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Production of Interleukin 8 by Circulating CLA+ T Cells With Skin Tropism in Patients With Psoriasis and in Healthy Controls
Producción preferente de IL-8 por linfocitos T CLA+ circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos
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Estudio ACTIDA" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Betlloch, R. Izu, M. Lleonart, M. Ferrer, J. Ferrando" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Betlloch" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Izu" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Lleonart" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Ferrer" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Ferrando" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706004?idApp=UINPBA000044" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706004/v1_201304241515/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Production of Interleukin 8 by Circulating CLA<span class="elsevierStyleSup">+</span> T Cells With Skin Tropism in Patients With Psoriasis and in Healthy Controls" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "151" "paginaFinal" => "155" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Ferran, A.B. Galván, A. Giménez-Arnau, R.M. Pujol, L.F. Santamaría-Babia" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Ferran" "email" => array:1 [ 0 => "mferran@imas.imim.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A.B." "apellidos" => "Galván" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Giménez-Arnau" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." 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"apellidos" => "Santamaría-Babia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar-IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Universidad Autónoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Instituto de investigación Biomédica, Universidad de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Producción preferente de IL-8 por linfocitos T CLA<span class="elsevierStyleSup">+</span> circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-17" "fechaAceptado" => "2009-07-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84688" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "T lymphocyte" 2 => "CLA" 3 => "Neutrophil" 4 => "IL-8" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84689" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Linfocitos T" 2 => "Antígeno de linfocito cutáneo" 3 => "Neutrófilos" 4 => "IL-8" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Psoriasis is an immune-mediated disease typically associated with cutaneous neutrophilic infiltration and Munro microabscesses. Interleukin (IL)-8 is one of the main neutrophil-attracting chemokines. Although keratinocytes have traditionally been considered to be the principal source of IL-8 in psoriasis, we present data that suggest that cutaneous lymphocyte associated antigen CLA<span class="elsevierStyleSup">+</span> T lymphocytes synthesize this cytokine.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Six patients with psoriasis and 6 healthy controls were studied. Immunomagnetic separation was used to isolate CLA<span class="elsevierStyleSup">+</span> and CLA<span class="elsevierStyleSup">−</span> T lymphocytes and IL-8 and interferon (IFN)-γ production was quantified for each cell subpopulation using enzyme-linked immunosorbent assay. Finally, gene expression of IL-8 was analyzed by reverse transcriptase-polymerase chain reaction.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">CLA<span class="elsevierStyleSup">+</span> and CLA<span class="elsevierStyleSup">−</span> T lymphocytes from patients with psoriasis and from controls showed a significantly increased production of IFN-γ when activated, whereas only activated CLA<span class="elsevierStyleSup">+</span> T lymphocytes (from patients and controls) synthesized IL-8. The higher level of expression of IL-8 and IFN-γ by CLA<span class="elsevierStyleSup">+</span> T lymphocytes in comparison to CLA<span class="elsevierStyleSup">−</span> cells was confirmed.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStyleSimplePara elsevierViewall">Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates, such as acute generalized exanthematous pustulosis, Behçet disease, and pustular psoriasis. We have confirmed the role of the subset of T lymphocytes with skin tropism (CLA<span class="elsevierStyleSup">+</span>) in IL-8 production in nonpustular psoriasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La psoriasis es una enfermedad mediada inmunológicamente, de causa desconocida, que característicamente presenta infiltración cutánea por polimorfonucleares neutrófilos y microabscesos de Munro. La interleucina (IL)-8 es una de las principales quemocinas atrayentes de los polimorfonucleares neutrófilos. Aunque la producción de IL-8 en psoriasis se ha atribuido principalmente al queratinocito, presentamos datos que apoyan la producción de esta por los linfocitos T antígeno de linfocito cutáneo (CLA)+.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 6 pacientes con psoriasis y 6 sanos. Mediante técnicas de separación inmunomagnética se aislaron los linfocitos T CLA+ y CLA-. Se cuantificó la producción de IL-8 e IFNγ de cada subpoblación celular a través de un ELISA. Finalmente, se analizó su expresión génica mediante reacción en cadena de la polimerasa a tiempo real.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Tanto los linfocitos T CLA+ como CLA-, de controles y pacientes con psoriasis, aumentaban significativamente la producción de IFNγ cuando eran activados, mientras que sólo los linfocitos T CLA+ activados, tanto de controles como de sujetos con psoriasis, producían IL-8. Se confirmó la expresión preferente de IL-8 e IFNγ en linfocitos T CLA+ respecto de CLA-.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">Estudios previos han demostrado la producción de IL-8 por linfocitos T en dermatosis inflamatorias ricas en neutrófilos, tales como la pustulosis exantemática aguda generalizada, la enfermedad de Behçet y la psoriasis pustulosa. Nosotros hemos confirmado el papel del subgrupo de linfocitos T con tropismo cutáneo (CLA+) en la producción de IL-8 en la psoriasis no pustulosa.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Gudjonsson" 1 => "J.T. Elder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Fitzpatrick's Dermatology in general medicine" "paginaInicial" => "169" "paginaFinal" => "193" "edicion" => "7th ed." "serieFecha" => "2008" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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| año/Mes | Html | Total | |
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| 2023 Septiembre | 36 | 35 | 71 |
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| 2023 Enero | 30 | 26 | 56 |
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| 2021 Diciembre | 20 | 45 | 65 |
| 2021 Noviembre | 25 | 52 | 77 |
| 2021 Octubre | 22 | 52 | 74 |
| 2021 Septiembre | 18 | 46 | 64 |
| 2021 Agosto | 11 | 32 | 43 |
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| 2021 Junio | 23 | 36 | 59 |
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| 2020 Noviembre | 11 | 10 | 21 |
| 2020 Octubre | 16 | 6 | 22 |
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| 2020 Agosto | 27 | 20 | 47 |
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| 2020 Mayo | 13 | 13 | 26 |
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| 2020 Febrero | 0 | 2 | 2 |
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| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 4 | 4 |
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| 2019 Febrero | 0 | 6 | 6 |
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| 2018 Marzo | 1 | 0 | 1 |
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| 2018 Enero | 19 | 6 | 25 |
| 2017 Diciembre | 16 | 7 | 23 |
| 2017 Noviembre | 13 | 4 | 17 |
| 2017 Octubre | 21 | 4 | 25 |
| 2017 Septiembre | 18 | 1 | 19 |
| 2017 Agosto | 27 | 10 | 37 |
| 2017 Julio | 25 | 3 | 28 |
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| 2017 Enero | 16 | 4 | 20 |
| 2016 Diciembre | 30 | 7 | 37 |
| 2016 Noviembre | 25 | 19 | 44 |
| 2016 Octubre | 19 | 26 | 45 |
| 2016 Septiembre | 23 | 4 | 27 |
| 2016 Agosto | 31 | 5 | 36 |
| 2016 Julio | 13 | 5 | 18 |
| 2016 Junio | 8 | 8 | 16 |
| 2016 Mayo | 5 | 6 | 11 |
| 2016 Abril | 4 | 6 | 10 |
| 2016 Marzo | 3 | 0 | 3 |
| 2016 Febrero | 10 | 1 | 11 |
| 2016 Enero | 11 | 1 | 12 |
| 2015 Diciembre | 6 | 0 | 6 |
| 2015 Noviembre | 14 | 5 | 19 |
| 2015 Octubre | 4 | 6 | 10 |
| 2015 Septiembre | 7 | 1 | 8 |
| 2015 Agosto | 12 | 5 | 17 |
| 2015 Julio | 31 | 6 | 37 |
| 2015 Junio | 34 | 4 | 38 |
| 2015 Mayo | 53 | 8 | 61 |
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| 2015 Marzo | 35 | 13 | 48 |
| 2015 Febrero | 20 | 7 | 27 |
| 2015 Enero | 13 | 4 | 17 |
| 2014 Diciembre | 20 | 9 | 29 |
| 2014 Noviembre | 15 | 14 | 29 |
| 2014 Octubre | 31 | 14 | 45 |
| 2014 Septiembre | 17 | 14 | 31 |
| 2014 Agosto | 26 | 10 | 36 |
| 2014 Julio | 32 | 18 | 50 |
| 2014 Junio | 27 | 11 | 38 |
| 2014 Mayo | 26 | 16 | 42 |
| 2014 Abril | 37 | 11 | 48 |
| 2014 Marzo | 33 | 13 | 46 |
| 2014 Febrero | 24 | 11 | 35 |
| 2014 Enero | 18 | 14 | 32 |
| 2013 Diciembre | 28 | 10 | 38 |
| 2013 Noviembre | 23 | 14 | 37 |
| 2013 Octubre | 24 | 13 | 37 |
| 2013 Septiembre | 31 | 17 | 48 |
| 2013 Agosto | 24 | 13 | 37 |
| 2013 Julio | 30 | 22 | 52 |
| 2013 Junio | 27 | 13 | 40 |
| 2013 Mayo | 25 | 10 | 35 |
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| 2013 Marzo | 28 | 19 | 47 |
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