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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La radiaci&#243;n ultravioleta B &#40;UVB&#41; de banda estrecha&#44; conocida con el acr&#243;nimo UVBBE&#44; es una modalidad de fototerapia que surgi&#243; de la coincidencia entre el espectro de acci&#243;n de la radiaci&#243;n UV en la psoriasis<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> con el espectro de emisi&#243;n a 311 nan&#243;metros &#40;nm&#41;&#44; y con menor capacidad en la inducci&#243;n del eritema<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a>&#46; Desde entonces otras enfermedades cut&#225;neas se benefician de este tratamiento&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La UVBBE puede causar prurito&#44; pero es el eritema el efecto adverso m&#225;s frecuente<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a>&#46; Su intensidad modifica tanto los incrementos de las dosis como la supresi&#243;n del tratamiento si es sintom&#225;tico y persistente&#46; Es importante se&#241;alar que son las formas leves&#44; asintom&#225;ticas&#44; las m&#225;s prevalentes<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La dosis de inicio es determinada bien por el fototipo bien por el c&#225;lculo de la dosis eritemat&#243;gena m&#237;nima &#40;DEM&#41;&#46; La DEM nos informa de la sensibilidad cut&#225;nea a la radiaci&#243;n UV de una fuente de luz determinada<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;6</span></a> y se define como la dosis requerida &#40;J&#47;cm<span class="elsevierStyleSup">2</span>&#41; para conseguir un m&#237;nimo eritema perceptible en la zona del fototest&#44; siendo la lectura a las 24<span class="elsevierStyleHsp" style=""></span>horas&#46; Sin embargo&#44; el c&#225;lculo de la DEM no se determina en la mayor&#237;a de las unidades de fototerapia debido a que consume tiempo adem&#225;s del requerimiento de una enfermer&#237;a experta&#46; El fototipo no es un buen par&#225;metro para la determinaci&#243;n de la dosis inicial&#44; ya que un mismo fototipo tiene valores muy discrepantes de la DEM<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La fotosensibilidad cl&#237;nica es otro efecto adverso&#59; el diagn&#243;stico requiere una precisa historia cl&#237;nica&#44; exploraci&#243;n dermatol&#243;gica y el fototest&#44; que confirma la fotosensibilidad<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">8&#44;9</span></a>&#46; Si bien algunas fotodermatosis presentan un fototest normal&#44; en la fotosensibilidad sist&#233;mica relacionada con f&#225;rmacos siempre ser&#225; patol&#243;gico<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46; En un estudio prospectivo Cameron et al&#46; identifican 3 grupos de f&#225;rmacos que alteran la DEM&#58; antiinflamatorios no esteroideos&#44; fenotiazinas y antagonistas del calcio<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Recientemente el Grupo Espa&#241;ol de Fotobiolog&#237;a ha estandarizado la DEM normal correspondiente a los distintos fototipos&#44; y reconociendo los individuos con DEM disminuida<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Las gu&#237;as brit&#225;nicas<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a>&#44; espa&#241;olas<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> y francesas<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> aportan directrices acerca de los protocolos de tratamiento&#44; pero &#250;nicamente la gu&#237;a brit&#225;nica apoya encarecidamente el c&#225;lculo de la DEM antes de iniciar la fototerapia con la finalidad de detectar una fotosensibilidad no sospechada por el m&#233;dico ni referida por el paciente<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a> La elecci&#243;n &#40;DEM vs fototipo&#41; no va a influir en la efectividad terap&#233;utica en pacientes afectos de psoriasis<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a>&#44; aunque al tratarse de pacientes con comorbilidades sujetos a tratamientos cr&#243;nicos el umbral para el eritema puede disminuir<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">11&#44;16</span></a>&#46; La DEM identificar&#237;a una fotosensibilidad sist&#233;mica&#44; previniendo las reacciones adversas graves&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nuestro objetivo ante una DEM disminuida es determinar la influencia que diferentes variables puedan tener&#44; como la edad&#44; el sexo&#44; los f&#225;rmacos que toma&#44; el diagn&#243;stico y la asociaci&#243;n con acitretina en pacientes con psoriasis&#44; y evidenciar si la DEM patol&#243;gica podr&#237;a provocar m&#225;s reacciones adversas y m&#225;s graves&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todo</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Dise&#241;o del estudio</span><p id="par0040" class="elsevierStylePara elsevierViewall">Estudio observacional de una cohorte retrospectiva que ha sido revisado y aprobado por el Comit&#233; de &#201;tica en la Investigaci&#243;n &#40;CEI&#41; de Lugo y Santiago&#46; Las investigaciones se han realizado de acuerdo con los principios de la Declaraci&#243;n de Helsinki&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Poblaci&#243;n del estudio</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los participantes en el estudio han sido los pacientes remitidos desde las consultas de dermatolog&#237;a a la Unidad de Fototerapia del Complejo Hospitalario Universitario Cl&#237;nico de Santiago de Compostela durante el per&#237;odo comprendido entre el 1 de febrero de 2009 al 31 de marzo de 2015&#44; para iniciar fototerapia con UVB de banda estrecha&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Se incluyeron en el estudio pacientes con enfermedades cut&#225;neas beneficiarias de fototerapia&#58; psoriasis&#44; dermatitis at&#243;pica&#44; vit&#237;ligo&#44; parapsoriasis en placa&#44; linfoma cut&#225;neo primario de c&#233;lulas T&#44; pitiriasis liquenoide aguda y cr&#243;nica&#44; pr&#250;rigo&#44; prurito sin materia&#44; prurito metab&#243;lico&#44; urticaria pigmentosa&#44; liquen ruber plano&#44; granuloma anular diseminado&#44; erupci&#243;n lum&#237;nica polimorfa y urticaria solar&#46; Se excluyeron los individuos menores de 14 a&#241;os a los que no se realiz&#243; el c&#225;lculo de la DEM&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protocolo del fototest</span><p id="par0055" class="elsevierStylePara elsevierViewall">Para el c&#225;lculo de la DEM se utiliz&#243; la propia cabina&#59; es un modelo UV 7002 &#40;Waldmann&#44; Schwenningen&#44; Alemania&#41; equipada con 21 tubos F79&#47;120W-TL01 &#40;311<span class="elsevierStyleHsp" style=""></span>nm&#41;&#46; Ocho &#225;reas de 1&#44;5<span class="elsevierStyleHsp" style=""></span>cm en una zona no afecta de la espalda fueron irradiadas con dosis progresivas correspondientes a incrementos del 20&#37;&#44; un d&#237;a antes del inicio del tratamiento&#46; En los fototipos <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">ii</span> las dosis correspondientes eran&#58; 0&#44;24&#59; 0&#44;29&#59; 0&#44;35&#59; 0&#44;42&#59; 0&#44;50&#59; 0&#44;60&#59; 0&#44;72 y 0&#44;86<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#46; En los <span class="elsevierStyleSmallCaps">iii</span> y <span class="elsevierStyleSmallCaps">iv</span> se incrementaba la dosis a 1&#44;00 y 1&#44;20<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#46; Con el fin de obtener la irradiancia eritem&#225;tica de las l&#225;mparas TL01 se calcul&#243; con un espectrorradi&#243;metro doble monocromador &#40;MACAM- SR 2271&#44; MACAM&#44; Escocia&#41;&#44; tanto la irradiancia absoluta &#40;4&#44;73<span class="elsevierStyleHsp" style=""></span>mw&#47;cm<span class="elsevierStyleSup">2</span>&#41; como la irradiancia con potencial eritem&#225;tico &#40;0&#44;26<span class="elsevierStyleHsp" style=""></span>mw&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#44; valores medidos anualmente&#46; El cociente resultante es el factor de correcci&#243;n utilizado para transformar estas dosis absolutas irradiadas &#40;J&#47;cm<span class="elsevierStyleSup">2</span>&#41; en dosis eritem&#225;ticas &#40;mJ&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#58; 13&#44;19&#59; 15&#44;94&#59; 19&#44;24&#59; 23&#44;09&#59; 27&#44;49&#59; 32&#44;99&#59; 39&#44;58&#59; 47&#44;28&#59; 54&#44;98 y 65&#44;97<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span>&#44; respectivamente&#46; Estas dosis biol&#243;gicas efectivas para eritema se corresponden con las dosis de los simuladores solares&#44; pudiendo conocer la DEM patol&#243;gica con las l&#225;mparas TL01&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Variables</span><p id="par0060" class="elsevierStylePara elsevierViewall">Se registraron las variables sociodemogr&#225;ficas de los pacientes&#44; antecedentes m&#233;dicos&#44; diagn&#243;stico&#44; fototipo y el valor de la DEM&#46; Asimismo&#44; se registraron los f&#225;rmacos&#44; las dosis de inicio&#44; final y total del tratamiento &#40;J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#44; el n&#250;mero de sesiones y las reacciones adversas&#58; eritema leve &#40;asintom&#225;tico&#41;&#44; moderado &#40;eritema y prurito transitorio<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h&#41; y grave &#40;eritema y prurito<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h&#41; y prurito&#46; Todos los datos se extrajeron de las historias espec&#237;ficas de fototerapia y del sistema de historias cl&#237;nicas electr&#243;nicas de Galicia&#44; IANUS&#46; Se dise&#241;&#243; una base de datos espec&#237;ficamente para este estudio&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">La cohorte retrospectiva se dividi&#243; en 2 grupos en funci&#243;n de la categorizaci&#243;n de la DEM en patol&#243;gica o no patol&#243;gica&#46; El umbral de las dosis eritemat&#243;genas correspondientes a DEM patol&#243;gica est&#225; ya definido&#44; utilizando como fuente el simulador solar&#44; en el trabajo de P&#233;rez Ferriols et al&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">As&#237;&#44; para los individuos con fototipo <span class="elsevierStyleSmallCaps">i</span> valores de DEM inferiores a 0&#44;12<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> corresponde a una dosis eritem&#225;tica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span>&#59; en los fototipos <span class="elsevierStyleSmallCaps">ii</span> inferiores a 0&#44;34<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;dosis eritem&#225;tica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>19<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#59; en los fototipos <span class="elsevierStyleSmallCaps">iii</span> menor a 0&#44;49<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> equivale a una dosis eritem&#225;tica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span> y en los fototipos <span class="elsevierStyleSmallCaps">iv</span> inferiores a 0&#44;69<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;dosis eritem&#225;tica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>38<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Tama&#241;o de la muestra</span><p id="par0075" class="elsevierStylePara elsevierViewall">Desde una perspectiva cl&#237;nica se conoce que la prevalencia de individuos con una DEM patol&#243;gica es aproximadamente del 5&#37;&#46; Se asumi&#243; una significaci&#243;n del 5&#37;&#44; un poder estad&#237;stico del 80&#37;&#44; y un porcentaje del 4&#37; de registro de datos en la historia cl&#237;nica&#44; por lo que fue necesario incluir 302 individuos para conseguir una precisi&#243;n del 2&#44;50&#37;&#46; En el c&#225;lculo se emple&#243; el programa estad&#237;stico para c&#225;lculos muestrales ene3&#46;0<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a>&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">M&#233;todo estad&#237;stico</span><p id="par0080" class="elsevierStylePara elsevierViewall">Se realizaron test bivariantes para comparar ambos grupos&#46; Las variables categ&#243;ricas se contrastaron con el test de Chi cuadrado y las continuas con la &#171;t&#187; de Student o la U de Mann-Whitney en funci&#243;n del ajuste a la normalidad&#44; que se determin&#243; con el test de Kolmogorov-Smnirnov &#40;con la correcci&#243;n de Lilliefors&#41;&#46; La determinaci&#243;n del riesgo de padecer reacciones adversas se realiz&#243; mediante el c&#225;lculo de las <span class="elsevierStyleItalic">odds ratio</span> con su intervalo de confianza al 95&#37; &#40;OR&#44; IC 95&#37;&#41;&#46; La t&#233;cnica de la valoraci&#243;n del riesgo fue la regresi&#243;n log&#237;stica&#46; Aquellas variables cuyo valor de p fue inferior a 0&#44;2 se consideraron candidatas para el modelo de regresi&#243;n log&#237;stica multivariante&#46; Todos los an&#225;lisis se realizaron con el paquete estad&#237;stico SPSS v19<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a>&#46; Se consideraron valores estad&#237;sticamente significativos los valores de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Descripci&#243;n de los pacientes</span><p id="par0085" class="elsevierStylePara elsevierViewall">Se estudiaron un total de 302 pacientes&#46; El 54&#37; eran hombres y la mediana de edad fue de 49 a&#241;os &#40;rango intercuart&#237;lico&#58; 34-60&#41;&#46; El diagn&#243;stico m&#225;s frecuente fue psoriasis con 49&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>148&#41;&#44; 11&#44;9&#37; &#40;36&#41; ten&#237;a dermatitis at&#243;pica&#44; 6&#44;0&#37; &#40;18&#41; linfoma cut&#225;neo de c&#233;lulas T&#44; 3&#44;6&#37; &#40;11&#41; fotodermatosis&#44; 4&#44;0&#37; &#40;12&#41; pr&#250;rigo y otro 4&#44;0&#37; liquen plano&#46; El 21&#44;5&#37; &#40;65&#41; de los pacientes correspond&#237;a a otros diagn&#243;sticos&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">El 51&#44;7&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>156&#41; de los pacientes no consum&#237;a f&#225;rmacos concomitantes&#44; el 25&#44;5&#37; &#40;74&#41; consum&#237;a un f&#225;rmaco y el 23&#44;8&#37; &#40;72&#41; consum&#237;a 2 o m&#225;s&#46; El 69&#44;2&#37; &#40;101&#41; de los pacientes consum&#237;a f&#225;rmacos fotosensibilizantes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">An&#225;lisis bivariante</span><p id="par0095" class="elsevierStylePara elsevierViewall">La muestra se dividi&#243; en 2 grupos en funci&#243;n de si la DEM era normal o patol&#243;gica<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#46; El 79&#44;5&#37; de los pacientes present&#243; una DEM normal &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>240&#41; y el 20&#44;5&#37; una DEM patol&#243;gica &#40;62&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Se encontraron diferencias estad&#237;sticamente significativas entre los grupos&#44; en el sexo &#40;DEM normal 47&#44;9&#37; de hombres DEM patol&#243;gica 77&#44;4&#37; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y en la edad &#40;la mediana de edad fue de 47 a&#241;os &#40;33-58&#41; en pacientes con una DEM normal y de 56 &#91;35&#44;5-70&#93; en los que ten&#237;an una DEM patol&#243;gica &#91;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#93;&#41;&#46; Tambi&#233;n se encontr&#243; significaci&#243;n estad&#237;stica en la distribuci&#243;n de los diagn&#243;sticos entre ambos grupos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Sin embargo&#44; no se encontraron diferencias en el n&#250;mero de f&#225;rmacos consumidos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;071&#41;&#44; aunque fueran f&#225;rmacos fotosensibilizantes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;806&#41;&#44; ni en la asociaci&#243;n de la fototerapia con acitretina &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;196&#41;&#46; Ciento diecisiete pacientes &#40;38&#44;7&#37;&#41; tuvieron reacciones adversas &#40;eritema&#44; prurito&#44; erupci&#243;n lum&#237;nica polimorfa y urticaria solar&#41;&#46; El 45&#44;2&#37; ten&#237;a una DEM disminuida frente al 37&#44;1&#37; con DEM normal&#46; El eritema se present&#243; con una diferencia cl&#237;nica relevante en los pacientes con DEM patol&#243;gica &#40;35&#44;5&#37;&#41; con respecto a los que ten&#237;an la DEM normal &#40;25&#44;4&#37;&#41;&#46; Sin embargo&#44; con el prurito no hay esa relevancia cl&#237;nica&#44; ya que los pacientes con DEM normal lo refirieron en un 17&#44;9&#37;&#44; frente al 21&#37; de los pacientes con DEM disminuida&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se pueden observar estos an&#225;lisis de forma m&#225;s pormenorizada&#46; En relaci&#243;n con los fototipos se evidencia que en los fototipos <span class="elsevierStyleSmallCaps">iv</span> el porcentaje de pacientes con DEM patol&#243;gica &#40;30&#44;6&#37;&#41; es superior a los que tienen una DEM normal &#40;14&#44;6&#37;&#41;&#44; con una p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;013&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">An&#225;lisis multivariante</span><p id="par0105" class="elsevierStylePara elsevierViewall">Para construir los modelos multivariantes y valorar el efecto de las reacciones adversas se seleccionaron como variables de ajuste aquellas que&#44; por un lado&#44; resultasen relevantes cl&#237;nicamente para la DEM y que&#44; por otro&#44; tuvieran un valor de p inferior a 0&#44;20 en el an&#225;lisis bivariante&#46; Cumplieron estas condiciones las variables sexo&#44; edad&#44; diagn&#243;stico y fototipo&#46; Como se puede observar en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> el modelo 1 estudia el riesgo de reacciones adversas en pacientes con la DEM patol&#243;gica respecto a los que tiene la DEM normal&#46; Los modelos 2 y 3&#44; por su parte&#44; analizan de forma individualizada los efectos adversos m&#225;s frecuentes&#58; eritema y prurito&#46; No se ha hallado que los pacientes con DEM patol&#243;gica tengan un riesgo mayor que los que tienen una DEM normal &#40;modelo 1&#41;&#46; Al pormenorizar por el tipo de reacci&#243;n adversa&#44; tampoco se obtuvo un riesgo significativo&#46; El riesgo de eritema en los pacientes con DEM patol&#243;gica fue OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;68 &#40;IC 95&#37;&#58; 0&#44;91-3&#44;29&#41; &#40;modelo 2&#41; y el riesgo de prurito fue de OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44;04 &#40;IC 95&#37;&#58; 0&#44;99-4&#44;22&#41; &#40;modelo 3&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Al realizar estos an&#225;lisis nos hemos encontrado con un hallazgo inesperado respecto al diagn&#243;stico&#46; El an&#225;lisis bivariante revel&#243; que la psoriasis podr&#237;a ser un factor protector de la DEM &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;31 &#91;IC 95&#37;&#58; 0&#44;17-0&#44;58&#93;&#41; y esta significaci&#243;n se mantuvo al plantear el an&#225;lisis multivariante ajustado por edad&#44; sexo y fototipo &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;31 &#91;IC 95&#37;&#58; 0&#44;16-0&#44;58&#41;&#93;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Estudio de la dosis y de la estacionalidad</span><p id="par0115" class="elsevierStylePara elsevierViewall">Se compararon los valores medios de la dosis en cada grupo y se obtuvo que la dosis inicial&#44; final y total ten&#237;a diferencias estad&#237;sticamente significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004 y p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; respectivamente&#41;&#46; Sin embargo&#44; el incremento de la dosis y el n&#250;mero de sesiones no resultaron significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;304&#41;&#46; Estos resultados se pueden apreciar en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; Finalmente se estudi&#243; si la distribuci&#243;n de la DEM era diferente en funci&#243;n de la estaci&#243;n del a&#241;o en que se determin&#243;&#44; pero no se encontraron diferencias significativas a este respecto&#46; Estos resultados se pueden observar en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discusi&#243;n</span><p id="par0120" class="elsevierStylePara elsevierViewall">En este estudio se ha puesto de manifiesto la idoneidad de determinar la DEM en las dermatosis susceptibles de ser tratadas con UVBBE&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Por un lado&#44; es aceptado que la UVBBE es una modalidad efectiva&#44; con reacciones adversas frecuentes como el eritema y el prurito&#46; Por otro&#44; se han descrito otros efectos adversos menos frecuentes&#59; as&#237;&#44; se ha publicado una fotosensibilidad observada durante la fototerapia&#58; un paciente al que no se le determin&#243; la DEM y que present&#243; una reacci&#243;n eccematosa&#44; siendo diagnosticado de una dermatitis act&#237;nica cr&#243;nica&#46; Otro estudio posterior en el que una paciente tambi&#233;n afecta de psoriasis fue diagnosticada de una dermatitis act&#237;nica cr&#243;nica al presentar una DEM patol&#243;gica&#59; el diagn&#243;stico fue corroborado con el estudio fotobiol&#243;gico<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">19&#44;20</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Otra reacci&#243;n adversa observada durante la fototerapia es la fotosensibilidad por f&#225;rmacos&#44; que en un estudio retrospectivo se present&#243; en un 10&#44;3&#37;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a>&#46; En otro estudio prospectivo se observ&#243; que los pacientes en tratamiento con antiinflamatorios no esteroideos&#44; antagonistas del calcio y fenotiazinas presentaban una DEM significativamente disminuida<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46; Sin embargo&#44; en nuestro trabajo ni el n&#250;mero ni la cualidad fotosensibilizante de los f&#225;rmacos concomitantes influyeron en el valor de la DEM&#46; Tan solo 2 de nuestros pacientes con DEM disminuida fueron diagnosticados de fotosensibilidad sist&#233;mica por f&#225;rmacos&#44; y 5 pacientes presentaron reacciones agudas eritematosas sospechosas de una fotosensibilidad por f&#225;rmacos no confirmada<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Dos pacientes que estaban siendo tratados con acitretina asociada a UVBBE presentaron una DEM patol&#243;gica&#59; uno en tratamiento con tamsulosina y otro con IECA&#44; metformina y estatina&#46; Consideramos que la DEM disminuida se relacion&#243; m&#225;s bien con estos f&#225;rmacos y no con el retinoide&#46; Hay estudios que confirmaron un mecanismo de fototoxicidad por etretinato<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a>&#44; pero no con respecto a la acitretina&#46; La recomendaci&#243;n de reducir la dosis en estos pacientes no es debido a la disminuci&#243;n de la DEM&#44; sino a un posible mecanismo de acci&#243;n que la acitretina tiene sobre la acantosis epid&#233;rmica<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">En nuestro estudio los pacientes de mayor edad y varones tuvieron una DEM disminuida&#46; Ya se han publicado resultados similares con respecto a la edad&#44; pero sin repercusi&#243;n cl&#237;nica&#44; si bien se evidenciaba un eritema m&#225;s persistente&#46; No hemos encontrado resultados similares con respecto al sexo y a la influencia que pudiera tener en el resultado de la DEM<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">24&#8211;26</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La distribuci&#243;n de los fototipos fue diferente en los individuos con DEM normal o patol&#243;gica&#46; Es un resultado dif&#237;cil de interpretar&#44; ya que otros estudios observaron que el fototipo no estaba relacionado con la DEM&#44; si bien los fototipos altos presentaron valores mayores de DEM<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">27&#44;28</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">En nuestro estudio la DEM disminuida no influy&#243;&#44; a diferencia de un estudio previo&#44; en el n&#250;mero de sesiones<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">La dosis inicial de los pacientes que recibieron fototerapia se determin&#243; en funci&#243;n de su DEM&#46; S&#237; hemos observado que fue significativamente m&#225;s baja en los pacientes con DEM patol&#243;gica&#44; y consecuentemente pudo evitar un mayor riesgo de sufrir reacciones adversas&#44; puesto que este riesgo es de naturaleza dosis dependiente<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46; Adem&#225;s de la dosis inicial&#44; pudimos comprobar que tanto la dosis final como la dosis total acumulada era significativamente menor en los individuos con DEM patol&#243;gica&#46; Y de hecho&#44; si no hemos tenido un riesgo mayor de reacciones adversas en este grupo de pacientes fue debido a iniciar la fototerapia a dosis m&#225;s bajas&#46; Por lo tanto&#44; de acuerdo con otros autores&#44; creemos que el ajuste de la dosis inicial en funci&#243;n de la DEM es un m&#233;todo &#250;til para reducir las reacciones adversas<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a>&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Con respecto al eritema y prurito&#44; aunque se presentaron m&#225;s frecuentemente en los pacientes con DEM disminuida&#44; el riesgo calculado no fue significativamente mayor&#46; Adem&#225;s&#44; el incremento de la dosis no mostr&#243; diferencias entre los individuos con DEM normal y patol&#243;gica&#44; cuando cabr&#237;a esperar que si el eritema o el prurito hubieran sido m&#225;s frecuentes en los individuos con DEM patol&#243;gica el incremento de la dosis hubiera sido menor&#46; Ser&#237;a otro motivo que justificar&#237;a la determinaci&#243;n de la DEM con la finalidad de prevenir las reacciones adversas inherentes a la fototerapia<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Finalmente&#44; hemos observado el efecto protector que los pacientes con psoriasis tienen sobre el resultado del fototest&#59; son pacientes que tienen menor riesgo a tener una DEM disminuida&#44; resultados no confirmados en estudios previos<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; Este hallazgo podr&#237;a justificar la decisi&#243;n de determinar la DEM en este grupo de pacientes&#44; con el fin de iniciar el tratamiento a una dosis m&#225;s elevada que la que le corresponder&#237;a por fototipo&#44; reduciendo as&#237; el n&#250;mero de tratamientos sin p&#233;rdida de efectividad terap&#233;utica&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Responsabilidades &#233;ticas</span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Protecci&#243;n de personas y animales</span><p id="par0170" class="elsevierStylePara elsevierViewall">Los autores declaran que para esta investigaci&#243;n no se han realizado experimentos en seres humanos ni en animales&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Confidencialidad de los datos</span><p id="par0175" class="elsevierStylePara elsevierViewall">Los autores declaran que han seguido los protocolos de su centro de trabajo sobre la publicaci&#243;n de datos de pacientes&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Derecho a la privacidad y consentimiento informado</span><p id="par0180" class="elsevierStylePara elsevierViewall">Los autores declaran que en este art&#237;culo no aparecen datos de pacientes&#46;</p></span></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Conflicto de intereses</span><p id="par0185" class="elsevierStylePara elsevierViewall">Todos los autores declaran no tener conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introducci&#243;n y objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La dosis de inicio en la fototerapia UVB de banda estrecha &#40;UVBBE&#41; viene determinada por el fototipo o por la determinaci&#243;n de la dosis eritemat&#243;gena m&#237;nima &#40;DEM&#41;&#46; El c&#225;lculo de la DEM identifica pacientes con fotosensibilidad no sospechada&#46; El objetivo de nuestro estudio es conocer la influencia que puedan tener en una DEM disminuida los f&#225;rmacos fotosensibilizantes concomitantes&#44; el diagn&#243;stico&#44; la asociaci&#243;n con acitretina en pacientes con psoriasis y evidenciar si la DEM alterada provoca m&#225;s reacciones adversas y m&#225;s graves&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio observacional de una cohorte retrospectiva desde el per&#237;odo comprendido entre el 1 de febrero de 2009 al 31 de marzo de 2015&#46; La determinaci&#243;n de la DEM se categoriz&#243; en DEM normal o patol&#243;gica&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Trescientos dos pacientes con distintas dermatosis inician UVBBE en funci&#243;n de la DEM&#46; No se han encontrado diferencias entre el grupo con DEM patol&#243;gica respecto al normal&#44; ni en el n&#250;mero de f&#225;rmacos consumidos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;071&#41;&#44; ni en el potencial fotosensibilizante &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;806&#41;&#46; El an&#225;lisis multivariante ajustado por edad&#44; sexo y fototipo revel&#243; que la psoriasis es un factor protector de DEM patol&#243;gica &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;31 &#91;IC 95&#37;&#58; 0&#44;16-0&#44;58&#93;&#41;&#46; No se encontr&#243; riesgo significativo de eritema ni prurito en los pacientes con DEM alterada OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;68 &#40;IC 95&#37;&#58; 0&#44;91-3&#44;29&#41; y OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44;04 &#40;IC 95&#37;&#58; 0&#44;99-4&#44;22&#41;&#44; respectivamente&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La psoriasis protege de tener una DEM patol&#243;gica&#46; Si bien el eritema y el prurito fueron m&#225;s frecuentes en los pacientes con DEM patol&#243;gica&#44; las diferencias no fueron estad&#237;sticamente significativas&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction and objectives</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The starting dose for narrowband UV-B phototherapy is determined by a patient&#39;s skin phototype or minimal erythema dose &#40;MED&#41;&#46; Calculation of MED identifies patients with unsuspected photosensitivity&#46; The aim of this study was to investigate the influence of factors such as concomitant use of photosensitizing agents&#44; diagnosis&#44; and combination with acitretin in patients with psoriasis on the frequency and severity of adverse effects in patients with a low MED to narrowband UV-B phototherapy&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We undertook a retrospective observational cohort study between February 1&#44; 2009 and March 31&#44; 2015&#46; MED values were classified as normal or low&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 302 patients with different skin conditions started narrowband UV-B phototherapy at a dose determined by their MED&#46; No differences were found between patients with a low MED and those with a normal MED for number of drugs taken &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;071&#41; or use of photosensitizing agents &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;806&#41;&#46; Following adjustment for age&#44; sex&#44; and phototype&#44; the multivariate analysis showed that psoriasis exerted a protective effect against a low MED &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;31 &#91;95&#37; <span class="elsevierStyleSmallCaps">CI</span>&#44; 0&#46;16-0&#46;58&#93;&#41;&#46; No significant risk of erythema or pruritus was detected in patients with a low MED &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;68&#59; 95&#37; CI&#44; 0&#46;91-3&#46;29 and OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#46;04&#59; 95&#37; CI&#44; 0&#46;99-4&#46;22&#44; respectively&#41;&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Psoriasis protects against a low MED&#46; Although erythema and pruritus were more common in patients with a low MED&#44; the differences were not significant&#46;</p></span>"
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            "identificador" => "abst0030"
            "titulo" => "Introduction and objectives"
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            "titulo" => "Material and methods"
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          2 => array:2 [
            "identificador" => "abst0040"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Variaci&#243;n de la DEM seg&#250;n las estaciones del a&#241;o&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Muestra global n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>302<br>n&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DEM normal n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>240 &#40;79&#44;5&#37;&#41;<br>n&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DEM patol&#243;gica n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>62 &#40;20&#44;5&#37;&#41;<br>n&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p valor<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sexo</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">&#40;hombres&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">163&#44; 54&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">115&#44; 47&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#44; 77&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Edad</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">&#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#44;00 &#40;33&#44;75&#8211;60&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#44;00 &#40;33&#44;00-58&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;35&#44;50&#8211;70&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Antecedentes m&#233;dicos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">205&#44; 67&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">157&#44; 65&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#44; 77&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diagn&#243;stico</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dermatitis at&#243;pica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44; 11&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44; 11&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44; 12&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">148&#44; 49&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">131&#44; 54&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44; 27&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Linfoma cut&#225;neo c&#233;l&#44; T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44; 6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44; 5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44; 8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fotodermatosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44; 3&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44; 3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44; 4&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pr&#250;rigo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44; 4&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44; 4&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44; 3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Liquen plano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44; 4&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44; 4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44; 1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#44; 21&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44; 16&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44; 41&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fototipo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>I-II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&#44; 36&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91&#44; 37&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44; 30&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">138&#44; 45&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">114&#44; 47&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44; 38&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#44; 17&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#44; 14&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44; 30&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Comorbilidades</span><a class="elsevierStyleCrossRefs" href="#tblfn0010"><span class="elsevierStyleSup">a&#44;c</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>HTA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#44; 21&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&#44; 19&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44; 29&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44; 6&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44; 6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44; 8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;609&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hiperlipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&#44; 23&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#44; 22&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44; 29&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;250&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>S&#237;ndrome ansioso-depresivo&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#44; 10&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44; 11&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44; 8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;468&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Artritis psori&#225;sica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44; 11&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44; 10&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44; 16&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;173&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Enfermedad tiroidea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44; 6&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44; 5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44; 11&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Asma o rinitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#44; 18&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44; 17&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44; 21&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;528&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">N&#44;&#176; de f&#225;rmacos</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No consume f&#225;rmacos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">156&#44; 51&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">131&#44; 54&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44; 40&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Consume 1 f&#225;rmaco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44; 25&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&#44; 24&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&#44; 25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Consume 2 o m&#225;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#44; 23&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#44; 21&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44; 33&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">F&#225;rmacos fotosensibilizantes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101&#44; 69&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#44; 69&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44; 67&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Acitretina</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44; 7&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44; 7&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44; 3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Efectos adversos</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117&#44; 38&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&#44; 37&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44; 45&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Tipo de efectos adversos</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&#44; <a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Eritema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83&#44; 27&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44; 25&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#44; 35&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Prurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44; 20&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#44; 17&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44; 21&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ELP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44; 8&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44; 8&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44; 8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>US&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44; 0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44; 0&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Se consideran valores estad&#237;sticamente significativos&#44; aquellos con un valor de p<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#60;</span><span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p>"
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              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Las variables categ&#243;ricas se describen con frecuencia y porcentaje&#46;</p>"
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              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Las variables continuas no normales se describen con la mediana y el rango intercuart&#237;lico&#46;</p>"
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            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Un paciente puede haber desarrollado m&#225;s de un evento&#46;</p>"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de los pacientes</p>"
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          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Modelos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">aOR &#40;IC 95&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p <a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Modelo 1 efectos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;40 &#40;0&#44;79-2&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;73 &#40;0&#44;91-3&#44;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;094&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Modelo 2 eritema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;61 &#40;0&#44;89-2&#44;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;115&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;68 &#40;0&#44;91-3&#44;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Modelo 3 prurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;87 &#40;0&#44;99-3&#44;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;04 &#40;0&#44;99-4&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "notaPie" => array:2 [
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              "identificador" => "tblfn0025"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Se considerar&#225;n valores estad&#237;sticamente significativos aquellos cuyo p valor sea<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05</p>"
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            1 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">aOR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>OR ajustado por sexo&#44; edad&#44; diagn&#243;stico y fototipo&#46;</p>"
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          ]
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        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Riesgo de reacciones adversas</p>"
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        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
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            "identificador" => "at3"
            "detalle" => "Tabla "
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        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>302&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;42 &#40;0&#44;35-0&#44;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;13 &#40;1&#44;49-2&#44;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;65 &#40;0&#44;54-2&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#44;004</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#44;23 &#40;20&#44;20&#8211;48&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#44;39 &#40;22&#44;70-48&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#44;95 &#40;6&#44;85-46&#44;03&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;56 &#40;1&#44;13-1&#44;82&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">N&#46;&#176; de sesiones</span><a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;21-32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;21-32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;19&#44;5-35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;884&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A new development in UVB phototherapy of psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; van Weelden"
                            1 => "H&#46;B&#46; de La Faille"
                            2 => "E&#46; Young"
                            3 => "J&#46;C&#46; van der Leun"
                          ]
                        ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1988"
                        "volumen" => "119"
                        "paginaInicial" => "11"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3408653"
                            "web" => "Medline"
                          ]
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                      ]
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              "identificador" => "bib0165"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of psoriasis with trioxsalen baths and dysprosium lamps"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Fischer"
                            1 => "J&#46; Alsins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1976"
                        "volumen" => "56"
                        "paginaInicial" => "383"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/78625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0170"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An update and guidance on narrowband ultraviolet B phototherapy&#58; A British Photodermatology Group Workshop Report"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "British Association of Dermatologists"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Ibbotson"
                            1 => "D&#46; Bilsland"
                            2 => "N&#46;H&#46; Cox"
                            3 => "R&#46;S&#46; Dawe"
                            4 => "B&#46; Diffey"
                            5 => "C&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2004.06128.x"
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                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2004"
                        "volumen" => "151"
                        "paginaInicial" => "283"
                        "paginaFinal" => "297"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15327535"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0175"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Audit of erythema in patients with psoriasis undergoing phototherapy with narrowband &#40;TL-01&#41; ultraviolet B&#58; Impact of the introduction of a comprehensive erythema-reporting protocol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Batchelor"
                            1 => "R&#46;F&#46; Rose"
                            2 => "A&#46; Yung"
                            3 => "B&#46; Rathmell"
                            4 => "D&#46; Turner"
                            5 => "V&#46; Goulden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.07775.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "156"
                        "paginaInicial" => "1045"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17313490"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population reference intervals for minimal erythemal doses in monochromator phototesting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Moseley"
                            1 => "H&#46; Naasan"
                            2 => "R&#46;S&#46; Dawe"
                            3 => "J&#46; Woods"
                            4 => "J&#46; Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0781.2009.00391.x"
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                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "8"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19152510"
                            "web" => "Medline"
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              "identificador" => "bib0185"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An intraindividual study of the characteristics of erythema induced by bath and oral methoxsalen photochemotherapy and narrowband ultraviolet B"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "J&#46; Ferguson"
                            3 => "S&#46;H&#46; Ibbotson"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Photochem Photobiol"
                        "fecha" => "2003"
                        "volumen" => "78"
                        "paginaInicial" => "55"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12929749"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phototesting prior to narrowband &#40;TL-01&#41; ultraviolet B phototherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "P&#46;J&#46; Saunders"
                            2 => "B&#46;L&#46; Diffey"
                            3 => "P&#46;M&#46; Farr"
                          ]
                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1998"
                        "volumen" => "139"
                        "paginaInicial" => "811"
                        "paginaFinal" => "814"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9892946"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
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              "etiqueta" => "8"
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                    0 => array:2 [
                      "titulo" => "Study of idiopathic&#44; exogenous photodermatoses&#44; part II&#58; Photobiologic testing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "J&#46; Sanchez"
                            3 => "A&#46; Garcia-Diez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.07.040"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "233"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24661955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            8 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "How should we diagnose and manage photosensitivity&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Ibbotson"
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                    0 => array:2 [
                      "doi" => "10.4997/JRCPE.2014.413"
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                        "tituloSerie" => "J R Coll Physicians Edinb"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "paginaInicial" => "308"
                        "paginaFinal" => "312"
                        "link" => array:1 [
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                          ]
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                    ]
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                ]
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              "identificador" => "bib0205"
              "etiqueta" => "10"
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                      "titulo" => "Normal minimal erythema dose responses in patients with suspected photosensitivity disorders"
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                          "autores" => array:4 [
                            0 => "S&#46;K&#46; Que"
                            1 => "J&#46;A&#46; Brauer"
                            2 => "N&#46;A&#46; Soter"
                            3 => "D&#46;E&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/phpp.12005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2012"
                        "volumen" => "28"
                        "paginaInicial" => "320"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23126294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0210"
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                    0 => array:2 [
                      "titulo" => "Photosensitizing drugs may lower the narrow-band ultraviolet B &#40;TL-01&#41; minimal erythema dose"
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                          "autores" => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2000"
                        "volumen" => "142"
                        "paginaInicial" => "389"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10730791"
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                    ]
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                ]
              ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determination of minimal erythema dose and anomalous reactions to UVA radiation by skin phototype"
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                          "etal" => true
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                      "doi" => "10.1016/j.ad.2014.05.001"
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                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "780"
                        "paginaFinal" => "788"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24996228"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consensus document on phototherapy&#58; PUVA therapy and narrow-band UVB therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Carrascosa"
                            1 => "J&#46; Gardeazabal"
                            2 => "A&#46; Perez-Ferriols"
                            3 => "A&#46; Alomar"
                            4 => "P&#46; Manrique"
                            5 => "M&#46; Jones-Caballero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "635"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Narrow-band UVB therapy in psoriasis vulgaris&#58; good practice guideline and recommendations of the French Society of Photodermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;C&#46; Beani"
                            1 => "M&#46; Jeanmougin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.annder.2009.12.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2010"
                        "volumen" => "137"
                        "paginaInicial" => "21"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20110064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of psoralen UV-A therapy vs&#46; narrowband UV-B therapy in chronic plaque psoriasis&#58; a systematic literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Archier"
                            1 => "S&#46; Devaux"
                            2 => "E&#46; Castela"
                            3 => "A&#46; Gallini"
                            4 => "F&#46; Aubin"
                            5 => "M&#46; Le Maitre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2012.04519.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2012"
                        "volumen" => "26"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "11"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22512676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodermatoses with onset in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Trakatelli"
                            1 => "S&#46; Charalampidis"
                            2 => "L&#46;B&#46; Novakovic"
                            3 => "A&#46; Patsatsi"
                            4 => "D&#46; Kalabalikis"
                            5 => "D&#46; Sotiriadis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09452.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "69"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19775360"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ene3&#46;0 &#40;2008&#41;&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;L&#46; Badiella-Busquets"
                            1 => "A&#46; Pedromingo-Marino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2008"
                        "editorial" => "GlaxoSmithKline SA"
                        "editorialLocalizacion" => "Barcelona&#44; Espa&#241;a"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Released 2010&#46; IBM SPSS Statistics for Windows&#44; Version 19&#46;0"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "IBM Corp"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2010"
                        "editorial" => "IBM Corp"
                        "editorialLocalizacion" => "Armonk&#44; NY"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic actinic dermatitis developing during narrowband UVB phototherapy for psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Asawanonda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2004"
                        "volumen" => "20"
                        "paginaInicial" => "66"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14738538"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic actinic dermatitis recognized on minimal erythema dose testing prior to narrow-band UVB treatment for psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;S&#46; Dawe"
                            1 => "G&#46; Arseculeratne"
                            2 => "J&#46; Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0781.2005.00140.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2005"
                        "volumen" => "21"
                        "paginaInicial" => "112"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15752132"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence des accidents par photosensibilisation m&#233;dicamenteuse au cours des phototh&#233;rapies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Vuillamie"
                            1 => "J&#46;J&#46; Parienti"
                            2 => "A&#46; Dompmartin"
                            3 => "D&#46; Leroy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2006"
                        "volumen" => "133"
                        "paginaInicial" => "333"
                        "paginaFinal" => "339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16733447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photosensitivity due to retinoids&#58; Clinical and laboratory studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Ferguson"
                            1 => "B&#46;E&#46; Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1986"
                        "volumen" => "115"
                        "paginaInicial" => "275"
                        "paginaFinal" => "283"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3530309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Narrowband UV-B&#44; monochromatic excimer laser&#44; and photodynamic therapy in psoriasis&#58; A consensus statement of the Spanish Psoriasis Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Carrascosa"
                            1 => "J&#46;L&#46; Lopez-Estebaranz"
                            2 => "G&#46; Carretero"
                            3 => "E&#46; Dauden"
                            4 => "C&#46; Ferrandiz"
                            5 => "D&#46; Vidal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2010.11.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "175"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21310368"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0275"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between chronological age and the erythemal response to ultraviolet B radiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;H&#46; Cox"
                            1 => "B&#46;L&#46; Diffey"
                            2 => "P&#46;M&#46; Farr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1992"
                        "volumen" => "126"
                        "paginaInicial" => "315"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1571251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age dependence of ultraviolet light-induced erythema following narrow-band UVB exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Gloor"
                            1 => "A&#46; Scherotzke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2002"
                        "volumen" => "18"
                        "paginaInicial" => "121"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12207674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0285"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reference limits for erythema-effective UV doses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Gambichler"
                            1 => "G&#46; Moussa"
                            2 => "N&#46;S&#46; Tomi"
                            3 => "V&#46; Paech"
                            4 => "P&#46; Altmeyer"
                            5 => "A&#46; Kreuter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1562/2006-02-06-RA-796"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photochem Photobiol"
                        "fecha" => "2006"
                        "volumen" => "82"
                        "paginaInicial" => "1097"
                        "paginaFinal" => "1102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16563026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0290"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Narrowband ultraviolet B phototherapy starting and incremental dose in patients with psoriasis&#58; Comparison of percentage dose and fixed dose protocols"
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                          "etal" => false
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                      ]
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                        "tituloSerie" => "Photodermatol Photoimmunol Photomed"
                        "fecha" => "2015"
                        "volumen" => "31"
                        "paginaInicial" => "90"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25377788"
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              "etiqueta" => "28"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of the usefulness of skin phototype and skin color as the parameter of cutaneous narrow band UVB sensitivity in psoriasis patients"
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                        0 => array:2 [
                          "etal" => false
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                            4 => "Y&#46;B&#46; Choe"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "261"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14535897"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0300"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Itch and scratching as predictors of time to clearance of psoriasis with narrow-band ultraviolet B therapy"
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                        ]
                      ]
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                      "doi" => "10.1111/j.1365-2133.2009.09236.x"
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                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "542"
                        "paginaFinal" => "546"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19538185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Narrowband ultraviolet B therapy in psoriasis&#58; Randomized double-blind comparison of high-dose and low-dose irradiation regimens"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09212.x"
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                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "1351"
                        "paginaFinal" => "1356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19466961"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized comparison of methods of selecting narrowband UV-B starting dose to treat chronic psoriasis"
                      "autores" => array:1 [
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