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siendo 38 varones &#40;69&#37;&#41; con una mediana de edad de 34 a&#241;os &#40;23-47&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El 60&#37; de los pacientes ten&#237;an un fototipo III&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">La DEM fue patol&#243;gica en 12 pacientes&#46; La mediana de n&#250;mero de sesiones fue de 29 &#40;21-38&#41;&#46; Las medianas de las dosis inicial&#44; final y total fueron&#58; 0&#44;25<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;0&#44;21-0&#44;35&#41;&#44; 1&#44;44<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;0&#44;86-1&#44;95&#41; y 25&#44;39<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;9&#44;52-39&#44;11&#41;&#44; respectivamente&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La diferencia entre el EASI inicial y final fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Se consigui&#243; un EASI 50 en 44 pacientes &#40;80&#37;&#41; y aclaramiento en 23&#46; No se determin&#243; el EASI final en 3 pacientes porque abandonaron la terapia por motivos personales&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">La diferencia entre Skindex-29 inicial y final&#44; calculado en 12 pacientes&#44; fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Ocho pacientes no respondieron al tratamiento&#58; 7 precisaron tratamiento inmunosupresor previo al ciclo de fototerapia &#40;5 corticoides orales&#59; uno azatioprina y uno ciclosporina&#41;&#46; Los tratados con azatioprina o ciclosporina respondieron significativamente peor &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En 47 pacientes la fototerapia se combin&#243; con corticoides orales &#40;12 pacientes&#41;&#44; t&#243;picos &#40;15 pacientes&#41; o UVA &#40;20 pacientes&#41;&#44; con una mediana de EASI inicial de 27&#44;10 &#40;22&#44;42-42&#44;50&#41;&#59; 18 &#40;7&#44;20-25&#41; y 16&#44;40 &#40;10&#44;20-23&#44;55&#41;&#44; respectivamente&#44; superior al del grupo tratado solo con fototerapia &#40;EASI inicial&#58; 12 &#91;7&#44;17-19&#44;25&#93;&#41;&#46; La diferencia entre el EASI final de ambos grupos no fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;331&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Respecto a los EA&#44; 8 presentaron eritema &#40;en 4 leve y en los restantes&#44; moderado&#41; y uno&#44; una erupci&#243;n polimorfa lum&#237;nica&#46; Siete redujeron en un 50&#37; el EASI inicial &#40;EASI 50&#41;&#46; No fue necesario suspender el tratamiento por los EA&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La reducci&#243;n del EASI fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; con un porcentaje superior a lo previamente publicado<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Aunque se calcul&#243; el Skindex-29 solo en 12 pacientes&#44; la reducci&#243;n de las subescalas sintom&#225;tica y funcional estuvo por encima del 40&#37;&#44; que al igual que otros autores<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> creemos que fueron las subescalas m&#225;s influyentes en la actividad cotidiana&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Los pacientes m&#225;s graves fueron los que recibieron tratamientos combinados&#44; aunque esto no mejor&#243; significativamente su respuesta&#46; No encontramos otros estudios que avalen este resultado&#46; Tampoco los EA influyeron negativamente en la respuesta terap&#233;utica&#44; no encontrando referencias bibliogr&#225;ficas&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Nueve pacientes presentaron EA que no obligaron a interrumpir el tratamiento<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;8</span></a>&#46; No valoramos si el prurito asociado a la dermatitis at&#243;pica pudo condicionar la respuesta terap&#233;utica&#44; a diferencia de lo publicado en pacientes psori&#225;sicos<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">No encontramos que la DEM patol&#243;gica en 12 pacientes estuviese relacionada con medicaciones concomitantes ni influyese en un incremento en las reacciones adversas&#44; dada la modificaci&#243;n de protocolo realizada en base a ella<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Como limitaciones&#44; es un estudio retrospectivo y unic&#233;ntrico&#46; Uno de sus puntos fuertes fue el tama&#241;o muestral&#44; superior al de otros estudios&#46;</p></span>"
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                  \t\t\t\t">EASI final&nbsp;\t\t\t\t\t\t\n
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                            2 => "J&#46;A&#46; Pujol-Montcus&#237;"
                            3 => "A&#46; Mart&#237;n-Gorgojo"
                            4 => "M&#46; Campos-Dom&#237;nguez"
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Fototerapia ultravioleta B de banda estrecha en pacientes con dermatitis atópica: estudio en un hospital de tercer nivel: estudio retrospectivo y observacional
Narrowband UV-B Phototherapy in Patients With Atopic Dermatitis: A Retrospective Observational Study in a Tertiary Hospital
P. Pérez Feala,
Autor para correspondencia
patriciaperezfeal@gmail.com

Autor para correspondencia.
, A. Estany Gestalb, S. Rodríguez-Tubío Dapenaa, M.T. Rodríguez Granadosa
a Servicio de Dermatología, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España
b Unidad de Epidemiología, Fundación Instituto de Investigación de Santiago de Compostela (FIDIS), Santiago de Compostela, La Coruña, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La fototerapia es una de las principales opciones terap&#233;uticas en la dermatitis at&#243;pica &#40;DA&#41;&#44; siendo la radiaci&#243;n ultravioleta de banda estrecha &#40;UVBBE&#58; 311<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>nm&#41; una de las modalidades m&#225;s efectivas<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; Se describen los resultados de un estudio observacional retrospectivo&#44; realizado durante un periodo de un a&#241;o&#44; cuyo objetivo fue evaluar la efectividad de este tratamiento mediante escalas de gravedad y calidad de vida&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Se incluyeron los pacientes con da remitidos desde consultas de dermatolog&#237;a a la unidad de fototerapia para ser tratados con UVBBE&#46; El criterio de exclusi&#243;n&#44; adem&#225;s de los inherentes a la fototerapia&#44; fue la edad menor de 18 a&#241;os&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Se utiliz&#243; la cabina modelo UV-7002&#174; &#40;Waldmann&#44; Schwenningen&#44; Alemania&#41; con 21 tubos F79&#47;120W-TL01 &#40;311<span class="elsevierStyleHsp" style=""></span>nm&#41; y 21 de UVA&#46; Los pacientes entraron con gafas oscuras de protecci&#243;n ultravioleta y los varones con protecci&#243;n genital&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se recogieron variables sociodemogr&#225;ficas&#44; fototipo y dosis eritemat&#243;gena m&#237;nima &#40;DEM&#41; en J&#47;cm<span class="elsevierStyleSup">2</span> para el c&#225;lculo de la dosis inicial&#46; Se administr&#243; el tratamiento 3 d&#237;as a la semana con revisiones dermatol&#243;gicas semanales&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se recopilaron los tratamientos previos y asociados al ciclo de fototerapia&#44; as&#237; como las caracter&#237;sticas del tratamiento con UVBBE &#40;n&#250;mero de sesiones&#44; dosis de inicio&#44; final y total en J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Empleamos las escalas <span class="elsevierStyleItalic">Eczema Area and Severity Index</span> &#40;EASI&#41; y Skindex-29 para medir la gravedad de la enfermedad y calidad de vida de los pacientes&#44; respectivamente&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Los efectos adversos &#40;EA&#59; eritema y prurito&#41; se definieron como leve &#40;asintom&#225;tico&#41;&#44; moderado &#40;eritema y prurito transitorio &#60;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h&#41; y grave &#40;eritema y prurito &#62;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a>&#46; El prurito se midi&#243; al inicio y al final del tratamiento mediante una escala visual anal&#243;gica &#40;EVA&#41;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se determin&#243; el ajuste a la normalidad de las variables &#40;test de Kolmogorov-Smirnov&#41;&#46; Se realiz&#243; inferencia estad&#237;stica empleando el test de &#220; de Mann-Whitney&#44; Wilcoxon o ANOVA seg&#250;n correspondiese&#46; Se consideraron valores estad&#237;sticamente significativos aqu&#233;llos con p-valor inferior a 0&#44;05&#46; El programa empleado fue SPSS&#174; v&#46;25&#46;0&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Todos los aspectos siguieron la pr&#225;ctica cl&#237;nica habitual&#46; Los datos se recogieron de las historias de fototerapia y electr&#243;nicas&#46; Este estudio fue aprobado por el Comit&#233; de &#201;tica de Investigaci&#243;n de nuestra comunidad aut&#243;noma&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Se incluyeron 55 pacientes&#44; siendo 38 varones &#40;69&#37;&#41; con una mediana de edad de 34 a&#241;os &#40;23-47&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; El 60&#37; de los pacientes ten&#237;an un fototipo III&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">La DEM fue patol&#243;gica en 12 pacientes&#46; La mediana de n&#250;mero de sesiones fue de 29 &#40;21-38&#41;&#46; Las medianas de las dosis inicial&#44; final y total fueron&#58; 0&#44;25<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;0&#44;21-0&#44;35&#41;&#44; 1&#44;44<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;0&#44;86-1&#44;95&#41; y 25&#44;39<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;9&#44;52-39&#44;11&#41;&#44; respectivamente&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La diferencia entre el EASI inicial y final fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Se consigui&#243; un EASI 50 en 44 pacientes &#40;80&#37;&#41; y aclaramiento en 23&#46; No se determin&#243; el EASI final en 3 pacientes porque abandonaron la terapia por motivos personales&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">La diferencia entre Skindex-29 inicial y final&#44; calculado en 12 pacientes&#44; fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Ocho pacientes no respondieron al tratamiento&#58; 7 precisaron tratamiento inmunosupresor previo al ciclo de fototerapia &#40;5 corticoides orales&#59; uno azatioprina y uno ciclosporina&#41;&#46; Los tratados con azatioprina o ciclosporina respondieron significativamente peor &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En 47 pacientes la fototerapia se combin&#243; con corticoides orales &#40;12 pacientes&#41;&#44; t&#243;picos &#40;15 pacientes&#41; o UVA &#40;20 pacientes&#41;&#44; con una mediana de EASI inicial de 27&#44;10 &#40;22&#44;42-42&#44;50&#41;&#59; 18 &#40;7&#44;20-25&#41; y 16&#44;40 &#40;10&#44;20-23&#44;55&#41;&#44; respectivamente&#44; superior al del grupo tratado solo con fototerapia &#40;EASI inicial&#58; 12 &#91;7&#44;17-19&#44;25&#93;&#41;&#46; La diferencia entre el EASI final de ambos grupos no fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;331&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Respecto a los EA&#44; 8 presentaron eritema &#40;en 4 leve y en los restantes&#44; moderado&#41; y uno&#44; una erupci&#243;n polimorfa lum&#237;nica&#46; Siete redujeron en un 50&#37; el EASI inicial &#40;EASI 50&#41;&#46; No fue necesario suspender el tratamiento por los EA&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La reducci&#243;n del EASI fue estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; con un porcentaje superior a lo previamente publicado<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Aunque se calcul&#243; el Skindex-29 solo en 12 pacientes&#44; la reducci&#243;n de las subescalas sintom&#225;tica y funcional estuvo por encima del 40&#37;&#44; que al igual que otros autores<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> creemos que fueron las subescalas m&#225;s influyentes en la actividad cotidiana&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Los pacientes m&#225;s graves fueron los que recibieron tratamientos combinados&#44; aunque esto no mejor&#243; significativamente su respuesta&#46; No encontramos otros estudios que avalen este resultado&#46; Tampoco los EA influyeron negativamente en la respuesta terap&#233;utica&#44; no encontrando referencias bibliogr&#225;ficas&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Nueve pacientes presentaron EA que no obligaron a interrumpir el tratamiento<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;8</span></a>&#46; No valoramos si el prurito asociado a la dermatitis at&#243;pica pudo condicionar la respuesta terap&#233;utica&#44; a diferencia de lo publicado en pacientes psori&#225;sicos<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">No encontramos que la DEM patol&#243;gica en 12 pacientes estuviese relacionada con medicaciones concomitantes ni influyese en un incremento en las reacciones adversas&#44; dada la modificaci&#243;n de protocolo realizada en base a ella<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Como limitaciones&#44; es un estudio retrospectivo y unic&#233;ntrico&#46; Uno de sus puntos fuertes fue el tama&#241;o muestral&#44; superior al de otros estudios&#46;</p></span>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20&#44;83 &#40;3&#44;12-30&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
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ISSN: 00017310
Idioma original: Español
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