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Flores-Terry, M. García-Arpa, J.L. Santiago-Sánchez Mateo, G. Romero Aguilera" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.Á." "apellidos" => "Flores-Terry" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "García-Arpa" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Santiago-Sánchez Mateo" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Romero Aguilera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022001600?idApp=UINPBA000044" "url" => "/00017310/0000011300000007/v1_202207140532/S0001731022001600/v1_202207140532/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0001731021004427" "issn" => "00017310" "doi" => "10.1016/j.ad.2020.08.032" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "2829" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2022;113:719-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASOS PARA EL DIAGNÓSTICO</span>" "titulo" => "Equimosis espontáneas en una mujer joven, con propuesta de diagnóstico de síndrome de Ehlers-Danlos hipermóvil" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "719" "paginaFinal" => "720" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Spontaneous ecchymoses in a young woman leading to the diagnosis of hypermobile Ehlers-Danlos syndrome" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 508 "Ancho" => 900 "Tamanyo" => 64519 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Evaluación de la hipermovilidad articular con la escala de Beighton: capacidad de flexionar la columna colocando las palmas en el suelo sin doblar las rodillas (izquierda) – 1 punto, hiperextensión activa del codo > 10° (arriba derecha) – 1 punto cada lado, hiperextensión activa de la rodilla > 10° – no existió, aposición pasiva del pulgar hacia el antebrazo (abajo medio) – 1 punto cada lado, hiperextensión pasiva de la articulación metacarpofalángica del quinto dedo > 90° (abajo derecha) – 1 punto cada lado.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.F. Hernandez-Amaris, J. Victoria-Chaparro" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.F." "apellidos" => "Hernandez-Amaris" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Victoria-Chaparro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004427?idApp=UINPBA000044" "url" => "/00017310/0000011300000007/v1_202207140532/S0001731021004427/v1_202207140532/es/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0001731021004427" "issn" => "00017310" "doi" => "10.1016/j.ad.2020.08.032" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "2829" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2022;113:719-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASOS PARA EL DIAGNÓSTICO</span>" "titulo" => "Equimosis espontáneas en una mujer joven, con propuesta de diagnóstico de síndrome de Ehlers-Danlos hipermóvil" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "719" "paginaFinal" => "720" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Spontaneous ecchymoses in a young woman leading to the diagnosis of hypermobile Ehlers-Danlos syndrome" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 508 "Ancho" => 900 "Tamanyo" => 64519 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Evaluación de la hipermovilidad articular con la escala de Beighton: capacidad de flexionar la columna colocando las palmas en el suelo sin doblar las rodillas (izquierda) – 1 punto, hiperextensión activa del codo > 10° (arriba derecha) – 1 punto cada lado, hiperextensión activa de la rodilla > 10° – no existió, aposición pasiva del pulgar hacia el antebrazo (abajo medio) – 1 punto cada lado, hiperextensión pasiva de la articulación metacarpofalángica del quinto dedo > 90° (abajo derecha) – 1 punto cada lado.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.F. Hernandez-Amaris, J. Victoria-Chaparro" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.F." "apellidos" => "Hernandez-Amaris" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Victoria-Chaparro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004427?idApp=UINPBA000044" "url" => "/00017310/0000011300000007/v1_202207140532/S0001731021004427/v1_202207140532/es/main.assets" ] ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cases for Diagnosis</span>" "titulo" => " Spontaneous Ecchymoses in a Young Woman Leading to the Diagnosis of Hypermobile Ehlers-Danlos Syndrome" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T719" "paginaFinal" => "T720" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.F. Hernandez-Amaris, J. Victoria-Chaparro" "autores" => array:2 [ 0 => array:4 [ "nombre" => "M.F." "apellidos" => "Hernandez-Amaris" "email" => array:1 [ 0 => "mafhernandez_a@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Victoria-Chaparro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Universidad Libre, Cali, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Clínica Farallones, Cali, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Equimosis espontáneas en una mujer joven, con propuesta de diagnóstico de síndrome de Ehlers-Danlos hipermóvil" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 450 "Ancho" => 587 "Tamanyo" => 39598 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hyperelasticity of the skin, stretching beyond 3<span class="elsevierStyleHsp" style=""></span>cm in the neck (superior left); Pyezogenic papules (superior right); Atrophic scars (bottom).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case-report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 30-year-old female was seen in the outpatient clinic with recurrent bruising that appeared spontaneously, or after minimal trauma; these were barely painful and would disappear on their own after a few weeks leaving a greenish discoloration. She had a personal history of migraine and myopia, her mother had a history of surgery for retinal detachments in several occasions, and, since her father had a diagnosis of Von Willebrand's disease, she had already been evaluated by hematology, who ruled out a coagulation disorder after finding normal coagulation tests and platelet aggregation curve. Nevertheless, coagulation function was reassessed finding normal PT, PTT, platelet aggregation curve, VWF: Ag and hemogram, although a slightly prolonged bleeding time was found (13/9<span class="elsevierStyleHsp" style=""></span>min).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">The initial examination revealed several ecchymoses of different sizes predominantly in the lower extremities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Her skin was velvety in appearance and to the touch, she had some atrophic scars on her legs and arms, piezogenic papules and hyperelasticity of the skin (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). With these findings, joint mobility was assessed, scoring 7/9 in the Beighton scale (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>); based on these clinical findings, a diagnosis of hypermobile Ehlers-Danlos Syndrome (hEDS) was proposed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">What is the diagnosis?</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Diagnosis and evolution</span><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was referred to genetics, who considered ruling out classical EDS and ordered a genetic panel and complementary tests. A mild mitral prolapse was identified through M-mode echocardiogram (posterior mitral leaflet 2<span class="elsevierStyleHsp" style=""></span>mm above the annular plane). MRI and X-rays of the dorsolumbar spine and knees demonstrated mild scoliosis with facet joint stenosis, bilateral patellofemoral malalignment, and grade 1 chondromalacia patellae. The ophthalmologic evaluation found bilateral lattice degeneration of the retina with a small peripheral tear in the left eye, which was corrected through photocoagulation.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The EDS genetic panel was negative but diagnostic criteria for hEDS were met by the patient (<a class="elsevierStyleCrossRef" href="#sec0035">Table 1. Supplementary data</a>), and also by her mother. Paraclinical findings allowed starting an opportune multidisciplinary approach to attenuate further deterioration. Treatment with ascorbic acid 2<span class="elsevierStyleHsp" style=""></span>g daily was started, the patient referred decreased bruising.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">EDS encloses a broad group of genetic disorders of the connective tissue; according to the latest classification, there are 13 subtypes, being hypermobile the most frequent one with an estimated prevalence of 1:5000.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> hEDS is inherited in an autosomal dominant pattern, it is characterized by generalized joint hypermobility predisposing to instability and early degenerative joint disease, skin hyperextensibility that is milder than in other EDS subtypes, and easy bruising. It may be associated with mitral valve prolapse, migraines, postural orthostatic tachycardia syndrome (POTS), ocular alterations (including myopia and predisposition to retinal detachments), chronic pain, and psychologic disturbances.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A genetic mutation hasn’t been identified yet, hence the diagnosis remains clinical and based on the criteria established by the International Consortium on Ehlers-Danlos Syndrome & Related Disorders in association with the Ehlers-Danlos society<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>; three criteria must be met: The presence of generalized joint hypermobility; systemic manifestations, family history, and/or musculoskeletal complications; and the exclusion of alternate diagnosis (<a class="elsevierStyleCrossRef" href="#sec0035">Table 1</a>).</p><p id="par0040" class="elsevierStylePara elsevierViewall">Given the broad compromise, patients require multidisciplinary management aiming to prevent the complications that might present, and should be tailored to the particular manifestations of each patient; there is no standardized approach for soft tissue fragility and its manifestations, but the use of high doses of ascorbic acid (1–4<span class="elsevierStyleHsp" style=""></span>g daily) may improve wound healing and decrease easy bruising.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> It is also advisable, when practicing procedures in these patients, to consider longer times for suture removal, up to 5 days later than in non-EDS patients.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Ehlers-Danlos syndrome is an entity with a variable presentation that usually has cutaneous manifestations, these may be the leading cause of consultation, so the dermatologist must be aware and alert to the identification of the different signs suggestive of the disease. In this case, the presence of ecchymoses led to the diagnosis and allowed the opportune identification and management of subclinical multisystemic compromise.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interests</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case-report" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Physical examination" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Diagnosis and evolution" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interests" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0060" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0035" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 550 "Ancho" => 644 "Tamanyo" => 39518 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bruises, spontaneous ecchymoses, and postinflammatory hyperpigmentation predominantly on extensor surfaces of the lower extremities.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 450 "Ancho" => 587 "Tamanyo" => 39598 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hyperelasticity of the skin, stretching beyond 3<span class="elsevierStyleHsp" style=""></span>cm in the neck (superior left); Pyezogenic papules (superior right); Atrophic scars (bottom).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 310 "Ancho" => 549 "Tamanyo" => 30353 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Assessment of joint hypermobility with the Beighton score: Ability to flex spine placing palms to floor without bending knees (Left) – 1 point; Active hyperextension of elbow >10° (Superior right) – 1 point each side; Active hyperextension of knee >10° – was not present; Passive apposition of thumb to forearm (Bottom middle) – 1 point each side; Passive hyperextension of fifth metacarpal-phalangeal joint >90° (Bottom right) – 1 point each side.</p>" ] ] 3 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 157118 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 2017 international classification of the Ehlers-Danlos syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. 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año/Mes | Html | Total | |
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2024 Noviembre | 40 | 16 | 56 |
2024 Octubre | 232 | 67 | 299 |
2024 Septiembre | 259 | 53 | 312 |
2024 Agosto | 224 | 86 | 310 |
2024 Julio | 225 | 53 | 278 |
2024 Junio | 141 | 71 | 212 |
2024 Mayo | 131 | 57 | 188 |
2024 Abril | 97 | 39 | 136 |
2024 Marzo | 125 | 43 | 168 |
2024 Febrero | 155 | 41 | 196 |
2024 Enero | 175 | 31 | 206 |
2023 Diciembre | 241 | 14 | 255 |
2023 Noviembre | 221 | 42 | 263 |
2023 Octubre | 228 | 34 | 262 |
2023 Septiembre | 210 | 22 | 232 |
2023 Agosto | 200 | 21 | 221 |
2023 Julio | 204 | 40 | 244 |
2023 Junio | 143 | 33 | 176 |
2023 Mayo | 253 | 33 | 286 |
2023 Abril | 161 | 28 | 189 |
2023 Marzo | 179 | 40 | 219 |
2023 Febrero | 120 | 27 | 147 |
2023 Enero | 190 | 58 | 248 |
2022 Diciembre | 149 | 54 | 203 |
2022 Noviembre | 121 | 63 | 184 |
2022 Octubre | 235 | 43 | 278 |
2022 Septiembre | 139 | 49 | 188 |
2022 Agosto | 261 | 80 | 341 |
2022 Julio | 181 | 49 | 230 |
2022 Junio | 159 | 43 | 202 |
2022 Mayo | 115 | 69 | 184 |