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Increased Risk of Developing a Second Primary Cutaneous Nevus-Associated Melanoma in Patients Previously Diagnosed with the Disease
Riesgo aumentado del desarrollo de un segundo melanoma cutáneo primario sobre un nevo en pacientes diagnosticados previamente de melanoma cutáneo primario sobre nevo
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"apellidos" => "Echeverría" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Botella-Estrada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Serra-Guillén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Martorell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Traves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "C." 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"apellidos" => "Nagore" "email" => array:1 [ 0 => "eduyame@meditex.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Riesgo aumentado del desarrollo de un segundo melanoma cutáneo primario sobre un nevo en pacientes diagnosticados previamente de melanoma cutáneo primario sobre nevo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-11-26" "fechaAceptado" => "2010-03-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84803" "palabras" => array:4 [ 0 => "Nevus-associated melanoma" 1 => "Second melanomas" 2 => "Risk factors" 3 => "Multiple melanoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84802" "palabras" => array:4 [ 0 => "Melanoma sobre nevo" 1 => "Segundos melanomas" 2 => "Factores de riesgo" 3 => "Melanoma múltiple" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patients diagnosed with primary cutaneous melanoma have a greater lifetime risk of developing further melanomas. Most of these melanomas appear to arise de novo, but a proportion of them develop in pre-existing melanocytic nevi.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine risk factors associated with the development of a second cutaneous melanoma arising on a nevus in patients diagnosed with cutaneous melanoma.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A series of 981 patients diagnosed with cutaneous melanoma was selected; 47 of them had been diagnosed with a second melanoma. These 47 patients were classified into 2 groups according to whether or not there was histological evidence that the melanoma was associated with a nevus.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Age at diagnosis less than 40 years, tumor location on the trunk, and superficial spreading subtype were independent risk factors for the appearance of a primary melanoma on a nevus. The only factor associated with the appearance of a second nevusassociated melanoma was that the first melanoma was also associated with a nevus (odds ratio, 9.51; 95% confidence interval 1.6–56.56; P=.042).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Nevus-associated melanomas develop mainly in young patients, on the trunk, and are of the superficial spreading subtype. A history of primary cutaneous melanoma arising on a nevus is associated with a 9-fold increase in the risk of developing a second nevus-associated melanoma. These findings highlight the need for careful follow-up of all melanocytic lesions in patients who have had a primary nevus-associated melanoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes diagnosticados de un melanoma cutáneo tienen más riesgo que el resto de la población de padecer nuevos melanomas a lo largo de su vida. La mayoría de estos melanomas aparecen «de novo», pero existe un porcentaje de ellos que se desarrolla sobre nevos melanocíticos previos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar los factores de riesgo asociados al desarrollo de un segundo melanoma cutáneo sobre nevo en pacientes diagnosticados de melanoma cutáneo.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron los datos de 981 pacientes diagnosticados de un primer melanoma cutáneo, 47 de los cuales habían sido diagnosticados de un segundo melanoma. Todos los pacientes fueron clasificados en función de si el melanoma presentó o no asociación histológica a un nevo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La edad inferior a 40 años, la localización en el tronco y el subtipo histológico de extensión superficial fueron los factores de riesgo independientes asociados al desarrollo de un primer melanoma sobre nevo. El único factor asociado al desarrollo de un segundo melanoma sobre nevo fue que el primer melanoma también se hubiera presentado asociado a un nevo (OR: 9,51, 95% de intervalo de confianza: 1,6–56,56; p = 0,042).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los melanomas se desarrollan asociados a un nevo principalmente en pacientes jóvenes, en el tronco y del subtipo tipo de extensión superficial. A su vez, el desarrollo de un primer melanoma sobre nevo aumenta el riesgo hasta 9 veces de desarrollar un segundo melanoma sobre un nevo previo. Estos hallazgos subrayan la importancia del seguimiento estrecho de todas las lesiones melánicas en los pacientes que han desarrollado un primer melanoma sobre nevo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 expression and risk factors for cutaneous melanoma: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.C. Whiteman" 1 => "P.G. Parsons" 2 => "A.C. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 13 | 17 | 30 |
| 2024 Octubre | 53 | 33 | 86 |
| 2024 Septiembre | 51 | 29 | 80 |
| 2024 Agosto | 102 | 68 | 170 |
| 2024 Julio | 99 | 35 | 134 |
| 2024 Junio | 52 | 15 | 67 |
| 2024 Mayo | 71 | 25 | 96 |
| 2024 Abril | 62 | 24 | 86 |
| 2024 Marzo | 55 | 22 | 77 |
| 2024 Febrero | 45 | 35 | 80 |
| 2024 Enero | 35 | 38 | 73 |
| 2023 Diciembre | 40 | 18 | 58 |
| 2023 Noviembre | 42 | 33 | 75 |
| 2023 Octubre | 59 | 46 | 105 |
| 2023 Septiembre | 48 | 28 | 76 |
| 2023 Agosto | 26 | 22 | 48 |
| 2023 Julio | 49 | 62 | 111 |
| 2023 Junio | 31 | 36 | 67 |
| 2023 Mayo | 37 | 33 | 70 |
| 2023 Abril | 28 | 22 | 50 |
| 2023 Marzo | 21 | 23 | 44 |
| 2023 Febrero | 21 | 11 | 32 |
| 2023 Enero | 27 | 23 | 50 |
| 2022 Diciembre | 35 | 43 | 78 |
| 2022 Noviembre | 13 | 30 | 43 |
| 2022 Octubre | 13 | 11 | 24 |
| 2022 Septiembre | 11 | 40 | 51 |
| 2022 Agosto | 16 | 37 | 53 |
| 2022 Julio | 14 | 35 | 49 |
| 2022 Junio | 12 | 22 | 34 |
| 2022 Mayo | 72 | 35 | 107 |
| 2022 Abril | 41 | 36 | 77 |
| 2022 Marzo | 41 | 59 | 100 |
| 2022 Febrero | 19 | 27 | 46 |
| 2022 Enero | 22 | 44 | 66 |
| 2021 Diciembre | 16 | 40 | 56 |
| 2021 Noviembre | 23 | 48 | 71 |
| 2021 Octubre | 33 | 42 | 75 |
| 2021 Septiembre | 18 | 54 | 72 |
| 2021 Agosto | 23 | 27 | 50 |
| 2021 Julio | 20 | 36 | 56 |
| 2021 Junio | 21 | 41 | 62 |
| 2021 Mayo | 13 | 28 | 41 |
| 2021 Abril | 29 | 55 | 84 |
| 2021 Marzo | 54 | 27 | 81 |
| 2021 Febrero | 42 | 18 | 60 |
| 2021 Enero | 22 | 18 | 40 |
| 2020 Diciembre | 15 | 17 | 32 |
| 2020 Noviembre | 22 | 26 | 48 |
| 2020 Octubre | 19 | 12 | 31 |
| 2020 Septiembre | 6 | 13 | 19 |
| 2020 Agosto | 36 | 28 | 64 |
| 2020 Julio | 12 | 10 | 22 |
| 2020 Junio | 23 | 23 | 46 |
| 2020 Mayo | 24 | 25 | 49 |
| 2020 Abril | 21 | 25 | 46 |
| 2020 Marzo | 23 | 15 | 38 |
| 2020 Febrero | 0 | 2 | 2 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 15 | 15 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 2 | 2 |
| 2019 Junio | 0 | 25 | 25 |
| 2019 Mayo | 0 | 29 | 29 |
| 2019 Abril | 0 | 3 | 3 |
| 2019 Marzo | 0 | 4 | 4 |
| 2018 Mayo | 0 | 3 | 3 |
| 2018 Febrero | 11 | 3 | 14 |
| 2018 Enero | 14 | 4 | 18 |
| 2017 Diciembre | 19 | 8 | 27 |
| 2017 Noviembre | 15 | 3 | 18 |
| 2017 Octubre | 12 | 2 | 14 |
| 2017 Septiembre | 18 | 5 | 23 |
| 2017 Agosto | 24 | 7 | 31 |
| 2017 Julio | 27 | 6 | 33 |
| 2017 Junio | 29 | 20 | 49 |
| 2017 Mayo | 26 | 4 | 30 |
| 2017 Abril | 30 | 7 | 37 |
| 2017 Marzo | 41 | 8 | 49 |
| 2017 Febrero | 15 | 10 | 25 |
| 2017 Enero | 14 | 9 | 23 |
| 2016 Diciembre | 29 | 12 | 41 |
| 2016 Noviembre | 23 | 5 | 28 |
| 2016 Octubre | 21 | 12 | 33 |
| 2016 Septiembre | 26 | 1 | 27 |
| 2016 Agosto | 31 | 7 | 38 |
| 2016 Julio | 18 | 4 | 22 |
| 2016 Junio | 9 | 5 | 14 |
| 2016 Mayo | 7 | 0 | 7 |
| 2016 Abril | 7 | 0 | 7 |
| 2016 Marzo | 4 | 1 | 5 |
| 2016 Febrero | 9 | 1 | 10 |
| 2016 Enero | 6 | 1 | 7 |
| 2015 Diciembre | 12 | 1 | 13 |
| 2015 Noviembre | 7 | 0 | 7 |
| 2015 Octubre | 6 | 1 | 7 |
| 2015 Septiembre | 6 | 2 | 8 |
| 2015 Agosto | 18 | 6 | 24 |
| 2015 Julio | 18 | 10 | 28 |
| 2015 Junio | 24 | 6 | 30 |
| 2015 Mayo | 47 | 2 | 49 |
| 2015 Abril | 29 | 6 | 35 |
| 2015 Marzo | 23 | 4 | 27 |
| 2015 Febrero | 18 | 6 | 24 |
| 2015 Enero | 14 | 12 | 26 |
| 2014 Diciembre | 27 | 17 | 44 |
| 2014 Noviembre | 13 | 6 | 19 |
| 2014 Octubre | 31 | 10 | 41 |
| 2014 Septiembre | 22 | 21 | 43 |
| 2014 Agosto | 27 | 18 | 45 |
| 2014 Julio | 29 | 13 | 42 |
| 2014 Junio | 21 | 10 | 31 |
| 2014 Mayo | 32 | 9 | 41 |
| 2014 Abril | 38 | 12 | 50 |
| 2014 Marzo | 38 | 13 | 51 |
| 2014 Febrero | 21 | 10 | 31 |
| 2014 Enero | 30 | 15 | 45 |
| 2013 Diciembre | 30 | 11 | 41 |
| 2013 Noviembre | 28 | 16 | 44 |
| 2013 Octubre | 30 | 13 | 43 |
| 2013 Septiembre | 29 | 15 | 44 |
| 2013 Agosto | 24 | 12 | 36 |
| 2013 Julio | 20 | 28 | 48 |
| 2013 Junio | 17 | 13 | 30 |
| 2013 Mayo | 14 | 5 | 19 |
| 2013 Abril | 19 | 19 | 38 |
| 2013 Marzo | 28 | 14 | 42 |
| 2013 Febrero | 11 | 12 | 23 |
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