Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
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Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Las Células Tipo Epidermodisplasia Verruciforme Como Marcador Histológico de Inmunodepresión: Revisión de 229 Carcinomas Espinocelulares" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84166" "palabras" => array:4 [ 0 => "epidermodysplasia verruciformis" 1 => "immunosuppression" 2 => "papillomavirus" 3 => "solar elastosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84165" "palabras" => array:4 [ 0 => "epidermodisplasia verruciforme" 1 => "inmunodepresión" 2 => "papilomavirus" 3 => "elastosis solar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Epidermodysplasia verruciformis (EV) is associated with greater susceptibility to infection by certain oncogenic subtypes of human papillomavirus (HPV). Among other histologic findings, large, clear, oval or rounded cells (EV cells) are observed in the granular layer in EV, and some authors consider these cells to be markers of immunosuppression.</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 229 squamous cell carcinomas (SCC) to determine whether EV cells were present and to assess whether their presence was associated either with localized or cutaneous immunosuppression (tumors with signs of severe chronic actinic damage or severe stasis dermatitis) or with systemic immunosuppression (immunocompromised or elderly patients).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed EV cells in 33 SCC. No statistically significant relationship was observed between the presence of EV cells and immunosuppression. We performed polymerase chain reaction in 8 lesions, but the results were not informative as the DNA was denatured.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We found no relationship between the presence of EV cells and localized or systemic immunosuppression, possibly because the sample was inadequate (almost all SCC studied were associated with signs of immunosuppression, irrespective of the presence or absence of EV cells). Further studies will be required to compare lesions associated with immunosuppression with those in which immunosuppression is absent. The presence of EV cells may be the result of cytopathic effects of certain HPV subtypes, such as HPV 5 or 8, but this will need to be demonstrated using techniques such as polymerase chain reaction.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La epidermodisplasia verruciforme (EV) es una enfermedad en la que existe una mayor susceptibilidad genética a la infección por determinados subtipos oncogénicos del virus del papiloma humano (VPH). Entre otros hallazgos histológicos, en la EV suelen observarse unas células claras, grandes, ovaladas o redondeadas (células EV) en la capa granulosa, que según algunos autores se podrían considerar como un marcador histológico de inmunodepresión.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 229 carcinomas espinocelulares (CE) para valorar si presentaban células EV y si se relacionaban con inmunodepresión, tanto localizada o cutánea (tumores con signos de intenso daño solar crónico o con una dermatitis de estasis intensa), como sistémica (pacientes inmunodeprimidos o ancianos).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos células EV en 33 carcinomas. No hemos encontrado relación significativa entre la existencia de células EV e inmunodepresión. Realizamos reacción en cadena de la polimerasa (PCR) en 8 lesiones, pero los resultados no fueron valorables porque el ADN estaba desnaturalizado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">No hemos demostrado relación entre las células EV e inmunodepresión, localizada o sistémica, posiblemente porque la muestra no era adecuada (se podría considerar que prácticamente todos los CE estudiados se asociaban a signos de inmunodepresión, tanto aquellos que presentaban células EV como los que no). Serían necesarios más estudios que comparasen lesiones asociadas a inmunodepresión con otras que no. Es posible que estas células EV sean el resultado de los efectos citopáticos de determinados subtipos de VPH, como el VPH-5 o el VPH-8, aunque sería necesario demostrar esta hipótesis mediante técnicas de PCR o similar.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">2006 August C. Stiefel Award.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermodysplasia verruciformis as a model of Human Papillomavirus-inducel genetic cancer of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Majewski" 1 => "S. 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año/Mes | Html | Total | |
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2024 Noviembre | 2 | 10 | 12 |
2024 Octubre | 64 | 47 | 111 |
2024 Septiembre | 71 | 31 | 102 |
2024 Agosto | 98 | 62 | 160 |
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2023 Diciembre | 53 | 30 | 83 |
2023 Noviembre | 46 | 23 | 69 |
2023 Octubre | 35 | 27 | 62 |
2023 Septiembre | 38 | 27 | 65 |
2023 Agosto | 18 | 19 | 37 |
2023 Julio | 25 | 47 | 72 |
2023 Junio | 30 | 17 | 47 |
2023 Mayo | 33 | 23 | 56 |
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2023 Marzo | 24 | 23 | 47 |
2023 Febrero | 27 | 21 | 48 |
2023 Enero | 25 | 25 | 50 |
2022 Diciembre | 28 | 35 | 63 |
2022 Noviembre | 11 | 60 | 71 |
2022 Octubre | 15 | 16 | 31 |
2022 Septiembre | 20 | 36 | 56 |
2022 Agosto | 11 | 30 | 41 |
2022 Julio | 18 | 30 | 48 |
2022 Junio | 22 | 36 | 58 |
2022 Mayo | 23 | 38 | 61 |
2022 Abril | 22 | 47 | 69 |
2022 Marzo | 23 | 44 | 67 |
2022 Febrero | 21 | 27 | 48 |
2022 Enero | 23 | 35 | 58 |
2021 Diciembre | 19 | 39 | 58 |
2021 Noviembre | 24 | 45 | 69 |
2021 Octubre | 23 | 42 | 65 |
2021 Septiembre | 17 | 30 | 47 |
2021 Agosto | 19 | 34 | 53 |
2021 Julio | 26 | 36 | 62 |
2021 Junio | 19 | 38 | 57 |
2021 Mayo | 31 | 45 | 76 |
2021 Abril | 38 | 63 | 101 |
2021 Marzo | 60 | 14 | 74 |
2021 Febrero | 65 | 22 | 87 |
2021 Enero | 31 | 13 | 44 |
2020 Diciembre | 24 | 18 | 42 |
2020 Noviembre | 33 | 18 | 51 |
2020 Octubre | 26 | 10 | 36 |
2020 Septiembre | 35 | 11 | 46 |
2020 Agosto | 30 | 16 | 46 |
2020 Julio | 19 | 13 | 32 |
2020 Junio | 23 | 25 | 48 |
2020 Mayo | 29 | 18 | 47 |
2020 Abril | 24 | 16 | 40 |
2020 Marzo | 17 | 27 | 44 |
2020 Febrero | 3 | 1 | 4 |
2020 Enero | 0 | 8 | 8 |
2019 Diciembre | 0 | 12 | 12 |
2019 Noviembre | 0 | 4 | 4 |
2019 Octubre | 0 | 4 | 4 |
2019 Septiembre | 0 | 4 | 4 |
2019 Agosto | 0 | 1 | 1 |
2019 Julio | 0 | 9 | 9 |
2019 Junio | 0 | 13 | 13 |
2019 Mayo | 1 | 67 | 68 |
2019 Abril | 2 | 13 | 15 |
2019 Marzo | 0 | 4 | 4 |
2019 Febrero | 0 | 6 | 6 |
2019 Enero | 0 | 1 | 1 |
2018 Agosto | 0 | 1 | 1 |
2018 Julio | 0 | 1 | 1 |
2018 Junio | 0 | 2 | 2 |
2018 Mayo | 0 | 14 | 14 |
2018 Abril | 0 | 3 | 3 |
2018 Marzo | 1 | 1 | 2 |
2018 Febrero | 7 | 9 | 16 |
2018 Enero | 18 | 7 | 25 |
2017 Diciembre | 16 | 11 | 27 |
2017 Noviembre | 9 | 6 | 15 |
2017 Octubre | 17 | 10 | 27 |
2017 Septiembre | 10 | 11 | 21 |
2017 Agosto | 14 | 6 | 20 |
2017 Julio | 10 | 6 | 16 |
2017 Junio | 16 | 22 | 38 |
2017 Mayo | 9 | 26 | 35 |
2017 Abril | 19 | 7 | 26 |
2017 Marzo | 18 | 13 | 31 |
2017 Febrero | 12 | 12 | 24 |
2017 Enero | 13 | 8 | 21 |
2016 Diciembre | 31 | 7 | 38 |
2016 Noviembre | 25 | 4 | 29 |
2016 Octubre | 30 | 10 | 40 |
2016 Septiembre | 31 | 7 | 38 |
2016 Agosto | 26 | 5 | 31 |
2016 Julio | 27 | 5 | 32 |
2016 Junio | 6 | 5 | 11 |
2016 Mayo | 8 | 4 | 12 |
2016 Abril | 8 | 7 | 15 |
2016 Marzo | 2 | 17 | 19 |
2016 Febrero | 2 | 20 | 22 |
2016 Enero | 9 | 15 | 24 |
2015 Diciembre | 10 | 9 | 19 |
2015 Noviembre | 12 | 6 | 18 |
2015 Octubre | 11 | 11 | 22 |
2015 Septiembre | 10 | 11 | 21 |
2015 Agosto | 12 | 2 | 14 |
2015 Julio | 26 | 9 | 35 |
2015 Junio | 27 | 8 | 35 |
2015 Mayo | 78 | 6 | 84 |
2015 Abril | 26 | 8 | 34 |
2015 Marzo | 32 | 1 | 33 |
2015 Febrero | 26 | 6 | 32 |
2015 Enero | 27 | 10 | 37 |
2014 Diciembre | 19 | 2 | 21 |
2014 Noviembre | 22 | 8 | 30 |
2014 Octubre | 37 | 7 | 44 |
2014 Septiembre | 29 | 9 | 38 |
2014 Agosto | 45 | 19 | 64 |
2014 Julio | 41 | 21 | 62 |
2014 Junio | 35 | 7 | 42 |
2014 Mayo | 53 | 13 | 66 |
2014 Abril | 33 | 10 | 43 |
2014 Marzo | 48 | 19 | 67 |
2014 Febrero | 33 | 13 | 46 |
2014 Enero | 27 | 14 | 41 |
2013 Diciembre | 36 | 9 | 45 |
2013 Noviembre | 25 | 17 | 42 |
2013 Octubre | 27 | 18 | 45 |
2013 Septiembre | 22 | 15 | 37 |
2013 Agosto | 27 | 38 | 65 |
2013 Julio | 39 | 31 | 70 |
2013 Junio | 28 | 26 | 54 |
2013 Mayo | 21 | 25 | 46 |
2013 Abril | 28 | 45 | 73 |
2013 Marzo | 30 | 32 | 62 |
2013 Febrero | 26 | 9 | 35 |
2013 Enero | 14 | 4 | 18 |