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Presentación de un caso clínico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "737" "paginaFinal" => "739" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ocular Syphilis Diagnosed After Evaluation of Key Skin Signs: A Case Report" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1016 "Ancho" => 1250 "Tamanyo" => 159837 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clavos sifilíticos. Pápulas planas hiperqueratósicas eritemato-amarillentas que afectan a las palmas de ambas manos (A) y a las plantas de ambos pies (B).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Luna-Bastante, L. Vergara-de-la-Campa, E.R. Martínez-Lorenzo, P. Clavo-Escribano" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Luna-Bastante" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Vergara-de-la-Campa" ] 2 => array:2 [ "nombre" => "E.R." "apellidos" => "Martínez-Lorenzo" ] 3 => array:2 [ "nombre" => "P." 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Krasnovska, E. Sendagorta Cudos, V. Baena Romero, F. de la Calle-Prieto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "K." "apellidos" => "Krasnovska" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Sendagorta Cudos" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Baena Romero" ] 3 => array:2 [ "nombre" => "F." 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"apellidos" => "Krasnovska" "email" => array:1 [ 0 => "khrystyna.kn@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Sendagorta Cudos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Baena Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "de la Calle-Prieto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Medicina Tropical y del Viajero, CSUR Patología Importada, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lesiones petequiales periumbilicales en paciente crítica, signo a conocer por un dermatólogo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 673 "Ancho" => 901 "Tamanyo" => 77199 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Petechiae grouped in a reticular pattern in the periumbilical region and on both thighs.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 33-year-old woman of Peruvian nationality was admitted to the intensive care unit with a pulmonary embolism. While admitted to the hospital, she presented multiple complications, such as consecutive episodes of sepsis due to <span class="elsevierStyleItalic">Escherichia coli</span>, <span class="elsevierStyleItalic">Klebsiella</span><span class="elsevierStyleItalic">pneumoniae</span>, and <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>, which required hemodynamic support, mechanical ventilation, and broad antibiotic coverage. Seven weeks after admission, a dermatologic assessment was requested due to skin lesions that had appeared on the torso and later spread to the proximal part of the lower limbs. The week prior to admission, the patient had undergone surgery for a suprasellar meningioma, with no immediate complications, after which she was prescribed high-dose corticosteroid treatment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The physical examination revealed exanthema consisting of nonpalpable petechiae, grouped in a reticular pattern, in the periumbilical region and on the anterior and proximal surfaces of both thighs; the petechiae did not fade under glass (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). Histopathology revealed a moderate perivascular infiltrate in the superficial and deep dermis, with lymphocytes and eosinophils. Moreover, elongated structures were observed in the deep dermis, among the strands of collagen, with basophilic stippling in their interior; the structures were identified as nematode larvae (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Blood tests revealed anemia and leukocytosis with eosinophilia, and nematode larvae were detected in the microbiologic study of the bronchoalveolar lavage.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The microorganism was identified as <span class="elsevierStyleItalic">Strongyloides stercoralis</span> and cultures of bronchoalveolar lavage and feces confirmed growth; the patient was therefore diagnosed with <span class="elsevierStyleItalic">Strongyloides</span> hyperinfestation and disseminated strongyloidiasis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment was instated with ivermectin administered via nasogastric tube. As no improvement was observed in terms of blood tests or parasite load, and in light of suspected poor digestive absorption due to the patient's critical state and paralytic ileus, the medication was then administered subcutaneously at a dosage of 200<span class="elsevierStyleHsp" style=""></span>μg/kg/d, after requesting compassionate use. The parasite load fell with the treatment, but the patient never recovered from the neurologic clinical symptoms, suffered a continuous series of superinfections, and died.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Strongyloidiasis is a disease caused by the parasite <span class="elsevierStyleItalic">S. stercoralis.</span> This is a nematode with a global distribution, whose main reservoir is humans; it is endemic in rural areas of tropical and subtropical regions and, in Peru, it is considered to be highly endemic.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> It has 2 reproductive cycles, a free-living cycle in the soil and a parasitic cycle in the host intestine. Thus, in the filariform stage, the larvae penetrate the skin and migrate through the venous system to the lungs and the intestine, where they mature and reproduce; the eggs and larvae are eliminated by the host via the feces. They have the ability to complete their cycle in the human host, produce autoinfection, and evade the host immune response, producing chronic disease lasting decades. In this way, they rarely produce symptoms, except for nonspecific gastrointestinal symptoms accompanied by eosinophilia in blood tests. Systemic dissemination is rare and may occur in immunosuppressed patients, especially during treatment with corticosteroids, with high mortality (between 70% and 90%).<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Development of disseminated disease should be suspected in patients with a history of travel to areas where the disease is endemic (even when many years have since passed), a history of corticosteroid therapy, persistent bacteremia with organisms of enteric origin (as the parasites tend to serve as carriers for those organisms), nonspecific gastrointestinal and respiratory systems, neurological abnormalities, and concomitant infection with other intestinal parasites.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> Eosinophilia is characteristic of the disease, although it may be absent in immunosuppressed patients.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Cutaneous manifestations are rare and may appear as a purpuric petechial rash; periumbilical petechial rash is a sign of poor prognosis, previously described in the literature.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> The lesions are purpuric, nonpalpable, and take on the appearance of fingerprints, typically located in the periumbilical region and on the anterior surface of the thighs. The biopsy may show parasites around the blood vessels, with no signs of vasculitis.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The microbiologic diagnosis is based on serology, specific culture in feces, or direct observation of the nematode. The treatment of choice is oral ivermectin at a dosage of 200<span class="elsevierStyleHsp" style=""></span>μg/kg/d.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> On very specific occasions, it is necessary to use the subcutaneous presentation of this drug, especially in cases of gastrointestinal involvement secondary to hyperinfestation with obstruction or paralytic ileus, and in patients with a low level of consciousness—situations where absorption and tolerance of the orally administered drug are in question. Subcutaneous administration constitutes compassionate use and favorable results have been reported in the literature.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Thiabendazole and albendazole are therapeutic alternatives.</p><p id="par0045" class="elsevierStylePara elsevierViewall">As dermatologists, we must suspect strongyloidiasis in the case of a patient with periumbilical petechial rash, especially if the patient has traveled to regions where the disease is endemic and has received immunosuppressant treatment, including oral corticosteroids. It is essential to rule out strongyloidiasis by means of serological screening in at-risk patients before instating immunosuppressant or biologic treatment.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 673 "Ancho" => 901 "Tamanyo" => 77199 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Petechiae grouped in a reticular pattern in the periumbilical region and on both thighs.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 563 "Ancho" => 901 "Tamanyo" => 54192 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Detail of the retiform petechial lesions on the anterior surface of the thigh.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 675 "Ancho" => 901 "Tamanyo" => 173503 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Moderate perivascular inflammatory infiltrate in the dermis with lymphocytes and eosinophils. Elongated structures with interior basophilic stippling in the deep dermis, which correspond to nematode larvae (box).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Strongyloides stercoralis</span>: global distribution and risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Schär" 1 => "U. Trostdorf" 2 => "F. Giardina" 3 => "V. Khieu" 4 => "S. Muth" 5 => "H. 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año/Mes | Html | Total | |
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2024 Noviembre | 15 | 13 | 28 |
2024 Octubre | 155 | 68 | 223 |
2024 Septiembre | 142 | 50 | 192 |
2024 Agosto | 189 | 101 | 290 |
2024 Julio | 188 | 56 | 244 |
2024 Junio | 173 | 62 | 235 |
2024 Mayo | 90 | 49 | 139 |
2024 Abril | 80 | 42 | 122 |
2024 Marzo | 182 | 43 | 225 |
2024 Febrero | 151 | 41 | 192 |
2024 Enero | 173 | 31 | 204 |
2023 Diciembre | 109 | 19 | 128 |
2023 Noviembre | 189 | 33 | 222 |
2023 Octubre | 151 | 49 | 200 |
2023 Septiembre | 175 | 29 | 204 |
2023 Agosto | 165 | 20 | 185 |
2023 Julio | 166 | 39 | 205 |
2023 Junio | 104 | 31 | 135 |
2023 Mayo | 219 | 30 | 249 |
2023 Abril | 164 | 25 | 189 |
2023 Marzo | 182 | 42 | 224 |
2023 Febrero | 121 | 25 | 146 |
2023 Enero | 145 | 51 | 196 |
2022 Diciembre | 179 | 41 | 220 |
2022 Noviembre | 143 | 44 | 187 |
2022 Octubre | 179 | 49 | 228 |
2022 Septiembre | 147 | 38 | 185 |
2022 Agosto | 150 | 58 | 208 |
2022 Julio | 196 | 68 | 264 |
2022 Junio | 57 | 50 | 107 |