Case and Research Letters
Multiple Clustered Dermatofibromas: An Atypical Presentation of a Common Disease
Lo común a veces puede ser atípico: dermatofibromas múltiples agrupados
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Cuatro casos en la misma empresa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1188 "Ancho" => 1583 "Tamanyo" => 284298 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Threebond sealant responsible for allergic contact dermatitis in our patients, 1 of whom had a vesicular reaction to the 2% Threebond solution.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Romaguera, J. Vilaplana, M. Llagostera, R. Grimalt" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Romaguera" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Vilaplana" ] 2 => array:2 [ "nombre" => "M." 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Castellanos-González, J.L. Rodríguez-Peralto, C. Zarco, P. Ortíz-Romero" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Castellanos-González" "email" => array:1 [ 0 => "maria.castellanos.gonzalez@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.L." "apellidos" => "Rodríguez-Peralto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Zarco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Ortíz-Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología y Venereología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lo común a veces puede ser atípico: dermatofibromas múltiples agrupados" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 615 "Ancho" => 950 "Tamanyo" => 78934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Shiny, erythematous papules on the medial surface of the right thigh.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Dermatofibroma is the most common fibrohistiocytic tumor of the skin and one of the benign neoplasias that generates most visits to the dermatologist. It usually presents as an isolated lesion and rarely occurs as multiple lesions. The term multiple dermatofibroma is defined either as the appearance of at least 15 dermatofibromas within a few months<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> or, more recently, as 5 to 8 dermatofibromas in 4 months.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In 1984, Dupré et al<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> described another form of presentation that is far less common: multiple clustered dermatofibromas. We report a new case of this rare condition. A 25-year-old woman was seen in our department for small, erythematous papular lesions, with a dark center and paler borders, and asymptomatic, residual hyperpigmented macules in smaller numbers, all located on the medial surface of the right thigh. The lesions had appeared at 1 year of age, increased in number and size over 2 to 3 months, and subsequently remained stable except for partial remission of isolated lesions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The patient reported no general or local history of interest. She brought a magnetic resonance imaging scan that had been performed previously to rule out lymphangioma and that showed no atrophy of the adipose tissue or muscle, and no other relevant alterations.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Biopsy of a lesion revealed epidermal hyperplasia and a proliferation of spindle cells arranged in fascicles or whorls interspersed in bundles of thickened collagen in the underlying reticular dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Immunohistochemistry showed an intense, diffuse expression of vimentin and factor XIIIa. Smooth muscle actin, muscle-specific actin, and CD34 were negative. After histopathological confirmation of the diagnosis of dermatofibroma, it was decided to follow up the patient but to apply no treatment.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">We have found 13 cases of multiple clustered dermatofibromas described in the literature, the majority of which were reported in the review by Gershtenson.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> There is no clinical, histological, or phenotypic differentiation between the individual lesions of multiple clustered dermatofibroma and isolated dermatofibroma lesions. No local triggering factors have been described and, unlike multiple dermatofibromas, no association has been found with states of immunosuppression or other comorbid conditions. Only on 1 occasion did the lesions arise over a thrombosed superficial vein in a patient who had undergone kidney transplantation 1 month earlier. In most of the articles published the lesions had appeared on lower limbs, as was the case in our patient. Apart from our case and 1 case of congenital lesions,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> the dermatofibromas developed in patients up to 30 years of age. A benign course was reported for all patients and no malignant change or secondary metastases have been described to date. Berbis<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> reports a case followed for 20 years without complications. We believe it is important to bear this in mind for the management and follow-up of this condition.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In our patient, the symptoms, distribution of the lesions, and histopathology were identical to those previously described in the literature, although the onset of the condition at an early age is noteworthy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion, we highlight the atypical presentation of multiple clustered dermatofibromas, a subgroup of a very common condition as is dermatofibroma, and its benign course in all the cases described to date.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Castellanos-González M, et al. Lo común a veces puede ser atípico: dermatofibromas múltiples agrupados. Actas Dermosifiliogr.2011;102:467-479.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 615 "Ancho" => 950 "Tamanyo" => 78934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Shiny, erythematous papules on the medial surface of the right thigh.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 587 "Ancho" => 950 "Tamanyo" => 234623 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Proliferation of spindle cells between keloid-like collagen fascicles (hematoxylin-eosin, original magnification x150).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple histiocytomas, report of a case" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.S. Baraf" 1 => "L. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1970" "volumen" => "101" "paginaInicial" => "588" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4315412" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple eruptive dermatofibromas in three men with HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.T. Ammirati" 1 => "C. Mann" 2 => "I.K. Hornstra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1997" "volumen" => "195" "paginaInicial" => "344" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9529554" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histiocytofibromes multiples groupés" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Dupré" 1 => "B. Christol" 2 => "D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "1984" "volumen" => "111" "paginaInicial" => "163" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6326650" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple clustered dermatofibroma: case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.C. Gershtenson" 1 => "A.L. Krunic" 2 => "H.M. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2009.01325.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2010" "volumen" => "37" "paginaInicial" => "e42" "paginaFinal" => "e45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19614987" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital multiple clustered dermatofibroma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. De Unamuno" 1 => "Y. Carames" 2 => "E. Fernández-López" 3 => "A. Hernández-Martín" 4 => "C. Peña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2000" "volumen" => "142" "paginaInicial" => "1040" "paginaFinal" => "1043" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10809870" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple clustered dermatofibromas evolution over 20 years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Berbis" 1 => "T. Benderitter" 2 => "C. Perier" 3 => "J. Frey" 4 => "Y. Privat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1988" "volumen" => "177" "paginaInicial" => "185" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3169344" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010200000006/v1_201304241225/S1578219011000047/v1_201304241225/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000006/v1_201304241225/S1578219011000047/v1_201304241225/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000047?idApp=UINPBA000044" ]
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| 2024 Julio | 114 | 27 | 141 |
| 2024 Junio | 129 | 32 | 161 |
| 2024 Mayo | 108 | 33 | 141 |
| 2024 Abril | 82 | 19 | 101 |
| 2024 Marzo | 128 | 31 | 159 |
| 2024 Febrero | 104 | 32 | 136 |
| 2024 Enero | 106 | 31 | 137 |
| 2023 Diciembre | 84 | 19 | 103 |
| 2023 Noviembre | 73 | 28 | 101 |
| 2023 Octubre | 96 | 27 | 123 |
| 2023 Septiembre | 94 | 36 | 130 |
| 2023 Agosto | 72 | 24 | 96 |
| 2023 Julio | 83 | 28 | 111 |
| 2023 Junio | 94 | 25 | 119 |
| 2023 Mayo | 114 | 24 | 138 |
| 2023 Abril | 70 | 23 | 93 |
| 2023 Marzo | 93 | 28 | 121 |
| 2023 Febrero | 54 | 26 | 80 |
| 2023 Enero | 36 | 45 | 81 |
| 2022 Diciembre | 65 | 46 | 111 |
| 2022 Noviembre | 36 | 26 | 62 |
| 2022 Octubre | 41 | 28 | 69 |
| 2022 Septiembre | 42 | 36 | 78 |
| 2022 Agosto | 58 | 35 | 93 |
| 2022 Julio | 42 | 42 | 84 |
| 2022 Junio | 30 | 28 | 58 |
| 2022 Mayo | 48 | 37 | 85 |
| 2022 Abril | 76 | 25 | 101 |
| 2022 Marzo | 89 | 48 | 137 |
| 2022 Febrero | 55 | 24 | 79 |
| 2022 Enero | 83 | 33 | 116 |
| 2021 Diciembre | 56 | 46 | 102 |
| 2021 Noviembre | 54 | 57 | 111 |
| 2021 Octubre | 94 | 53 | 147 |
| 2021 Septiembre | 54 | 51 | 105 |
| 2021 Agosto | 52 | 32 | 84 |
| 2021 Julio | 66 | 39 | 105 |
| 2021 Junio | 44 | 25 | 69 |
| 2021 Mayo | 52 | 35 | 87 |
| 2021 Abril | 99 | 56 | 155 |
| 2021 Marzo | 93 | 24 | 117 |
| 2021 Febrero | 67 | 27 | 94 |
| 2021 Enero | 52 | 17 | 69 |
| 2020 Diciembre | 59 | 7 | 66 |
| 2020 Noviembre | 40 | 16 | 56 |
| 2020 Octubre | 24 | 9 | 33 |
| 2020 Septiembre | 42 | 14 | 56 |
| 2020 Agosto | 30 | 18 | 48 |
| 2020 Julio | 35 | 13 | 48 |
| 2020 Junio | 37 | 29 | 66 |
| 2020 Mayo | 23 | 22 | 45 |
| 2020 Abril | 24 | 19 | 43 |
| 2020 Marzo | 31 | 19 | 50 |
| 2020 Febrero | 5 | 0 | 5 |
| 2019 Diciembre | 4 | 1 | 5 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 5 | 5 | 10 |
| 2019 Agosto | 2 | 1 | 3 |
| 2019 Junio | 2 | 1 | 3 |
| 2019 Mayo | 1 | 17 | 18 |
| 2019 Abril | 2 | 10 | 12 |
| 2019 Marzo | 3 | 8 | 11 |
| 2019 Febrero | 0 | 2 | 2 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 1 | 1 | 2 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 3 | 2 | 5 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Marzo | 3 | 1 | 4 |
| 2018 Febrero | 21 | 2 | 23 |
| 2018 Enero | 45 | 6 | 51 |
| 2017 Diciembre | 42 | 5 | 47 |
| 2017 Noviembre | 39 | 1 | 40 |
| 2017 Octubre | 42 | 6 | 48 |
| 2017 Septiembre | 30 | 4 | 34 |
| 2017 Agosto | 20 | 7 | 27 |
| 2017 Julio | 16 | 5 | 21 |
| 2017 Junio | 28 | 4 | 32 |
| 2017 Mayo | 30 | 6 | 36 |
| 2017 Abril | 61 | 8 | 69 |
| 2017 Marzo | 26 | 2 | 28 |
| 2017 Febrero | 21 | 4 | 25 |
| 2017 Enero | 22 | 7 | 29 |
| 2016 Diciembre | 44 | 6 | 50 |
| 2016 Noviembre | 56 | 5 | 61 |
| 2016 Octubre | 60 | 4 | 64 |
| 2016 Septiembre | 41 | 3 | 44 |
| 2016 Agosto | 33 | 5 | 38 |
| 2016 Julio | 33 | 2 | 35 |
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