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A, Preoperative image, showing a brownish, slightly raised plaque at the level of the fourth commissure. B, Postoperative appearance.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 12-year-old girl with no medical history was referred to the pediatric plastic surgery department for a lesion that had appeared 3 months earlier on the back of her right hand and consisted of an indurated, slightly raised brownish plaque that was painful to the touch (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The first diagnostic test performed was a Doppler ultrasound, which revealed a subcutaneous lesion compatible with an arteriovenous malformation. Subsequent magnetic resonance imaging (MRI) supported this suspicion. After presenting the case to the Vascular Anomalies Committee at our center, we opted for treatment with embolization and subsequent surgery. Embolization was not possible due to imaging findings compatible with thrombosis of the malformative nidus. As the patient was asymptomatic at the time, a wait-and-see approach with ultrasound monitoring was adopted.</p><p id="par0015" class="elsevierStylePara elsevierViewall">One year later, the patient requested treatment for pain related to trauma and the visible lesion was surgically resected. Histopathology of the lesion indicated a plexiform fibrohistiocytic tumor without tumor-free margins. The neoformation affected the subcutaneous cellular tissue and superficial areas of the skeletal muscle, sparing the overlying skin. It presented a plexiform distribution, with tumor nests composed of spindle cells or monomorphic epithelioid cells accompanied by giant multinucleated cells. A fibrous stroma with dilated vessels was evident between the nests. The proliferative index was less than 3% and no atypical mitoses, necrosis, or xanthomatous cells were observed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Immunohistochemistry was negative for CD31, CD34, Wilms tumor protein 1 (WT1), and glucose transporter-1 (GLUT1).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A thoracic computed tomography scan, performed as part of the tumor extension study, revealed a nodule of 3<span class="elsevierStyleHsp" style=""></span>mm in the right lower pulmonary lobe. The pediatric thoracic surgery team proceeded with thoracoscopic resection of the nodule, which was compatible with a carcinoid tumorlet.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The results of imaging studies of the right hand revealed a residual lesion with invasion of muscle and tendon and erosion of the cortical bone of the fourth metacarpal. After discussing the case with a multidisciplinary team consisting of oncologists, plastic surgeons, traumatologists, radiologists and pathologists, 2 therapeutic options were established: close clinical observation or complete resection of the lesion. Ultimately, the family opted for surgery, and the fourth and fifth fingers of the right hand were amputated. Currently, the patient is asymptomatic and is undergoing follow-up and rehabilitation.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Plexiform fibrohistiocytic tumor, first reported by Enzinger and Zhang in 1988,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> is a rare soft-tissue tumor with intermediate potential for malignancy.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> It shows a predilection for children and young adults, affecting those under 20 years of age in 60%–70% of cases.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3,4</span></a> It is more prevalent in females and does not predominate in any ethnic group.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Its etiology is unknown, but congenital cases and those related to previous trauma have been reported.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3–6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinically it presents as a painless, slow-growing, indurated mass or plaque (1–3<span class="elsevierStyleHsp" style=""></span>cm) that affects the dermis and hypodermis. It can sometimes cause pain, ulceration, or changes in the color of the overlying skin, and in rare cases, including the present case, spreads to the skeletal muscle. It usually affects the upper limbs, mainly the fingers, hand, or wrist. Cases of lower limb, trunk, head, and neck involvement have been reported.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3–6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Initial clinical and radiological diagnosis is challenging. MRI shows an infiltrative lesion or plaque at the level of the subcutaneous tissue, with no specific signal characteristics that allow differentiation from other benign (including some types of vascular anomalies) or malignant entities.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> The definitive diagnosis is based on pathological findings. Histology shows nodules or fascicles of histiocytes, fibroblasts, and osteoclast-like cells, arranged in a characteristic plexiform pattern. Immunohistochemistry reveals CD68<span class="elsevierStyleSup">+</span> histiocytic cells and fibroblasts positive for smooth muscle actin and vimentin.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3–6,8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Surgical resection with negative margins is the treatment of choice. Local recurrence has been documented in 12.5%–40% of cases, and is often detected 1–2 years after surgery.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> After complete resection the clinical course of this tumor is typically benign, although regional lymph node (6%) and lung (2%–19%) metastases have been reported, necessitating long-term follow-up of affected patients.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3–5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In summary, we describe a case of plexiform fibrohistiocytic tumor in a 12-year-old girl. The decision to resect the tumor, despite a relatively low risk of nodal and pulmonary metastases, posed a conflict for the treating physicians as it involved amputation of 2 fingers on the affected hand. Ultimately the family, perhaps influenced by the incidental diagnosis of a pulmonary nodule in the tumor extension study, opted for surgery to avoid the potential risk of future metastasis.</p><p id="par0055" class="elsevierStylePara elsevierViewall">We wish to emphasize the importance of pathological anatomy in the diagnosis of soft-tissue tumors, which comprise multiple entities, the management and prognosis of which can vary considerably.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of Interest" ] 1 => array:2 [ "identificador" => "xack623182" "titulo" => "Acknowledgments" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 809 "Ancho" => 1242 "Tamanyo" => 132754 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Right hand of the patient. A, Preoperative image, showing a brownish, slightly raised plaque at the level of the fourth commissure. B, Postoperative appearance.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 441 "Ancho" => 1757 "Tamanyo" => 251761 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histological image of a plexiform fibrohistiocytic tumor. A, Hematoxylin–eosin (H–E), original magnification ×4. B, H–E, original magnification ×10. C, H–E, original magnification ×200.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plexiform fibrohistiocytic tumor presenting in children and young adults. An analysis of 65 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.M. Enzinger" 1 => "R.Y. 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Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2011.04173.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "2012" "volumen" => "60" "paginaInicial" => "1156" "paginaFinal" => "1158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22435737" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack623182" "titulo" => "Acknowledgments" "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">The authors thank Dr. Rodriguez and Dr. Espinola, pathologists at Hospital 12 de Octubre, Madrid, for providing the histological images associated with this clinical case. Thanks also to the staff in the departments of Pediatric Traumatology (Dr. Martí); Pediatric Thoracic Surgery (Dr. Morante, Dr. Lopez, and Dr. Antón-Pacheco); Pediatric Hemato-Oncology (Dr. Perez and Dr. Baro); and Pediatric Radiodiagnosis (Dr. Gallego) of the Hospital 12 de Octubre, Madrid, for their contributions to decision-making and patient management.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011300000008/v1_202208290519/S0001731022006081/v1_202208290519/en/main.assets" "Apartado" => array:4 [ "identificador" => "6143" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cartas científico-clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000008/v1_202208290519/S0001731022006081/v1_202208290519/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022006081?idApp=UINPBA000044" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 19 | 11 | 30 |
2024 Octubre | 105 | 47 | 152 |
2024 Septiembre | 125 | 33 | 158 |
2024 Agosto | 96 | 51 | 147 |
2024 Julio | 58 | 49 | 107 |
2024 Junio | 85 | 49 | 134 |
2024 Mayo | 60 | 42 | 102 |
2024 Abril | 49 | 27 | 76 |
2024 Marzo | 56 | 45 | 101 |
2024 Febrero | 46 | 29 | 75 |
2024 Enero | 46 | 25 | 71 |
2023 Diciembre | 64 | 11 | 75 |
2023 Noviembre | 50 | 35 | 85 |
2023 Octubre | 49 | 32 | 81 |
2023 Septiembre | 55 | 34 | 89 |
2023 Agosto | 45 | 14 | 59 |
2023 Julio | 54 | 52 | 106 |
2023 Junio | 51 | 31 | 82 |
2023 Mayo | 61 | 32 | 93 |
2023 Abril | 41 | 20 | 61 |
2023 Marzo | 64 | 28 | 92 |
2023 Febrero | 51 | 30 | 81 |
2023 Enero | 59 | 51 | 110 |
2022 Diciembre | 80 | 44 | 124 |
2022 Noviembre | 79 | 51 | 130 |
2022 Octubre | 70 | 45 | 115 |
2022 Septiembre | 173 | 97 | 270 |
2022 Agosto | 81 | 61 | 142 |
2022 Julio | 41 | 47 | 88 |