Original articles
Microcystic Adnexal Carcinoma: Mohs Micrographic Surgery as the Treatment of Choice
Carcinoma Anexial Microquístico : la Cirugía Micrográfica de Mohs Como Tratamiento de Elección
A. Martorell-Calatayuda,
, C. Requena-Caballeroa, R. Botella-Estradaa, S. Almenar-Medinab, O. Sanmartín-Jiméneza, B. Llombart-Cussaca, E. Nagore-Enguídanosa, C. Serra-Guilléna, B. Echeverría-Garcíaa, C. Guillén-Baronaa
Autor para correspondencia
antmarto@hotmail.com
Correspondence: Antonio Martorell Calatayud, C/ San José de la Montaña, 14, puerta 11, 46008 Valencia, Spain.
Correspondence: Antonio Martorell Calatayud, C/ San José de la Montaña, 14, puerta 11, 46008 Valencia, Spain.
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"apellidos" => "Guillén-Barona" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Antonio Martorell Calatayud, C/ San José de la Montaña, 14, puerta 11, 46008 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma Anexial Microquístico : la Cirugía Micrográfica de Mohs Como Tratamiento de Elección" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-01-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84578" "palabras" => array:3 [ 0 => "microcystic adnexal carcinoma" 1 => "Mohs surgery" 2 => "perineural invasion" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84577" "palabras" => array:3 [ 0 => "carcinoma anexial microquístico" 1 => "cirugía de Mohs" 2 => "invasión perineural" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">Microcystic adnexal carcinoma is a rare and aggressive tumor that manifests clinically as a subcutaneous nodule located on the head or neck. The tumor can be confused clinically and histologically with other benign and malignant skin lesions, often leading to inappropriate initial treatment. The chief concern with microcystic adnexal carcinoma is the elevated morbidity and the high rate of recurrence after wide local excision. Recent preliminary studies point to higher cure rates with Mohs micrographic surgery.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We reviewed the medical histories of 6 consecutive patients with microcystic adnexal carcinoma who underwent Mohs micrographic surgery in our dermatology department between 1995 and 2007.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In all cases, lesions were located on the head and were primary tumors. Seventy percent of the tumors were wrongly diagnosed initially as basal cell carcinoma. Perineural invasion was not detected in any patient, and all were free of recurrence after between 1 and 12 years of postoperative follow-up.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The absence of perineural involvement and substantial cell atypia can be attributed to the lesions being primary tumors. This would provide a rationale for definitive radical treatment of the primary tumor from the outset to avoid the complications associated with recurrence. The site and the absence of recurrence in all our patients who underwent Mohs micrographic surgery support the use of this technique as the treatment of choice in microcystic adnexal carcinoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">El carcinoma anexial microquístico (CAM) es un tumor raro y agresivo que clínicamente se manifiesta como un nódulo subcutáneo localizado en las regiones de cabeza y cuello. Esta tumoración puede ser clínica e histológicamente confundida con otras lesiones cutáneas benignas o malignas, loque con frecuencia conduce a un tratamiento inicial erróneo. La principal complicación del CAM es la alta morbilidad y la elevada tasa de recurrencia tras escisión local amplia. Estudios preliminares recientes han mostrado unas mayores tasas de curación mediante cirugía micrográfica de Mohs (CMM).</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se revisaron las historias clínicas de 6 pacientes consecutivos con CAM tratados mediante CMM en nuestro Servicio de Dermatología entre 1995 y 2007.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Todos los casos se localizaron en la cabeza y el 100% fue tumor primario. En el 70% de los casos el tumor fue inicialmente mal diagnosticado de carcinoma basocelular. No se detectó invasión perineural en ninguno de los casos y la recurrencia estuvo ausente en todos los pacientes tras un periodo de seguimiento comprendido entre 1 y 12 años posteriores a la CMM.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La ausencia de afectación perineural y de una importante atipia celular puede deberse al carácter primario de la tumoración. Ello justificaría la necesidad de un tratamiento definitivo radical inicial del tumor primario para evitar las complicaciones que implica una recidiva tumoral. La localización y la ausencia de recurrencia en todos nuestros casos tratados mediante CMM apoyan el uso de esta técnica como el tratamiento de elección para el CAM.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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| 2021 Octubre | 28 | 65 | 93 |
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| 2021 Agosto | 24 | 33 | 57 |
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| 2020 Octubre | 16 | 25 | 41 |
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| 2019 Noviembre | 0 | 19 | 19 |
| 2019 Octubre | 0 | 28 | 28 |
| 2019 Septiembre | 0 | 29 | 29 |
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| 2018 Abril | 0 | 1 | 1 |
| 2018 Febrero | 14 | 10 | 24 |
| 2018 Enero | 20 | 7 | 27 |
| 2017 Diciembre | 18 | 13 | 31 |
| 2017 Noviembre | 19 | 7 | 26 |
| 2017 Octubre | 14 | 19 | 33 |
| 2017 Septiembre | 11 | 12 | 23 |
| 2017 Agosto | 18 | 18 | 36 |
| 2017 Julio | 17 | 13 | 30 |
| 2017 Junio | 26 | 29 | 55 |
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| 2017 Febrero | 18 | 27 | 45 |
| 2017 Enero | 15 | 24 | 39 |
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| 2016 Noviembre | 27 | 21 | 48 |
| 2016 Octubre | 22 | 23 | 45 |
| 2016 Septiembre | 30 | 21 | 51 |
| 2016 Agosto | 30 | 18 | 48 |
| 2016 Julio | 29 | 8 | 37 |
| 2016 Junio | 8 | 8 | 16 |
| 2016 Mayo | 7 | 9 | 16 |
| 2016 Abril | 5 | 12 | 17 |
| 2016 Marzo | 1 | 15 | 16 |
| 2016 Febrero | 8 | 11 | 19 |
| 2016 Enero | 6 | 12 | 18 |
| 2015 Diciembre | 12 | 5 | 17 |
| 2015 Noviembre | 11 | 11 | 22 |
| 2015 Octubre | 14 | 13 | 27 |
| 2015 Septiembre | 5 | 3 | 8 |
| 2015 Agosto | 8 | 3 | 11 |
| 2015 Julio | 29 | 15 | 44 |
| 2015 Junio | 26 | 23 | 49 |
| 2015 Mayo | 61 | 29 | 90 |
| 2015 Abril | 36 | 29 | 65 |
| 2015 Marzo | 26 | 22 | 48 |
| 2015 Febrero | 20 | 24 | 44 |
| 2015 Enero | 22 | 23 | 45 |
| 2014 Diciembre | 35 | 26 | 61 |
| 2014 Noviembre | 27 | 30 | 57 |
| 2014 Octubre | 39 | 34 | 73 |
| 2014 Septiembre | 45 | 27 | 72 |
| 2014 Agosto | 49 | 25 | 74 |
| 2014 Julio | 55 | 27 | 82 |
| 2014 Junio | 38 | 10 | 48 |
| 2014 Mayo | 43 | 25 | 68 |
| 2014 Abril | 51 | 7 | 58 |
| 2014 Marzo | 47 | 31 | 78 |
| 2014 Febrero | 42 | 32 | 74 |
| 2014 Enero | 24 | 32 | 56 |
| 2013 Diciembre | 29 | 24 | 53 |
| 2013 Noviembre | 25 | 29 | 54 |
| 2013 Octubre | 39 | 26 | 65 |
| 2013 Septiembre | 36 | 28 | 64 |
| 2013 Agosto | 31 | 37 | 68 |
| 2013 Julio | 29 | 54 | 83 |
| 2013 Junio | 30 | 49 | 79 |
| 2013 Mayo | 29 | 38 | 67 |
| 2013 Abril | 33 | 31 | 64 |
| 2013 Marzo | 38 | 29 | 67 |
| 2013 Febrero | 41 | 13 | 54 |
| 2013 Enero | 7 | 3 | 10 |
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