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                      "doi" => "10.1056/NEJM198412273112601"
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                        "tituloSerie" => "N Engl J Med"
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                        "volumen" => "311"
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                        "paginaFinal" => "1652"
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                            3 => "A&#46; Selva"
                            4 => "P&#46; D&#237;az"
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                          "autores" => array:6 [
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                          0 => array:2 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Xantomatosis cerebro-tendinosa&#58; utilidad de la resonancia magn&#233;tica nuclear para el seguimiento y respuesta al tratamiento"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Cuende"
                            1 => "M&#46; G&#243;mez-Ruiz de Mendarozqueta"
                            2 => "J&#46;C&#46; Vesga"
                            3 => "N&#46; Sarac&#237;bar"
                            4 => "A&#46; Ib&#225;&#241;ez-Avil&#233;s"
                            5 => "C&#46; Castellano-Hurtado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Neurol"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "paginaInicial" => "1535"
                        "paginaFinal" => "1538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9064170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resonancia magn&#233;tica del cerebro y tendones aqu&#237;leos en la xantomatosis cerebrotendinosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pardo"
                            1 => "J&#46;M&#46; Prieto"
                            2 => "J&#46;R&#46; Rodr&#237;guez"
                            3 => "J&#46; Vadillo"
                            4 => "M&#46;D&#46; Dapena"
                            5 => "M&#46; Noya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurologia"
                        "fecha" => "1993"
                        "volumen" => "8"
                        "paginaInicial" => "268"
                        "paginaFinal" => "270"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8240840"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis&#58; clinical course&#44; genotypes and metabolic backgrounds"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;H&#46; Moghadasian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Invest Med"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "42"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15061585"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib11"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;J&#46; Cali"
                            1 => "C&#46;L&#46; Hsieh"
                            2 => "U&#46; Francke"
                            3 => "D&#46;W&#46; Russell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1991"
                        "volumen" => "266"
                        "paginaInicial" => "7779"
                        "paginaFinal" => "7783"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2019602"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis&#58; a rare disease with diverse manifestations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;H&#46; Moghadasian"
                            1 => "G&#46; Salen"
                            2 => "J&#46;J&#46; Frohlich"
                            3 => "C&#46;H&#46; Scudamore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2002"
                        "volumen" => "59"
                        "paginaInicial" => "527"
                        "paginaFinal" => "529"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11939886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "B&#46;G&#46; van Engelen"
                            2 => "R&#46;A&#46; Wevers"
                            3 => "B&#46;M&#46; van Geel"
                            4 => "J&#46;R&#46; Cruysberg"
                            5 => "L&#46;P&#46; van den Heuvel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2000"
                        "volumen" => "57"
                        "paginaInicial" => "520"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10768627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis&#58; clinical and biochemical evaluation of eight patients and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Kuriyama"
                            1 => "J&#46; Fujiyama"
                            2 => "H&#46; Yoshidome"
                            3 => "S&#46; Takenaga"
                            4 => "K&#46; Matsumuro"
                            5 => "T&#46; Kasama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1991"
                        "volumen" => "102"
                        "paginaInicial" => "225"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2072121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and molecular genetic characteristics of patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "L&#46;H&#46; Hoefsloot"
                            2 => "G&#46;C&#46; Steenbergen"
                            3 => "J&#46;P&#46; Theelen"
                            4 => "R&#46;A&#46; Wevers"
                            5 => "F&#46;J&#46; Gabre&#235;ls"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain"
                        "fecha" => "2000"
                        "volumen" => "123"
                        "paginaInicial" => "908"
                        "paginaFinal" => "919"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10775536"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Burghaus"
                            1 => "W&#46; Liu"
                            2 => "W&#46;F&#46; Haupt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2007-982053"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dtsch Med Wochenschr"
                        "fecha" => "2007"
                        "volumen" => "132"
                        "paginaInicial" => "1463"
                        "paginaFinal" => "1466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17583829"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normalisation of serum cholestanol concentration in a patient with cerebrotendinous xanthomatosis by combined treatment with chenodeoxycholic acid&#44; simvastatin and LDL apheresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;T&#46; Dotti"
                            1 => "D&#46; L&#252;tjohann"
                            2 => "K&#46; von Bergmann"
                            3 => "A&#46; Federico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10072-004-0320-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurol Sci"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "185"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15549503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of simvastatin in addition to chenodeoxycholic acid in patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "R&#46;A&#46; Wevers"
                            2 => "B&#46;G&#46; Van Engelen"
                            3 => "A&#46; Keyser"
                            4 => "B&#46;G&#46; Wolthers"
                            5 => "F&#46; Barkhof"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "1999"
                        "volumen" => "48"
                        "paginaInicial" => "233"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of cerebrotendinous xanthomatosis&#58; effects of chenodeoxycholic acid&#44; pravastatin&#44; and combined use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            1 => "Y&#46; Tokimura"
                            2 => "J&#46; Fujiyama"
                            3 => "Y&#46; Utatsu"
                            4 => "M&#46; Osame"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1994"
                        "volumen" => "125"
                        "paginaInicial" => "22"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7964884"
                            "web" => "Medline"
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Case reports
Cerebrotendinous Xanthomatosis: Report of 4 Patients
Xantomatosis Cerebrotendinosa: Descripción de 4 Casos
C. Ferrándiz-Pulidoa,
Autor para correspondencia
40879cfp@comb.es

Correspondence: Servicio de Dermatología, Hospital Universitario Vall d’Hebron, Paseo Vall d’Hebron, 119-129, 08035 Barcelona, Spain.
, R. Bartralota, M. Girósb, P. Bassasa, C. Herasa, D. Bodeta, R. Savallc, V. García-Patosa
a Servicio de Dermatología, Hospital Vall d’Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain
b Sección de Errores Congénitos del Metabolismo, Servicio de Bioquímica y Genética Molecular, Hospital Clínico, Barcelona and Centro de Investigaciones para Enfermedades Raras, CIBERER Instituto de Investigaciones Carlos III, Valencia, Spain
c Servicio de Dermatología, Hospital Sant Jaume, Calella, Barcelona, Spain
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        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Cerebrotendinous xanthomatosis &#40;CTX&#41; is an uncommon autosomal recessive disease caused by mutation of the <span class="elsevierStyleItalic">CYP27A1</span> gene&#46; It is characterized by the presence of xanthomas in different tissues&#44; principally brain and tendon&#44; due to the accumulation of &#946;-cholestanol&#46; Diagnosis is confirmed by measurement of serum &#946;-cholestanol and urinary bile alcohol levels&#46; Therapy with chenodeoxycholic acid has been shown to be the most effective treatment and can halt progression of the disease&#46; We present 4 patients with a history of neurological disorders since childhood and who were diagnosed with CTX after developing tendon xanthomas&#46; Although diagnostic suspicion depends to a large extent on recognition of tendon xanthomas&#44; these are not an early sign of the disease&#44; which can present with neurological disorders&#44; cataracts&#44; and chronic diarrhea&#46; Early diagnosis of CTX therefore rests on measurement of serum &#946;-cholestanol levels&#44; even in absence of tendon xanthomas&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La xantomatosis cerebrotendinosa &#40;XCT&#41; es una enfermedad hereditaria infrecuente causada por la mutaci&#243;n del gen <span class="elsevierStyleItalic">CYP27A1</span>&#46; Es caracter&#237;stica la aparici&#243;n de xantomas en diferentes tejidos&#44; principalmente en el cerebro y los tendones&#44; secundarios al dep&#243;sito de &#946;-colestanol&#46; El diagn&#243;stico se confirma mediante la determinaci&#243;n de &#946;-colestanol en suero&#44; y de los alcoholes biliares en orina&#46; El &#225;cido quenodesoxic&#243;lico es la terapia m&#225;s eficaz&#44; pudiendo llegar a frenar la progresi&#243;n de la enfermedad&#46; Presentamos4 pacientes con alteraciones neurol&#243;gicas desde la infancia que fueron diagnosticados de XCT tras el desarrollo de xantomas tendinosos&#46; El reconocimiento de los xantomas tendinosos es fundamental para orientar el diagn&#243;stico de XCT&#44; pero estos no son un signo inicial de la enfermedad&#44; que debuta con alteraciones neurol&#243;gicas&#44; cataratas o diarrea cr&#243;nica&#46; Por lo tanto&#44; el diagn&#243;stico temprano de la XCT requiere la determinaci&#243;n del &#946;-colestanol s&#233;rico en estos pacientes&#44; aun en ausencia de xantomas&#46;</p>"
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                      "titulo" => "Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid"
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                          "autores" => array:3 [
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                            2 => "S&#46; Shefer"
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                      "doi" => "10.1056/NEJM198412273112601"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1984"
                        "volumen" => "311"
                        "paginaInicial" => "1649"
                        "paginaFinal" => "1652"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6504105"
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                      "titulo" => "Cerebrotendinous xanthomatosis"
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                            0 => "S&#46; Bel"
                            1 => "V&#46; Garc&#237;a-Patos"
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                            3 => "A&#46; Selva"
                            4 => "P&#46; D&#237;az"
                            5 => "B&#46;G&#46; Wolthers"
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                      "doi" => "10.1067/mjd.2001.113690"
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                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "45"
                        "paginaInicial" => "292"
                        "paginaFinal" => "295"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11464194"
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                    0 => array:2 [
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                        "tituloSerie" => "Actas Dermosifiliogr"
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                        "paginaInicial" => "65"
                        "paginaFinal" => "106"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/696450"
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                        "tituloSerie" => "Actas Dermosifiliogr"
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                        "paginaFinal" => "194"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1274719"
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                        "tituloSerie" => "Neurol Sci"
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                        "volumen" => "27"
                        "paginaInicial" => "143"
                        "paginaFinal" => "149"
                        "link" => array:1 [
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                        0 => array:2 [
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                            4 => "M&#46; Gir&#243;s"
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                        "paginaFinal" => "650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12487962"
                            "web" => "Medline"
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                      "titulo" => "Xantomatosis cerebro-tendinosa&#58; utilidad de la resonancia magn&#233;tica nuclear para el seguimiento y respuesta al tratamiento"
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                        0 => array:2 [
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                            4 => "A&#46; Ib&#225;&#241;ez-Avil&#233;s"
                            5 => "C&#46; Castellano-Hurtado"
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                    0 => array:1 [
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                        "tituloSerie" => "Rev Neurol"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "paginaInicial" => "1535"
                        "paginaFinal" => "1538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9064170"
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                      "titulo" => "Resonancia magn&#233;tica del cerebro y tendones aqu&#237;leos en la xantomatosis cerebrotendinosa"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pardo"
                            1 => "J&#46;M&#46; Prieto"
                            2 => "J&#46;R&#46; Rodr&#237;guez"
                            3 => "J&#46; Vadillo"
                            4 => "M&#46;D&#46; Dapena"
                            5 => "M&#46; Noya"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurologia"
                        "fecha" => "1993"
                        "volumen" => "8"
                        "paginaInicial" => "268"
                        "paginaFinal" => "270"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8240840"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Invest Med"
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                        "paginaInicial" => "42"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15061585"
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                ]
              ]
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            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;J&#46; Cali"
                            1 => "C&#46;L&#46; Hsieh"
                            2 => "U&#46; Francke"
                            3 => "D&#46;W&#46; Russell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1991"
                        "volumen" => "266"
                        "paginaInicial" => "7779"
                        "paginaFinal" => "7783"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2019602"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis&#58; a rare disease with diverse manifestations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;H&#46; Moghadasian"
                            1 => "G&#46; Salen"
                            2 => "J&#46;J&#46; Frohlich"
                            3 => "C&#46;H&#46; Scudamore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2002"
                        "volumen" => "59"
                        "paginaInicial" => "527"
                        "paginaFinal" => "529"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11939886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "B&#46;G&#46; van Engelen"
                            2 => "R&#46;A&#46; Wevers"
                            3 => "B&#46;M&#46; van Geel"
                            4 => "J&#46;R&#46; Cruysberg"
                            5 => "L&#46;P&#46; van den Heuvel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2000"
                        "volumen" => "57"
                        "paginaInicial" => "520"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10768627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis&#58; clinical and biochemical evaluation of eight patients and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Kuriyama"
                            1 => "J&#46; Fujiyama"
                            2 => "H&#46; Yoshidome"
                            3 => "S&#46; Takenaga"
                            4 => "K&#46; Matsumuro"
                            5 => "T&#46; Kasama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1991"
                        "volumen" => "102"
                        "paginaInicial" => "225"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2072121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and molecular genetic characteristics of patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "L&#46;H&#46; Hoefsloot"
                            2 => "G&#46;C&#46; Steenbergen"
                            3 => "J&#46;P&#46; Theelen"
                            4 => "R&#46;A&#46; Wevers"
                            5 => "F&#46;J&#46; Gabre&#235;ls"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain"
                        "fecha" => "2000"
                        "volumen" => "123"
                        "paginaInicial" => "908"
                        "paginaFinal" => "919"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10775536"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Burghaus"
                            1 => "W&#46; Liu"
                            2 => "W&#46;F&#46; Haupt"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Dtsch Med Wochenschr"
                        "fecha" => "2007"
                        "volumen" => "132"
                        "paginaInicial" => "1463"
                        "paginaFinal" => "1466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17583829"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normalisation of serum cholestanol concentration in a patient with cerebrotendinous xanthomatosis by combined treatment with chenodeoxycholic acid&#44; simvastatin and LDL apheresis"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:4 [
                            0 => "M&#46;T&#46; Dotti"
                            1 => "D&#46; L&#252;tjohann"
                            2 => "K&#46; von Bergmann"
                            3 => "A&#46; Federico"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10072-004-0320-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurol Sci"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "185"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15549503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of simvastatin in addition to chenodeoxycholic acid in patients with cerebrotendinous xanthomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Verrips"
                            1 => "R&#46;A&#46; Wevers"
                            2 => "B&#46;G&#46; Van Engelen"
                            3 => "A&#46; Keyser"
                            4 => "B&#46;G&#46; Wolthers"
                            5 => "F&#46; Barkhof"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "1999"
                        "volumen" => "48"
                        "paginaInicial" => "233"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of cerebrotendinous xanthomatosis&#58; effects of chenodeoxycholic acid&#44; pravastatin&#44; and combined use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Kuriyama"
                            1 => "Y&#46; Tokimura"
                            2 => "J&#46; Fujiyama"
                            3 => "Y&#46; Utatsu"
                            4 => "M&#46; Osame"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1994"
                        "volumen" => "125"
                        "paginaInicial" => "22"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7964884"
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                ]
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