Original Article
Does the treatment ladder for systemic therapy in moderate to severe psoriasis only go up? The percentage of patients with severe psoriasis on biologics increases over time
Escalera terapéutica en la psoriasis moderada y grave ¿ Sólo hacia arriba?: El porcentaje de pacientes con psoriasis grave tratados con biológicos se incrementa con el tiempo
J.M. Carrascosaa,
, N. Riveraa, I. Garcia-Dovalb, G. Carreteroc, F. Vanaclochad, E. Daudéne, F.J. Gómez-Garcíaf, P. De-la-Cueva-Dobaog, E. Herrera-Ceballosh, I. Belinchóni, M. Alsinaj, J.L. Sánchez-Carazok, M. Ferránl, J.L. Lopez-Estebaranzm, B. Pérez-Zafrillab,n, M. Llamase, R. Riverad, C. Ferrándiza, the BIOBADADERM Study Group
Autor para correspondencia
a Hospital Universitari Germans Trías i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain
b Research Unit, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain
c Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain
d Hospital Universitario 12 de Octubre, Madrid, Spain
e Hospital Universitario la Princesa, Madrid, Spain
f Hospital Universitario Reina Sofía, Córdoba, Spain
g Hospital Infanta Leonor, Madrid, Spain
h Hospital Universitario Virgen de la Victoria, Málaga, Spain
i Hospital General Universitario de Alicante, Alicante, Spain
j Hospital Clínic de Barcelona, Barcelona, Spain
k Hospital General Universitario de Valencia, Valencia, Spain
l Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
m Hospital Universitario Fundación de Alcorcón, Madrid, Spain
n Hospital Universitario de Albacete, Albacete, Spain
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"apellidos" => "Sánchez-Carazo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff0055" ] ] ] 12 => array:3 [ "nombre" => "M." "apellidos" => "Ferrán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">l</span>" "identificador" => "aff0060" ] ] ] 13 => array:3 [ "nombre" => "J.L." "apellidos" => "Lopez-Estebaranz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">m</span>" "identificador" => "aff0065" ] ] ] 14 => array:3 [ "nombre" => "B." "apellidos" => "Pérez-Zafrilla" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">n</span>" "identificador" => "aff0070" ] ] ] 15 => array:3 [ "nombre" => "M." 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"apellidos" => "Ferrándiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 18 => array:1 [ "colaborador" => "the BIOBADADERM Study Group" ] ] "afiliaciones" => array:14 [ 0 => array:3 [ "entidad" => "Hospital Universitari Germans Trías i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Research Unit, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Hospital Universitario la Princesa, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital Universitario Reina Sofía, Córdoba, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Hospital Infanta Leonor, Madrid, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Hospital Universitario Virgen de la Victoria, Málaga, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Hospital Clínic de Barcelona, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] 10 => array:3 [ "entidad" => "Hospital General Universitario de Valencia, Valencia, Spain" "etiqueta" => "k" "identificador" => "aff0055" ] 11 => array:3 [ "entidad" => "Hospital del Mar, Parc de Salut Mar, Barcelona, Spain" "etiqueta" => "l" "identificador" => "aff0060" ] 12 => array:3 [ "entidad" => "Hospital Universitario Fundación de Alcorcón, Madrid, Spain" "etiqueta" => "m" "identificador" => "aff0065" ] 13 => array:3 [ "entidad" => "Hospital Universitario de Albacete, Albacete, Spain" "etiqueta" => "n" "identificador" => "aff0070" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Escalera terapéutica en la psoriasis moderada y grave ¿ Sólo hacia arriba?: El porcentaje de pacientes con psoriasis grave tratados con biológicos se incrementa con el tiempo" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The introduction of biologic therapy has changed the management of moderate to severe psoriasis, with these agents now representing the highest rung of the therapeutic ladder that starts with topical treatments and phototherapy.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> However, we do not know whether, in clinical practice, this therapeutic progression is always unidirectional and progressive or whether biologic therapy will eventually become just another option in the rotational strategies used, with patients switching back and forth between biologic therapy and classic treatments. The answer to this question is important because of its relevance to safety (in terms of cumulative exposure), efficacy (which may be affected by immunogenicity induced by intermittent use), and cost of treatment.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report on the switch from classic to biologic drugs and vice versa during the specified follow-up period in a cohort of patients with psoriasis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">BIOBADADERM is a prospective cohort of patients with moderate to severe psoriasis receiving systemic therapy. Patients from 12 Spanish hospitals have been enrolled in the cohort since 2008. The present study is based on data from patients enrolled before the end of October 2013. A more detailed description of 632 patients from this cohort has been published elsewhere.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Patients are included when they are first prescribed any specific conventional or biologic systemic treatment, and they are followed up continuously thereafter. Participating centers undertake to include all patients starting biologic treatment for the first time who meet the inclusion criteria. A control receiving nonbiologic systemic therapy is enrolled for each patient added to the biologic group. These criteria should produce an initial population in which 50% of patients are starting biologic therapy and 50% classic systemic therapy. The present study describes the evolution of treatment in this population, focusing on switches between classic and biologic therapy. The data for each patient refer to the follow-up period from the time of entry into the cohort until October 2013. The data were processed as follows: year 1 refers to the data from the first year of follow-up for all the patients in the cohort, year 2 refers to the second year of follow-up, and so on. To describe the changes, we have used the data in the registry on the first day of each 365-day period following each patient's inclusion in the cohort.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0020" class="elsevierStylePara elsevierViewall">The proportion of patients receiving biologic and nonbiologic treatment varies over time. In total, 47.3% of the patients (926/1956) were prescribed a classic systemic treatment and 52.7% (1030/1956) a biologic agent on entry into the study. Of the 741 patients who accumulated 5 years of follow-up, 21.9% (155) were receiving nonbiologic drugs and 78.1% (553) were on biologic therapy on the first day of their 5th year of follow-up (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">As the length of follow-up increased, so did the likelihood that a patient's therapy would be modified (from classic to biologic therapy or vice versa). However, more patients switched from a classic systemic agent to a biologic drug than the reverse. Per year of follow-up, the percentage of patients who switched from classic to biologic therapy ranged from 14.4% to 59.3%, while that of patients switching from a biologic agent to a classic systemic treatment ranged from 6.9% to 10% (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0030" class="elsevierStylePara elsevierViewall">The number of different treatments per patient was similar in both groups (classic and biologic therapy) and increased progressively with the length of follow-up (with a mean of 2.0 for classic and 2.3 for biologic therapy).</p><p id="par0035" class="elsevierStylePara elsevierViewall">For the first year of accumulated follow-up, the mean Psoriasis Area and Severity Index (PASI) score at start of treatment was higher in the patients on biologics (mean 15.7 vs. 9.9), and no significant change was observed in this tendency during follow-up.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The most common cause for switching cited in the database was inefficacy or loss of response, followed by adverse events and clinical remission. However, the percentage of patients switching from conventional to biologic therapy due to inefficacy or loss of efficacy was higher than the number switching from a biologic therapy to a classic systemic drug. By contrast, clinical remission was more frequently cited as a reason for switching in patients who were in the biologic cohort at recruitment. The percentage of patients who switched treatments because of adverse events was similar in both groups (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In a subset of the initial cohort of patients, all systemic treatment (nonbiologic and biologic) was discontinued. The percentage of patients who discontinued systemic therapy decreased over time, from 15.4% among patients in their second year of follow-up to 4.5% between the fourth and fifth years of treatment.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">In the BIOBADADERM cohort, patients with moderate to severe psoriasis on systemic treatment with classic or biologic drugs were frequently switched from one treatment to another. We observed that the proportion of patients receiving biologic therapy increased with longer follow-up, whereas the percentage of patients on classic treatment decreased over time. As the severity of psoriasis can vary over time in any given patient, this finding may indicate a tendency among dermatologists to prescribe biologic drugs to patients who have been receiving treatment for some time with a conventional therapy and present an exacerbation. After switching, the patient is more likely to remain in the biologic group. The reasons for this finding were not investigated in this study, but possible causes include the organ-specific toxicity associated with prolonged use of certain conventional systemic drugs, relapses, and the prospects of a better outcome with biologic agents in patients whose response to conventional treatment is inadequate.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The number of different treatments prescribed to each patient during follow-up increased over time similarly in both groups – conventional and biologic therapy – with each group having a median of two changes by the beginning of the 4th year of follow-up. This finding may indicate that all the patients who enter the cohort are likely to be switched from one treatment to another, irrespective of the initial treatment, and that the likelihood of a switch increases the longer the patient is followed up.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The reasons recorded in the BIOBADADERM registry for discontinuing therapy or switching are predefined. However, the actual decisions are taken in routine clinical practice at each center and do not necessarily coincide with the predefined criteria or with those applied in other centers. It is interesting to note, however, that inefficacy or loss of efficacy was the most common reason for switching in all cases, although this cause was cited more frequently in patients switching from conventional to biologic therapy than vice versa. This finding suggests that efficacy remains an important limitation, even with biologic therapy. Overall, adverse events were the second most frequent cause cited, but in the subgroup of patients switching from biologic to conventional therapy the second most frequent cause was remission. It can, therefore, be speculated that the strategy of rotating therapies for various reasons (i.e., therapeutic holidays, cost-effectiveness, etc.) continues to be used in some scenarios, even in the biologic era.</p><p id="par0065" class="elsevierStylePara elsevierViewall">An analysis of changes in therapy motivated by a variety of reasons in a cohort of patients with moderate to severe psoriasis monitored over a considerable period reveals a progressive increase in the proportion of patients on biologic therapy, a finding that may reflect the fact that these patients quite quickly move beyond the initial steps of the therapeutic ladder (treatment with classic systemic drugs) to biologic therapy – the latest addition to the therapeutic arsenal for the treatment of psoriasis. In any case, our findings suggest that a significant proportion of patients with moderate to severe psoriasis will eventually be treated with biologics, an eventuality that should be taken into account when estimating the overall cost of treating psoriasis. In the rotational strategies used before the advent of biologic agents, the main motive for switching treatments was to reduce the risk of adverse effects due to cumulative toxicity.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> However, in the case of biologic therapy, as seen in our series, patients may more often be switched because of lack of efficacy (primary treatment failure) or loss of efficacy (secondary failure) given the good safety profile and limited specific organ toxicity associated with these drugs.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,7</span></a> In some studies of patients with moderate to severe psoriasis, survival of treatment with biologic agents has been shown to be relatively short. For instance, an earlier study based on data from the Biobadaderm registry found the average survival of biologic therapy to be 1.5 years.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Other authors, including Esposito,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Clemmensen,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> and Gniadecki,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> have observed a progressive loss over time in the number of patients treated with each biologic drug. Thus, the promise of long standing continuous therapy with the same drug appears to be unrealistic even in the biologic era.</p><p id="par0070" class="elsevierStylePara elsevierViewall">It is of interest to note that a percentage of patients (between 4.5% and 15.7%) discontinued all systemic therapy. Although withdrawal might be temporary, this finding contradicts the idea that all patients should be on treatment all the time. In practice, periods without treatment occur for a number of reasons (remission, concomitant conditions, etc.).</p><p id="par0075" class="elsevierStylePara elsevierViewall">The present study has certain limitations. Although the population studied was large and representative of routine clinical practice, the results reflect the specific situation and prescribing habits of the environment in which the patients were recruited. However, given that the conditions and restrictions regulating prescription are stipulated by the European Medicines Agency, it is probable that the results are applicable within the European context. Ultimately, the assessment over time of the treatment received by patients with moderate to severe psoriasis suggests that a growing percentage of these patients receive biologic therapy at some point. This finding may have implications not only in terms of safety – cumulative exposure – but also with respect to the impact of the use of these more expensive treatments on the economic burden associated with the management of psoriasis.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding sources</span><p id="par0080" class="elsevierStylePara elsevierViewall">The BIOBADADERM project is financed by the <span class="elsevierStyleGrantSponsor" id="gs1"><span class="elsevierStyleItalic">Fundación Academia Española de Dermatología y Venereología</span></span> (FAEDV), which receives support from the <span class="elsevierStyleGrantSponsor" id="gs2">Spanish Medicines and Health Products Agency</span> (AEMPS) and from pharmaceutical companies (<span class="elsevierStyleGrantSponsor" id="gs3">Abbott</span>, <span class="elsevierStyleGrantSponsor" id="gs4">PfizerMSD</span> and <span class="elsevierStyleGrantSponsor" id="gs5">Janssen</span>). <span class="elsevierStyleBold">Role of the Sponsors:</span> The FAEDV provided administrative support and the AEMPS reviewed the study protocol. Apart from these contributions, none of the sponsors participated in the design or conduct of the study, in the collection, analysis, or interpretation of data, or in the preparation, review, or approval of the manuscript.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical responsibilities</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protection of human and animal subjects</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Confidentiality of data</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Right to privacy and informed consent</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors must have obtained the informed consent of the patients and/or subjects mentioned in the article. The author for correspondence must be in possession of this document.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">Dr Carrascosa served as a consultant and participated in speakers’ bureaus for Abbvie Laboratories, Janssen Pharmaceuticals Inc., MSD, Pfizer-Wyeth, Lilly, Novartis and Celgene. Dr Carretero served as a consultant for Abbott Laboratories, Janssen-Cilag Pty Limited, MSD, and Pfizer Inc.; gave expert testimony for Abbott Laboratories, MSD, and Pfizer Inc.; received grants from Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer Inc. and equipment from MSD and Pfizer Inc. Dr Vanaclocha participated in speakers’ bureaus for Abbott Laboratories, Pfizer Inc., MSD, and Janssen Pharmaceuticals Inc. Dr Daudén served as a consultant for Abbott Laboratories, Amgen, Astellas, Celgene, Centocor Ortho Biotech Inc., Galderma, Glaxo, Jannsenn-Cilag, Leo Pharma, MSD, Novartis, and Pfizer Inc.; received honoraria from Abbott Laboratories, Amgen, Celgene, Janssen-Cilag Pty Ltd, Leo Pharma, MSD, Novartis, and Pfizer Inc.; participated in speakers’ bureaus for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer Inc.; and received grants from Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer Inc. Dr Gómez-García declares no conflicts of interest. Dr Herrera-Ceballos served as a consultant and participated in speakers’ bureaus for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyett. Dr De la Cueva acted as a consultant for Janssen-Cilag, Abbott, MSD, Pfizer, Leo-Pharma and Novartis. Dr Belinchón acted as a consultant for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyeth. Dr Sánchez-Carazo acted as a consultant for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyeth. Dr Alsina gave expert testimony for Abbott Laboratories and Merck/Schering-Plough. Dr López-Estebaranz served as a consultant for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyeth; and participated in speakers’ bureaus for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyeth. Dr Ferrán acted as a consultant for Abbott Laboratories, Janssen Pharmaceuticals Inc., MSD, and Pfizer-Wyeth; participated in speakers’ bureaus for Janssen Pharmaceuticals Inc. and MSD; and received grants from Serono. Dr Ferrandiz served as a consultant for Abbott Laboratories, Janssen Pharmaceuticals Inc., and Almirall SA; received honoraria from Abbott Laboratories, Almirall SA, Janssen Pharmaceuticals Inc., and Pfizer Inc.; participated in a speaker's bureau for Abbott Laboratories, Almirall SA, and Janssen Pharmaceuticals Inc.; and received grants from Abbott Laboratories.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres563323" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec579845" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres563324" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec579846" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding sources" ] 9 => array:3 [ "identificador" => "sec0030" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of interest" ] 11 => array:2 [ "identificador" => "xack189996" "titulo" => "Acknowledgments" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-02-19" "fechaAceptado" => "2015-04-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec579845" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biologic" 2 => "Therapy" 3 => "Systemic" 4 => "Conventional" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec579846" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biológico" 2 => "Tratamiento" 3 => "Sistémico" 4 => "Convencional" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">With the advent of biologic drugs in the management of moderate to severe psoriasis, there may have been a shift in therapeutic approach from rotational strategies to a unidirectional progression from topical treatments to the highest rung of the therapeutic ladder. We studied the frequency of switching from classic to biologic therapy and vice versa in a cohort of patients with psoriasis over a period of up to 5 years.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients are included in the BIOBADADERM prospective registry when they are first prescribed any specific conventional or biologic systemic treatment. The data for each patient refer to the follow-up period from the time they entered the cohort until October 2013. To describe the pattern of switches from classic to biologic therapy and vice versa, we used the data in the registry on the first day of every 365-day period following the date each patient was included in the cohort.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In total, 47.3% of the patients (926/1956) were prescribed a classic systemic drug and 52.7% (1030/1956) a biologic agent on entry into the study. Of the 741 patients who accumulated 5 years of follow-up, 21.9% (155) were receiving nonbiologic drugs and 78.1% (553) were on biologic therapy on the first day of their 5th year of follow-up.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The proportion of patients receiving biologic therapy increased with longer follow-up.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Con el advenimiento de fármacos biológicos en el manejo de la psoriasis moderada a grave, es probable que haya habido un cambio en la actitud terapéutica desde estrategias de rotación a una progresión unidireccional desde tratamientos tópicos al escalón más alta de la escalera terapéutica. Evaluamos la frecuencia del cambio desde el tratamiento clásico al biológico y vice-versa en una cohorte de pacientes con psoriasis durante un periodo de hasta 5 años.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron incluidos en el registro prospectivo de Biobadaderm cuando se les fueron prescritos por primera vez cualquier tratamiento convencional o biológico sistémico. Los datos para cada paciente se refieren al período de seguimiento desde la hora de su inclusión en la cohorte hasta octubre de 2013. Para describir el patrón de cambio desde el tratamiento clásico al biológico y vice-versa, utilizamos los datos en el registro en el primer día de cada periodo de 365 días después de la fecha de inclusión de cada paciente en la cohorte.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En total, 47,3% de los pacientes (926/1956) fueren prescritos un medicamento sistémico clásico y 52,7% (1030/1956) un biológico al entrar en el estudio. De los 741 pacientes que acabaron 5 años de seguimiento, 21,9% (155) recibieron medicamentos no biológicos y 78,1% (553) recibieron tratamiento biológico en el primera día del quinto año de seguimiento.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La proporción de pacientes recibiendo tratamiento biológico aumento con el seguimiento más prolongado.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col">Treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up period</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year 1 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year 2 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year 3 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year 4 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year 5 \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Patients in each group on the first day of the period, <span class="elsevierStyleItalic">n</span> (% of all patients in treatment) (% of patients in the registry)</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Classic systemic agents</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">926 (47.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">494 (36.8%) (31%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">329 (29.2%) (25.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">241 (25.6%) (23.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">155 (21.9%) (20.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Biologic drugs</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1030 (52.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">848 (63.2%) (53.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">797 (70.8%) (62.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">701 (74.4%) (68.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">553 (78.1%) (74.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Not receiving treatment</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">245(15.%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">146 (11.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">82 (8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (4.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Total</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1956 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1587 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1272 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1024 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">741 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">No. of switches during the period</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>From biologic drug to classic systemic agent (% of all patients who started the period with a biologic agent and switched to nonbiologic therapy during the year) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71 (6.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">83 (9.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80 (10.0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 (9.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47 (8.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>From classic systemic agent to biologic drug (% of all patients who started the period with a nonbiologic agent and switched to biologic therapy during the year) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133 (14.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">205 (41.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">180 (54.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">143 (59.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">89 (57.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">No. of treatments per patient since entry into study</span>,<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">mean (SD), median (95% CI)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Patients who started with biologic therapy</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0</td><td class="td" title="table-entry " align="char" valign="top">1.4 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.9 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.1 (1.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.3 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">1 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1–4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1–4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Patients who started with classic systemic agents</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0</td><td class="td" title="table-entry " align="char" valign="top">1.3 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.6 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.9 (1.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.0 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">1 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1–4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1–5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">PASI score upon starting the treatment patients were receiving on the first day of the period</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Biologic agents(ANOVA, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.44, linear trend test, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.7 (9.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.7 (9.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.0 (9.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.0 (9.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.0(10.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Controls(ANOVA, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.63, linear trend test, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.9 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.2(6.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.9 (6.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.6 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.3 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>All patients treated(ANOVA, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.44, linear trend test, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.94) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.4 (9.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.8 (9.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.6 (9.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.7 (9.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.9 (9.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab913346.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">No data is available on reasons for switching prior to the patient's enrolment in BIOBADADERM.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The proportion of patients receiving biologic and nonbiologic treatment over time.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reason for switching \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biologic to conventional \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Conventional to biologic \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Inefficacy or loss of efficacy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68 (35.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">169 (56%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">237 (48%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Adverse event \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (17.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">63 (21%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">96 (19.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Pregnancy or intention to become pregnant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (1.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (1.42%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Loss of patient \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Remission \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37 (19.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (5.63%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 (11%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 (15.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">96 (19.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">192 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">302 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">494 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab913345.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">No data is available on reasons for switching prior to the patient's enrolment in BIOBADADERM.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Reasons for switching therapy in both cohorts.<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a></p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de consenso sobre la evaluación y el tratamiento de la psoriasis moderada/grave del Grupo Español de Psoriasis de la Academia Española de Dermatología y Venereología" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. 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BIOBADADERM Study Group Members: Cristina Carazo, José Bañuls, Juan Francisco Silvestre, Pilar Albares, Isabel Betlloch, Monserrat Hernández, Diana Ruiz-Genao, Almudena Nuño, Patricia Guillem, Begoña Echeverría, Esther Margarit, Carlos Muñoz-Santos, Sara Pedregosa, Lara Ferrándiz, and Beatriz Pérez Zafrilla.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015002240/v1_201510020746/en/main.assets" "Apartado" => array:4 [ "identificador" => "14153" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010600000008/v1_201510020746/S0001731015002240/v1_201510020746/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002240?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 13 | 18 |
| 2024 Octubre | 47 | 44 | 91 |
| 2024 Septiembre | 71 | 28 | 99 |
| 2024 Agosto | 98 | 53 | 151 |
| 2024 Julio | 56 | 40 | 96 |
| 2024 Junio | 77 | 52 | 129 |
| 2024 Mayo | 50 | 31 | 81 |
| 2024 Abril | 53 | 61 | 114 |
| 2024 Marzo | 47 | 44 | 91 |
| 2024 Febrero | 41 | 30 | 71 |
| 2024 Enero | 33 | 33 | 66 |
| 2023 Diciembre | 45 | 36 | 81 |
| 2023 Noviembre | 45 | 48 | 93 |
| 2023 Octubre | 40 | 40 | 80 |
| 2023 Septiembre | 46 | 49 | 95 |
| 2023 Agosto | 25 | 23 | 48 |
| 2023 Julio | 48 | 67 | 115 |
| 2023 Junio | 52 | 46 | 98 |
| 2023 Mayo | 47 | 31 | 78 |
| 2023 Abril | 36 | 23 | 59 |
| 2023 Marzo | 53 | 24 | 77 |
| 2023 Febrero | 45 | 29 | 74 |
| 2023 Enero | 30 | 42 | 72 |
| 2022 Diciembre | 60 | 41 | 101 |
| 2022 Noviembre | 51 | 46 | 97 |
| 2022 Octubre | 84 | 38 | 122 |
| 2022 Septiembre | 41 | 55 | 96 |
| 2022 Agosto | 48 | 50 | 98 |
| 2022 Julio | 40 | 53 | 93 |
| 2022 Junio | 34 | 35 | 69 |
| 2022 Mayo | 37 | 38 | 75 |
| 2022 Abril | 43 | 52 | 95 |
| 2022 Marzo | 52 | 59 | 111 |
| 2022 Febrero | 35 | 43 | 78 |
| 2022 Enero | 53 | 58 | 111 |
| 2021 Diciembre | 39 | 50 | 89 |
| 2021 Noviembre | 41 | 61 | 102 |
| 2021 Octubre | 51 | 75 | 126 |
| 2021 Septiembre | 28 | 32 | 60 |
| 2021 Agosto | 31 | 40 | 71 |
| 2021 Julio | 31 | 42 | 73 |
| 2021 Junio | 52 | 30 | 82 |
| 2021 Mayo | 43 | 34 | 77 |
| 2021 Abril | 48 | 72 | 120 |
| 2021 Marzo | 82 | 36 | 118 |
| 2021 Febrero | 95 | 35 | 130 |
| 2021 Enero | 58 | 21 | 79 |
| 2020 Diciembre | 41 | 19 | 60 |
| 2020 Noviembre | 31 | 36 | 67 |
| 2020 Octubre | 40 | 20 | 60 |
| 2020 Septiembre | 56 | 26 | 82 |
| 2020 Agosto | 42 | 25 | 67 |
| 2020 Julio | 41 | 18 | 59 |
| 2020 Junio | 53 | 48 | 101 |
| 2020 Mayo | 50 | 17 | 67 |
| 2020 Abril | 59 | 29 | 88 |
| 2020 Marzo | 27 | 27 | 54 |
| 2020 Febrero | 4 | 7 | 11 |
| 2020 Enero | 4 | 9 | 13 |
| 2019 Diciembre | 10 | 6 | 16 |
| 2019 Noviembre | 4 | 8 | 12 |
| 2019 Octubre | 2 | 5 | 7 |
| 2019 Septiembre | 10 | 1 | 11 |
| 2019 Agosto | 4 | 5 | 9 |
| 2019 Julio | 4 | 8 | 12 |
| 2019 Junio | 4 | 8 | 12 |
| 2019 Mayo | 8 | 37 | 45 |
| 2019 Abril | 2 | 7 | 9 |
| 2019 Marzo | 3 | 5 | 8 |
| 2019 Febrero | 6 | 5 | 11 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 2 | 6 | 8 |
| 2018 Noviembre | 3 | 2 | 5 |
| 2018 Octubre | 2 | 1 | 3 |
| 2018 Septiembre | 4 | 3 | 7 |
| 2018 Agosto | 0 | 1 | 1 |
| 2018 Mayo | 0 | 5 | 5 |
| 2018 Abril | 0 | 6 | 6 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 16 | 4 | 20 |
| 2018 Enero | 24 | 6 | 30 |
| 2017 Diciembre | 23 | 6 | 29 |
| 2017 Noviembre | 19 | 10 | 29 |
| 2017 Octubre | 25 | 6 | 31 |
| 2017 Septiembre | 20 | 10 | 30 |
| 2017 Agosto | 11 | 7 | 18 |
| 2017 Julio | 10 | 1 | 11 |
| 2017 Junio | 12 | 17 | 29 |
| 2017 Mayo | 12 | 10 | 22 |
| 2017 Abril | 12 | 14 | 26 |
| 2017 Marzo | 5 | 11 | 16 |
| 2017 Febrero | 6 | 12 | 18 |
| 2017 Enero | 8 | 10 | 18 |
| 2016 Diciembre | 14 | 22 | 36 |
| 2016 Noviembre | 13 | 28 | 41 |
| 2016 Octubre | 13 | 26 | 39 |
| 2016 Septiembre | 1 | 0 | 1 |
| 2016 Agosto | 1 | 1 | 2 |
| 2016 Julio | 7 | 3 | 10 |
| 2016 Junio | 14 | 6 | 20 |
| 2016 Mayo | 9 | 4 | 13 |
| 2016 Abril | 4 | 9 | 13 |
| 2016 Marzo | 0 | 8 | 8 |
| 2016 Febrero | 0 | 11 | 11 |
| 2015 Diciembre | 0 | 12 | 12 |
| 2015 Noviembre | 0 | 19 | 19 |
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