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Effector Function of CLA+ T Lymphocytes on Autologous Keratinocytes in Psoriasis
Función Efectora de Linfocitos T CLA1 Sobre Queratinocitos Autólogos en Psoriasis
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Conde-Taboada, F.J. González-Barcala, J. Toribio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Conde-Taboada" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "González-Barcala" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703457?idApp=UINPBA000044" "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703457/v1_201304241441/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Effector Function of CLA+ T Lymphocytes on Autologous Keratinocytes in Psoriasis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "701" "paginaFinal" => "707" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Ferran, A.M. Giménez-Arnau, B. Bellosillo, R.M. Pujol, L.F. Santamaría-Babi" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Ferran" "email" => array:1 [ 0 => "mferran@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A.M." "apellidos" => "Giménez-Arnau" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Bellosillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "L.F." "apellidos" => "Santamaría-Babi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar-IMAS/IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital del Mar-IMAS/IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Función Efectora de Linfocitos T CLA1 Sobre Queratinocitos Autólogos en Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84316" "palabras" => array:4 [ 0 => "psoriasis" 1 => "cutaneous lymphocyte antigen" 2 => "keratinocyte" 3 => "inducible nitric oxide synthase" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84315" "palabras" => array:5 [ 0 => "psoriasis" 1 => "antígeno linfocitario cutáneo" 2 => "CLA" 3 => "queratinocito" 4 => "iNOS" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Cutaneous lymphocyte antigen (CLA) is expressed by a subgroup of memory T cells that exhibit skin homing and are implicated in cutaneous T-cell-mediated diseases.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Expression of genes associated with psoriasis was analyzed in keratinocytes taken from patients and healthy individuals and cultured under different conditions, including activation using supernatants from CLA<span class="elsevierStyleSup">+</span> T lymphocytes activated with anti-CD3 and anti-CD28 antibodies.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Keratinocytes from psoriasis patients activated by CLA<span class="elsevierStyleSup">+</span> T lymphocytes expressed higher levels of interferon-inducible protein 10, HLA-DR, intercellular cell adhesion molecule 1, and inducible nitric oxide synthase.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our results suggest that we have developed an in vitro model that will allow analysis of the effector role of CLA<span class="elsevierStyleSup">+</span> T lymphocytes on keratinocytes in psoriasis. This model may allow the identification of genes involved in the pathology of psoriasis through induction by CLA<span class="elsevierStyleSup">+</span> T lymphocytes.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los linfocitos T CLA+ representan un subgrupo de linfocitos T de memoria con tropismo cutáneo que están implicados en diferentes enfermedades cutáneas mediadas por células T.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió la expresión de algunos genes asociados a la psoriasis en queratinocitos de enfermos y sanos cultivados en diferentes condiciones, entre ellas la activación por sobrenadantes de linfocitos T CLA+ activados mediante anti-CD3/anti-CD28.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los queratinocitos psoriásicos activados por linfocitos CLA+ expresan más IP-10, HLA-DR, ICAM-1 e iNOS.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados sugieren que hemos establecido un modelo <span class="elsevierStyleItalic">in vitro</span> que permite estudiar la función efectora de los linfocitos T CLA+ sobre los queratinocitos en la psoriasis. Este modelo puede permitir la identificación de genes relevantes en la patogenia de la psoriasis al ser inducidos por linfocitos T CLA+.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Study financed by an award from Fundation Salud 2000 for study of clinical immunology of psoriasis (2003).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CLA (+) T cells in cutaneous diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.F. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 8 | 17 |
| 2024 Octubre | 69 | 61 | 130 |
| 2024 Septiembre | 63 | 31 | 94 |
| 2024 Agosto | 93 | 56 | 149 |
| 2024 Julio | 63 | 30 | 93 |
| 2024 Junio | 54 | 24 | 78 |
| 2024 Mayo | 52 | 31 | 83 |
| 2024 Abril | 43 | 22 | 65 |
| 2024 Marzo | 61 | 48 | 109 |
| 2024 Febrero | 64 | 40 | 104 |
| 2024 Enero | 44 | 37 | 81 |
| 2023 Diciembre | 43 | 31 | 74 |
| 2023 Noviembre | 39 | 36 | 75 |
| 2023 Octubre | 32 | 19 | 51 |
| 2023 Septiembre | 32 | 30 | 62 |
| 2023 Agosto | 26 | 18 | 44 |
| 2023 Julio | 34 | 40 | 74 |
| 2023 Junio | 46 | 22 | 68 |
| 2023 Mayo | 37 | 27 | 64 |
| 2023 Abril | 26 | 17 | 43 |
| 2023 Marzo | 19 | 23 | 42 |
| 2023 Febrero | 39 | 22 | 61 |
| 2023 Enero | 22 | 27 | 49 |
| 2022 Diciembre | 28 | 32 | 60 |
| 2022 Noviembre | 15 | 22 | 37 |
| 2022 Octubre | 16 | 19 | 35 |
| 2022 Septiembre | 15 | 36 | 51 |
| 2022 Agosto | 19 | 42 | 61 |
| 2022 Julio | 13 | 28 | 41 |
| 2022 Junio | 17 | 31 | 48 |
| 2022 Mayo | 21 | 41 | 62 |
| 2022 Abril | 35 | 39 | 74 |
| 2022 Marzo | 49 | 62 | 111 |
| 2022 Febrero | 19 | 32 | 51 |
| 2022 Enero | 21 | 38 | 59 |
| 2021 Diciembre | 45 | 46 | 91 |
| 2021 Noviembre | 24 | 48 | 72 |
| 2021 Octubre | 24 | 55 | 79 |
| 2021 Septiembre | 18 | 39 | 57 |
| 2021 Agosto | 26 | 35 | 61 |
| 2021 Julio | 25 | 30 | 55 |
| 2021 Junio | 14 | 36 | 50 |
| 2021 Mayo | 33 | 40 | 73 |
| 2021 Abril | 58 | 58 | 116 |
| 2021 Marzo | 65 | 39 | 104 |
| 2021 Febrero | 31 | 24 | 55 |
| 2021 Enero | 22 | 25 | 47 |
| 2020 Diciembre | 14 | 18 | 32 |
| 2020 Noviembre | 18 | 15 | 33 |
| 2020 Octubre | 22 | 10 | 32 |
| 2020 Septiembre | 33 | 12 | 45 |
| 2020 Agosto | 30 | 27 | 57 |
| 2020 Julio | 32 | 17 | 49 |
| 2020 Junio | 26 | 12 | 38 |
| 2020 Mayo | 28 | 14 | 42 |
| 2020 Abril | 12 | 24 | 36 |
| 2020 Marzo | 17 | 16 | 33 |
| 2020 Febrero | 2 | 7 | 9 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 2 | 2 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 4 | 4 |
| 2019 Junio | 0 | 3 | 3 |
| 2019 Mayo | 0 | 48 | 48 |
| 2019 Abril | 0 | 4 | 4 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 2 | 2 |
| 2018 Diciembre | 1 | 0 | 1 |
| 2018 Noviembre | 0 | 1 | 1 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Febrero | 9 | 5 | 14 |
| 2018 Enero | 17 | 5 | 22 |
| 2017 Diciembre | 16 | 8 | 24 |
| 2017 Noviembre | 12 | 4 | 16 |
| 2017 Octubre | 20 | 6 | 26 |
| 2017 Septiembre | 14 | 2 | 16 |
| 2017 Agosto | 19 | 4 | 23 |
| 2017 Julio | 17 | 6 | 23 |
| 2017 Junio | 25 | 5 | 30 |
| 2017 Mayo | 28 | 4 | 32 |
| 2017 Abril | 27 | 19 | 46 |
| 2017 Marzo | 27 | 9 | 36 |
| 2017 Febrero | 17 | 4 | 21 |
| 2017 Enero | 10 | 8 | 18 |
| 2016 Diciembre | 31 | 4 | 35 |
| 2016 Noviembre | 23 | 10 | 33 |
| 2016 Octubre | 29 | 24 | 53 |
| 2016 Septiembre | 31 | 5 | 36 |
| 2016 Agosto | 34 | 14 | 48 |
| 2016 Julio | 23 | 8 | 31 |
| 2016 Junio | 16 | 3 | 19 |
| 2016 Mayo | 7 | 7 | 14 |
| 2016 Abril | 6 | 6 | 12 |
| 2016 Marzo | 5 | 8 | 13 |
| 2016 Febrero | 6 | 12 | 18 |
| 2016 Enero | 5 | 13 | 18 |
| 2015 Diciembre | 12 | 5 | 17 |
| 2015 Noviembre | 17 | 1 | 18 |
| 2015 Octubre | 10 | 12 | 22 |
| 2015 Septiembre | 2 | 5 | 7 |
| 2015 Agosto | 23 | 3 | 26 |
| 2015 Julio | 36 | 20 | 56 |
| 2015 Junio | 43 | 20 | 63 |
| 2015 Mayo | 75 | 27 | 102 |
| 2015 Abril | 39 | 25 | 64 |
| 2015 Marzo | 53 | 19 | 72 |
| 2015 Febrero | 28 | 39 | 67 |
| 2015 Enero | 21 | 41 | 62 |
| 2014 Diciembre | 29 | 38 | 67 |
| 2014 Noviembre | 24 | 25 | 49 |
| 2014 Octubre | 31 | 32 | 63 |
| 2014 Septiembre | 27 | 23 | 50 |
| 2014 Agosto | 50 | 16 | 66 |
| 2014 Julio | 47 | 25 | 72 |
| 2014 Junio | 37 | 16 | 53 |
| 2014 Mayo | 42 | 15 | 57 |
| 2014 Abril | 31 | 14 | 45 |
| 2014 Marzo | 38 | 17 | 55 |
| 2014 Febrero | 25 | 23 | 48 |
| 2014 Enero | 29 | 21 | 50 |
| 2013 Diciembre | 36 | 14 | 50 |
| 2013 Noviembre | 34 | 16 | 50 |
| 2013 Octubre | 40 | 20 | 60 |
| 2013 Septiembre | 31 | 29 | 60 |
| 2013 Agosto | 33 | 30 | 63 |
| 2013 Julio | 35 | 48 | 83 |
| 2013 Junio | 35 | 44 | 79 |
| 2013 Mayo | 37 | 28 | 65 |
| 2013 Abril | 27 | 33 | 60 |
| 2013 Marzo | 29 | 34 | 63 |
| 2013 Febrero | 29 | 11 | 40 |
| 2013 Enero | 19 | 7 | 26 |
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