Advances in dermatology
Clinical Applications of Reflectance Confocal Microscopy in the Management of Cutaneous Tumors
Aplicaciones Clínicas de la Microscopía Confocal de Reflectancia en el Manejo de Los Tumores Cutáneos
S. González
Autor para correspondencia
gonzals6@mskcc.org
Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA.
Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA.
Dermatology Service. Memorial Sloan-Kettering Cancer Center, New York, USA Servicio de Dermatología. Hospital Ramón y Cajal, Madrid, Spain
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García Franco, A. España" "autores" => array:2 [ 0 => array:2 [ "nombre" => "C.E." "apellidos" => "García Franco" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "España" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703081?idApp=UINPBA000044" "url" => "/15782190/0000009900000007/v1_201304241437/S1578219008703081/v1_201304241437/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Advances in dermatology</span>" "titulo" => "Clinical Applications of Reflectance Confocal Microscopy in the Management of Cutaneous Tumors" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "528" "paginaFinal" => "531" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. González" "autores" => array:1 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "González" "email" => array:1 [ 0 => "gonzals6@mskcc.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Dermatology Service. Memorial Sloan-Kettering Cancer Center, New York, USA Servicio de Dermatología. Hospital Ramón y Cajal, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53rd Street, New York, NY10022, USA." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicaciones Clínicas de la Microscopía Confocal de Reflectancia en el Manejo de Los Tumores Cutáneos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-12-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84251" "palabras" => array:4 [ 0 => "reflectance confocal microscopy" 1 => "cutaneous tumors" 2 => "virtual biopsy" 3 => "noninvasive technology" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84252" "palabras" => array:4 [ 0 => "microscopía confocal de reflectancia" 1 => "tumores cutáneos" 2 => "biopsia virtual" 3 => "tecnología no invasiva" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Reflectance confocal microscopy is a noninvasive tool that allows skin cells and structure to be imaged in real time. The technique has been used to assess benign and malignant lesions and has shown great potential in basic research and clinical dermatology. As might be expected, it also has great potential in longitudinal clinical studies and in the evaluation of dynamic processes such as those that occur after exposure to UV radiation or during the tumor response to noninvasive therapy. This article briefly describes the fundamental aspects and basic principles of reflectance confocal microscopy and discusses its clinical applications essentially in the management of cutaneous tumors. We also consider the limitations of the technique associated with the optical properties of the skin, with instrumentation, and with interpretation of the images.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La microscopía confocal de reflectancia es una herramienta de imágenes que permite la visualización de células y estructuras de la piel de forma no invasiva y en tiempo real. Ésta se ha usado para la evaluación de lesiones benignas y malignas, demostrando un gran potencial para aplicaciones en investigación básica y en dermatología clínica. Como cabría pensar, esta tecnología tiene un gran potencial en estudios clínicos longitudinales y en la evaluación de procesos dinámicos como los que acontecen tras la exposición a radiación ultravioleta o durante la respuesta de los tumores a terapias no invasivas. Este artículo discute brevemente los fundamentos o principios básicos de la microscopía confocal de reflectancia, sus aplicaciones clínicas, fundamentalmente en el manejo de los tumores cutáneos, y las limitaciones que la técnica presenta asociadas a las propiedades ópticas de la piel, con la instrumentación y con la interpretación de las imágenes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo optical coherence tomography imaging of human skin: norm and pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.D. Gladkova" 1 => "G.A. Petrova" 2 => "N.K. Nikulin" 3 => "S.G. Radenska-Lopovok" 4 => "L.B. Snopova" 5 => "Y.P. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 10 | 15 |
| 2024 Octubre | 71 | 48 | 119 |
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| 2023 Septiembre | 27 | 19 | 46 |
| 2023 Agosto | 19 | 16 | 35 |
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| 2023 Enero | 16 | 18 | 34 |
| 2022 Diciembre | 28 | 35 | 63 |
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| 2022 Febrero | 26 | 29 | 55 |
| 2022 Enero | 13 | 32 | 45 |
| 2021 Diciembre | 30 | 43 | 73 |
| 2021 Noviembre | 29 | 39 | 68 |
| 2021 Octubre | 21 | 42 | 63 |
| 2021 Septiembre | 22 | 37 | 59 |
| 2021 Agosto | 21 | 21 | 42 |
| 2021 Julio | 31 | 27 | 58 |
| 2021 Junio | 38 | 43 | 81 |
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| 2020 Noviembre | 27 | 18 | 45 |
| 2020 Octubre | 14 | 2 | 16 |
| 2020 Septiembre | 17 | 10 | 27 |
| 2020 Agosto | 25 | 20 | 45 |
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| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 3 | 3 |
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| 2018 Febrero | 14 | 8 | 22 |
| 2018 Enero | 14 | 11 | 25 |
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| 2017 Noviembre | 12 | 19 | 31 |
| 2017 Octubre | 9 | 4 | 13 |
| 2017 Septiembre | 15 | 11 | 26 |
| 2017 Agosto | 22 | 14 | 36 |
| 2017 Julio | 21 | 10 | 31 |
| 2017 Junio | 30 | 18 | 48 |
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| 2017 Marzo | 16 | 11 | 27 |
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| 2016 Diciembre | 22 | 20 | 42 |
| 2016 Noviembre | 26 | 11 | 37 |
| 2016 Octubre | 21 | 22 | 43 |
| 2016 Septiembre | 28 | 23 | 51 |
| 2016 Agosto | 21 | 4 | 25 |
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| 2016 Junio | 13 | 10 | 23 |
| 2016 Mayo | 5 | 4 | 9 |
| 2016 Abril | 11 | 11 | 22 |
| 2016 Marzo | 5 | 11 | 16 |
| 2016 Febrero | 10 | 12 | 22 |
| 2016 Enero | 12 | 16 | 28 |
| 2015 Diciembre | 8 | 13 | 21 |
| 2015 Noviembre | 11 | 12 | 23 |
| 2015 Octubre | 8 | 11 | 19 |
| 2015 Septiembre | 10 | 4 | 14 |
| 2015 Agosto | 13 | 2 | 15 |
| 2015 Julio | 22 | 10 | 32 |
| 2015 Junio | 25 | 11 | 36 |
| 2015 Mayo | 65 | 24 | 89 |
| 2015 Abril | 22 | 20 | 42 |
| 2015 Marzo | 22 | 11 | 33 |
| 2015 Febrero | 24 | 23 | 47 |
| 2015 Enero | 12 | 14 | 26 |
| 2014 Diciembre | 20 | 13 | 33 |
| 2014 Noviembre | 14 | 22 | 36 |
| 2014 Octubre | 29 | 25 | 54 |
| 2014 Septiembre | 24 | 17 | 41 |
| 2014 Agosto | 25 | 22 | 47 |
| 2014 Julio | 31 | 25 | 56 |
| 2014 Junio | 33 | 16 | 49 |
| 2014 Mayo | 30 | 22 | 52 |
| 2014 Abril | 32 | 9 | 41 |
| 2014 Marzo | 38 | 21 | 59 |
| 2014 Febrero | 24 | 26 | 50 |
| 2014 Enero | 33 | 17 | 50 |
| 2013 Diciembre | 34 | 17 | 51 |
| 2013 Noviembre | 27 | 23 | 50 |
| 2013 Octubre | 27 | 24 | 51 |
| 2013 Septiembre | 27 | 25 | 52 |
| 2013 Agosto | 36 | 25 | 61 |
| 2013 Julio | 35 | 26 | 61 |
| 2013 Junio | 26 | 22 | 48 |
| 2013 Mayo | 29 | 17 | 46 |
| 2013 Abril | 16 | 16 | 32 |
| 2013 Marzo | 24 | 35 | 59 |
| 2013 Febrero | 32 | 12 | 44 |
| 2013 Enero | 16 | 6 | 22 |
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