array:23 [
  "pii" => "S1578219008702506"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(08)70250-6"
  "estado" => "S300"
  "fechaPublicacion" => "2008-05-01"
  "aid" => "70250"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2008;99:269-74"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2401
    "formatos" => array:3 [
      "EPUB" => 36
      "HTML" => 1439
      "PDF" => 926
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219008702518"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70251-8"
    "estado" => "S300"
    "fechaPublicacion" => "2008-05-01"
    "aid" => "70251"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:275-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2329
      "formatos" => array:3 [
        "EPUB" => 32
        "HTML" => 1543
        "PDF" => 754
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
      "titulo" => "Mohs Micrographic Surgery&#58; Our First 100 Patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "275"
          "paginaFinal" => "280"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Cirug&#237;a de Mohs&#58; Nuestros Primeros Cien Pacientes"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Alonso, P&#46; S&#225;nchez, A&#46; Gonz&#225;lez, J&#46; Ingelmo, I&#46; Ruiz, S&#46; Delgado, M&#46;A&#46; Rodr&#237;guez"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Alonso"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Ingelmo"
            ]
            4 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Ruiz"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Delgado"
            ]
            6 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Rodr&#237;guez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702518?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000004/v1_201304241431/S1578219008702518/v1_201304241431/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S157821900870249X"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70249-X"
    "estado" => "S300"
    "fechaPublicacion" => "2008-05-01"
    "aid" => "70249"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:262-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3512
      "formatos" => array:3 [
        "EPUB" => 32
        "HTML" => 1547
        "PDF" => 1933
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Advances in dermatology</span>"
      "titulo" => "Recent Advances in Laser Therapy and Other Technologies"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "262"
          "paginaFinal" => "268"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recientes Avances en L&#225;ser y Otras Tecnolog&#237;as"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Boixeda, M&#46; Calvo, L&#46; Bagazgoitia"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Boixeda"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Calvo"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Bagazgoitia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900870249X?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000004/v1_201304241431/S157821900870249X/v1_201304241431/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
    "titulo" => "Epidermodysplasia Verruciformis-Like Cells as Histologic Markers of Immunosuppression&#58; Review of 229 Squamous Cell Carcinomas<a class="elsevierStyleCrossRef" href="#fn1"><span class="elsevierStyleSup">&#42;</span></a>"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "269"
        "paginaFinal" => "274"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Corbal&#225;n-V&#233;lez, J&#46;A&#46; Ruiz-Maci&#225;, C&#46; Brufau, J&#46;M&#46; L&#243;pez-Lozano, E&#46; Mart&#237;nez-Barba, J&#46; Mart&#237;nez-Escribano, F&#46;J&#46; Carapeto"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Corbal&#225;n-V&#233;lez"
            "email" => array:1 [
              0 => "raulcorb&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Ruiz-Maci&#225;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Brufau"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "L&#243;pez-Lozano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Mart&#237;nez-Barba"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Mart&#237;nez-Escribano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Carapeto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff6"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Vega Baja&#44; Orihuela&#44; Alicante&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Reina Sof&#237;a&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Medicina Preventiva&#44; Hospital Vega Baja&#44; Orihuela&#44; Alicante&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff4"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff5"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario Lozano Blesa&#44; Zaragoza&#44; Spain<a class="elsevierStyleCrossRef" href="#fn1"><span class="elsevierStyleSup">&#42;</span></a>"
            "etiqueta" => "<span class="elsevierStyleSup">f</span>"
            "identificador" => "aff6"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital Universitario Virgen de la Arrixaca&#44; Ctra&#46; Murcia-Cartagena&#44; s&#47;n&#44; 30120 El Palmar&#44; Murcia&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Las C&#233;lulas Tipo Epidermodisplasia Verruciforme Como Marcador Histol&#243;gico de Inmunodepresi&#243;n&#58; Revisi&#243;n de 229 Carcinomas Espinocelulares"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2007-09-11"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84166"
          "palabras" => array:4 [
            0 => "epidermodysplasia verruciformis"
            1 => "immunosuppression"
            2 => "papillomavirus"
            3 => "solar elastosis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84165"
          "palabras" => array:4 [
            0 => "epidermodisplasia verruciforme"
            1 => "inmunodepresi&#243;n"
            2 => "papilomavirus"
            3 => "elastosis solar"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Epidermodysplasia verruciformis &#40;EV&#41; is associated with greater susceptibility to infection by certain oncogenic subtypes of human papillomavirus &#40;HPV&#41;&#46; Among other histologic findings&#44; large&#44; clear&#44; oval or rounded cells &#40;EV cells&#41; are observed in the granular layer in EV&#44; and some authors consider these cells to be markers of immunosuppression&#46;</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 229 squamous cell carcinomas &#40;SCC&#41; to determine whether EV cells were present and to assess whether their presence was associated either with localized or cutaneous immunosuppression &#40;tumors with signs of severe chronic actinic damage or severe stasis dermatitis&#41; or with systemic immunosuppression &#40;immunocompromised or elderly patients&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed EV cells in 33 SCC&#46; No statistically significant relationship was observed between the presence of EV cells and immunosuppression&#46; We performed polymerase chain reaction in 8 lesions&#44; but the results were not informative as the DNA was denatured&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We found no relationship between the presence of EV cells and localized or systemic immunosuppression&#44; possibly because the sample was inadequate &#40;almost all SCC studied were associated with signs of immunosuppression&#44; irrespective of the presence or absence of EV cells&#41;&#46; Further studies will be required to compare lesions associated with immunosuppression with those in which immunosuppression is absent&#46; The presence of EV cells may be the result of cytopathic effects of certain HPV subtypes&#44; such as HPV 5 or 8&#44; but this will need to be demonstrated using techniques such as polymerase chain reaction&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La epidermodisplasia verruciforme &#40;EV&#41; es una enfermedad en la que existe una mayor susceptibilidad gen&#233;tica a la infecci&#243;n por determinados subtipos oncog&#233;nicos del virus del papiloma humano &#40;VPH&#41;&#46; Entre otros hallazgos histol&#243;gicos&#44; en la EV suelen observarse unas c&#233;lulas claras&#44; grandes&#44; ovaladas o redondeadas &#40;c&#233;lulas EV&#41; en la capa granulosa&#44; que seg&#250;n algunos autores se podr&#237;an considerar como un marcador histol&#243;gico de inmunodepresi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 229 carcinomas espinocelulares &#40;CE&#41; para valorar si presentaban c&#233;lulas EV y si se relacionaban con inmunodepresi&#243;n&#44; tanto localizada o cut&#225;nea &#40;tumores con signos de intenso da&#241;o solar cr&#243;nico o con una dermatitis de estasis intensa&#41;&#44; como sist&#233;mica &#40;pacientes inmunodeprimidos o ancianos&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos c&#233;lulas EV en 33 carcinomas&#46; No hemos encontrado relaci&#243;n significativa entre la existencia de c&#233;lulas EV e inmunodepresi&#243;n&#46; Realizamos reacci&#243;n en cadena de la polimerasa &#40;PCR&#41; en 8 lesiones&#44; pero los resultados no fueron valorables porque el ADN estaba desnaturalizado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">No hemos demostrado relaci&#243;n entre las c&#233;lulas EV e inmunodepresi&#243;n&#44; localizada o sist&#233;mica&#44; posiblemente porque la muestra no era adecuada &#40;se podr&#237;a considerar que pr&#225;cticamente todos los CE estudiados se asociaban a signos de inmunodepresi&#243;n&#44; tanto aquellos que presentaban c&#233;lulas EV como los que no&#41;&#46; Ser&#237;an necesarios m&#225;s estudios que comparasen lesiones asociadas a inmunodepresi&#243;n con otras que no&#46; Es posible que estas c&#233;lulas EV sean el resultado de los efectos citop&#225;ticos de determinados subtipos de VPH&#44; como el VPH-5 o el VPH-8&#44; aunque ser&#237;a necesario demostrar esta hip&#243;tesis mediante t&#233;cnicas de PCR o similar&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara">2006 August C&#46; Stiefel Award&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis as a model of Human Papillomavirus-inducel genetic cancer of the skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Majewski"
                            1 => "S&#46; Jablonska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1995"
                        "volumen" => "131"
                        "paginaInicial" => "1312"
                        "paginaFinal" => "1318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7503577"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodisplasia verruciforme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46;P&#46; S&#225;nchez-Garc&#237;a"
                            1 => "A&#46; Sanz"
                            2 => "C&#46; Eloy"
                            3 => "A&#46; Vera"
                            4 => "T&#46; Mart&#237;n"
                            5 => "F&#46; S&#225;nchez-Fajardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "531"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical aspects of epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;R&#46; de Oliveira"
                            1 => "C&#46; Festa Neto"
                            2 => "P&#46;L&#46; Rady"
                            3 => "S&#46;K&#46; Tyring"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "394"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12834447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Majewski"
                            1 => "E&#46; Skipinska-Rozewska"
                            2 => "S&#46; Jablonska"
                            3 => "M&#46; Wasik"
                            4 => "J&#46; Misiewicz"
                            5 => "G&#46; Orth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1986"
                        "volumen" => "15"
                        "paginaInicial" => "966"
                        "paginaFinal" => "973"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3491095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural cell-mediated cytotoxicity against various target cells in patients with epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Majewski"
                            1 => "J&#46; Malejczyk"
                            2 => "S&#46; Jablonska"
                            3 => "J&#46; Misiewicz"
                            4 => "L&#46; Rudnicka"
                            5 => "S&#46; Obalek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1990"
                        "volumen" => "22"
                        "paginaInicial" => "423"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2155952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histologic spectrum of Epidermodysplasia Verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;J&#46; Nuovo"
                            1 => "M&#46; Ishag"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "2000"
                        "volumen" => "24"
                        "paginaInicial" => "1400"
                        "paginaFinal" => "1406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Viral diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Weedon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Skin Pathology"
                        "paginaInicial" => "583"
                        "paginaFinal" => "603"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin cancer in organ transplant recipients&#58; Epidemiology&#44; pathogenesis&#44; and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Berg"
                            1 => "C&#46;C&#46; Otley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "1"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12077575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shortage of circulating naive CD8 &#63;&#63;T cells provides new insights on immunodeficiency in aging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Fagnoni"
                            1 => "R&#46; Vescovini"
                            2 => "G&#46; Passeri"
                            3 => "G&#46; Bologna"
                            4 => "M&#46; Pedrazzoni"
                            5 => "G&#46; Lavagetto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2000"
                        "volumen" => "95"
                        "paginaInicial" => "2860"
                        "paginaFinal" => "2868"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10779432"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a e inmunopatogenia del c&#225;ncer cut&#225;neo no melanoma&#46; El papel iniciador y promotor del VPH"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;G&#46; Villarrubia"
                            1 => "L&#46;A&#46; Costa"
                            2 => "M&#46; P&#233;rez"
                            3 => "S&#46; Vidal"
                            4 => "P&#46; Jaen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "428"
                        "paginaFinal" => "438"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism involved in ultraviolet light-induced immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Aubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "515"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14721768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efectos de la radiaci&#243;n ultravioleta sobre el sistema inmunitario&#46; Implicaciones terap&#233;uticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "303"
                        "paginaFinal" => "312"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformisassociated papillomavirus infection complicating human immunodeficiency virus disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46;G&#46; Berger"
                            1 => "W&#46;S&#46; Sawchuk"
                            2 => "C&#46; Leonardi"
                            3 => "A&#46; Langenberg"
                            4 => "J&#46; Tappero"
                            5 => "P&#46;E&#46; Leboit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1991"
                        "volumen" => "124"
                        "paginaInicial" => "79"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1847068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in a patient with Hodgkin&#39;s disease&#58; characterization of a new papilloma virus type and interferon treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Gross"
                            1 => "K&#46; Ellinger"
                            2 => "A&#46; Roussaki"
                            3 => "P&#46;G&#46; Fuchs"
                            4 => "H&#46;H&#46; Peter"
                            5 => "H&#46; Pfister"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1989"
                        "volumen" => "91"
                        "paginaInicial" => "43"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2838553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis associated with severe immunodeficiency&#44; lymphoma&#44; and disseminated molluscum contagiosum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;D&#46; Slawsky"
                            1 => "R&#46;T&#46; Gilson"
                            2 => "A&#46;J&#46; Hockley"
                            3 => "L&#46;F&#46; Libow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1992"
                        "volumen" => "27"
                        "paginaInicial" => "448"
                        "paginaFinal" => "450"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1401282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Swollen keratinocytes&#58; a histologic marker of unusual human papillomavirus-type infection and immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;S&#46; Penneys"
                            1 => "A&#46; Friend"
                            2 => "W&#46;Y&#46; Zhu"
                            3 => "C&#46; Leonardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1992"
                        "volumen" => "12"
                        "paginaInicial" => "217"
                        "paginaFinal" => "220"
                        "itemHostRev" => array:3 [
                          "pii" => "S001651071002331X"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "M&#233;todos moleculares de detecci&#243;n de mutaciones en dermatolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Unamuno"
                            1 => "R&#46; G&#243;nzalez Sarmiento"
                            2 => "S&#46; Mallo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioestad&#237;stica&#46; M&#233;todos estad&#237;sticos para investigadores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Dom&#233;nech Massons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1982"
                        "editorial" => "Herder"
                        "editorialLocalizacion" => "Barcelona"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Qu&#233; es una odds ratio&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez Gonz&#225;lez"
                            1 => "J&#46; Irala Est&#233;vez"
                            2 => "F&#46; Guill&#233;n Grima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1999"
                        "volumen" => "112"
                        "paginaInicial" => "416"
                        "paginaFinal" => "422"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinomas espinocelulares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Y&#225;&#241;ez-D&#237;az"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Tumores Cut&#225;neos"
                        "paginaInicial" => "97"
                        "paginaFinal" => "116"
                        "serieFecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoma espinocelular cut&#225;neo y papilomavirus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Corbal&#225;n-V&#233;lez"
                            1 => "J&#46;A&#46; Ruiz-Maci&#225;"
                            2 => "C&#46; Brufau"
                            3 => "F&#46;J&#46; Carapeto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "583"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17961447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;M&#46; Tieben"
                            1 => "R&#46;J&#46; Berkhout"
                            2 => "H&#46;L&#46; Smits"
                            3 => "J&#46;N&#46; Bouves Bavinck"
                            4 => "B&#46;J&#46; Vermeer"
                            5 => "J&#46;A&#46; Bruijn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1994"
                        "volumen" => "131"
                        "paginaInicial" => "226"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7917987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of human papillomavirus type 5 DNA in skin cancers of an immunosupressed renal allograft recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Lutzner"
                            1 => "G&#46; Orth"
                            2 => "V&#46; Dutronquay"
                            3 => "M&#46;F&#46; Ducasse"
                            4 => "H&#46; Kreis"
                            5 => "J&#46; Crosnier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1983"
                        "volumen" => "2"
                        "paginaInicial" => "422"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6147500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;L&#46; Boxman"
                            1 => "L&#46;H&#46; Mulder"
                            2 => "A&#46; Russell"
                            3 => "J&#46;N&#46; Bouwes Bavinck"
                            4 => "A&#46; Green"
                            5 => "J&#46; Ter Schegget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "141"
                        "paginaInicial" => "246"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of polymerase chain reaction amplification for the detection of genital human papillomavirus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;M&#46; Manos"
                            1 => "Y&#46; Ting"
                            2 => "D&#46;K&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Cel"
                        "fecha" => "1989"
                        "volumen" => "7"
                        "paginaInicial" => "209"
                        "paginaFinal" => "214"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detecci&#243;n y tipado de papilomavirus humano por amplificaci&#243;n gen&#243;mica en biopsias&#44; frotis y orina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mart&#237;nez"
                            1 => "R&#46; N&#225;s"
                            2 => "C&#46; LaCruz"
                            3 => "T&#46; Hell&#237;n"
                            4 => "J&#46;C&#46; Tercero"
                            5 => "E&#46; Valverde"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ginecol&#243;gica"
                        "fecha" => "1995"
                        "volumen" => "52"
                        "paginaInicial" => "51"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of polymerase chain reaction and catalyzed signal amplification in situ hybridization methods for human papillomavirus detection in paraffin-embedded cervical preneoplastic and neoplastic lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;M&#46; Dabic"
                            1 => "L&#46; Hlupic"
                            2 => "D&#46; Babic"
                            3 => "S&#46; Jukic"
                            4 => "S&#46; Seiwerth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arcmed.2004.07.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Med Res"
                        "fecha" => "2004"
                        "volumen" => "35"
                        "paginaInicial" => "511"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15631876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702506?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Original articles
Epidermodysplasia Verruciformis-Like Cells as Histologic Markers of Immunosuppression: Review of 229 Squamous Cell Carcinomas*
Las Células Tipo Epidermodisplasia Verruciforme Como Marcador Histológico de Inmunodepresión: Revisión de 229 Carcinomas Espinocelulares
R. Corbalán-Véleza,
Autor para correspondencia
raulcorb@gmail.com

Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
, J.A. Ruiz-Maciáb, C. Brufauc, J.M. López-Lozanod, E. Martínez-Barbae, J. Martínez-Escribanoa, F.J. Carapetof
a Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
b Servicio de Anatomía Patológica, Hospital Vega Baja, Orihuela, Alicante, Spain
c Servicio de Dermatología, Hospital General Reina Sofía, Murcia, Spain
d Servicio de Medicina Preventiva, Hospital Vega Baja, Orihuela, Alicante, Spain
e Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
f Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain*
Leído
6034
Veces
se ha leído el artículo
2676
Total PDF
3358
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219008702506"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(08)70250-6"
  "estado" => "S300"
  "fechaPublicacion" => "2008-05-01"
  "aid" => "70250"
  "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2008;99:269-74"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2401
    "formatos" => array:3 [
      "EPUB" => 36
      "HTML" => 1439
      "PDF" => 926
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219008702518"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70251-8"
    "estado" => "S300"
    "fechaPublicacion" => "2008-05-01"
    "aid" => "70251"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:275-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2329
      "formatos" => array:3 [
        "EPUB" => 32
        "HTML" => 1543
        "PDF" => 754
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
      "titulo" => "Mohs Micrographic Surgery&#58; Our First 100 Patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "275"
          "paginaFinal" => "280"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Cirug&#237;a de Mohs&#58; Nuestros Primeros Cien Pacientes"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Alonso, P&#46; S&#225;nchez, A&#46; Gonz&#225;lez, J&#46; Ingelmo, I&#46; Ruiz, S&#46; Delgado, M&#46;A&#46; Rodr&#237;guez"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Alonso"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Ingelmo"
            ]
            4 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Ruiz"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Delgado"
            ]
            6 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Rodr&#237;guez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702518?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000004/v1_201304241431/S1578219008702518/v1_201304241431/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S157821900870249X"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70249-X"
    "estado" => "S300"
    "fechaPublicacion" => "2008-05-01"
    "aid" => "70249"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:262-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3512
      "formatos" => array:3 [
        "EPUB" => 32
        "HTML" => 1547
        "PDF" => 1933
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Advances in dermatology</span>"
      "titulo" => "Recent Advances in Laser Therapy and Other Technologies"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "262"
          "paginaFinal" => "268"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recientes Avances en L&#225;ser y Otras Tecnolog&#237;as"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Boixeda, M&#46; Calvo, L&#46; Bagazgoitia"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Boixeda"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Calvo"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Bagazgoitia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900870249X?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000004/v1_201304241431/S157821900870249X/v1_201304241431/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
    "titulo" => "Epidermodysplasia Verruciformis-Like Cells as Histologic Markers of Immunosuppression&#58; Review of 229 Squamous Cell Carcinomas<a class="elsevierStyleCrossRef" href="#fn1"><span class="elsevierStyleSup">&#42;</span></a>"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "269"
        "paginaFinal" => "274"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Corbal&#225;n-V&#233;lez, J&#46;A&#46; Ruiz-Maci&#225;, C&#46; Brufau, J&#46;M&#46; L&#243;pez-Lozano, E&#46; Mart&#237;nez-Barba, J&#46; Mart&#237;nez-Escribano, F&#46;J&#46; Carapeto"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Corbal&#225;n-V&#233;lez"
            "email" => array:1 [
              0 => "raulcorb&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Ruiz-Maci&#225;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Brufau"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "L&#243;pez-Lozano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Mart&#237;nez-Barba"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Mart&#237;nez-Escribano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Carapeto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff6"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Vega Baja&#44; Orihuela&#44; Alicante&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Reina Sof&#237;a&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Medicina Preventiva&#44; Hospital Vega Baja&#44; Orihuela&#44; Alicante&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff4"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff5"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario Lozano Blesa&#44; Zaragoza&#44; Spain<a class="elsevierStyleCrossRef" href="#fn1"><span class="elsevierStyleSup">&#42;</span></a>"
            "etiqueta" => "<span class="elsevierStyleSup">f</span>"
            "identificador" => "aff6"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital Universitario Virgen de la Arrixaca&#44; Ctra&#46; Murcia-Cartagena&#44; s&#47;n&#44; 30120 El Palmar&#44; Murcia&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Las C&#233;lulas Tipo Epidermodisplasia Verruciforme Como Marcador Histol&#243;gico de Inmunodepresi&#243;n&#58; Revisi&#243;n de 229 Carcinomas Espinocelulares"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2007-09-11"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84166"
          "palabras" => array:4 [
            0 => "epidermodysplasia verruciformis"
            1 => "immunosuppression"
            2 => "papillomavirus"
            3 => "solar elastosis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84165"
          "palabras" => array:4 [
            0 => "epidermodisplasia verruciforme"
            1 => "inmunodepresi&#243;n"
            2 => "papilomavirus"
            3 => "elastosis solar"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Epidermodysplasia verruciformis &#40;EV&#41; is associated with greater susceptibility to infection by certain oncogenic subtypes of human papillomavirus &#40;HPV&#41;&#46; Among other histologic findings&#44; large&#44; clear&#44; oval or rounded cells &#40;EV cells&#41; are observed in the granular layer in EV&#44; and some authors consider these cells to be markers of immunosuppression&#46;</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 229 squamous cell carcinomas &#40;SCC&#41; to determine whether EV cells were present and to assess whether their presence was associated either with localized or cutaneous immunosuppression &#40;tumors with signs of severe chronic actinic damage or severe stasis dermatitis&#41; or with systemic immunosuppression &#40;immunocompromised or elderly patients&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed EV cells in 33 SCC&#46; No statistically significant relationship was observed between the presence of EV cells and immunosuppression&#46; We performed polymerase chain reaction in 8 lesions&#44; but the results were not informative as the DNA was denatured&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We found no relationship between the presence of EV cells and localized or systemic immunosuppression&#44; possibly because the sample was inadequate &#40;almost all SCC studied were associated with signs of immunosuppression&#44; irrespective of the presence or absence of EV cells&#41;&#46; Further studies will be required to compare lesions associated with immunosuppression with those in which immunosuppression is absent&#46; The presence of EV cells may be the result of cytopathic effects of certain HPV subtypes&#44; such as HPV 5 or 8&#44; but this will need to be demonstrated using techniques such as polymerase chain reaction&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La epidermodisplasia verruciforme &#40;EV&#41; es una enfermedad en la que existe una mayor susceptibilidad gen&#233;tica a la infecci&#243;n por determinados subtipos oncog&#233;nicos del virus del papiloma humano &#40;VPH&#41;&#46; Entre otros hallazgos histol&#243;gicos&#44; en la EV suelen observarse unas c&#233;lulas claras&#44; grandes&#44; ovaladas o redondeadas &#40;c&#233;lulas EV&#41; en la capa granulosa&#44; que seg&#250;n algunos autores se podr&#237;an considerar como un marcador histol&#243;gico de inmunodepresi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 229 carcinomas espinocelulares &#40;CE&#41; para valorar si presentaban c&#233;lulas EV y si se relacionaban con inmunodepresi&#243;n&#44; tanto localizada o cut&#225;nea &#40;tumores con signos de intenso da&#241;o solar cr&#243;nico o con una dermatitis de estasis intensa&#41;&#44; como sist&#233;mica &#40;pacientes inmunodeprimidos o ancianos&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos c&#233;lulas EV en 33 carcinomas&#46; No hemos encontrado relaci&#243;n significativa entre la existencia de c&#233;lulas EV e inmunodepresi&#243;n&#46; Realizamos reacci&#243;n en cadena de la polimerasa &#40;PCR&#41; en 8 lesiones&#44; pero los resultados no fueron valorables porque el ADN estaba desnaturalizado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">No hemos demostrado relaci&#243;n entre las c&#233;lulas EV e inmunodepresi&#243;n&#44; localizada o sist&#233;mica&#44; posiblemente porque la muestra no era adecuada &#40;se podr&#237;a considerar que pr&#225;cticamente todos los CE estudiados se asociaban a signos de inmunodepresi&#243;n&#44; tanto aquellos que presentaban c&#233;lulas EV como los que no&#41;&#46; Ser&#237;an necesarios m&#225;s estudios que comparasen lesiones asociadas a inmunodepresi&#243;n con otras que no&#46; Es posible que estas c&#233;lulas EV sean el resultado de los efectos citop&#225;ticos de determinados subtipos de VPH&#44; como el VPH-5 o el VPH-8&#44; aunque ser&#237;a necesario demostrar esta hip&#243;tesis mediante t&#233;cnicas de PCR o similar&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara">2006 August C&#46; Stiefel Award&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis as a model of Human Papillomavirus-inducel genetic cancer of the skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Majewski"
                            1 => "S&#46; Jablonska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1995"
                        "volumen" => "131"
                        "paginaInicial" => "1312"
                        "paginaFinal" => "1318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7503577"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodisplasia verruciforme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46;P&#46; S&#225;nchez-Garc&#237;a"
                            1 => "A&#46; Sanz"
                            2 => "C&#46; Eloy"
                            3 => "A&#46; Vera"
                            4 => "T&#46; Mart&#237;n"
                            5 => "F&#46; S&#225;nchez-Fajardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "531"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical aspects of epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;R&#46; de Oliveira"
                            1 => "C&#46; Festa Neto"
                            2 => "P&#46;L&#46; Rady"
                            3 => "S&#46;K&#46; Tyring"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "394"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12834447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Majewski"
                            1 => "E&#46; Skipinska-Rozewska"
                            2 => "S&#46; Jablonska"
                            3 => "M&#46; Wasik"
                            4 => "J&#46; Misiewicz"
                            5 => "G&#46; Orth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1986"
                        "volumen" => "15"
                        "paginaInicial" => "966"
                        "paginaFinal" => "973"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3491095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural cell-mediated cytotoxicity against various target cells in patients with epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Majewski"
                            1 => "J&#46; Malejczyk"
                            2 => "S&#46; Jablonska"
                            3 => "J&#46; Misiewicz"
                            4 => "L&#46; Rudnicka"
                            5 => "S&#46; Obalek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1990"
                        "volumen" => "22"
                        "paginaInicial" => "423"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2155952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histologic spectrum of Epidermodysplasia Verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;J&#46; Nuovo"
                            1 => "M&#46; Ishag"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "2000"
                        "volumen" => "24"
                        "paginaInicial" => "1400"
                        "paginaFinal" => "1406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Viral diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Weedon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Skin Pathology"
                        "paginaInicial" => "583"
                        "paginaFinal" => "603"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin cancer in organ transplant recipients&#58; Epidemiology&#44; pathogenesis&#44; and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Berg"
                            1 => "C&#46;C&#46; Otley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "1"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12077575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shortage of circulating naive CD8 &#63;&#63;T cells provides new insights on immunodeficiency in aging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Fagnoni"
                            1 => "R&#46; Vescovini"
                            2 => "G&#46; Passeri"
                            3 => "G&#46; Bologna"
                            4 => "M&#46; Pedrazzoni"
                            5 => "G&#46; Lavagetto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2000"
                        "volumen" => "95"
                        "paginaInicial" => "2860"
                        "paginaFinal" => "2868"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10779432"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a e inmunopatogenia del c&#225;ncer cut&#225;neo no melanoma&#46; El papel iniciador y promotor del VPH"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;G&#46; Villarrubia"
                            1 => "L&#46;A&#46; Costa"
                            2 => "M&#46; P&#233;rez"
                            3 => "S&#46; Vidal"
                            4 => "P&#46; Jaen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "428"
                        "paginaFinal" => "438"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism involved in ultraviolet light-induced immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Aubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "515"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14721768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efectos de la radiaci&#243;n ultravioleta sobre el sistema inmunitario&#46; Implicaciones terap&#233;uticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "303"
                        "paginaFinal" => "312"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformisassociated papillomavirus infection complicating human immunodeficiency virus disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46;G&#46; Berger"
                            1 => "W&#46;S&#46; Sawchuk"
                            2 => "C&#46; Leonardi"
                            3 => "A&#46; Langenberg"
                            4 => "J&#46; Tappero"
                            5 => "P&#46;E&#46; Leboit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1991"
                        "volumen" => "124"
                        "paginaInicial" => "79"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1847068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in a patient with Hodgkin&#39;s disease&#58; characterization of a new papilloma virus type and interferon treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Gross"
                            1 => "K&#46; Ellinger"
                            2 => "A&#46; Roussaki"
                            3 => "P&#46;G&#46; Fuchs"
                            4 => "H&#46;H&#46; Peter"
                            5 => "H&#46; Pfister"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1989"
                        "volumen" => "91"
                        "paginaInicial" => "43"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2838553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis associated with severe immunodeficiency&#44; lymphoma&#44; and disseminated molluscum contagiosum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;D&#46; Slawsky"
                            1 => "R&#46;T&#46; Gilson"
                            2 => "A&#46;J&#46; Hockley"
                            3 => "L&#46;F&#46; Libow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1992"
                        "volumen" => "27"
                        "paginaInicial" => "448"
                        "paginaFinal" => "450"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1401282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Swollen keratinocytes&#58; a histologic marker of unusual human papillomavirus-type infection and immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;S&#46; Penneys"
                            1 => "A&#46; Friend"
                            2 => "W&#46;Y&#46; Zhu"
                            3 => "C&#46; Leonardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1992"
                        "volumen" => "12"
                        "paginaInicial" => "217"
                        "paginaFinal" => "220"
                        "itemHostRev" => array:3 [
                          "pii" => "S001651071002331X"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "M&#233;todos moleculares de detecci&#243;n de mutaciones en dermatolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Unamuno"
                            1 => "R&#46; G&#243;nzalez Sarmiento"
                            2 => "S&#46; Mallo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioestad&#237;stica&#46; M&#233;todos estad&#237;sticos para investigadores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Dom&#233;nech Massons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1982"
                        "editorial" => "Herder"
                        "editorialLocalizacion" => "Barcelona"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Qu&#233; es una odds ratio&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez Gonz&#225;lez"
                            1 => "J&#46; Irala Est&#233;vez"
                            2 => "F&#46; Guill&#233;n Grima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1999"
                        "volumen" => "112"
                        "paginaInicial" => "416"
                        "paginaFinal" => "422"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinomas espinocelulares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Y&#225;&#241;ez-D&#237;az"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Tumores Cut&#225;neos"
                        "paginaInicial" => "97"
                        "paginaFinal" => "116"
                        "serieFecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoma espinocelular cut&#225;neo y papilomavirus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Corbal&#225;n-V&#233;lez"
                            1 => "J&#46;A&#46; Ruiz-Maci&#225;"
                            2 => "C&#46; Brufau"
                            3 => "F&#46;J&#46; Carapeto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "583"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17961447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;M&#46; Tieben"
                            1 => "R&#46;J&#46; Berkhout"
                            2 => "H&#46;L&#46; Smits"
                            3 => "J&#46;N&#46; Bouves Bavinck"
                            4 => "B&#46;J&#46; Vermeer"
                            5 => "J&#46;A&#46; Bruijn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1994"
                        "volumen" => "131"
                        "paginaInicial" => "226"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7917987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of human papillomavirus type 5 DNA in skin cancers of an immunosupressed renal allograft recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Lutzner"
                            1 => "G&#46; Orth"
                            2 => "V&#46; Dutronquay"
                            3 => "M&#46;F&#46; Ducasse"
                            4 => "H&#46; Kreis"
                            5 => "J&#46; Crosnier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1983"
                        "volumen" => "2"
                        "paginaInicial" => "422"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6147500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;L&#46; Boxman"
                            1 => "L&#46;H&#46; Mulder"
                            2 => "A&#46; Russell"
                            3 => "J&#46;N&#46; Bouwes Bavinck"
                            4 => "A&#46; Green"
                            5 => "J&#46; Ter Schegget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "141"
                        "paginaInicial" => "246"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of polymerase chain reaction amplification for the detection of genital human papillomavirus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;M&#46; Manos"
                            1 => "Y&#46; Ting"
                            2 => "D&#46;K&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Cel"
                        "fecha" => "1989"
                        "volumen" => "7"
                        "paginaInicial" => "209"
                        "paginaFinal" => "214"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detecci&#243;n y tipado de papilomavirus humano por amplificaci&#243;n gen&#243;mica en biopsias&#44; frotis y orina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mart&#237;nez"
                            1 => "R&#46; N&#225;s"
                            2 => "C&#46; LaCruz"
                            3 => "T&#46; Hell&#237;n"
                            4 => "J&#46;C&#46; Tercero"
                            5 => "E&#46; Valverde"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ginecol&#243;gica"
                        "fecha" => "1995"
                        "volumen" => "52"
                        "paginaInicial" => "51"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of polymerase chain reaction and catalyzed signal amplification in situ hybridization methods for human papillomavirus detection in paraffin-embedded cervical preneoplastic and neoplastic lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;M&#46; Dabic"
                            1 => "L&#46; Hlupic"
                            2 => "D&#46; Babic"
                            3 => "S&#46; Jukic"
                            4 => "S&#46; Seiwerth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arcmed.2004.07.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Med Res"
                        "fecha" => "2004"
                        "volumen" => "35"
                        "paginaInicial" => "511"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15631876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000004/v1_201304241431/S1578219008702506/v1_201304241431/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702506?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 2 10 12
2024 Octubre 64 47 111
2024 Septiembre 71 31 102
2024 Agosto 98 62 160
2024 Julio 72 46 118
2024 Junio 78 41 119
2024 Mayo 49 33 82
2024 Abril 70 24 94
2024 Marzo 65 53 118
2024 Febrero 43 38 81
2024 Enero 56 36 92
2023 Diciembre 53 30 83
2023 Noviembre 46 23 69
2023 Octubre 35 27 62
2023 Septiembre 38 27 65
2023 Agosto 18 19 37
2023 Julio 25 47 72
2023 Junio 30 17 47
2023 Mayo 33 23 56
2023 Abril 25 19 44
2023 Marzo 24 23 47
2023 Febrero 27 21 48
2023 Enero 25 25 50
2022 Diciembre 28 35 63
2022 Noviembre 11 60 71
2022 Octubre 15 16 31
2022 Septiembre 20 36 56
2022 Agosto 11 30 41
2022 Julio 18 30 48
2022 Junio 22 36 58
2022 Mayo 23 38 61
2022 Abril 22 47 69
2022 Marzo 23 44 67
2022 Febrero 21 27 48
2022 Enero 23 35 58
2021 Diciembre 19 39 58
2021 Noviembre 24 45 69
2021 Octubre 23 42 65
2021 Septiembre 17 30 47
2021 Agosto 19 34 53
2021 Julio 26 36 62
2021 Junio 19 38 57
2021 Mayo 31 45 76
2021 Abril 38 63 101
2021 Marzo 60 14 74
2021 Febrero 65 22 87
2021 Enero 31 13 44
2020 Diciembre 24 18 42
2020 Noviembre 33 18 51
2020 Octubre 26 10 36
2020 Septiembre 35 11 46
2020 Agosto 30 16 46
2020 Julio 19 13 32
2020 Junio 23 25 48
2020 Mayo 29 18 47
2020 Abril 24 16 40
2020 Marzo 17 27 44
2020 Febrero 3 1 4
2020 Enero 0 8 8
2019 Diciembre 0 12 12
2019 Noviembre 0 4 4
2019 Octubre 0 4 4
2019 Septiembre 0 4 4
2019 Agosto 0 1 1
2019 Julio 0 9 9
2019 Junio 0 13 13
2019 Mayo 1 67 68
2019 Abril 2 13 15
2019 Marzo 0 4 4
2019 Febrero 0 6 6
2019 Enero 0 1 1
2018 Agosto 0 1 1
2018 Julio 0 1 1
2018 Junio 0 2 2
2018 Mayo 0 14 14
2018 Abril 0 3 3
2018 Marzo 1 1 2
2018 Febrero 7 9 16
2018 Enero 18 7 25
2017 Diciembre 16 11 27
2017 Noviembre 9 6 15
2017 Octubre 17 10 27
2017 Septiembre 10 11 21
2017 Agosto 14 6 20
2017 Julio 10 6 16
2017 Junio 16 22 38
2017 Mayo 9 26 35
2017 Abril 19 7 26
2017 Marzo 18 13 31
2017 Febrero 12 12 24
2017 Enero 13 8 21
2016 Diciembre 31 7 38
2016 Noviembre 25 4 29
2016 Octubre 30 10 40
2016 Septiembre 31 7 38
2016 Agosto 26 5 31
2016 Julio 27 5 32
2016 Junio 6 5 11
2016 Mayo 8 4 12
2016 Abril 8 7 15
2016 Marzo 2 17 19
2016 Febrero 2 20 22
2016 Enero 9 15 24
2015 Diciembre 10 9 19
2015 Noviembre 12 6 18
2015 Octubre 11 11 22
2015 Septiembre 10 11 21
2015 Agosto 12 2 14
2015 Julio 26 9 35
2015 Junio 27 8 35
2015 Mayo 78 6 84
2015 Abril 26 8 34
2015 Marzo 32 1 33
2015 Febrero 26 6 32
2015 Enero 27 10 37
2014 Diciembre 19 2 21
2014 Noviembre 22 8 30
2014 Octubre 37 7 44
2014 Septiembre 29 9 38
2014 Agosto 45 19 64
2014 Julio 41 21 62
2014 Junio 35 7 42
2014 Mayo 53 13 66
2014 Abril 33 10 43
2014 Marzo 48 19 67
2014 Febrero 33 13 46
2014 Enero 27 14 41
2013 Diciembre 36 9 45
2013 Noviembre 25 17 42
2013 Octubre 27 18 45
2013 Septiembre 22 15 37
2013 Agosto 27 38 65
2013 Julio 39 31 70
2013 Junio 28 26 54
2013 Mayo 21 25 46
2013 Abril 28 45 73
2013 Marzo 30 32 62
2013 Febrero 26 9 35
2013 Enero 14 4 18
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?