Original article
Clinical Findings in 67 Patients With Tuberous Sclerosis
Esclerosis Tuberosa. Hallazgos Clínicos en 67 Pacientes
M. Fernández-Guarinoa,
, P. Boixedaa, M.J. Anayab, P. Beldarc, P. Jaéna
Autor para correspondencia
montsefdez@msn.com
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Crta. Colmenar Viejo km 9,100, 28034 Madrid, Spain.
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Crta. Colmenar Viejo km 9,100, 28034 Madrid, Spain.
a Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
b Servicio de Medicina Interna, Hospital Fernando Fonseca, Universidad de Lisboa, Lisboa, Portugal
c Servicio de Dermatología, Universidad de Alcalá de Henares, Hospital Universitario de Guadalajara, Guadalajara, Spain
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Colmenar Viejo km 9,100, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esclerosis Tuberosa. Hallazgos Clínicos en 67 Pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-11-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84544" "palabras" => array:3 [ 0 => "tuberous sclerosis" 1 => "skin manifestations" 2 => "neurological manifestations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84543" "palabras" => array:3 [ 0 => "esclerosis tuberosa" 1 => "manifestaciones dermatológicas" 2 => "manifestaciones neurológicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Tuberous sclerosis is an uncommon neurocutaneous syndrome characterized by the appearance of hamartomas in multiple organs. Diagnosis is based on clinical criteria.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To report the clinical findings in a series of 67 patients with tuberous sclerosis.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a descriptive and observational retrospective study of patients with tuberous sclerosis referred to our dermatology clinics between January 1994 and March 2007.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All patients presented neurological or dermatological disorders. Other disorders, in descending frequency, were psychiatric (55.5%), renal (32.8%), cardiac (22.4%), skeletal and pulmonary (13.4%), and ophthalmological (11.9%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We report the clinical findings in a series of patients with tuberous sclerosis. According to our literature search, this is the first such study in the Spanish population. Overall, our findings support those already published.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La esclerosis tuberosa (ET) es un síndrome neurocutáneo infrecuente caracterizado por la aparición de hamartomas en múltiples órganos. Su diagnóstico se basa en criterios clínicos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir los hallazgos clínicos en una serie de 67 pacientes afectos de ET.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio retrospectivo, descriptivo y observacional de los pacientes con ET remitidos a nuestras consultas de Dermatología entre enero de 1994 y marzo de 2007.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 100% de los pacientes presentaron alteraciones neurológicas o dermatológicas. El resto fueron, por orden: psiquiátricas (55,5%), renales (32,8%), cardíacas (22,4%), esqueléticas y pulmonares (13,4%) y oftalmológicas (11,9%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Describimos los hallazgos clínicos en una serie de pacientes afectos de ET. Se trata, según la literatura revisada, del primer estudio de este tipo en la población española. Globalmente, nuestros datos apoyan lo hasta ahora publicado.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cutaneous features of tuberous sclerosis: a population study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.W. Webb" 1 => "A. Clarke" 2 => "A. Fryer" 3 => "J.P. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 8 | 12 |
| 2024 Octubre | 55 | 47 | 102 |
| 2024 Septiembre | 58 | 39 | 97 |
| 2024 Agosto | 89 | 58 | 147 |
| 2024 Julio | 51 | 44 | 95 |
| 2024 Junio | 61 | 34 | 95 |
| 2024 Mayo | 60 | 39 | 99 |
| 2024 Abril | 55 | 29 | 84 |
| 2024 Marzo | 56 | 51 | 107 |
| 2024 Febrero | 51 | 33 | 84 |
| 2024 Enero | 43 | 40 | 83 |
| 2023 Diciembre | 46 | 34 | 80 |
| 2023 Noviembre | 47 | 30 | 77 |
| 2023 Octubre | 51 | 79 | 130 |
| 2023 Septiembre | 37 | 30 | 67 |
| 2023 Agosto | 46 | 19 | 65 |
| 2023 Julio | 74 | 57 | 131 |
| 2023 Junio | 36 | 31 | 67 |
| 2023 Mayo | 56 | 19 | 75 |
| 2023 Abril | 45 | 18 | 63 |
| 2023 Marzo | 65 | 26 | 91 |
| 2023 Febrero | 36 | 20 | 56 |
| 2023 Enero | 37 | 19 | 56 |
| 2022 Diciembre | 37 | 42 | 79 |
| 2022 Noviembre | 13 | 34 | 47 |
| 2022 Octubre | 20 | 21 | 41 |
| 2022 Septiembre | 13 | 30 | 43 |
| 2022 Agosto | 16 | 37 | 53 |
| 2022 Julio | 8 | 29 | 37 |
| 2022 Junio | 16 | 30 | 46 |
| 2022 Mayo | 29 | 33 | 62 |
| 2022 Abril | 35 | 31 | 66 |
| 2022 Marzo | 38 | 63 | 101 |
| 2022 Febrero | 35 | 27 | 62 |
| 2022 Enero | 19 | 33 | 52 |
| 2021 Diciembre | 30 | 52 | 82 |
| 2021 Noviembre | 30 | 37 | 67 |
| 2021 Octubre | 35 | 43 | 78 |
| 2021 Septiembre | 28 | 41 | 69 |
| 2021 Agosto | 25 | 22 | 47 |
| 2021 Julio | 29 | 26 | 55 |
| 2021 Junio | 23 | 32 | 55 |
| 2021 Mayo | 19 | 25 | 44 |
| 2021 Abril | 39 | 44 | 83 |
| 2021 Marzo | 52 | 13 | 65 |
| 2021 Febrero | 45 | 25 | 70 |
| 2021 Enero | 24 | 14 | 38 |
| 2020 Diciembre | 31 | 10 | 41 |
| 2020 Noviembre | 30 | 18 | 48 |
| 2020 Octubre | 20 | 12 | 32 |
| 2020 Septiembre | 19 | 9 | 28 |
| 2020 Agosto | 27 | 12 | 39 |
| 2020 Julio | 13 | 11 | 24 |
| 2020 Junio | 22 | 23 | 45 |
| 2020 Mayo | 32 | 11 | 43 |
| 2020 Abril | 24 | 21 | 45 |
| 2020 Marzo | 25 | 13 | 38 |
| 2020 Febrero | 2 | 1 | 3 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 13 | 13 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Julio | 0 | 12 | 12 |
| 2019 Junio | 0 | 2 | 2 |
| 2019 Mayo | 2 | 52 | 54 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 4 | 4 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Febrero | 10 | 2 | 12 |
| 2018 Enero | 17 | 6 | 23 |
| 2017 Diciembre | 17 | 7 | 24 |
| 2017 Noviembre | 18 | 5 | 23 |
| 2017 Octubre | 18 | 3 | 21 |
| 2017 Septiembre | 20 | 4 | 24 |
| 2017 Agosto | 31 | 10 | 41 |
| 2017 Julio | 24 | 1 | 25 |
| 2017 Junio | 26 | 15 | 41 |
| 2017 Mayo | 17 | 4 | 21 |
| 2017 Abril | 16 | 16 | 32 |
| 2017 Marzo | 23 | 29 | 52 |
| 2017 Febrero | 27 | 9 | 36 |
| 2017 Enero | 15 | 7 | 22 |
| 2016 Diciembre | 37 | 15 | 52 |
| 2016 Noviembre | 26 | 6 | 32 |
| 2016 Octubre | 29 | 9 | 38 |
| 2016 Septiembre | 37 | 4 | 41 |
| 2016 Agosto | 31 | 7 | 38 |
| 2016 Julio | 25 | 11 | 36 |
| 2016 Junio | 7 | 10 | 17 |
| 2016 Mayo | 6 | 9 | 15 |
| 2016 Abril | 9 | 1 | 10 |
| 2016 Marzo | 4 | 0 | 4 |
| 2016 Febrero | 7 | 0 | 7 |
| 2016 Enero | 6 | 3 | 9 |
| 2015 Diciembre | 9 | 0 | 9 |
| 2015 Noviembre | 11 | 1 | 12 |
| 2015 Octubre | 9 | 2 | 11 |
| 2015 Septiembre | 7 | 3 | 10 |
| 2015 Agosto | 13 | 2 | 15 |
| 2015 Julio | 32 | 8 | 40 |
| 2015 Junio | 34 | 6 | 40 |
| 2015 Mayo | 77 | 9 | 86 |
| 2015 Abril | 35 | 12 | 47 |
| 2015 Marzo | 29 | 10 | 39 |
| 2015 Febrero | 40 | 10 | 50 |
| 2015 Enero | 20 | 9 | 29 |
| 2014 Diciembre | 39 | 6 | 45 |
| 2014 Noviembre | 20 | 6 | 26 |
| 2014 Octubre | 31 | 7 | 38 |
| 2014 Septiembre | 28 | 10 | 38 |
| 2014 Agosto | 28 | 10 | 38 |
| 2014 Julio | 43 | 17 | 60 |
| 2014 Junio | 41 | 11 | 52 |
| 2014 Mayo | 31 | 7 | 38 |
| 2014 Abril | 36 | 10 | 46 |
| 2014 Marzo | 51 | 14 | 65 |
| 2014 Febrero | 39 | 9 | 48 |
| 2014 Enero | 37 | 11 | 48 |
| 2013 Diciembre | 35 | 8 | 43 |
| 2013 Noviembre | 25 | 11 | 36 |
| 2013 Octubre | 30 | 12 | 42 |
| 2013 Septiembre | 29 | 15 | 44 |
| 2013 Agosto | 30 | 11 | 41 |
| 2013 Julio | 45 | 26 | 71 |
| 2013 Junio | 28 | 20 | 48 |
| 2013 Mayo | 28 | 6 | 34 |
| 2013 Abril | 34 | 18 | 52 |
| 2013 Marzo | 32 | 11 | 43 |
| 2013 Febrero | 23 | 13 | 36 |
| 2013 Enero | 7 | 3 | 10 |
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