Review article
Radiotherapy inb Dermatology
Radioterapia en Dermatología
A. Marína,
, E. Vargas-Díezb, L. Cerezoa
Autor para correspondencia
amarin.hlpr@salud.madrid.org
Correspondence: Servicio de Oncología Radioterápica, Hospital Universitario de La Princesa, C/ Diego de León, 62, 28006 Madrid, Spain.
Correspondence: Servicio de Oncología Radioterápica, Hospital Universitario de La Princesa, C/ Diego de León, 62, 28006 Madrid, Spain.
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"apellidos" => "Marín" "email" => array:1 [ 0 => "amarin.hlpr@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Vargas-Díez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Cerezo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Oncología Radioterápica, Hospital Universitario de La Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Oncología Radioterápica, Hospital Universitario de La Princesa, C/ Diego de León, 62, 28006 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Radioterapia en Dermatología" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84420" "palabras" => array:4 [ 0 => "radiotherapy" 1 => "skin cancer" 2 => "electrons" 3 => "high-dose-rate brachytherapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84419" "palabras" => array:4 [ 0 => "radioterapia" 1 => "cáncer de piel" 2 => "electrones" 3 => "braquiterapia de alta tasa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Ionizing radiation causes cell death through DNA damage and has a stronger effect on undifferentiated tumor cells with a high mitotic rate. The use of a fractionated radiotherapy regimen improves both efficacy and tolerance. In addition, greater fractionation, with lower doses per session, minimizes adverse effects. In the majority of tumors treated with radical radiotherapy, the tumor cells do not disappear immediately after treatment, and assessment of the final response to treatment before three months is premature. Radiotherapy is an important treatment modality in selected patients with skin cancer. Modern radiotherapy equipment and techniques achieve excellent rates of tumor control, associated with good cosmetic results, preserved function, and a low rate of complications. The choice of technique is determined by tumor size and site and the thickness. The techniques most widely used at the present time include external beam radiotherapy with linear accelerator sand high-dose-rate brachytherapy.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El mecanismo por el cual las radiaciones ionizantes producen muerte celular es el daño al ADN, que afecta más a las células tumorales de mayor actividad mitótica e indiferenciadas. La administración de radioterapia en dosis fraccionadas aumenta la eficacia y la tolerabilidad del tratamiento; esquemas más fraccionados en dosis bajas por sesión minimizan los efectos secundarios. La mayoría de los tumores irradiados en dosis radical no desaparecen de forma rápida al final del tratamiento. Una valoración de la respuesta definitiva antes de los tres meses es prematura. La radioterapia es un tratamiento importante en pacientes seleccionados con cáncer de piel. Se obtienen excelentes tasas de control tumoral, con buen resultado cosmético, preservación funcional e infrecuentes complicaciones con los modernos equipos y las técnicas de radioterapia. La elección de la técnica se determina por el tamaño, el espesor y la localización anatómica del tumor. Las técnicas actualmente más extendidas para el tratamiento del cáncer de piel son la radioterapia externa con electrones de acelerador lineal y la braquiterapia de alta tasa de dosis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:77 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.S.M. Wong" 1 => "R.C. Strange" 2 => "J.T. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 2 | 2 | 4 |
| 2024 Octubre | 57 | 56 | 113 |
| 2024 Septiembre | 56 | 48 | 104 |
| 2024 Agosto | 90 | 63 | 153 |
| 2024 Julio | 62 | 49 | 111 |
| 2024 Junio | 49 | 39 | 88 |
| 2024 Mayo | 57 | 45 | 102 |
| 2024 Abril | 65 | 30 | 95 |
| 2024 Marzo | 42 | 51 | 93 |
| 2024 Febrero | 42 | 46 | 88 |
| 2024 Enero | 49 | 53 | 102 |
| 2023 Diciembre | 31 | 48 | 79 |
| 2023 Noviembre | 43 | 61 | 104 |
| 2023 Octubre | 36 | 50 | 86 |
| 2023 Septiembre | 35 | 39 | 74 |
| 2023 Agosto | 31 | 26 | 57 |
| 2023 Julio | 46 | 81 | 127 |
| 2023 Junio | 38 | 50 | 88 |
| 2023 Mayo | 37 | 63 | 100 |
| 2023 Abril | 32 | 48 | 80 |
| 2023 Marzo | 21 | 47 | 68 |
| 2023 Febrero | 26 | 34 | 60 |
| 2023 Enero | 24 | 35 | 59 |
| 2022 Diciembre | 31 | 50 | 81 |
| 2022 Noviembre | 23 | 42 | 65 |
| 2022 Octubre | 16 | 31 | 47 |
| 2022 Septiembre | 18 | 38 | 56 |
| 2022 Agosto | 16 | 39 | 55 |
| 2022 Julio | 12 | 43 | 55 |
| 2022 Junio | 11 | 42 | 53 |
| 2022 Mayo | 17 | 54 | 71 |
| 2022 Abril | 29 | 58 | 87 |
| 2022 Marzo | 36 | 64 | 100 |
| 2022 Febrero | 15 | 43 | 58 |
| 2022 Enero | 22 | 47 | 69 |
| 2021 Diciembre | 20 | 42 | 62 |
| 2021 Noviembre | 33 | 58 | 91 |
| 2021 Octubre | 38 | 54 | 92 |
| 2021 Septiembre | 32 | 46 | 78 |
| 2021 Agosto | 22 | 32 | 54 |
| 2021 Julio | 21 | 37 | 58 |
| 2021 Junio | 25 | 28 | 53 |
| 2021 Mayo | 16 | 24 | 40 |
| 2021 Abril | 27 | 26 | 53 |
| 2021 Marzo | 71 | 24 | 95 |
| 2021 Febrero | 70 | 22 | 92 |
| 2021 Enero | 47 | 18 | 65 |
| 2020 Diciembre | 18 | 21 | 39 |
| 2020 Noviembre | 22 | 21 | 43 |
| 2020 Octubre | 11 | 12 | 23 |
| 2020 Septiembre | 22 | 5 | 27 |
| 2020 Agosto | 85 | 21 | 106 |
| 2020 Julio | 66 | 10 | 76 |
| 2020 Junio | 36 | 27 | 63 |
| 2020 Mayo | 24 | 31 | 55 |
| 2020 Abril | 13 | 25 | 38 |
| 2020 Marzo | 19 | 23 | 42 |
| 2020 Febrero | 0 | 15 | 15 |
| 2020 Enero | 0 | 7 | 7 |
| 2019 Diciembre | 0 | 5 | 5 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Octubre | 0 | 7 | 7 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 8 | 8 |
| 2019 Julio | 0 | 8 | 8 |
| 2019 Junio | 0 | 3 | 3 |
| 2019 Mayo | 0 | 36 | 36 |
| 2019 Abril | 0 | 2 | 2 |
| 2019 Marzo | 0 | 6 | 6 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 2 | 1 | 3 |
| 2018 Febrero | 17 | 13 | 30 |
| 2018 Enero | 16 | 8 | 24 |
| 2017 Diciembre | 33 | 13 | 46 |
| 2017 Noviembre | 28 | 9 | 37 |
| 2017 Octubre | 13 | 6 | 19 |
| 2017 Septiembre | 15 | 10 | 25 |
| 2017 Agosto | 22 | 9 | 31 |
| 2017 Julio | 17 | 10 | 27 |
| 2017 Junio | 23 | 11 | 34 |
| 2017 Mayo | 17 | 10 | 27 |
| 2017 Abril | 18 | 4 | 22 |
| 2017 Marzo | 24 | 12 | 36 |
| 2017 Febrero | 10 | 6 | 16 |
| 2017 Enero | 12 | 12 | 24 |
| 2016 Diciembre | 21 | 12 | 33 |
| 2016 Noviembre | 31 | 10 | 41 |
| 2016 Octubre | 33 | 16 | 49 |
| 2016 Septiembre | 30 | 12 | 42 |
| 2016 Agosto | 31 | 11 | 42 |
| 2016 Julio | 20 | 11 | 31 |
| 2016 Junio | 6 | 12 | 18 |
| 2016 Mayo | 8 | 26 | 34 |
| 2016 Abril | 7 | 18 | 25 |
| 2016 Marzo | 9 | 12 | 21 |
| 2016 Febrero | 8 | 11 | 19 |
| 2016 Enero | 5 | 11 | 16 |
| 2015 Diciembre | 9 | 11 | 20 |
| 2015 Noviembre | 11 | 9 | 20 |
| 2015 Octubre | 4 | 11 | 15 |
| 2015 Septiembre | 8 | 8 | 16 |
| 2015 Agosto | 21 | 5 | 26 |
| 2015 Julio | 45 | 7 | 52 |
| 2015 Junio | 44 | 43 | 87 |
| 2015 Mayo | 73 | 9 | 82 |
| 2015 Abril | 49 | 20 | 69 |
| 2015 Marzo | 36 | 14 | 50 |
| 2015 Febrero | 36 | 15 | 51 |
| 2015 Enero | 44 | 12 | 56 |
| 2014 Diciembre | 54 | 15 | 69 |
| 2014 Noviembre | 22 | 13 | 35 |
| 2014 Octubre | 44 | 19 | 63 |
| 2014 Septiembre | 30 | 15 | 45 |
| 2014 Agosto | 44 | 15 | 59 |
| 2014 Julio | 48 | 27 | 75 |
| 2014 Junio | 60 | 14 | 74 |
| 2014 Mayo | 51 | 16 | 67 |
| 2014 Abril | 51 | 15 | 66 |
| 2014 Marzo | 62 | 20 | 82 |
| 2014 Febrero | 30 | 26 | 56 |
| 2014 Enero | 48 | 18 | 66 |
| 2013 Diciembre | 45 | 21 | 66 |
| 2013 Noviembre | 21 | 21 | 42 |
| 2013 Octubre | 27 | 31 | 58 |
| 2013 Septiembre | 32 | 47 | 79 |
| 2013 Agosto | 34 | 54 | 88 |
| 2013 Julio | 28 | 44 | 72 |
| 2013 Junio | 24 | 37 | 61 |
| 2013 Mayo | 26 | 28 | 54 |
| 2013 Abril | 32 | 30 | 62 |
| 2013 Marzo | 35 | 27 | 62 |
| 2013 Febrero | 33 | 13 | 46 |
| 2013 Enero | 11 | 3 | 14 |
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