that remain to be fully characterized&#59; curved arrows indicate the autologous production of chemokines &#40;ligands&#41; by the tumor cells leading to autocrine effects&#46; CNS indicates central nervous system&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Melanoma has increased in frequency more than any other cancer in recent years&#44; and in affected patients the development of metastasis is the strongest predictor of mortality&#44; given the absence of clearly effective treatments for metastatic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The expression of certain chemokines and their receptors has been implicated in the molecular mechanisms that favor or inhibit metastatic spread of melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> Understanding the molecular mechanisms underlying tumor progression in melanoma is an important step that will ultimately allow not only prediction but also therapeutic intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">The Chemokines</span><p id="par0010" class="elsevierStylePara elsevierViewall">The chemokines are low-molecular-weight &#40;8-17 kDa&#41; chemotactic cytokines that cause directed cell migration and whose expression is induced by inflammatory cytokines&#44; growth factors&#44; and pathogenic stimuli&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> They have been classified into 4 families&#58; CXC&#44; CC&#44; CX3C&#44; and XC chemokines&#44; defined according to the position of the first 2 cysteine residues located in the amino-terminal region&#46; To date&#44; more than 50 chemokines and at least 19 different chemokine receptors have been identified<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Although in many cases the same receptor can recognize various different chemokine ligands&#44; 6 of the known chemokine receptors only recognize a single ligand&#46; It is thought that any cell type can express chemokines or their receptors&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The expression of chemokine receptors is dependent upon cell type&#44; differentiation state&#44; the concentration of chemokines present in the microenvironment&#44; the presence of inflammatory cytokines&#44; and the occurrence of local hypoxia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The binding of chemokines to their receptors at the cell surface leads to a complex series of cellular responses&#44; such as activation of different signaling pathways and cytoskeletal reorganization&#44; which favor the formation of pseudopodia and facilitate cell movement&#46; Chemokine receptors act through heterotrimeric G proteins that regulate signaling pathways such as those involving mitogen-associated protein kinases&#44; phospholipase C-&#946;&#44; phosphoinositol-3-kinase&#44; RAS&#44; and Rho-family GTPases&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7&#44;8</span></a> RhoC is thought to play an important role in the occurrence of metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Chemokines can also act in synergy with metalloproteinases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Selective Spread of Metastasis</span><p id="par0015" class="elsevierStylePara elsevierViewall">One of the great enigmas that has faced oncological pathology in the last 2 centuries is the question of how metastasis selectively targets some organs and not others irrespective of the blood flow they receive and&#44; therefore&#44; the quantities of circulating tumor cells that reach them&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In 1889&#44; after studying more than 900 autopsies&#44; Stephen Paget<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> proposed the &#8220;seed and soil&#8221; hypothesis to explain this phenomenon&#46; According to this theory&#44; metastases do not occur randomly&#59; instead&#44; certain tumor cells &#40;the &#8220;seeds&#8221;&#41; have a particular affinity for the microenvironment of the affected organ &#40;the &#8220;soil&#8221;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The site of distant metastases also has prognostic value in patients with melanoma&#46; Metastases found in the skin&#44; subcutaneous tissue&#44; and lymph nodes are associated with longer survival than visceral metastases&#46; Consequently&#44; the American Joint Committee on Cancer subclassifies metastases into M1a for distant cutaneous&#44; subcutaneous&#44; and lymph-node metastases&#44; M1b for lung metastases&#44; and M1c for metastases to other visceral sites&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Over the last decade&#44; it has been recognized that chemokines and their receptors play a role in metastatic spread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;16</span></a> Muller et al<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> observed overexpression of CXCR4&#44; CCR10&#44; and CCR7 in melanoma cell lines&#46; Since CXCL12&#44; the ligand for the receptor CXCR4&#44; is preferentially detected in the lymph nodes&#44; lungs&#44; liver&#44; and bone marrow&#44; the authors proposed a role for the receptor in the selective spread of metastases to these sites &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In support of this hypothesis&#44; expression of CXCR4 has been detected in subcutaneous and lymph-node metastases of melanoma in humans and in melanoma cell lines&#44; where it facilitates the adhesion and migration of tumor cells through interaction with its ligands&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Interactions between CXCR4 and CXCL12 are responsible for cell migration during embryogenesis and the mobilization of hematopoietic stem cells&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;17</span></a> and they have a recognized role in metastatic spread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> At least 1 subpopulation of tumor cells expresses CXCR4 in many types of cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Situations such as hypoxia that increase activation of the so-called hypoxia-inducible factor cause an increase in the expression of CXCR4 by tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The only known ligand of CXCR4 is CXCL12&#44; a 68-amino-acid chemokine that has angiogenic properties&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> promotes tumor growth&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> and facilitates tissue invasion by increasing the production of various metalloproteinases&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> In the B16 cell line&#44; a well-characterized mouse melanoma cell line with known metastatic potential&#44; tumor cells transfected with CXCR4 are reported to have a 10-fold greater capacity to cause lung metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The receptor CCR7 also plays an important role in melanoma&#44; and its ligands &#40;CCL19 and CCL21&#41; are expressed in dermal lymph vessels&#44; paracortical areas of the lymph nodes&#44; and high endothelial venules of the lymph nodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> The interaction of CCR7 with its ligands has been implicated in the development of lymph-node metastases in an experimental mouse model of melanoma<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Mechanisms have also been described to control the expression of the ligands of CCR7&#44; particularly CCL21&#44; in lymph nodes where melanoma metastasis has occurred&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> As we will see&#44; however&#44; the role of CCL21 and CCR7 in metastasis is complex&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The tendency of melanomas to produce skin metastases is a well-known phenomenon&#46; A role in this process has been proposed for the receptor CCR10&#44; whose ligand CCL27 is predominantly expressed in the basal cells of the epidermis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Patients with hematogenous spread of melanoma often also have gastrointestinal metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> CCR9 participates in the development of metastases in the small intestine&#44; which expresses its ligand CCL25<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The receptor CCR4 has also recently been implicated in cerebral metastases of melanoma<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">It has also been shown in recent years that tumor cells from various types of cancer&#44; including melanoma&#44; express not only chemokine receptors but also the chemokines themselves&#46; This coordinated expression thus generates circuits or autocrine feedback loops in the tumor cells themselves&#46; Notable examples are CXCL12 and its receptor CXCR4 and CCL21 and its receptor CCR7&#44; which play an essential role in tumor growth and migration&#44; and therefore the aggressiveness of the tumor cells&#46; These autocrine loops stimulate not only the proliferative capacity but also the invasive capacity or metastatic potential of tumor cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Angiogenesis</span><p id="par0045" class="elsevierStylePara elsevierViewall">Angiogenesis is essential for tumor growth and correlates with the development of metastasis&#46; The role of chemokines in this process is also complex&#46; In general&#44; CXC chemokines containing glu-leu-arg &#40;ELR according to the single-letter code for amino acids&#41; domains&#8212;specifically CXCL2&#44; CXCL3&#44; CXCL5&#44; CXCL6&#44; CXCL7&#44; and CXCL8 &#40;all ligands of CXCR2&#41;&#8212;function as angiogenic cytokines&#44; although CXCL12&#44; which does not contain ELR domains&#44; also has angiogenic effects&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> CXCL8 is a particularly angiogenic chemokine and its receptors CXCR1 and CXCR2 are expressed on endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> CXCL8 exerts its effect largely by inducing expression of the metalloproteinases MMP2 and MMP9&#44; and also vascular endothelial growth factor&#44; which has an autocrine effect on its receptor in the same endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> In contrast&#44; CXCL4&#44; CXCL9&#44; CXCL10&#44; and CXCL11 are antiangiogenic&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Immune Response</span><p id="par0050" class="elsevierStylePara elsevierViewall">Chemokines act as mediators in the recruitment of different types of cells in the tumor microenvironment&#59; these include lymphocytes&#44; tumor-associated macrophages &#40;TAM&#41; and neutrophils &#40;TAN&#41;&#44; fibroblasts&#44; mesenchymal stem cells&#44; and endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two types of TAM and TAN have been identified&#58; type 1&#44; which are antitumoral&#44; and type 2&#44; which are protumoral&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32&#44;33</span></a> The T-helper 1 &#40;T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>1&#41; lymphocyte response&#44; which is greater in regressing melanomas&#44;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#44;35</span></a> has an antitumoral effect&#44; whereas the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>2 response facilitates tumor progression&#46; Nevertheless&#44; the situation is complex&#46; This is highlighted by the chemokines CXCL10 and CXCL4&#44; which both have affinity for the receptor CXCR3 but nevertheless have opposing effects&#46; CXCL10 induces production of the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>1 cytokine interferon-&#947; by T cells&#44; whereas CXCL4 promotes expression of the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>2 cytokines interleukin 4&#44; 5&#44; and 13&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> CXCL10 appears to act preferentially on CXCR3A&#44; whereas CXCL4 binds a variant of the same receptor&#44; CXCR3B&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> There is increasing evidence that the chemokines present in human tumors contribute more to tumor growth and progression and to immunosuppression than they generally do to an effective antitumor response&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> What is clear is that the interactions between chemokines and their receptors sometimes potentiate and sometimes inhibit the immune response&#46; Thus&#44; the expression of CCL27 is an important inducer of the immune response in squamous cell tumors and its inhibition contributes to an evasion of the immune response and favors tumor progression&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> In fact&#44; expression of CCL27 is lower in melanoma metastases than in primary cutaneous melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> However&#44; overexpression of CCR10&#44; the receptor for CCL27&#44; in the B16 melanoma cell line&#44; probably stimulated by high levels of CCL27 expression in the epidermis&#44; appears to increase the resistance of these cells to the immune response against the tumor and protects against Fas-mediated apoptosis&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> In fact&#44; overexpression of CCR10 in B16 melanoma cells leads to a notable increase in the occurrence of lymph-node metastases in mice following injection of the transfected cells into the skin&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Increased expression of CCR10 has also been observed by immunohistochemistry in primary melanomas from patients with positive sentinel lymph node biopsy compared to those in whom biopsy was negative for metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Contradictory data have been obtained regarding the influence of CXCL12 on the antitumoral immune response&#46; The production of CXCL12 by tumor cells can reduce the immune response to the tumor by attracting and promoting the survival of dendritic cell precursors &#40;pre-DC2&#41; that express CXCR4 and altering the distribution&#44; immunity&#44; and stimulus of fibrosis of pre-DC1 cells&#44; causing immature dendritic cells not to present tumor antigens&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> However&#44; it has also been reported that the production of CXCL12 by B16F1 melanoma cells that have been genetically modified to produce the cytokine and injected into immunocompetent mice led to rejection in 50&#37; of cases and induced specific memory responses to the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Consistent with this observation&#44; secretion of CXCL12 by genetically modified melanoma cells attracts CXCR4-positive cutaneous T lymphocytes in organotypic cultures and facilitates tumor regression&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">One of the most recent and striking advances in relation to the role of chemokines in the immune response relates to CCL21&#46; Under normal circumstances&#44; this cytokine is produced by fibroblastic reticular cells &#40;FRC&#41; in the paracortex of the lymph nodes and attracts both antigen-presenting cells and melanoma cells to that site&#44; since both express CCR7&#46; It has been shown that the tumor cells from different types of cancer&#44; including melanoma&#44; can produce CCL19 and CCL21 under conditions of slow interstitial flow and lead to an autocrine effect referred to as autologous chemotaxis&#44; which potentiates cell migration in the direction of the flow towards the lymph vessels&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Comparison of the behavior of B16 melanoma cells expressing high and low levels of CCL21 following implantation into syngeneic immunocompetent mice revealed that cells expressing high levels of the chemokine produced larger tumors despite attracting more leukocytes and antigen-presenting cells&#46; This effect&#44; which is not observed in vitro&#44; depends on the host response&#44; since it does not occur in immunodeficient mice&#46; In other words&#44; high endogenous expression of CCL21 in melanoma cells favors immune tolerance and therefore progression of the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> Tumors expressing high levels of CCL21 have more CD4<span class="elsevierStyleSup">&#43;</span>&#44; CD25<span class="elsevierStyleSup">&#43;</span>&#44; FoxP3<span class="elsevierStyleSup">&#43;</span> regulatory T cells and express more transforming growth factor &#946;1&#44; which favors phenotypic change of M1 &#40;antitumoral&#41; to M2 &#40;protumoral&#41; macrophages&#46; Lymphoid tissue inducer cells were also present along with a network of FRC cells and some vessels with characteristics of high endothelial venules&#46; However&#44; tumors with low levels of CCL21 expression had a fundamentally cytotoxic T-cell response&#44; with greater production of interferon-&#947; and interleukins 2 and 4&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Survival of Tumor Cells</span><p id="par0065" class="elsevierStylePara elsevierViewall">CXCL12 promotes survival of tumor cells expressing the receptor CXCR4 when grown under suboptimal conditions such as in the hypoxic environment commonly found in tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> CXCL12 can also stimulate the production of metalloproteinases&#44; which facilitate tissue invasion by the tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The interaction between CXCL9 and CXCR3 that occurs in tumor cells also potentiates their survival<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> and the transendothelial migration of melanoma cells&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> In fact&#44; high expression of both CXCR4 and CXCR3 by melanoma cells is a sign of poor prognosis in affected patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#8211;50</span></a> although high-level expression of CXCR3 in circulating lymphocytes in patients with stage 3 melanoma is an indicator of a good immune response against the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> High levels of CXCL10 expression also reduce the proliferative and invasive capacity of melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> The role of the more recently described receptor CXCR7 remains to be fully determined&#46; It is known to bind both CXCL12 and CXCL11 and appears to eliminate them&#44; but its effects in melanomas are unclear&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The effect of ligands for CXCR2 during tumor progression is complex&#46; An intriguing observation is that chemokine signaling through CXCR2 induces senescence in the initial phases of tumor development but not in later phases&#44; when it also has tumorigenic effects&#44; perhaps due to the accumulation of genetic abnormalities in the tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> Thus&#44; high expression of CXCR1 and CXCR2 in melanoma cells confers an aggressive phenotype as a result of a greater proliferative&#44; migratory&#44; and growth capacity of the tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a> The role of CCL2&#44; although not fully elucidated&#44; also appears to be biphasic&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Interestingly&#44; when cells become isolated during the process of migration and dissemination&#44; they become susceptible to a type of apoptosis known as anoikis&#44; but expression of CXCR4 and CCR7 allows them to escape this process by reducing expression of the modifying factor bcl-2&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Therapeutic Targets</span><p id="par0080" class="elsevierStylePara elsevierViewall">The confirmation that expression of certain chemokine receptors and their corresponding ligands influences the development of metastasis has led to the proposal of using antagonists&#44; inhibitors&#44; or inactivators of those receptors and ligands to prevent metastatic spread of melanoma&#46; Thus&#44; neutralization of the interaction of some chemokines with their receptors&#8212;such as CXCL12 with CXCR4 or CCL19 and CCL21 with CCR7&#8212;could be predicted to prevent the development of metastasis&#46; Preclinical studies in melanoma and other cancers appear to confirm this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;19&#44;57&#44;58</span></a> The interaction between CXCL12 and CXCR4&#44; however&#44; has a wide range of important physiological roles&#44; and as a result&#44; may not represent a viable therapeutic target in patients with melanoma&#46; Nevertheless&#44; CXCR4 is the therapeutic target against which most treatments are directed in multiple myeloma and leukemia&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">There is evidence that expression of CXCL8 in melanoma functions as an autocrine or paracrine growth factor and promotes angiogenesis and tumor invasion through its interaction with the receptors CXCR1 and CXCR2&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> As a consequence&#44; these chemokine receptors are potential therapeutic targets&#46; Indeed&#44; inhibitors of these receptors &#40;SCH-479833 and SCH-527123&#41; and also humanized neutralizing antibodies against them inhibit the proliferation&#44; invasion&#44; and metastatic growth of melanomas in immunodeficient mice&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> Other molecules that function as antagonists of these 2 receptors &#40;repertaxin for CXCR1 and SB-225002 and SB-332235 for CXCR2&#41; have been used in inflammatory conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Somewhat paradoxically&#44; high endogenous production of CCL21 by melanoma cells causes immunosuppression&#44; whereas exogenous provision of this chemokine has an effective antitumor effect&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> Care should therefore be taken when considering the use of CCL21 antagonists such as the recently proposed Chemotrap-1&#44; which blocks in vitro and in vivo migration of melanoma cells towards the lymph vessels and inhibits in-transit metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0095" class="elsevierStylePara elsevierViewall">The participation of chemokines and their receptors in the progression of melanoma is important&#44; complex&#44; and dynamic&#44; and is dependent on both the characteristics of the tumor cells and on those of other cells present in the host microenvironment of the tumor&#46; Cellular and molecular interactions determine whether a potentiating effect that favors tumor progression or an antitumor effect that favors regression or at least stabilization of the melanoma predominates&#46; Given the essential role of interactions such as CXCR4-CXCL12 in the physiology of different organs and systems&#44; care should be taken in any attempts to block their function until more information is available on the potential effects&#46; Drugs targeting the chemokines and their receptors have begun to be used in some cancers and inflammatory conditions&#44; and this will provide important information regarding the advantages and drawbacks of exploiting these interactions as therapeutic targets before they are used in patients with melanoma&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:2 [
          "identificador" => "xres95347"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec82507"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres95348"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec82508"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "The Chemokines"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Selective Spread of Metastasis"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Angiogenesis"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Immune Response"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Survival of Tumor Cells"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Therapeutic Targets"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conclusions"
        ]
        12 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflicts of Interest"
        ]
        13 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-01-06"
    "fechaAceptado" => "2011-03-08"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec82507"
          "palabras" => array:4 [
            0 => "Chemokines"
            1 => "Metastasis"
            2 => "Melanoma"
            3 => "Receptors"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82508"
          "palabras" => array:4 [
            0 => "Quimiocinas"
            1 => "Metastasis"
            2 => "Melanoma"
            3 => "Receptores"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Metastasis is the main cause of death from melanoma&#46; Chemokines are low molecular weight chemotactic cytokines that facilitate cellular migration&#46; Thus&#44; cells that express receptors for a given chemokine are attracted to the site of its production&#46; As certain chemokines are found in abundance in organs that are common targets of metastasis and receptors for these chemokines are expressed by tumor cells&#44; it was hypothesized that chemokine gradients might selectively facilitate metastasis to these organs&#46; A later finding that these chemokines were produced by tumor cells&#44; with evidence of autocrine effects&#44; obliged the modification of that hypothesis&#46; Many chemokines are also known to have opposing effects according to the type of cell they are acting on &#40;tumor&#44; inflammatory&#47;immune&#44; or endothelial cells&#41;&#44; their functional status&#44; or interactions with other molecules&#46; The expression of chemokines and their receptors by melanoma cells enhances tumor progression by altering their microenvironment&#44; stimulating angiogenesis&#44; and inhibiting the immune response&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las met&#225;stasis son la principal causa de mortalidad en el melanoma&#46; Las quimiocinas son citocinas quimiot&#225;cticas de bajo peso molecular que permiten la migraci&#243;n celular&#44; atrayendo a c&#233;lulas que expresan sus receptores&#46; Como algunas quimiocinas son abundantes en &#243;rganos que son asiento com&#250;n de metastasis&#44; y sus receptores son expresados por las c&#233;lulas tumorales&#44; se plante&#243; la hip&#243;tesis de que un gradiente de estas quimiocinas facilitar&#237;a selectivamente las met&#225;stasis a esos &#243;rganos&#46; El hallazgo posterior de la producci&#243;n de estas quimiocinas por las propias c&#233;lulas tumorales&#44; y su efecto autocrino&#44; obliga a modular esta hip&#243;tesis&#46; Adem&#225;s&#44; muchas quimiocinas tienen efectos contrapuestos dependiendo del tipo celular sobre el que act&#250;an &#40;tumoral&#44; inflamatorio&#47; inmunitario&#44; endotelial&#41;&#44; su estado funcional y otras interacciones moleculares&#46; En el melanoma las c&#233;lulas tumorales adquieren ventajas de la expresi&#243;n de quimiocinas y receptores alterando su microambiente&#44; estimulando la angiog&#233;nesis y evadiendo la respuesta inmune&#44; facilitando as&#237; la progresi&#243;n tumoral&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Monteagudo C&#44; et al&#46; Papel de las quimiocinas en la progresi&#243;n del melanoma&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;498-504&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2424
            "Ancho" => 2500
            "Tamanyo" => 262194
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Involvement of chemokines and their receptors in selective metastasis in patients with cutaneous melanoma&#46; Black arrows indicate well-characterized interactions between chemokines and their receptors&#59; gray arrows indicate potential associations that remain to be fully characterized&#59; curved arrows indicate the autologous production of chemokines &#40;ligands&#41; by the tumor cells leading to autocrine effects&#46; CNS indicates central nervous system&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Family&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Receptor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Chemokines&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL6 and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL1&#44; 2&#44; 3&#44; 5&#44; 6&#44; 7&#44; and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL9&#44; 10 and 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL11 and 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL3&#44; 4&#44; 5&#44; 7&#44; 14&#44; 15&#44; 16&#44; and 23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL2&#44; 7&#44; 8&#44; 12&#44; and 13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL5&#44; 7&#44; 11&#44; 13&#44; 15&#44; 24&#44; 26&#44; and 28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL2&#44; 3&#44; 5&#44; 17&#44; and 22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL3&#44; 4&#44; 5&#44; and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL19 and 21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL1&#44; 4&#44; and 17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL27 and 28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3CR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3CL1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XCL1 and 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab181792.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of Chemokines and Their Receptors&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:61 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent progress in understanding the pathology of malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Kuphal"
                            1 => "A&#46; Bosserhoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.2617"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "2009"
                        "volumen" => "219"
                        "paginaInicial" => "400"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19771562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The good and the bad of chemokines&#47;chemokine receptors in melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Richmond"
                            1 => "J&#46; Yang"
                            2 => "Y&#46; Su"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1755-148X.2009.00554.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pigment Cell Melanoma Res"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "175"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19222802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines and chemokine receptors&#58; new insights into cancer-related inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Lazennec"
                            1 => "A&#46; Richmond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.molmed.2010.01.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Mol Med"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "133"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20163989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of chemokine receptors in breast cancer metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; M&#252;ller"
                            1 => "B&#46; Homey"
                            2 => "H&#46; Soto"
                            3 => "N&#46; Ge"
                            4 => "D&#46; Catron"
                            5 => "M&#46;E&#46; Buchanan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35065016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2001"
                        "volumen" => "410"
                        "paginaInicial" => "50"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11242036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer and the chemokine network"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Balkwill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrc1388"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Cancer"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "540"
                        "paginaFinal" => "550"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15229479"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines in tumor progression and metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Tanaka"
                            1 => "Z&#46; Bai"
                            2 => "Y&#46; Srinoulprasert"
                            3 => "B&#46;G&#46; Yang"
                            4 => "H&#46; Hayasaka"
                            5 => "M&#46; Miyasaka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1349-7006.2005.00059.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Sci"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "317"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15958053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Robledo"
                            1 => "R&#46;A&#46; Bartolom&#233;"
                            2 => "N&#46; Longo"
                            3 => "J&#46;M&#46; Rodr&#237;guez-Frade"
                            4 => "M&#46; Mellado"
                            5 => "I&#46; Longo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M106912200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2001"
                        "volumen" => "276"
                        "paginaInicial" => "45098"
                        "paginaFinal" => "45105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11571298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How chemokines invite leukocytes to dance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Thelen"
                            1 => "J&#46;V&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ni.f.207"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Immunol"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "953"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18711432"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genomic analysis of metastasis reveals an essential role for RhoC"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Clark"
                            1 => "T&#46;R&#46; Golub"
                            2 => "E&#46;S&#46; Lander"
                            3 => "R&#46;O&#46; Hynes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35020106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2000"
                        "volumen" => "406"
                        "paginaInicial" => "532"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10952316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing&#44; whereas it degrades CTAP-III&#44; PF-4&#44; and GRO-alfa and leaves RANTES and MCP-2 intact"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;E&#46; Van den Steen"
                            1 => "P&#46; Proost"
                            2 => "A&#46; Wuyts"
                            3 => "J&#46; Van Damme"
                            4 => "G&#46; Opdenakker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2000"
                        "volumen" => "96"
                        "paginaInicial" => "2673"
                        "paginaFinal" => "2681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023497"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal cell-derived factor-1&#945; promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Bartolom&#233;"
                            1 => "B&#46;G&#46; G&#225;lvez"
                            2 => "N&#46; Longo"
                            3 => "F&#46; Baleux"
                            4 => "G&#46;N&#46; Van Muijen"
                            5 => "P&#46; S&#225;nchez-Mateos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "2534"
                        "paginaFinal" => "2543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15059909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Bartolom&#233;"
                            1 => "S&#46; Ferreiro"
                            2 => "M&#46;E&#46; Miquilena-Colina"
                            3 => "L&#46; Mart&#237;nez-Prats"
                            4 => "M&#46;L&#46; Soto-Montenegro"
                            5 => "D&#46; Garc&#237;a-Bernal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2353/ajpath.2009.080636"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2009"
                        "volumen" => "174"
                        "paginaInicial" => "602"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19147814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of cancer metastasis&#58; the &#8220;seed and soil&#8221; hypothesis revisited"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;J&#46; Fidler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature Rev Cancer"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "453"
                        "paginaFinal" => "458"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The distribution of secondary growths in cancer of the breast"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Paget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1889"
                        "volumen" => "1"
                        "paginaInicial" => "571"
                        "paginaFinal" => "573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Final version of 2009 AJCC melanoma staging and classification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Balch"
                            1 => "J&#46;E&#46; Gershenwald"
                            2 => "S&#46;J&#46; Soong"
                            3 => "J&#46;F&#46; Thompson"
                            4 => "M&#46;B&#46; Atkins"
                            5 => "D&#46;R&#46; Byrd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2009.23.4799"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "6199"
                        "paginaFinal" => "6206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19917835"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An attractive force in metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Liotta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35065180"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2001"
                        "volumen" => "410"
                        "paginaInicial" => "24"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11242022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dependence of human stem cell engraftment and repopulation of NOD&#47;SCID mice on CXCR4"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Peled"
                            1 => "I&#46; Petit"
                            2 => "O&#46; Kollet"
                            3 => "M&#46; Magid"
                            4 => "T&#46; Ponomaryov"
                            5 => "T&#46; Byk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Science"
                        "fecha" => "1999"
                        "volumen" => "283"
                        "paginaInicial" => "845"
                        "paginaFinal" => "848"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9933168"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606694853"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of the chemokine receptor CXCR4 by hypoxia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Schioppa"
                            1 => "B&#46; Uranchimeg"
                            2 => "A&#46; Saccani"
                            3 => "S&#46;K&#46; Biswas"
                            4 => "A&#46; Doni"
                            5 => "A&#46; Rapisarda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20030267"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "2003"
                        "volumen" => "198"
                        "paginaInicial" => "1391"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14597738"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blockade of the stromal cell-derived factor&#47;CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Guleng"
                            1 => "K&#46; Tateishi"
                            2 => "M&#46; Ohta"
                            3 => "F&#46; Kanai"
                            4 => "A&#46; Jazag"
                            5 => "H&#46; Ijichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-04-3833"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "65"
                        "paginaInicial" => "5864"
                        "paginaFinal" => "5871"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1&#47;CXCL12 secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Orimo"
                            1 => "P&#46;B&#46; Gupta"
                            2 => "D&#46;C&#46; Sgroi"
                            3 => "F&#46; Arenzana-Seisdedos"
                            4 => "T&#46; Delaunay"
                            5 => "R&#46; Naeem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cell.2005.02.034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "2005"
                        "volumen" => "121"
                        "paginaInicial" => "335"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15882617"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Murakami"
                            1 => "W&#46; Maki"
                            2 => "A&#46;R&#46; Cardones"
                            3 => "H&#46; Fang"
                            4 => "A&#46; Tun Kyi"
                            5 => "F&#46;O&#46; Nestle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2002"
                        "volumen" => "62"
                        "paginaInicial" => "7328"
                        "paginaFinal" => "7334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12499276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lessons learned from lymphocytes&#58; CC chemokine receptor&#8211;7 involved in lymphogenic metastasis of melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Forster"
                            1 => "L&#46; Ohl"
                            2 => "G&#46; Henning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2001"
                        "volumen" => "93"
                        "paginaInicial" => "1588"
                        "paginaFinal" => "1589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11698555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;E&#46; Wiley"
                            1 => "E&#46;B&#46; Gonz&#225;lez"
                            2 => "W&#46; Maki"
                            3 => "M&#46;T&#46; Wu"
                            4 => "S&#46;T&#46; Hwang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2001"
                        "volumen" => "93"
                        "paginaInicial" => "1638"
                        "paginaFinal" => "1643"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11698568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CCL21 chemokine regulates receptor CCR7 bearing malignant melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Takeuchi"
                            1 => "A&#46; Fujimoto"
                            2 => "M&#46; Tanaka"
                            3 => "T&#46; Yamano"
                            4 => "E&#46; Hsueh"
                            5 => "D&#46;S&#46; Hoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "2351"
                        "paginaFinal" => "2358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15073111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer cells regulate lymphocyte recruitment and leukocyte-endothelium interactions in the tumor-draining lymph node"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Carri&#232;re"
                            1 => "R&#46; Colisson"
                            2 => "C&#46; Jiguet-Jiglaire"
                            3 => "E&#46; Bellard"
                            4 => "G&#46; Bouche"
                            5 => "T&#46; Al Saati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-05-1190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "65"
                        "paginaInicial" => "11639"
                        "paginaFinal" => "11648"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16357175"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma in the gastrointestinal tract"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Blecker"
                            1 => "S&#46; Abraham"
                            2 => "E&#46;E&#46; Furth"
                            3 => "M&#46;L&#46; Kochman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.1999.01604.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1999"
                        "volumen" => "94"
                        "paginaInicial" => "3427"
                        "paginaFinal" => "3433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10606298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of CCR9 &#47; CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Amersi"
                            1 => "A&#46;M&#46; Terando"
                            2 => "Y&#46; Goto"
                            3 => "R&#46;A&#46; Scolyer"
                            4 => "J&#46;F&#46; Thompson"
                            5 => "A&#46;N&#46; Tran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-07-2025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "638"
                        "paginaFinal" => "645"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18245522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokine-chemokine receptor axes in melanoma brain metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Izraely"
                            1 => "A&#46; Klein"
                            2 => "O&#46; Sagi-Assif"
                            3 => "T&#46; Meshel"
                            4 => "G&#46; Tsarfaty"
                            5 => "D&#46;S&#46; Hoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.imlet.2009.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Lett"
                        "fecha" => "2010"
                        "volumen" => "130"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20005902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Kang"
                            1 => "R&#46;E&#46; Mansel"
                            2 => "W&#46;G&#46; Liang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Oncol"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "1429"
                        "paginaFinal" => "1434"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15809737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Shields"
                            1 => "M&#46;E&#46; Fleury"
                            2 => "C&#46; Yong"
                            3 => "A&#46;A&#46; Tomei"
                            4 => "G&#46;J&#46; Randolph"
                            5 => "M&#46;A&#46; Swartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccr.2007.04.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Cell"
                        "fecha" => "2007"
                        "volumen" => "11"
                        "paginaInicial" => "526"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCL8 and its cognate receptors in melanoma progression and metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Singh"
                            1 => "A&#46;P&#46; Singh"
                            2 => "B&#46; Sharma"
                            3 => "L&#46;B&#46; Owen"
                            4 => "R&#46;K&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/fon.09.128"
                      "Revista" => array:6 [
                        "tituloSerie" => "Future Oncol"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "111"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20021212"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuning inflammation and immunity by chemokine sequestration&#58; decoys and more"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Mantovani"
                            1 => "R&#46; Bonecchi"
                            2 => "M&#46; Locati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nri1964"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Immunol"
                        "fecha" => "2006"
                        "volumen" => "6"
                        "paginaInicial" => "907"
                        "paginaFinal" => "918"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17124512"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polarization of tumor-associated neutrophil phenotype by TGF-beta&#58; &#8220;N1&#8221; versus &#8220;N2&#8221; TAN"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46;G&#46; Fridlender"
                            1 => "J&#46; Sun"
                            2 => "S&#46; Kim"
                            3 => "V&#46; Kapoor"
                            4 => "G&#46; Cheng"
                            5 => "L&#46; Ling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccr.2009.06.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Cell"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "183"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19732719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T Helper 1 cytokine mRNA is increased in spontaneously regressing primary melanomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;A&#46; Lowes"
                            1 => "G&#46;A&#46; Bishop"
                            2 => "K&#46; Crotty"
                            3 => "R&#46;C&#46; Barnetson"
                            4 => "G&#46;M&#46; Halliday"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1997"
                        "volumen" => "108"
                        "paginaInicial" => "914"
                        "paginaFinal" => "919"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9182821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCl10 reduces melanoma proliferation and invasivity in vitro and in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Antonicelli"
                            1 => "J&#46; Lorin"
                            2 => "S&#46; Kurdykowski"
                            3 => "S&#46;C&#46; Gangloff"
                            4 => "R&#46; Le Naour"
                            5 => "J&#46;M&#46; Sallenave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2010.10176.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "164"
                        "paginaInicial" => "720"
                        "paginaFinal" => "728"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21155750"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Romagnani"
                            1 => "L&#46; Maggi"
                            2 => "B&#46; Mazzinghi"
                            3 => "L&#46; Cosmi"
                            4 => "L&#46; Lasagni"
                            5 => "F&#46; Liotta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2005.09.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2005"
                        "volumen" => "116"
                        "paginaInicial" => "1372"
                        "paginaFinal" => "1379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16337473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and cancer&#58; back to Virchow"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Balkwill"
                            1 => "A&#46; Mantovani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(00)04046-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "357"
                        "paginaInicial" => "539"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11229684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor immune escape by the loss of homeostatic chemokine expression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Pivarcsi"
                            1 => "A&#46; M&#252;ller"
                            2 => "A&#46; Hippe"
                            3 => "J&#46; Rieker"
                            4 => "A&#46; van Lierop"
                            5 => "M&#46; Steinhoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "P Natl Acad Sci USA"
                        "fecha" => "2007"
                        "volumen" => "104"
                        "paginaInicial" => "19055"
                        "paginaFinal" => "19060"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene expression signatures for tumor progression&#44; tumor subtype&#44; and tumor thickness in laser-microdissected melanoma tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jaeger"
                            1 => "D&#46; Koczan"
                            2 => "H&#46;J&#46; Thiesen"
                            3 => "S&#46;M&#46; Ibrahim"
                            4 => "G&#46; Gross"
                            5 => "R&#46; Spang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-06-1820"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "paginaInicial" => "806"
                        "paginaFinal" => "815"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune evasion by murine melanoma mediated through chemokine receptor-10"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Murakami"
                            1 => "A&#46;R&#46; Cardones"
                            2 => "S&#46;E&#46; Finkelstein"
                            3 => "N&#46;P&#46; Restifo"
                            4 => "B&#46;A&#46; Klaunberg"
                            5 => "F&#46;O&#46; Nestle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20030593"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "2003"
                        "volumen" => "198"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Simonetti"
                            1 => "G&#46; Goteri"
                            2 => "G&#46; Lucarini"
                            3 => "A&#46; Filosa"
                            4 => "T&#46; Pieramici"
                            5 => "C&#46; Rubini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2006.01.043"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16644201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Zou"
                            1 => "V&#46; Machelon"
                            2 => "A&#46; Coulomb-L&#8217;Hermin"
                            3 => "J&#46; Borvak"
                            4 => "F&#46; Nome"
                            5 => "T&#46; Isaeva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nm1201-1339"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature Med"
                        "fecha" => "2001"
                        "volumen" => "7"
                        "paginaInicial" => "1339"
                        "paginaFinal" => "1346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11726975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 &#40;SDF-1&#41;&#58; local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Dunussi-Joannopoulos"
                            1 => "K&#46; Zuberek"
                            2 => "K&#46; Runyon"
                            3 => "R&#46;G&#46; Hawley"
                            4 => "A&#46; Wong"
                            5 => "J&#46; Erickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2002"
                        "volumen" => "100"
                        "paginaInicial" => "1551"
                        "paginaFinal" => "1558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12176869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXC chemokine ligand 12 &#40;stromal cell-derived factor 1 alpha&#41; and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Zhang"
                            1 => "R&#46; Somasundaram"
                            2 => "K&#46; Berencsi"
                            3 => "L&#46; Caputo"
                            4 => "P&#46; Rani"
                            5 => "D&#46; Guerry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2005"
                        "volumen" => "174"
                        "paginaInicial" => "5856"
                        "paginaFinal" => "5863"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15843590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;D&#46; Shields"
                            1 => "I&#46;C&#46; Kourtis"
                            2 => "A&#46;A&#46; Tomei"
                            3 => "J&#46;M&#46; Roberts"
                            4 => "M&#46;A&#46; Swartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1185837"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "328"
                        "paginaInicial" => "749"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20339029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Kawada"
                            1 => "M&#46; Sonoshita"
                            2 => "H&#46; Sakashita"
                            3 => "A&#46; Takabayashi"
                            4 => "Y&#46; Yamaoka"
                            5 => "T&#46; Manabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-03-1757"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "4010"
                        "paginaFinal" => "4017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15173015"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCL9 induces chemotaxis&#44; chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Amatschek"
                            1 => "R&#46; Lucas"
                            2 => "A&#46; Eger"
                            3 => "M&#46; Pflueger"
                            4 => "H&#46; Hundsberger"
                            5 => "C&#46; Knoll"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6606056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2011"
                        "volumen" => "104"
                        "paginaInicial" => "469"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21179030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Scala"
                            1 => "A&#46; Ottaiano"
                            2 => "P&#46;A&#46; Ascierto"
                            3 => "M&#46; Cavalli"
                            4 => "E&#46; Simeone"
                            5 => "P&#46; Giuliano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-04-1887"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "11"
                        "paginaInicial" => "1835"
                        "paginaFinal" => "1841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15756007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of CXCR3 and CXCR4 expression in primary melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;I&#46; Longo-Imedio"
                            1 => "N&#46; Longo"
                            2 => "I&#46; Trevi&#241;o"
                            3 => "P&#46; L&#225;zaro"
                            4 => "P&#46; Sanchez-Mateos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.21269"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2005"
                        "volumen" => "117"
                        "paginaInicial" => "861"
                        "paginaFinal" => "865"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15981210"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma&#58; correlation with clinicopathological prognostic factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Monteagudo"
                            1 => "J&#46;M&#46; Martin"
                            2 => "E&#46; Jorda"
                            3 => "A&#46; Llombart-Bosch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jcp.2005.032144"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pathol"
                        "fecha" => "2007"
                        "volumen" => "60"
                        "paginaInicial" => "596"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16522748"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXC chemokine receptor 3 expression by activated CD8&#43; T cells is associated with survival in melanoma patients with stage III disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Mullins"
                            1 => "C&#46;L&#46; Slingluff"
                            2 => "J&#46;K&#46; Lee"
                            3 => "C&#46;F&#46; Garbee"
                            4 => "J&#46; Shu"
                            5 => "S&#46;G&#46; Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-04-2059"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "7697"
                        "paginaFinal" => "7701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15520172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A role for CXCR2 in senescence&#44; but what about in cancer&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;C&#46; Acosta"
                            1 => "J&#46; Gil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-08-3772"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2009"
                        "volumen" => "69"
                        "paginaInicial" => "2167"
                        "paginaFinal" => "2170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19276354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR2 expression and progression of cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Terradez"
                            1 => "N&#46; Santonja"
                            2 => "C&#46; Monteagudo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Virchows Archiv"
                        "fecha" => "2008"
                        "volumen" => "452"
                        "paginaInicial" => "S256"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR1 and CXCR2 enhances human melanoma tumourigenesis&#44; growth and invasion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Singh"
                            1 => "K&#46;C&#46; Nannuru"
                            2 => "A&#46; Sadanandam"
                            3 => "M&#46;L&#46; Varney"
                            4 => "R&#46;K&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6605055"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2009"
                        "volumen" => "100"
                        "paginaInicial" => "1638"
                        "paginaFinal" => "1646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19401689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune modulation by melanoma-derived factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Ilkovitch"
                            1 => "D&#46;M&#46; L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0625.2008.00779.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2008"
                        "volumen" => "17"
                        "paginaInicial" => "977"
                        "paginaFinal" => "985"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18643844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kochetkova"
                            1 => "S&#46; Kumar"
                            2 => "S&#46;R&#46; McColl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/cdd.2008.190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Death Differ"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "664"
                        "paginaFinal" => "673"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19136936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines and their receptors as therapeutic targets&#58; the role of the SDF-1&#47;CXCR4 axis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Ju&#225;rez"
                            1 => "L&#46; Bendall"
                            2 => "K&#46; Bradstock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Pharm Res"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "1245"
                        "paginaFinal" => "1259"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Takenaga"
                            1 => "H&#46; Tamamura"
                            2 => "K&#46; Hiramatsu"
                            3 => "N&#46; Nakamura"
                            4 => "Y&#46; Yamaguchi"
                            5 => "A&#46; Kitagawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bbrc.2004.05.155"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "2004"
                        "volumen" => "320"
                        "paginaInicial" => "226"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15207725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM&#47;MUC18 and IL-8"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;O&#46; Melnikova"
                            1 => "M&#46; Bar-Eli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0749.2006.00331.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pigment Cell Res"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "395"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16965268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Delivery of CCL21 to metastatic disease improves the efficacy of adoptive T-cell therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Thanarajasingam"
                            1 => "L&#46; Sanz"
                            2 => "R&#46; Diaz"
                            3 => "J&#46; Qiao"
                            4 => "L&#46; S&#225;nchez-P&#233;rez"
                            5 => "T&#46; Kottke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-06-1017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2007"
                        "volumen" => "67"
                        "paginaInicial" => "300"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17210711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemotrap-1&#58; an engineered soluble receptor that blocks chemokine-induced migration of metastatic cancer cells in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lanati"
                            1 => "D&#46;B&#46; Dunn"
                            2 => "M&#46; Roussign&#233;"
                            3 => "M&#46;S&#46; Emmett"
                            4 => "V&#46; Carriere"
                            5 => "D&#46; Jullien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-10-0175"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2010"
                        "volumen" => "70"
                        "paginaInicial" => "8138"
                        "paginaFinal" => "8148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20736366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000424/v1_201304241231/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6170"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Novelties in Dermatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000007/v1_201304241231/S1578219011000424/v1_201304241231/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000424?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Novelties in Dermatology
Role of Chemokines in Melanoma Progression
Papel de las quimiocinas en la progresión del melanoma
C. Monteagudoa,
Autor para correspondencia
Carlos.Monteagudo@uv.es

Corresponding author.
, A. Pellín-Carceléna, J.M. Martínb, D. Ramosa
a Departamento de Patología, Universidad de Valencia, Valencia, Spain
b Servicio de Dermatología, Hospital Clínico Universitario-INCLIVA, Universidad de Valencia, Valencia, Spain
Leído
8027
Veces
se ha leído el artículo
2500
Total PDF
5527
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219011000424"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.03.004"
  "estado" => "S300"
  "fechaPublicacion" => "2011-09-01"
  "aid" => "374"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Actas Dermosifiliogr. 2011;102:498-504"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3580
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 2800
      "PDF" => 734
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011001402"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2011-09-01"
      "aid" => "374"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Actas Dermosifiliogr. 2011;102:498-504"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5153
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3679
          "PDF" => 1472
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Novedades en dermatolog&#237;a</span>"
        "titulo" => "Papel de las quimiocinas en la progresi&#243;n del melanoma"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "498"
            "paginaFinal" => "504"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Role of Chemokines in Melanoma Progression"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2424
                "Ancho" => 2500
                "Tamanyo" => 275857
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Participaci&#243;n de las quimiocinas y receptores en la distribuci&#243;n selectiva de las met&#225;stasis en los pacientes con melanoma cut&#225;neo&#58; las flechas gruesas negras corresponden a interacciones bien caracterizadas quimiocinas-receptor&#46; Las flechas gruesas grises indican asociaciones potenciales no completamente caracterizadas&#46; Las flechas curvas delgadas representan la producci&#243;n aut&#243;loga de las quimiocinas &#40;ligandos&#41; por las propias c&#233;lulas tumorales con efectos autocrinos&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Monteagudo, A&#46; Pell&#237;n-Carcel&#233;n, J&#46;M&#46; Mart&#237;n, D&#46; Ramos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Monteagudo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Pell&#237;n-Carcel&#233;n"
              ]
              2 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Mart&#237;n"
              ]
              3 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ramos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219011000424"
          "doi" => "10.1016/j.adengl.2011.03.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000424?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001402?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000007/v1_201304241332/S0001731011001402/v1_201304241332/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219011000576"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.03.007"
    "estado" => "S300"
    "fechaPublicacion" => "2011-09-01"
    "aid" => "387"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2011;102:505-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3572
      "formatos" => array:3 [
        "EPUB" => 40
        "HTML" => 2399
        "PDF" => 1133
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Practical Dermatology</span>"
      "titulo" => "Psoriasis and Obesity&#58; A Review and Practical Recommendations"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "505"
          "paginaFinal" => "509"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Psoriasis y obesidad&#58; revisi&#243;n y recomendaciones pr&#225;cticas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;M&#46; Far&#237;as, V&#46; Serrano, C&#46; de la Cruz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;M&#46;"
              "apellidos" => "Far&#237;as"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Serrano"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "de la Cruz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011001712"
        "doi" => "10.1016/j.ad.2011.03.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001712?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000576?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000576/v1_201304241231/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219011000412"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.03.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-09-01"
    "aid" => "372"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2011;102:487-97"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 8107
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 6333
        "PDF" => 1732
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Connective Tissue Diseases and Psoriasis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "487"
          "paginaFinal" => "497"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Conectivopat&#237;as y psoriasis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1736
              "Ancho" => 2403
              "Tamanyo" => 196687
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Naive T helper &#40;T<span class="elsevierStyleInf">H</span>&#41; cells differentiate into 3 different subsets &#40;T<span class="elsevierStyleInf">H</span>1&#44;T<span class="elsevierStyleInf">H</span>2&#44;and T<span class="elsevierStyleInf">H</span>17&#41; depending on the cytokine stimuli they receive&#46; Transforming growth factor &#40;TGF&#41; &#946; and interleukin &#40;IL&#41; 6 are the primary mediators of differentiation into T<span class="elsevierStyleInf">H</span>17 cells&#44; while IL-23 contributes to the survival and proliferation of these cells&#46; Among the many cytokines secreted by T<span class="elsevierStyleInf">H</span>17 cells&#44; IL-21 intervenes in a positive feedback loop&#46; IFN indicates interferon&#59; TNF&#44; tumor necrosis factor&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Cuesta-Montero, I&#46; Belinch&#243;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Cuesta-Montero"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011001384"
        "doi" => "10.1016/j.ad.2011.03.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001384?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000412?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000412/v1_201304241231/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Novelties in Dermatology</span>"
    "titulo" => "Role of Chemokines in Melanoma Progression"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "498"
        "paginaFinal" => "504"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Monteagudo, A&#46; Pell&#237;n-Carcel&#233;n, J&#46;M&#46; Mart&#237;n, D&#46; Ramos"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "Monteagudo"
            "email" => array:1 [
              0 => "Carlos&#46;Monteagudo&#64;uv&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Pell&#237;n-Carcel&#233;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Patolog&#237;a&#44; Universidad de Valencia&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario-INCLIVA&#44; Universidad de Valencia&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de las quimiocinas en la progresi&#243;n del melanoma"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2424
            "Ancho" => 2500
            "Tamanyo" => 262194
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Involvement of chemokines and their receptors in selective metastasis in patients with cutaneous melanoma&#46; Black arrows indicate well-characterized interactions between chemokines and their receptors&#59; gray arrows indicate potential associations that remain to be fully characterized&#59; curved arrows indicate the autologous production of chemokines &#40;ligands&#41; by the tumor cells leading to autocrine effects&#46; CNS indicates central nervous system&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Melanoma has increased in frequency more than any other cancer in recent years&#44; and in affected patients the development of metastasis is the strongest predictor of mortality&#44; given the absence of clearly effective treatments for metastatic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The expression of certain chemokines and their receptors has been implicated in the molecular mechanisms that favor or inhibit metastatic spread of melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> Understanding the molecular mechanisms underlying tumor progression in melanoma is an important step that will ultimately allow not only prediction but also therapeutic intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">The Chemokines</span><p id="par0010" class="elsevierStylePara elsevierViewall">The chemokines are low-molecular-weight &#40;8-17 kDa&#41; chemotactic cytokines that cause directed cell migration and whose expression is induced by inflammatory cytokines&#44; growth factors&#44; and pathogenic stimuli&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> They have been classified into 4 families&#58; CXC&#44; CC&#44; CX3C&#44; and XC chemokines&#44; defined according to the position of the first 2 cysteine residues located in the amino-terminal region&#46; To date&#44; more than 50 chemokines and at least 19 different chemokine receptors have been identified<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Although in many cases the same receptor can recognize various different chemokine ligands&#44; 6 of the known chemokine receptors only recognize a single ligand&#46; It is thought that any cell type can express chemokines or their receptors&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The expression of chemokine receptors is dependent upon cell type&#44; differentiation state&#44; the concentration of chemokines present in the microenvironment&#44; the presence of inflammatory cytokines&#44; and the occurrence of local hypoxia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The binding of chemokines to their receptors at the cell surface leads to a complex series of cellular responses&#44; such as activation of different signaling pathways and cytoskeletal reorganization&#44; which favor the formation of pseudopodia and facilitate cell movement&#46; Chemokine receptors act through heterotrimeric G proteins that regulate signaling pathways such as those involving mitogen-associated protein kinases&#44; phospholipase C-&#946;&#44; phosphoinositol-3-kinase&#44; RAS&#44; and Rho-family GTPases&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7&#44;8</span></a> RhoC is thought to play an important role in the occurrence of metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Chemokines can also act in synergy with metalloproteinases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Selective Spread of Metastasis</span><p id="par0015" class="elsevierStylePara elsevierViewall">One of the great enigmas that has faced oncological pathology in the last 2 centuries is the question of how metastasis selectively targets some organs and not others irrespective of the blood flow they receive and&#44; therefore&#44; the quantities of circulating tumor cells that reach them&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In 1889&#44; after studying more than 900 autopsies&#44; Stephen Paget<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> proposed the &#8220;seed and soil&#8221; hypothesis to explain this phenomenon&#46; According to this theory&#44; metastases do not occur randomly&#59; instead&#44; certain tumor cells &#40;the &#8220;seeds&#8221;&#41; have a particular affinity for the microenvironment of the affected organ &#40;the &#8220;soil&#8221;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The site of distant metastases also has prognostic value in patients with melanoma&#46; Metastases found in the skin&#44; subcutaneous tissue&#44; and lymph nodes are associated with longer survival than visceral metastases&#46; Consequently&#44; the American Joint Committee on Cancer subclassifies metastases into M1a for distant cutaneous&#44; subcutaneous&#44; and lymph-node metastases&#44; M1b for lung metastases&#44; and M1c for metastases to other visceral sites&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Over the last decade&#44; it has been recognized that chemokines and their receptors play a role in metastatic spread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;16</span></a> Muller et al<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> observed overexpression of CXCR4&#44; CCR10&#44; and CCR7 in melanoma cell lines&#46; Since CXCL12&#44; the ligand for the receptor CXCR4&#44; is preferentially detected in the lymph nodes&#44; lungs&#44; liver&#44; and bone marrow&#44; the authors proposed a role for the receptor in the selective spread of metastases to these sites &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In support of this hypothesis&#44; expression of CXCR4 has been detected in subcutaneous and lymph-node metastases of melanoma in humans and in melanoma cell lines&#44; where it facilitates the adhesion and migration of tumor cells through interaction with its ligands&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Interactions between CXCR4 and CXCL12 are responsible for cell migration during embryogenesis and the mobilization of hematopoietic stem cells&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;17</span></a> and they have a recognized role in metastatic spread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> At least 1 subpopulation of tumor cells expresses CXCR4 in many types of cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Situations such as hypoxia that increase activation of the so-called hypoxia-inducible factor cause an increase in the expression of CXCR4 by tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The only known ligand of CXCR4 is CXCL12&#44; a 68-amino-acid chemokine that has angiogenic properties&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> promotes tumor growth&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> and facilitates tissue invasion by increasing the production of various metalloproteinases&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> In the B16 cell line&#44; a well-characterized mouse melanoma cell line with known metastatic potential&#44; tumor cells transfected with CXCR4 are reported to have a 10-fold greater capacity to cause lung metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The receptor CCR7 also plays an important role in melanoma&#44; and its ligands &#40;CCL19 and CCL21&#41; are expressed in dermal lymph vessels&#44; paracortical areas of the lymph nodes&#44; and high endothelial venules of the lymph nodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> The interaction of CCR7 with its ligands has been implicated in the development of lymph-node metastases in an experimental mouse model of melanoma<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Mechanisms have also been described to control the expression of the ligands of CCR7&#44; particularly CCL21&#44; in lymph nodes where melanoma metastasis has occurred&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> As we will see&#44; however&#44; the role of CCL21 and CCR7 in metastasis is complex&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The tendency of melanomas to produce skin metastases is a well-known phenomenon&#46; A role in this process has been proposed for the receptor CCR10&#44; whose ligand CCL27 is predominantly expressed in the basal cells of the epidermis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Patients with hematogenous spread of melanoma often also have gastrointestinal metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> CCR9 participates in the development of metastases in the small intestine&#44; which expresses its ligand CCL25<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The receptor CCR4 has also recently been implicated in cerebral metastases of melanoma<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">It has also been shown in recent years that tumor cells from various types of cancer&#44; including melanoma&#44; express not only chemokine receptors but also the chemokines themselves&#46; This coordinated expression thus generates circuits or autocrine feedback loops in the tumor cells themselves&#46; Notable examples are CXCL12 and its receptor CXCR4 and CCL21 and its receptor CCR7&#44; which play an essential role in tumor growth and migration&#44; and therefore the aggressiveness of the tumor cells&#46; These autocrine loops stimulate not only the proliferative capacity but also the invasive capacity or metastatic potential of tumor cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Angiogenesis</span><p id="par0045" class="elsevierStylePara elsevierViewall">Angiogenesis is essential for tumor growth and correlates with the development of metastasis&#46; The role of chemokines in this process is also complex&#46; In general&#44; CXC chemokines containing glu-leu-arg &#40;ELR according to the single-letter code for amino acids&#41; domains&#8212;specifically CXCL2&#44; CXCL3&#44; CXCL5&#44; CXCL6&#44; CXCL7&#44; and CXCL8 &#40;all ligands of CXCR2&#41;&#8212;function as angiogenic cytokines&#44; although CXCL12&#44; which does not contain ELR domains&#44; also has angiogenic effects&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> CXCL8 is a particularly angiogenic chemokine and its receptors CXCR1 and CXCR2 are expressed on endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> CXCL8 exerts its effect largely by inducing expression of the metalloproteinases MMP2 and MMP9&#44; and also vascular endothelial growth factor&#44; which has an autocrine effect on its receptor in the same endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> In contrast&#44; CXCL4&#44; CXCL9&#44; CXCL10&#44; and CXCL11 are antiangiogenic&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Immune Response</span><p id="par0050" class="elsevierStylePara elsevierViewall">Chemokines act as mediators in the recruitment of different types of cells in the tumor microenvironment&#59; these include lymphocytes&#44; tumor-associated macrophages &#40;TAM&#41; and neutrophils &#40;TAN&#41;&#44; fibroblasts&#44; mesenchymal stem cells&#44; and endothelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two types of TAM and TAN have been identified&#58; type 1&#44; which are antitumoral&#44; and type 2&#44; which are protumoral&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32&#44;33</span></a> The T-helper 1 &#40;T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>1&#41; lymphocyte response&#44; which is greater in regressing melanomas&#44;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#44;35</span></a> has an antitumoral effect&#44; whereas the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>2 response facilitates tumor progression&#46; Nevertheless&#44; the situation is complex&#46; This is highlighted by the chemokines CXCL10 and CXCL4&#44; which both have affinity for the receptor CXCR3 but nevertheless have opposing effects&#46; CXCL10 induces production of the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>1 cytokine interferon-&#947; by T cells&#44; whereas CXCL4 promotes expression of the T<span class="elsevierStyleInf"><span class="elsevierStyleSmallCaps">H</span></span>2 cytokines interleukin 4&#44; 5&#44; and 13&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> CXCL10 appears to act preferentially on CXCR3A&#44; whereas CXCL4 binds a variant of the same receptor&#44; CXCR3B&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> There is increasing evidence that the chemokines present in human tumors contribute more to tumor growth and progression and to immunosuppression than they generally do to an effective antitumor response&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> What is clear is that the interactions between chemokines and their receptors sometimes potentiate and sometimes inhibit the immune response&#46; Thus&#44; the expression of CCL27 is an important inducer of the immune response in squamous cell tumors and its inhibition contributes to an evasion of the immune response and favors tumor progression&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> In fact&#44; expression of CCL27 is lower in melanoma metastases than in primary cutaneous melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> However&#44; overexpression of CCR10&#44; the receptor for CCL27&#44; in the B16 melanoma cell line&#44; probably stimulated by high levels of CCL27 expression in the epidermis&#44; appears to increase the resistance of these cells to the immune response against the tumor and protects against Fas-mediated apoptosis&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> In fact&#44; overexpression of CCR10 in B16 melanoma cells leads to a notable increase in the occurrence of lymph-node metastases in mice following injection of the transfected cells into the skin&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Increased expression of CCR10 has also been observed by immunohistochemistry in primary melanomas from patients with positive sentinel lymph node biopsy compared to those in whom biopsy was negative for metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Contradictory data have been obtained regarding the influence of CXCL12 on the antitumoral immune response&#46; The production of CXCL12 by tumor cells can reduce the immune response to the tumor by attracting and promoting the survival of dendritic cell precursors &#40;pre-DC2&#41; that express CXCR4 and altering the distribution&#44; immunity&#44; and stimulus of fibrosis of pre-DC1 cells&#44; causing immature dendritic cells not to present tumor antigens&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> However&#44; it has also been reported that the production of CXCL12 by B16F1 melanoma cells that have been genetically modified to produce the cytokine and injected into immunocompetent mice led to rejection in 50&#37; of cases and induced specific memory responses to the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Consistent with this observation&#44; secretion of CXCL12 by genetically modified melanoma cells attracts CXCR4-positive cutaneous T lymphocytes in organotypic cultures and facilitates tumor regression&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">One of the most recent and striking advances in relation to the role of chemokines in the immune response relates to CCL21&#46; Under normal circumstances&#44; this cytokine is produced by fibroblastic reticular cells &#40;FRC&#41; in the paracortex of the lymph nodes and attracts both antigen-presenting cells and melanoma cells to that site&#44; since both express CCR7&#46; It has been shown that the tumor cells from different types of cancer&#44; including melanoma&#44; can produce CCL19 and CCL21 under conditions of slow interstitial flow and lead to an autocrine effect referred to as autologous chemotaxis&#44; which potentiates cell migration in the direction of the flow towards the lymph vessels&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Comparison of the behavior of B16 melanoma cells expressing high and low levels of CCL21 following implantation into syngeneic immunocompetent mice revealed that cells expressing high levels of the chemokine produced larger tumors despite attracting more leukocytes and antigen-presenting cells&#46; This effect&#44; which is not observed in vitro&#44; depends on the host response&#44; since it does not occur in immunodeficient mice&#46; In other words&#44; high endogenous expression of CCL21 in melanoma cells favors immune tolerance and therefore progression of the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> Tumors expressing high levels of CCL21 have more CD4<span class="elsevierStyleSup">&#43;</span>&#44; CD25<span class="elsevierStyleSup">&#43;</span>&#44; FoxP3<span class="elsevierStyleSup">&#43;</span> regulatory T cells and express more transforming growth factor &#946;1&#44; which favors phenotypic change of M1 &#40;antitumoral&#41; to M2 &#40;protumoral&#41; macrophages&#46; Lymphoid tissue inducer cells were also present along with a network of FRC cells and some vessels with characteristics of high endothelial venules&#46; However&#44; tumors with low levels of CCL21 expression had a fundamentally cytotoxic T-cell response&#44; with greater production of interferon-&#947; and interleukins 2 and 4&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Survival of Tumor Cells</span><p id="par0065" class="elsevierStylePara elsevierViewall">CXCL12 promotes survival of tumor cells expressing the receptor CXCR4 when grown under suboptimal conditions such as in the hypoxic environment commonly found in tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> CXCL12 can also stimulate the production of metalloproteinases&#44; which facilitate tissue invasion by the tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The interaction between CXCL9 and CXCR3 that occurs in tumor cells also potentiates their survival<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> and the transendothelial migration of melanoma cells&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> In fact&#44; high expression of both CXCR4 and CXCR3 by melanoma cells is a sign of poor prognosis in affected patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#8211;50</span></a> although high-level expression of CXCR3 in circulating lymphocytes in patients with stage 3 melanoma is an indicator of a good immune response against the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> High levels of CXCL10 expression also reduce the proliferative and invasive capacity of melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> The role of the more recently described receptor CXCR7 remains to be fully determined&#46; It is known to bind both CXCL12 and CXCL11 and appears to eliminate them&#44; but its effects in melanomas are unclear&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The effect of ligands for CXCR2 during tumor progression is complex&#46; An intriguing observation is that chemokine signaling through CXCR2 induces senescence in the initial phases of tumor development but not in later phases&#44; when it also has tumorigenic effects&#44; perhaps due to the accumulation of genetic abnormalities in the tumor cells&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> Thus&#44; high expression of CXCR1 and CXCR2 in melanoma cells confers an aggressive phenotype as a result of a greater proliferative&#44; migratory&#44; and growth capacity of the tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a> The role of CCL2&#44; although not fully elucidated&#44; also appears to be biphasic&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Interestingly&#44; when cells become isolated during the process of migration and dissemination&#44; they become susceptible to a type of apoptosis known as anoikis&#44; but expression of CXCR4 and CCR7 allows them to escape this process by reducing expression of the modifying factor bcl-2&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Therapeutic Targets</span><p id="par0080" class="elsevierStylePara elsevierViewall">The confirmation that expression of certain chemokine receptors and their corresponding ligands influences the development of metastasis has led to the proposal of using antagonists&#44; inhibitors&#44; or inactivators of those receptors and ligands to prevent metastatic spread of melanoma&#46; Thus&#44; neutralization of the interaction of some chemokines with their receptors&#8212;such as CXCL12 with CXCR4 or CCL19 and CCL21 with CCR7&#8212;could be predicted to prevent the development of metastasis&#46; Preclinical studies in melanoma and other cancers appear to confirm this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;19&#44;57&#44;58</span></a> The interaction between CXCL12 and CXCR4&#44; however&#44; has a wide range of important physiological roles&#44; and as a result&#44; may not represent a viable therapeutic target in patients with melanoma&#46; Nevertheless&#44; CXCR4 is the therapeutic target against which most treatments are directed in multiple myeloma and leukemia&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">There is evidence that expression of CXCL8 in melanoma functions as an autocrine or paracrine growth factor and promotes angiogenesis and tumor invasion through its interaction with the receptors CXCR1 and CXCR2&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> As a consequence&#44; these chemokine receptors are potential therapeutic targets&#46; Indeed&#44; inhibitors of these receptors &#40;SCH-479833 and SCH-527123&#41; and also humanized neutralizing antibodies against them inhibit the proliferation&#44; invasion&#44; and metastatic growth of melanomas in immunodeficient mice&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> Other molecules that function as antagonists of these 2 receptors &#40;repertaxin for CXCR1 and SB-225002 and SB-332235 for CXCR2&#41; have been used in inflammatory conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Somewhat paradoxically&#44; high endogenous production of CCL21 by melanoma cells causes immunosuppression&#44; whereas exogenous provision of this chemokine has an effective antitumor effect&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> Care should therefore be taken when considering the use of CCL21 antagonists such as the recently proposed Chemotrap-1&#44; which blocks in vitro and in vivo migration of melanoma cells towards the lymph vessels and inhibits in-transit metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0095" class="elsevierStylePara elsevierViewall">The participation of chemokines and their receptors in the progression of melanoma is important&#44; complex&#44; and dynamic&#44; and is dependent on both the characteristics of the tumor cells and on those of other cells present in the host microenvironment of the tumor&#46; Cellular and molecular interactions determine whether a potentiating effect that favors tumor progression or an antitumor effect that favors regression or at least stabilization of the melanoma predominates&#46; Given the essential role of interactions such as CXCR4-CXCL12 in the physiology of different organs and systems&#44; care should be taken in any attempts to block their function until more information is available on the potential effects&#46; Drugs targeting the chemokines and their receptors have begun to be used in some cancers and inflammatory conditions&#44; and this will provide important information regarding the advantages and drawbacks of exploiting these interactions as therapeutic targets before they are used in patients with melanoma&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:2 [
          "identificador" => "xres95347"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec82507"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres95348"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec82508"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "The Chemokines"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Selective Spread of Metastasis"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Angiogenesis"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Immune Response"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Survival of Tumor Cells"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Therapeutic Targets"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conclusions"
        ]
        12 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflicts of Interest"
        ]
        13 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-01-06"
    "fechaAceptado" => "2011-03-08"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec82507"
          "palabras" => array:4 [
            0 => "Chemokines"
            1 => "Metastasis"
            2 => "Melanoma"
            3 => "Receptors"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82508"
          "palabras" => array:4 [
            0 => "Quimiocinas"
            1 => "Metastasis"
            2 => "Melanoma"
            3 => "Receptores"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Metastasis is the main cause of death from melanoma&#46; Chemokines are low molecular weight chemotactic cytokines that facilitate cellular migration&#46; Thus&#44; cells that express receptors for a given chemokine are attracted to the site of its production&#46; As certain chemokines are found in abundance in organs that are common targets of metastasis and receptors for these chemokines are expressed by tumor cells&#44; it was hypothesized that chemokine gradients might selectively facilitate metastasis to these organs&#46; A later finding that these chemokines were produced by tumor cells&#44; with evidence of autocrine effects&#44; obliged the modification of that hypothesis&#46; Many chemokines are also known to have opposing effects according to the type of cell they are acting on &#40;tumor&#44; inflammatory&#47;immune&#44; or endothelial cells&#41;&#44; their functional status&#44; or interactions with other molecules&#46; The expression of chemokines and their receptors by melanoma cells enhances tumor progression by altering their microenvironment&#44; stimulating angiogenesis&#44; and inhibiting the immune response&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las met&#225;stasis son la principal causa de mortalidad en el melanoma&#46; Las quimiocinas son citocinas quimiot&#225;cticas de bajo peso molecular que permiten la migraci&#243;n celular&#44; atrayendo a c&#233;lulas que expresan sus receptores&#46; Como algunas quimiocinas son abundantes en &#243;rganos que son asiento com&#250;n de metastasis&#44; y sus receptores son expresados por las c&#233;lulas tumorales&#44; se plante&#243; la hip&#243;tesis de que un gradiente de estas quimiocinas facilitar&#237;a selectivamente las met&#225;stasis a esos &#243;rganos&#46; El hallazgo posterior de la producci&#243;n de estas quimiocinas por las propias c&#233;lulas tumorales&#44; y su efecto autocrino&#44; obliga a modular esta hip&#243;tesis&#46; Adem&#225;s&#44; muchas quimiocinas tienen efectos contrapuestos dependiendo del tipo celular sobre el que act&#250;an &#40;tumoral&#44; inflamatorio&#47; inmunitario&#44; endotelial&#41;&#44; su estado funcional y otras interacciones moleculares&#46; En el melanoma las c&#233;lulas tumorales adquieren ventajas de la expresi&#243;n de quimiocinas y receptores alterando su microambiente&#44; estimulando la angiog&#233;nesis y evadiendo la respuesta inmune&#44; facilitando as&#237; la progresi&#243;n tumoral&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Monteagudo C&#44; et al&#46; Papel de las quimiocinas en la progresi&#243;n del melanoma&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;498-504&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2424
            "Ancho" => 2500
            "Tamanyo" => 262194
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Involvement of chemokines and their receptors in selective metastasis in patients with cutaneous melanoma&#46; Black arrows indicate well-characterized interactions between chemokines and their receptors&#59; gray arrows indicate potential associations that remain to be fully characterized&#59; curved arrows indicate the autologous production of chemokines &#40;ligands&#41; by the tumor cells leading to autocrine effects&#46; CNS indicates central nervous system&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Family&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Receptor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Chemokines&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL6 and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL1&#44; 2&#44; 3&#44; 5&#44; 6&#44; 7&#44; and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL9&#44; 10 and 11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCR7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CXCL11 and 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL3&#44; 4&#44; 5&#44; 7&#44; 14&#44; 15&#44; 16&#44; and 23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL2&#44; 7&#44; 8&#44; 12&#44; and 13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL5&#44; 7&#44; 11&#44; 13&#44; 15&#44; 24&#44; 26&#44; and 28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL2&#44; 3&#44; 5&#44; 17&#44; and 22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL3&#44; 4&#44; 5&#44; and 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL19 and 21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL1&#44; 4&#44; and 17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCR10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CCL27 and 28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3CR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CX3CL1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XCR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XCL1 and 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab181792.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of Chemokines and Their Receptors&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:61 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent progress in understanding the pathology of malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Kuphal"
                            1 => "A&#46; Bosserhoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.2617"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "2009"
                        "volumen" => "219"
                        "paginaInicial" => "400"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19771562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The good and the bad of chemokines&#47;chemokine receptors in melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Richmond"
                            1 => "J&#46; Yang"
                            2 => "Y&#46; Su"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1755-148X.2009.00554.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pigment Cell Melanoma Res"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "175"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19222802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines and chemokine receptors&#58; new insights into cancer-related inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Lazennec"
                            1 => "A&#46; Richmond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.molmed.2010.01.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Mol Med"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "133"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20163989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of chemokine receptors in breast cancer metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; M&#252;ller"
                            1 => "B&#46; Homey"
                            2 => "H&#46; Soto"
                            3 => "N&#46; Ge"
                            4 => "D&#46; Catron"
                            5 => "M&#46;E&#46; Buchanan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35065016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2001"
                        "volumen" => "410"
                        "paginaInicial" => "50"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11242036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer and the chemokine network"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Balkwill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrc1388"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Cancer"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "540"
                        "paginaFinal" => "550"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15229479"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines in tumor progression and metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Tanaka"
                            1 => "Z&#46; Bai"
                            2 => "Y&#46; Srinoulprasert"
                            3 => "B&#46;G&#46; Yang"
                            4 => "H&#46; Hayasaka"
                            5 => "M&#46; Miyasaka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1349-7006.2005.00059.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Sci"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "317"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15958053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Robledo"
                            1 => "R&#46;A&#46; Bartolom&#233;"
                            2 => "N&#46; Longo"
                            3 => "J&#46;M&#46; Rodr&#237;guez-Frade"
                            4 => "M&#46; Mellado"
                            5 => "I&#46; Longo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M106912200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2001"
                        "volumen" => "276"
                        "paginaInicial" => "45098"
                        "paginaFinal" => "45105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11571298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How chemokines invite leukocytes to dance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Thelen"
                            1 => "J&#46;V&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ni.f.207"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Immunol"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "953"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18711432"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genomic analysis of metastasis reveals an essential role for RhoC"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Clark"
                            1 => "T&#46;R&#46; Golub"
                            2 => "E&#46;S&#46; Lander"
                            3 => "R&#46;O&#46; Hynes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35020106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2000"
                        "volumen" => "406"
                        "paginaInicial" => "532"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10952316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing&#44; whereas it degrades CTAP-III&#44; PF-4&#44; and GRO-alfa and leaves RANTES and MCP-2 intact"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;E&#46; Van den Steen"
                            1 => "P&#46; Proost"
                            2 => "A&#46; Wuyts"
                            3 => "J&#46; Van Damme"
                            4 => "G&#46; Opdenakker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2000"
                        "volumen" => "96"
                        "paginaInicial" => "2673"
                        "paginaFinal" => "2681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023497"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal cell-derived factor-1&#945; promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Bartolom&#233;"
                            1 => "B&#46;G&#46; G&#225;lvez"
                            2 => "N&#46; Longo"
                            3 => "F&#46; Baleux"
                            4 => "G&#46;N&#46; Van Muijen"
                            5 => "P&#46; S&#225;nchez-Mateos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "2534"
                        "paginaFinal" => "2543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15059909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Bartolom&#233;"
                            1 => "S&#46; Ferreiro"
                            2 => "M&#46;E&#46; Miquilena-Colina"
                            3 => "L&#46; Mart&#237;nez-Prats"
                            4 => "M&#46;L&#46; Soto-Montenegro"
                            5 => "D&#46; Garc&#237;a-Bernal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2353/ajpath.2009.080636"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2009"
                        "volumen" => "174"
                        "paginaInicial" => "602"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19147814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of cancer metastasis&#58; the &#8220;seed and soil&#8221; hypothesis revisited"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;J&#46; Fidler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature Rev Cancer"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "453"
                        "paginaFinal" => "458"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The distribution of secondary growths in cancer of the breast"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Paget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1889"
                        "volumen" => "1"
                        "paginaInicial" => "571"
                        "paginaFinal" => "573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Final version of 2009 AJCC melanoma staging and classification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Balch"
                            1 => "J&#46;E&#46; Gershenwald"
                            2 => "S&#46;J&#46; Soong"
                            3 => "J&#46;F&#46; Thompson"
                            4 => "M&#46;B&#46; Atkins"
                            5 => "D&#46;R&#46; Byrd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2009.23.4799"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "6199"
                        "paginaFinal" => "6206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19917835"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An attractive force in metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Liotta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/35065180"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2001"
                        "volumen" => "410"
                        "paginaInicial" => "24"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11242022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dependence of human stem cell engraftment and repopulation of NOD&#47;SCID mice on CXCR4"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Peled"
                            1 => "I&#46; Petit"
                            2 => "O&#46; Kollet"
                            3 => "M&#46; Magid"
                            4 => "T&#46; Ponomaryov"
                            5 => "T&#46; Byk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Science"
                        "fecha" => "1999"
                        "volumen" => "283"
                        "paginaInicial" => "845"
                        "paginaFinal" => "848"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9933168"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606694853"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of the chemokine receptor CXCR4 by hypoxia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Schioppa"
                            1 => "B&#46; Uranchimeg"
                            2 => "A&#46; Saccani"
                            3 => "S&#46;K&#46; Biswas"
                            4 => "A&#46; Doni"
                            5 => "A&#46; Rapisarda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20030267"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "2003"
                        "volumen" => "198"
                        "paginaInicial" => "1391"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14597738"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blockade of the stromal cell-derived factor&#47;CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Guleng"
                            1 => "K&#46; Tateishi"
                            2 => "M&#46; Ohta"
                            3 => "F&#46; Kanai"
                            4 => "A&#46; Jazag"
                            5 => "H&#46; Ijichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-04-3833"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "65"
                        "paginaInicial" => "5864"
                        "paginaFinal" => "5871"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1&#47;CXCL12 secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Orimo"
                            1 => "P&#46;B&#46; Gupta"
                            2 => "D&#46;C&#46; Sgroi"
                            3 => "F&#46; Arenzana-Seisdedos"
                            4 => "T&#46; Delaunay"
                            5 => "R&#46; Naeem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cell.2005.02.034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "2005"
                        "volumen" => "121"
                        "paginaInicial" => "335"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15882617"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Murakami"
                            1 => "W&#46; Maki"
                            2 => "A&#46;R&#46; Cardones"
                            3 => "H&#46; Fang"
                            4 => "A&#46; Tun Kyi"
                            5 => "F&#46;O&#46; Nestle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2002"
                        "volumen" => "62"
                        "paginaInicial" => "7328"
                        "paginaFinal" => "7334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12499276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lessons learned from lymphocytes&#58; CC chemokine receptor&#8211;7 involved in lymphogenic metastasis of melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Forster"
                            1 => "L&#46; Ohl"
                            2 => "G&#46; Henning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2001"
                        "volumen" => "93"
                        "paginaInicial" => "1588"
                        "paginaFinal" => "1589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11698555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;E&#46; Wiley"
                            1 => "E&#46;B&#46; Gonz&#225;lez"
                            2 => "W&#46; Maki"
                            3 => "M&#46;T&#46; Wu"
                            4 => "S&#46;T&#46; Hwang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2001"
                        "volumen" => "93"
                        "paginaInicial" => "1638"
                        "paginaFinal" => "1643"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11698568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CCL21 chemokine regulates receptor CCR7 bearing malignant melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Takeuchi"
                            1 => "A&#46; Fujimoto"
                            2 => "M&#46; Tanaka"
                            3 => "T&#46; Yamano"
                            4 => "E&#46; Hsueh"
                            5 => "D&#46;S&#46; Hoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "2351"
                        "paginaFinal" => "2358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15073111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer cells regulate lymphocyte recruitment and leukocyte-endothelium interactions in the tumor-draining lymph node"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Carri&#232;re"
                            1 => "R&#46; Colisson"
                            2 => "C&#46; Jiguet-Jiglaire"
                            3 => "E&#46; Bellard"
                            4 => "G&#46; Bouche"
                            5 => "T&#46; Al Saati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-05-1190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "65"
                        "paginaInicial" => "11639"
                        "paginaFinal" => "11648"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16357175"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma in the gastrointestinal tract"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Blecker"
                            1 => "S&#46; Abraham"
                            2 => "E&#46;E&#46; Furth"
                            3 => "M&#46;L&#46; Kochman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.1999.01604.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1999"
                        "volumen" => "94"
                        "paginaInicial" => "3427"
                        "paginaFinal" => "3433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10606298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of CCR9 &#47; CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Amersi"
                            1 => "A&#46;M&#46; Terando"
                            2 => "Y&#46; Goto"
                            3 => "R&#46;A&#46; Scolyer"
                            4 => "J&#46;F&#46; Thompson"
                            5 => "A&#46;N&#46; Tran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-07-2025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "638"
                        "paginaFinal" => "645"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18245522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokine-chemokine receptor axes in melanoma brain metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Izraely"
                            1 => "A&#46; Klein"
                            2 => "O&#46; Sagi-Assif"
                            3 => "T&#46; Meshel"
                            4 => "G&#46; Tsarfaty"
                            5 => "D&#46;S&#46; Hoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.imlet.2009.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Lett"
                        "fecha" => "2010"
                        "volumen" => "130"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20005902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Kang"
                            1 => "R&#46;E&#46; Mansel"
                            2 => "W&#46;G&#46; Liang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Oncol"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "1429"
                        "paginaFinal" => "1434"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15809737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Shields"
                            1 => "M&#46;E&#46; Fleury"
                            2 => "C&#46; Yong"
                            3 => "A&#46;A&#46; Tomei"
                            4 => "G&#46;J&#46; Randolph"
                            5 => "M&#46;A&#46; Swartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccr.2007.04.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Cell"
                        "fecha" => "2007"
                        "volumen" => "11"
                        "paginaInicial" => "526"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCL8 and its cognate receptors in melanoma progression and metastasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Singh"
                            1 => "A&#46;P&#46; Singh"
                            2 => "B&#46; Sharma"
                            3 => "L&#46;B&#46; Owen"
                            4 => "R&#46;K&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/fon.09.128"
                      "Revista" => array:6 [
                        "tituloSerie" => "Future Oncol"
                        "fecha" => "2010"
                        "volumen" => "6"
                        "paginaInicial" => "111"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20021212"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuning inflammation and immunity by chemokine sequestration&#58; decoys and more"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Mantovani"
                            1 => "R&#46; Bonecchi"
                            2 => "M&#46; Locati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nri1964"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Immunol"
                        "fecha" => "2006"
                        "volumen" => "6"
                        "paginaInicial" => "907"
                        "paginaFinal" => "918"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17124512"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polarization of tumor-associated neutrophil phenotype by TGF-beta&#58; &#8220;N1&#8221; versus &#8220;N2&#8221; TAN"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46;G&#46; Fridlender"
                            1 => "J&#46; Sun"
                            2 => "S&#46; Kim"
                            3 => "V&#46; Kapoor"
                            4 => "G&#46; Cheng"
                            5 => "L&#46; Ling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccr.2009.06.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Cell"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "183"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19732719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T Helper 1 cytokine mRNA is increased in spontaneously regressing primary melanomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;A&#46; Lowes"
                            1 => "G&#46;A&#46; Bishop"
                            2 => "K&#46; Crotty"
                            3 => "R&#46;C&#46; Barnetson"
                            4 => "G&#46;M&#46; Halliday"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1997"
                        "volumen" => "108"
                        "paginaInicial" => "914"
                        "paginaFinal" => "919"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9182821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCl10 reduces melanoma proliferation and invasivity in vitro and in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Antonicelli"
                            1 => "J&#46; Lorin"
                            2 => "S&#46; Kurdykowski"
                            3 => "S&#46;C&#46; Gangloff"
                            4 => "R&#46; Le Naour"
                            5 => "J&#46;M&#46; Sallenave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2010.10176.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "164"
                        "paginaInicial" => "720"
                        "paginaFinal" => "728"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21155750"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Romagnani"
                            1 => "L&#46; Maggi"
                            2 => "B&#46; Mazzinghi"
                            3 => "L&#46; Cosmi"
                            4 => "L&#46; Lasagni"
                            5 => "F&#46; Liotta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2005.09.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2005"
                        "volumen" => "116"
                        "paginaInicial" => "1372"
                        "paginaFinal" => "1379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16337473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and cancer&#58; back to Virchow"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Balkwill"
                            1 => "A&#46; Mantovani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(00)04046-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "357"
                        "paginaInicial" => "539"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11229684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor immune escape by the loss of homeostatic chemokine expression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Pivarcsi"
                            1 => "A&#46; M&#252;ller"
                            2 => "A&#46; Hippe"
                            3 => "J&#46; Rieker"
                            4 => "A&#46; van Lierop"
                            5 => "M&#46; Steinhoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "P Natl Acad Sci USA"
                        "fecha" => "2007"
                        "volumen" => "104"
                        "paginaInicial" => "19055"
                        "paginaFinal" => "19060"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene expression signatures for tumor progression&#44; tumor subtype&#44; and tumor thickness in laser-microdissected melanoma tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jaeger"
                            1 => "D&#46; Koczan"
                            2 => "H&#46;J&#46; Thiesen"
                            3 => "S&#46;M&#46; Ibrahim"
                            4 => "G&#46; Gross"
                            5 => "R&#46; Spang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-06-1820"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "paginaInicial" => "806"
                        "paginaFinal" => "815"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune evasion by murine melanoma mediated through chemokine receptor-10"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Murakami"
                            1 => "A&#46;R&#46; Cardones"
                            2 => "S&#46;E&#46; Finkelstein"
                            3 => "N&#46;P&#46; Restifo"
                            4 => "B&#46;A&#46; Klaunberg"
                            5 => "F&#46;O&#46; Nestle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20030593"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "2003"
                        "volumen" => "198"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Simonetti"
                            1 => "G&#46; Goteri"
                            2 => "G&#46; Lucarini"
                            3 => "A&#46; Filosa"
                            4 => "T&#46; Pieramici"
                            5 => "C&#46; Rubini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2006.01.043"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16644201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Zou"
                            1 => "V&#46; Machelon"
                            2 => "A&#46; Coulomb-L&#8217;Hermin"
                            3 => "J&#46; Borvak"
                            4 => "F&#46; Nome"
                            5 => "T&#46; Isaeva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nm1201-1339"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature Med"
                        "fecha" => "2001"
                        "volumen" => "7"
                        "paginaInicial" => "1339"
                        "paginaFinal" => "1346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11726975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 &#40;SDF-1&#41;&#58; local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Dunussi-Joannopoulos"
                            1 => "K&#46; Zuberek"
                            2 => "K&#46; Runyon"
                            3 => "R&#46;G&#46; Hawley"
                            4 => "A&#46; Wong"
                            5 => "J&#46; Erickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2002"
                        "volumen" => "100"
                        "paginaInicial" => "1551"
                        "paginaFinal" => "1558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12176869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXC chemokine ligand 12 &#40;stromal cell-derived factor 1 alpha&#41; and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Zhang"
                            1 => "R&#46; Somasundaram"
                            2 => "K&#46; Berencsi"
                            3 => "L&#46; Caputo"
                            4 => "P&#46; Rani"
                            5 => "D&#46; Guerry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2005"
                        "volumen" => "174"
                        "paginaInicial" => "5856"
                        "paginaFinal" => "5863"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15843590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;D&#46; Shields"
                            1 => "I&#46;C&#46; Kourtis"
                            2 => "A&#46;A&#46; Tomei"
                            3 => "J&#46;M&#46; Roberts"
                            4 => "M&#46;A&#46; Swartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1185837"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "328"
                        "paginaInicial" => "749"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20339029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Kawada"
                            1 => "M&#46; Sonoshita"
                            2 => "H&#46; Sakashita"
                            3 => "A&#46; Takabayashi"
                            4 => "Y&#46; Yamaoka"
                            5 => "T&#46; Manabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-03-1757"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "4010"
                        "paginaFinal" => "4017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15173015"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCL9 induces chemotaxis&#44; chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Amatschek"
                            1 => "R&#46; Lucas"
                            2 => "A&#46; Eger"
                            3 => "M&#46; Pflueger"
                            4 => "H&#46; Hundsberger"
                            5 => "C&#46; Knoll"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6606056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2011"
                        "volumen" => "104"
                        "paginaInicial" => "469"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21179030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Scala"
                            1 => "A&#46; Ottaiano"
                            2 => "P&#46;A&#46; Ascierto"
                            3 => "M&#46; Cavalli"
                            4 => "E&#46; Simeone"
                            5 => "P&#46; Giuliano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-04-1887"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "11"
                        "paginaInicial" => "1835"
                        "paginaFinal" => "1841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15756007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of CXCR3 and CXCR4 expression in primary melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;I&#46; Longo-Imedio"
                            1 => "N&#46; Longo"
                            2 => "I&#46; Trevi&#241;o"
                            3 => "P&#46; L&#225;zaro"
                            4 => "P&#46; Sanchez-Mateos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.21269"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2005"
                        "volumen" => "117"
                        "paginaInicial" => "861"
                        "paginaFinal" => "865"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15981210"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma&#58; correlation with clinicopathological prognostic factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Monteagudo"
                            1 => "J&#46;M&#46; Martin"
                            2 => "E&#46; Jorda"
                            3 => "A&#46; Llombart-Bosch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jcp.2005.032144"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pathol"
                        "fecha" => "2007"
                        "volumen" => "60"
                        "paginaInicial" => "596"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16522748"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXC chemokine receptor 3 expression by activated CD8&#43; T cells is associated with survival in melanoma patients with stage III disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Mullins"
                            1 => "C&#46;L&#46; Slingluff"
                            2 => "J&#46;K&#46; Lee"
                            3 => "C&#46;F&#46; Garbee"
                            4 => "J&#46; Shu"
                            5 => "S&#46;G&#46; Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-04-2059"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "7697"
                        "paginaFinal" => "7701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15520172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A role for CXCR2 in senescence&#44; but what about in cancer&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;C&#46; Acosta"
                            1 => "J&#46; Gil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-08-3772"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2009"
                        "volumen" => "69"
                        "paginaInicial" => "2167"
                        "paginaFinal" => "2170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19276354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR2 expression and progression of cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Terradez"
                            1 => "N&#46; Santonja"
                            2 => "C&#46; Monteagudo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Virchows Archiv"
                        "fecha" => "2008"
                        "volumen" => "452"
                        "paginaInicial" => "S256"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CXCR1 and CXCR2 enhances human melanoma tumourigenesis&#44; growth and invasion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Singh"
                            1 => "K&#46;C&#46; Nannuru"
                            2 => "A&#46; Sadanandam"
                            3 => "M&#46;L&#46; Varney"
                            4 => "R&#46;K&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6605055"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2009"
                        "volumen" => "100"
                        "paginaInicial" => "1638"
                        "paginaFinal" => "1646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19401689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune modulation by melanoma-derived factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Ilkovitch"
                            1 => "D&#46;M&#46; L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0625.2008.00779.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2008"
                        "volumen" => "17"
                        "paginaInicial" => "977"
                        "paginaFinal" => "985"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18643844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kochetkova"
                            1 => "S&#46; Kumar"
                            2 => "S&#46;R&#46; McColl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/cdd.2008.190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Death Differ"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "664"
                        "paginaFinal" => "673"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19136936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemokines and their receptors as therapeutic targets&#58; the role of the SDF-1&#47;CXCR4 axis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Ju&#225;rez"
                            1 => "L&#46; Bendall"
                            2 => "K&#46; Bradstock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Pharm Res"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "1245"
                        "paginaFinal" => "1259"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Takenaga"
                            1 => "H&#46; Tamamura"
                            2 => "K&#46; Hiramatsu"
                            3 => "N&#46; Nakamura"
                            4 => "Y&#46; Yamaguchi"
                            5 => "A&#46; Kitagawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bbrc.2004.05.155"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "2004"
                        "volumen" => "320"
                        "paginaInicial" => "226"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15207725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM&#47;MUC18 and IL-8"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;O&#46; Melnikova"
                            1 => "M&#46; Bar-Eli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0749.2006.00331.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pigment Cell Res"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "395"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16965268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Delivery of CCL21 to metastatic disease improves the efficacy of adoptive T-cell therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Thanarajasingam"
                            1 => "L&#46; Sanz"
                            2 => "R&#46; Diaz"
                            3 => "J&#46; Qiao"
                            4 => "L&#46; S&#225;nchez-P&#233;rez"
                            5 => "T&#46; Kottke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-06-1017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2007"
                        "volumen" => "67"
                        "paginaInicial" => "300"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17210711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemotrap-1&#58; an engineered soluble receptor that blocks chemokine-induced migration of metastatic cancer cells in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lanati"
                            1 => "D&#46;B&#46; Dunn"
                            2 => "M&#46; Roussign&#233;"
                            3 => "M&#46;S&#46; Emmett"
                            4 => "V&#46; Carriere"
                            5 => "D&#46; Jullien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-10-0175"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2010"
                        "volumen" => "70"
                        "paginaInicial" => "8138"
                        "paginaFinal" => "8148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20736366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000007/v1_201304241231/S1578219011000424/v1_201304241231/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6170"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Novelties in Dermatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000007/v1_201304241231/S1578219011000424/v1_201304241231/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000424?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 12 11 23
2024 Octubre 60 60 120
2024 Septiembre 61 25 86
2024 Agosto 89 64 153
2024 Julio 70 38 108
2024 Junio 91 35 126
2024 Mayo 72 31 103
2024 Abril 66 24 90
2024 Marzo 70 38 108
2024 Febrero 46 33 79
2024 Enero 63 36 99
2023 Diciembre 40 15 55
2023 Noviembre 74 32 106
2023 Octubre 71 31 102
2023 Septiembre 62 31 93
2023 Agosto 39 27 66
2023 Julio 36 38 74
2023 Junio 52 26 78
2023 Mayo 57 33 90
2023 Abril 57 20 77
2023 Marzo 30 24 54
2023 Febrero 52 21 73
2023 Enero 56 27 83
2022 Diciembre 77 43 120
2022 Noviembre 29 23 52
2022 Octubre 30 22 52
2022 Septiembre 28 46 74
2022 Agosto 26 38 64
2022 Julio 29 35 64
2022 Junio 26 25 51
2022 Mayo 64 27 91
2022 Abril 57 36 93
2022 Marzo 59 68 127
2022 Febrero 46 26 72
2022 Enero 35 45 80
2021 Diciembre 40 38 78
2021 Noviembre 39 42 81
2021 Octubre 91 52 143
2021 Septiembre 28 39 67
2021 Agosto 57 30 87
2021 Julio 34 27 61
2021 Junio 43 48 91
2021 Mayo 57 37 94
2021 Abril 65 32 97
2021 Marzo 76 34 110
2021 Febrero 56 24 80
2021 Enero 41 30 71
2020 Diciembre 26 22 48
2020 Noviembre 31 14 45
2020 Octubre 29 14 43
2020 Septiembre 22 15 37
2020 Agosto 18 16 34
2020 Julio 23 11 34
2020 Junio 33 26 59
2020 Mayo 22 26 48
2020 Abril 34 13 47
2020 Marzo 25 22 47
2020 Febrero 5 1 6
2020 Enero 0 1 1
2019 Diciembre 2 3 5
2019 Noviembre 0 1 1
2019 Octubre 0 1 1
2019 Septiembre 4 0 4
2019 Agosto 0 4 4
2019 Julio 0 6 6
2019 Junio 2 9 11
2019 Mayo 2 17 19
2019 Abril 0 11 11
2019 Marzo 2 5 7
2019 Febrero 0 6 6
2019 Enero 2 1 3
2018 Diciembre 2 0 2
2018 Octubre 2 0 2
2018 Septiembre 3 0 3
2018 Julio 0 1 1
2018 Mayo 0 2 2
2018 Abril 0 1 1
2018 Marzo 3 2 5
2018 Febrero 36 4 40
2018 Enero 57 7 64
2017 Diciembre 62 7 69
2017 Noviembre 54 3 57
2017 Octubre 38 4 42
2017 Septiembre 50 5 55
2017 Agosto 84 10 94
2017 Julio 76 6 82
2017 Junio 81 5 86
2017 Mayo 84 5 89
2017 Abril 73 5 78
2017 Marzo 61 12 73
2017 Febrero 38 5 43
2017 Enero 33 6 39
2016 Diciembre 69 5 74
2016 Noviembre 88 4 92
2016 Octubre 96 15 111
2016 Septiembre 84 12 96
2016 Agosto 65 2 67
2016 Julio 54 9 63
2016 Junio 9 8 17
2016 Mayo 4 6 10
2016 Abril 7 1 8
2016 Marzo 5 1 6
2016 Febrero 6 3 9
2016 Enero 8 10 18
2015 Diciembre 5 7 12
2015 Noviembre 15 12 27
2015 Octubre 18 12 30
2015 Septiembre 5 4 9
2015 Agosto 21 1 22
2015 Julio 59 16 75
2015 Junio 61 8 69
2015 Mayo 114 17 131
2015 Abril 57 17 74
2015 Marzo 48 13 61
2015 Febrero 30 7 37
2015 Enero 43 15 58
2014 Diciembre 39 5 44
2014 Noviembre 29 20 49
2014 Octubre 49 16 65
2014 Septiembre 47 14 61
2014 Agosto 40 19 59
2014 Julio 54 23 77
2014 Junio 80 13 93
2014 Mayo 96 17 113
2014 Abril 65 17 82
2014 Marzo 75 17 92
2014 Febrero 52 22 74
2014 Enero 60 16 76
2013 Diciembre 59 26 85
2013 Noviembre 49 23 72
2013 Octubre 47 23 70
2013 Septiembre 27 13 40
2013 Agosto 5 8 13
2013 Julio 6 21 27
2013 Junio 7 16 23
2013 Mayo 8 12 20
2013 Abril 12 9 21
2013 Marzo 12 6 18
2013 Febrero 31 5 36
2013 Enero 17 8 25
2012 Diciembre 9 3 12
2012 Octubre 0 1 1
2012 Septiembre 3 0 3
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?