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Laboratory data showed leukocytes within the normal range &#40;8100<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">&#8722;3</span> with 32&#37; neutrophils&#41;&#44; normal liver and renal function&#44; elevated immunoglobulin &#40;Ig&#41; G &#40;2172<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; and positive titers of antinuclear antibody &#40;1&#58;1280&#41;&#44; anti SS-A antibody &#40;37&#46;0<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#59; normal&#44; &#60;7&#46;0<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#41;&#44; and anticentromere antibody &#40;index of 34&#46;4&#59; normal&#44; &#60;10&#41;&#46; Serum complement levels and antibodies against SS-B&#44; ds-DNA&#44; and Sm were all within normal limits&#46; A second biopsy taken from a lesion on the dorsum of the nose showed parakeratosis&#44; follicular plugging&#44; liquefaction of the basal layer&#44; and focal cellular infiltration in the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; There was eosinophilic material in the upper dermis&#44; which was positive with Congo red and Dylon staining &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41; and anticytokeratin antibody 34&#946;E12 staining &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; The direct immunofluorescence study revealed IgM deposits at the dermal-epidermal junction&#44; but no amyloid deposits were observed in another DLE specimen taken from the back of the ear&#46; A detailed eye exam revealed decreased lacrimation&#44; but saliva production measured by the Saxon test was normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Few papers have reported on secondary amyloid deposition in DLE&#44; but it has been suggested that this phenomenon might be underreported&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Powell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> reported 3 cases of DLE on the head and neck with amyloid deposition&#46; They also retrospectively examined 18 cases of DLE&#44; and detected amyloid deposition in 1 case&#46; In a Japanese series&#44; Khan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> detected amyloid deposition in all 4 cases of hypertrophic DLE analyzed but in just 1 of 12 cases of nonhypertrophic DLE&#46; They speculated that cutaneous amyloid material might have been deposited secondary to abnormalities in the basement membrane zone following repeated sunlight exposure for long periods&#46; Our case was not hypertrophic-type DLE&#44; but amyloid deposition was detected on the nose&#44; which had an evident keratotic appearance&#46; The fact that amyloid deposits were not detected in the DLE lesion on the back of the ear suggests that UV radiation may play a role in inducing basement membrane impairment&#44; resulting in secondary amyloid deposition&#46; The amyloid material also stained positively for 34&#946;E12&#44; suggesting that the origin of the amyloid was degenerating epidermal keratinocytes&#44; which may be precursors of cutaneous amyloid&#46; The presence of lamina densa-like substances or disturbed keratinization in the basal layers might also be involved in amyloid production&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Our patient also developed Sj&#246;gren syndrome&#44; although she did not show any symptoms of dry mouth&#46; Because systemic sclerosis was ruled out&#44; the presence of serum anticentromere antibody was considered to be associated with Sj&#246;gren syndrome&#44; although coexistence of this condition with DLE is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Anticentromere antibody has been detected in 10&#37; of Japanese patients with primary Sj&#246;gren syndrome<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#59; these patients had lower mononuclear cell infiltration in the minor salivary glands&#44; possibly explaining the lower frequency of dry mouth in this subgroup of patients&#46; This hallmark symptom of Sj&#246;gren syndrome was also absent in our patient&#46; In conclusion&#44; there have been few reports on secondary amyloid deposition in DLE&#44; but there may be more cases&#44; especially in hyperkeratotic lesions in sun-exposed areas&#46;</p></span>"
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Case and Research Letter
Secondary Amyloid Deposition in Discoid Lupus Erythematosus
Depósitos de amiloide secundarios a lupus eritematoso discoide
Y. Hanami, T. Yamamoto
Autor para correspondencia
toyamade@fmu.ac.jp

Corresponding author.
Department of Dermatology, Fukushima Medical University, Fukushima, Japan
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Secondary amyloid deposition is occasionally associated with skin tumors and inflammatory skin disorders&#44; but it is rarely seen in discoid lupus erythematosus &#40;DLE&#41;&#46; We describe a case of secondary amyloid deposition in the lesional skin of DLE&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 47-year-old woman presented with keratotic erythema on the nose 3 years ago&#46; The erythema had been present for 1 year and the histological features were compatible with DLE&#46; Three years later&#44; she revisited our hospital because the scaly erythematous patches had gradually increased in number&#46; Physical examination revealed several reddish&#44; well-circumscribed plaques with slightly elevated borders on the forehead&#44; nose&#44; cheeks&#44; lip&#44; and ear &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Laboratory data showed leukocytes within the normal range &#40;8100<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">&#8722;3</span> with 32&#37; neutrophils&#41;&#44; normal liver and renal function&#44; elevated immunoglobulin &#40;Ig&#41; G &#40;2172<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; and positive titers of antinuclear antibody &#40;1&#58;1280&#41;&#44; anti SS-A antibody &#40;37&#46;0<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#59; normal&#44; &#60;7&#46;0<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#41;&#44; and anticentromere antibody &#40;index of 34&#46;4&#59; normal&#44; &#60;10&#41;&#46; Serum complement levels and antibodies against SS-B&#44; ds-DNA&#44; and Sm were all within normal limits&#46; A second biopsy taken from a lesion on the dorsum of the nose showed parakeratosis&#44; follicular plugging&#44; liquefaction of the basal layer&#44; and focal cellular infiltration in the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; There was eosinophilic material in the upper dermis&#44; which was positive with Congo red and Dylon staining &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41; and anticytokeratin antibody 34&#946;E12 staining &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; The direct immunofluorescence study revealed IgM deposits at the dermal-epidermal junction&#44; but no amyloid deposits were observed in another DLE specimen taken from the back of the ear&#46; A detailed eye exam revealed decreased lacrimation&#44; but saliva production measured by the Saxon test was normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Few papers have reported on secondary amyloid deposition in DLE&#44; but it has been suggested that this phenomenon might be underreported&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Powell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> reported 3 cases of DLE on the head and neck with amyloid deposition&#46; They also retrospectively examined 18 cases of DLE&#44; and detected amyloid deposition in 1 case&#46; In a Japanese series&#44; Khan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> detected amyloid deposition in all 4 cases of hypertrophic DLE analyzed but in just 1 of 12 cases of nonhypertrophic DLE&#46; They speculated that cutaneous amyloid material might have been deposited secondary to abnormalities in the basement membrane zone following repeated sunlight exposure for long periods&#46; Our case was not hypertrophic-type DLE&#44; but amyloid deposition was detected on the nose&#44; which had an evident keratotic appearance&#46; The fact that amyloid deposits were not detected in the DLE lesion on the back of the ear suggests that UV radiation may play a role in inducing basement membrane impairment&#44; resulting in secondary amyloid deposition&#46; The amyloid material also stained positively for 34&#946;E12&#44; suggesting that the origin of the amyloid was degenerating epidermal keratinocytes&#44; which may be precursors of cutaneous amyloid&#46; The presence of lamina densa-like substances or disturbed keratinization in the basal layers might also be involved in amyloid production&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Our patient also developed Sj&#246;gren syndrome&#44; although she did not show any symptoms of dry mouth&#46; Because systemic sclerosis was ruled out&#44; the presence of serum anticentromere antibody was considered to be associated with Sj&#246;gren syndrome&#44; although coexistence of this condition with DLE is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Anticentromere antibody has been detected in 10&#37; of Japanese patients with primary Sj&#246;gren syndrome<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#59; these patients had lower mononuclear cell infiltration in the minor salivary glands&#44; possibly explaining the lower frequency of dry mouth in this subgroup of patients&#46; This hallmark symptom of Sj&#246;gren syndrome was also absent in our patient&#46; In conclusion&#44; there have been few reports on secondary amyloid deposition in DLE&#44; but there may be more cases&#44; especially in hyperkeratotic lesions in sun-exposed areas&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Multiple keratotic plaques scattered on the face&#46; &#40;B&#41; Biopsy showed parakeratosis with focal hyperkeratosis&#44; follicular plugging&#44; liquefaction changes to the basal layers of the epidermis&#44; and cellular infiltrates in the upper dermis &#40;hematoxylin&#8211;eosin stain&#44; original magnification 100&#215;&#41;&#46; &#40;C&#41; Dylon staining revealed amyloid deposition in the upper dermis &#40;original magnification 200&#215;&#41;&#46; &#40;D&#41; The upper dermis was also positive for keratin &#40;original magnification 200&#215;&#41;&#46;</p>"
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