array:24 [
  "pii" => "S0001731012005571"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2012.10.020"
  "estado" => "S300"
  "fechaPublicacion" => "2013-10-01"
  "aid" => "782"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:731-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4873
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 4454
      "PDF" => 380
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1578219013001893"
      "issn" => "15782190"
      "doi" => "10.1016/j.adengl.2012.10.013"
      "estado" => "S300"
      "fechaPublicacion" => "2013-10-01"
      "aid" => "782"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:731-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1149
        "formatos" => array:3 [
          "EPUB" => 41
          "HTML" => 651
          "PDF" => 457
        ]
      ]
      "en" => array:8 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
        "titulo" => "Acquired Epidermodysplasia Verruciformis in a Patient With Congenital HIV Infection"
        "tienePdf" => "en"
        "tieneTextoCompleto" => 0
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "731"
            "paginaFinal" => "733"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Epidermodisplasia verruciforme adquirido en un paciente con infecci&#243;n cong&#233;nita por VIH"
          ]
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0001731012005571"
          "doi" => "10.1016/j.ad.2012.10.020"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012005571?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001893?idApp=UINPBA000044"
      "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001893/v1_201309240048/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S000173101300152X"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "835"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:734"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1544
      "formatos" => array:3 [
        "EPUB" => 2
        "HTML" => 1219
        "PDF" => 323
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
      "titulo" => "R&#233;plica a&#58; &#171;Lipodistrofia generalizada adquirida de inicio tard&#237;o y con afectaci&#243;n muscular&#187;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "734"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Response to Comments on &#171;Late-Onset Acquired Generalized Lipodystrophy With Muscle Involvement&#187;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Llamas-Velasco, E&#46; Daud&#233;n, G&#46; Mart&#237;nez-Pe&#241;as, A&#46; Garc&#237;a-Diez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Llamas-Velasco"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Daud&#233;n"
            ]
            2 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Mart&#237;nez-Pe&#241;as"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Garc&#237;a-Diez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S157821901300187X"
        "doi" => "10.1016/j.adengl.2013.02.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901300187X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300152X?idApp=UINPBA000044"
    "url" => "/00017310/0000010400000008/v1_201309240051/S000173101300152X/v1_201309240051/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731012004590"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2012.08.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "742"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:729-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3903
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 2702
        "PDF" => 1200
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Hoyuelos cut&#225;neos como consecuencia de amniocentesis&#58; hallazgos histopatol&#243;gicos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "729"
          "paginaFinal" => "731"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Skin Dimpling as a Complication of Amniocentesis&#58; Histopathologic Findings"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1289
              "Ancho" => 1497
              "Tamanyo" => 517452
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Imagen panor&#225;mica&#44; epidermis con 2 zonas festoneadas y dermis compacta y ancha con pocos anejos &#40;H-E&#44; &#215;20&#41;&#46; B&#41; A mayor detalle&#44; en dermis&#44; haces de col&#225;geno adelgazados &#40;H-E&#44; &#215;100&#41;&#46; C&#41; Fibras el&#225;sticas fragmentadas y disminuidas en dermis &#40;orce&#237;na&#44; &#215;100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Monteagudo, J&#46; del Pozo, B&#46; Su&#225;rez-Traba, F&#46; Sacrist&#225;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Monteagudo"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "del Pozo"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Su&#225;rez-Traba"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Sacrist&#225;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219013001868"
        "doi" => "10.1016/j.adengl.2012.08.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001868?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004590?idApp=UINPBA000044"
    "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012004590/v1_201309240051/es/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Acquired Epidermodysplasia Verruciformis in a Patient With Congenital HIV Infection"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "731"
        "paginaFinal" => "733"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46;A&#46; Castro-Perez, I&#46; Sorin, A&#46;I&#46; Bravo, L&#46;D&#46; Mazzuoccolo"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;A&#46;"
            "apellidos" => "Castro-Perez"
            "email" => array:1 [
              0 => "gimecastroperez&#64;yahoo&#46;com&#46;ar"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Sorin"
          ]
          2 => array:2 [
            "nombre" => "A&#46;I&#46;"
            "apellidos" => "Bravo"
          ]
          3 => array:2 [
            "nombre" => "L&#46;D&#46;"
            "apellidos" => "Mazzuoccolo"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Departamentos de Dermatolog&#237;a&#44; Anatom&#237;a Patol&#243;gica y Unidad de Inmunopatolog&#237;a&#44; Hospital Interzonal General de Agudos &#8220;Eva Per&#243;n&#8221;&#44; Buenos Aires&#44; Argentina"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Epidermodisplasia verruciforme adquirido en un paciente con infecci&#243;n cong&#233;nita por VIH"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 449936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos in the epidermis &#40;hematoxylin and eosin&#44; original magnification 40&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermodysplasia verruciformis &#40;EV&#41; is a rare autosomal recessive genodermatosis characterized by a defect in cell-mediated immunity and increased susceptibility to infections by group B human papillomavirus &#40;HPV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Its main clinical features are a rash resembling pityriasis versicolor and flat warts distributed in sun-exposed areas&#46; In the last decade&#44; several cases of acquired EV have been reported&#44; particularly in immunocompromised patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 19-year-old White man with congenital human immunodeficiency virus &#40;HIV&#41; infection presented with a skin eruption of 4 years&#8217; duration&#46; Physical examination revealed a macular and papular eruption on the trunk and arms&#46; There were multiple erythematous macules with desquamation on the chest and arms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and hundreds of disseminated small pink-brownish papules&#44; with the appearance of flat warts&#44; on the back of the trunk and on the shoulders and arms &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The papules were arranged in a linear pattern &#40;Koebner phenomenon&#41;&#46; The lesions were asymptomatic&#44; but had increased in number in recent months&#46; At the time of his first evaluation the patient had a CD4 count of 544 cells&#47;mm<span class="elsevierStyleSup">3</span> and an undetectable viral load&#46; He was receiving highly active antiretroviral therapy &#40;HAART&#41; with raltegravir&#44; ritonavir&#44; tenofovir&#44; and darunavir&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Skin biopsy of a papule on the trunk showed large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; HPV type 5 was isolated using the nested polymerase chain reaction technique at the department of oncogenic viruses of the National Institute of Infectious Diseases Dr&#46; Carlos Malbran&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Based on the above clinical and histological features&#44; we made a diagnosis of EV-like eruption&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For treatment we decided to divide the back into 4 quadrants&#46; The first quadrant was treated with topical tretinoin 0&#46;05&#37; cream&#44; applied once daily for 2 months&#44; while the second quadrant was treated with topical imiquimod 5&#37; gel&#44; applied once daily for 3 months&#46; The third and fourth quadrants were treated with electrocauterization and cryosurgery&#44; respectively&#46; The patient was also advised to take sun protection measures&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">After 3 months of treatment&#44; we found that none of the therapeutic options had yielded satisfactory results&#46; The patient is still receiving HAART and undergoes periodic skin examination&#46; No signs of malignant transformation have been detected&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">EV-like eruption is an HPV-related disease that is rarely seen in immunocompromised patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6</span></a> It is caused by mutations in two genes&#44; <span class="elsevierStyleItalic">EVER1</span> and <span class="elsevierStyleItalic">EVER2</span>&#44; located on chromosome 17q25&#46; It was first described in kidney transplant recipients<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and then in HIV-positive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In the HIV-positive population&#44; men and women are equally affected&#46; Lowe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>proposed that this entity was more frequent in young&#44; vertically HIV-infected patients than in adults infected later in life&#46; This would be because younger patients would be infected by HPV when their cell-mediated immunity was already affected by HIV&#46; On the contrary&#44; by the time older patients are infected with HIV&#44; they have developed better immune mechanisms against HPV infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The skin lesions appear years after HIV diagnosis following a long period of immunosuppression&#44; and tend to be chronic and refractory to the different therapies available&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> The mucosal membranes are usually unaffected&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Typical histological findings are acanthosis&#44; a prominent granular layer&#44; vacuolated keratinocytes with perinuclear halos and blue-gray pallor cytoplasm&#44; and rare koilocytotic keratinocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">According to the literature&#44; the progression of cutaneous lesions is not influenced by the immunological status of the patient and response to treatment is poor&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequent HPV strains implicated in skin eruptions are HPV subtypes 5 and 8&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5&#44;6&#44;8&#44;9</span></a> Co-infection with other HPV types has also been documented in several publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When oncogenic HPV subtypes are involved&#44; cutaneous lesions can progress to invasive nonmelanoma skin cancer &#40;mostly Bowen disease and invasive squamous cell carcinomas<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#41; after several years of cellular immunodeficiency and sun exposure&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">While this is not the first report of EV-like eruption in a patient with congenital HIV&#44; we believe that it is of educational value and would like to stress the importance of determining the type of HPV involved in the development of disease in order to estimate the degree of oncogenic potential&#46; We also believe it is important to closely follow all patients with EV-like eruptions&#44; with periodic complete skin examinations&#44; skin biopsy of suspicious lesions&#44; avoidance of radiation therapies&#44; improvement of immunological status&#44; and strong recommendations to avoid sun exposure&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1221
            "Ancho" => 1584
            "Tamanyo" => 176373
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pityriasis versicolor-like macules on the chest and arms&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1667
            "Ancho" => 1252
            "Tamanyo" => 259960
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hundreds of flat warts on the back of the trunk and on the shoulders and arms &#40;Koebner phenomenon&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 449936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos in the epidermis &#40;hematoxylin and eosin&#44; original magnification 40&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in human immunodeficiency virus-infected patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Jacobelli"
                            1 => "H&#46; Laude"
                            2 => "A&#46; Carlotti"
                            3 => "F&#46; Rozenberg"
                            4 => "J&#46; Deleuza"
                            5 => "J&#46;P&#46; Morini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2010.399"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2011"
                        "volumen" => "147"
                        "paginaInicial" => "590"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21242344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Generalized verrucosis&#58; a review of the associated diseases&#44; evaluation&#44; and treatments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Sri"
                            1 => "M&#46;I&#46; Dubina"
                            2 => "G&#46;F&#46; Kao"
                            3 => "P&#46;L&#46; Rady"
                            4 => "S&#46;K&#46; Tyring"
                            5 => "A&#46;A&#46; Gaspari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2010.12.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2012"
                        "volumen" => "66"
                        "paginaInicial" => "292"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21571393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;M&#46; Paternoster"
                            1 => "M&#46; Cester"
                            2 => "C&#46; Resente"
                            3 => "I&#46; Pascoli"
                            4 => "K&#46; Nanhorngue"
                            5 => "F&#46; Manchini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2008.05.074"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "1877"
                        "paginaFinal" => "1880"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18675077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis in a renal transplant recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Gomez-Bernal"
                            1 => "L&#46; Rodr&#237;guez-Pazos"
                            2 => "M&#46;M&#46; Pereiro-Ferreir&#243;s"
                            3 => "J&#46; Toribio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Dermosifilogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "159"
                        "paginaFinal" => "161"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Morrison"
                            1 => "Y&#46; Eliezri"
                            2 => "C&#46; Magro"
                            3 => "G&#46;J&#46; Nuovo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "480"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12207742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in a patient with HIV infection&#58; no response to highly active antiretroviral therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Carr&#233;"
                            1 => "A&#46; Dompmartin"
                            2 => "L&#46; Verneuil"
                            3 => "R&#46; Verdon"
                            4 => "F&#46; Comoz"
                            5 => "E&#46; Le Brun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12694498"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis due to multiple and unusual HPV infection among vertically infected&#44; HIV-positive adolescents in Zimbabwe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Lowe"
                            1 => "L&#46; Katsidzira"
                            2 => "R&#46; Meys"
                            3 => "J&#46;C&#46; Sterling"
                            4 => "M&#46; de Koning"
                            5 => "W&#46; Quint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Infec Dis"
                        "fecha" => "2012"
                        "volumen" => "54"
                        "paginaInicial" => "e119"
                        "paginaFinal" => "e123"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;D&#46; Rogers"
                            1 => "J&#46;L&#46; MacGregor"
                            2 => "K&#46;M&#46; Nord"
                            3 => "S&#46; Tyring"
                            4 => "P&#46; Rady"
                            5 => "D&#46;E&#46; Engler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Am Acad Deramtol"
                        "fecha" => "2009"
                        "paginaInicial" => "315"
                        "paginaFinal" => "320"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of antibodies against virus-like particlules of epidermodysplasia verruciformis-associated HPV8 in patients at risk of skin cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Stark"
                            1 => "A&#46;K&#46; Petridis"
                            2 => "S&#46;J&#46; Ghim"
                            3 => "A&#46;B&#46; Jenson"
                            4 => "J&#46;N&#46; Bowes Bavinck"
                            5 => "G&#46; Gross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00360.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "111"
                        "paginaInicial" => "696"
                        "paginaFinal" => "701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764856"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "identificador" => "xack63548"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">We would like to thank Dr&#46; Alejandra Picconi and Ms&#46; Mariel Correa of the Department of Virology &#40;Oncogenic Viruses Unit&#41; at the National Institute of Infectious Diseases Dr&#46; Carlos Malbran for their diagnostic help&#46;</p>"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012005571/v1_201309240051/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6160"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010400000008/v1_201309240051/S0001731012005571/v1_201309240051/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012005571?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Acquired Epidermodysplasia Verruciformis in a Patient With Congenital HIV Infection
Epidermodisplasia verruciforme adquirido en un paciente con infección congénita por VIH
G.A. Castro-Perez
Autor para correspondencia
gimecastroperez@yahoo.com.ar

Corresponding author.
, I. Sorin, A.I. Bravo, L.D. Mazzuoccolo
Departamentos de Dermatología, Anatomía Patológica y Unidad de Inmunopatología, Hospital Interzonal General de Agudos “Eva Perón”, Buenos Aires, Argentina
Leído
10611
Veces
se ha leído el artículo
2175
Total PDF
8436
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0001731012005571"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2012.10.020"
  "estado" => "S300"
  "fechaPublicacion" => "2013-10-01"
  "aid" => "782"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:731-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4873
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 4454
      "PDF" => 380
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1578219013001893"
      "issn" => "15782190"
      "doi" => "10.1016/j.adengl.2012.10.013"
      "estado" => "S300"
      "fechaPublicacion" => "2013-10-01"
      "aid" => "782"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:731-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1149
        "formatos" => array:3 [
          "EPUB" => 41
          "HTML" => 651
          "PDF" => 457
        ]
      ]
      "en" => array:8 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
        "titulo" => "Acquired Epidermodysplasia Verruciformis in a Patient With Congenital HIV Infection"
        "tienePdf" => "en"
        "tieneTextoCompleto" => 0
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "731"
            "paginaFinal" => "733"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Epidermodisplasia verruciforme adquirido en un paciente con infecci&#243;n cong&#233;nita por VIH"
          ]
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0001731012005571"
          "doi" => "10.1016/j.ad.2012.10.020"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012005571?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001893?idApp=UINPBA000044"
      "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001893/v1_201309240048/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S000173101300152X"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "835"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:734"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1544
      "formatos" => array:3 [
        "EPUB" => 2
        "HTML" => 1219
        "PDF" => 323
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
      "titulo" => "R&#233;plica a&#58; &#171;Lipodistrofia generalizada adquirida de inicio tard&#237;o y con afectaci&#243;n muscular&#187;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "734"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Response to Comments on &#171;Late-Onset Acquired Generalized Lipodystrophy With Muscle Involvement&#187;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Llamas-Velasco, E&#46; Daud&#233;n, G&#46; Mart&#237;nez-Pe&#241;as, A&#46; Garc&#237;a-Diez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Llamas-Velasco"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Daud&#233;n"
            ]
            2 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Mart&#237;nez-Pe&#241;as"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Garc&#237;a-Diez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S157821901300187X"
        "doi" => "10.1016/j.adengl.2013.02.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901300187X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300152X?idApp=UINPBA000044"
    "url" => "/00017310/0000010400000008/v1_201309240051/S000173101300152X/v1_201309240051/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731012004590"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2012.08.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-10-01"
    "aid" => "742"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:729-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3903
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 2702
        "PDF" => 1200
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Hoyuelos cut&#225;neos como consecuencia de amniocentesis&#58; hallazgos histopatol&#243;gicos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "729"
          "paginaFinal" => "731"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Skin Dimpling as a Complication of Amniocentesis&#58; Histopathologic Findings"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1289
              "Ancho" => 1497
              "Tamanyo" => 517452
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Imagen panor&#225;mica&#44; epidermis con 2 zonas festoneadas y dermis compacta y ancha con pocos anejos &#40;H-E&#44; &#215;20&#41;&#46; B&#41; A mayor detalle&#44; en dermis&#44; haces de col&#225;geno adelgazados &#40;H-E&#44; &#215;100&#41;&#46; C&#41; Fibras el&#225;sticas fragmentadas y disminuidas en dermis &#40;orce&#237;na&#44; &#215;100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Monteagudo, J&#46; del Pozo, B&#46; Su&#225;rez-Traba, F&#46; Sacrist&#225;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Monteagudo"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "del Pozo"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Su&#225;rez-Traba"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Sacrist&#225;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219013001868"
        "doi" => "10.1016/j.adengl.2012.08.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001868?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004590?idApp=UINPBA000044"
    "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012004590/v1_201309240051/es/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Acquired Epidermodysplasia Verruciformis in a Patient With Congenital HIV Infection"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "731"
        "paginaFinal" => "733"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46;A&#46; Castro-Perez, I&#46; Sorin, A&#46;I&#46; Bravo, L&#46;D&#46; Mazzuoccolo"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;A&#46;"
            "apellidos" => "Castro-Perez"
            "email" => array:1 [
              0 => "gimecastroperez&#64;yahoo&#46;com&#46;ar"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Sorin"
          ]
          2 => array:2 [
            "nombre" => "A&#46;I&#46;"
            "apellidos" => "Bravo"
          ]
          3 => array:2 [
            "nombre" => "L&#46;D&#46;"
            "apellidos" => "Mazzuoccolo"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Departamentos de Dermatolog&#237;a&#44; Anatom&#237;a Patol&#243;gica y Unidad de Inmunopatolog&#237;a&#44; Hospital Interzonal General de Agudos &#8220;Eva Per&#243;n&#8221;&#44; Buenos Aires&#44; Argentina"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Epidermodisplasia verruciforme adquirido en un paciente con infecci&#243;n cong&#233;nita por VIH"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 449936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos in the epidermis &#40;hematoxylin and eosin&#44; original magnification 40&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermodysplasia verruciformis &#40;EV&#41; is a rare autosomal recessive genodermatosis characterized by a defect in cell-mediated immunity and increased susceptibility to infections by group B human papillomavirus &#40;HPV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Its main clinical features are a rash resembling pityriasis versicolor and flat warts distributed in sun-exposed areas&#46; In the last decade&#44; several cases of acquired EV have been reported&#44; particularly in immunocompromised patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 19-year-old White man with congenital human immunodeficiency virus &#40;HIV&#41; infection presented with a skin eruption of 4 years&#8217; duration&#46; Physical examination revealed a macular and papular eruption on the trunk and arms&#46; There were multiple erythematous macules with desquamation on the chest and arms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and hundreds of disseminated small pink-brownish papules&#44; with the appearance of flat warts&#44; on the back of the trunk and on the shoulders and arms &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The papules were arranged in a linear pattern &#40;Koebner phenomenon&#41;&#46; The lesions were asymptomatic&#44; but had increased in number in recent months&#46; At the time of his first evaluation the patient had a CD4 count of 544 cells&#47;mm<span class="elsevierStyleSup">3</span> and an undetectable viral load&#46; He was receiving highly active antiretroviral therapy &#40;HAART&#41; with raltegravir&#44; ritonavir&#44; tenofovir&#44; and darunavir&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Skin biopsy of a papule on the trunk showed large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; HPV type 5 was isolated using the nested polymerase chain reaction technique at the department of oncogenic viruses of the National Institute of Infectious Diseases Dr&#46; Carlos Malbran&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Based on the above clinical and histological features&#44; we made a diagnosis of EV-like eruption&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For treatment we decided to divide the back into 4 quadrants&#46; The first quadrant was treated with topical tretinoin 0&#46;05&#37; cream&#44; applied once daily for 2 months&#44; while the second quadrant was treated with topical imiquimod 5&#37; gel&#44; applied once daily for 3 months&#46; The third and fourth quadrants were treated with electrocauterization and cryosurgery&#44; respectively&#46; The patient was also advised to take sun protection measures&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">After 3 months of treatment&#44; we found that none of the therapeutic options had yielded satisfactory results&#46; The patient is still receiving HAART and undergoes periodic skin examination&#46; No signs of malignant transformation have been detected&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">EV-like eruption is an HPV-related disease that is rarely seen in immunocompromised patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6</span></a> It is caused by mutations in two genes&#44; <span class="elsevierStyleItalic">EVER1</span> and <span class="elsevierStyleItalic">EVER2</span>&#44; located on chromosome 17q25&#46; It was first described in kidney transplant recipients<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and then in HIV-positive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In the HIV-positive population&#44; men and women are equally affected&#46; Lowe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>proposed that this entity was more frequent in young&#44; vertically HIV-infected patients than in adults infected later in life&#46; This would be because younger patients would be infected by HPV when their cell-mediated immunity was already affected by HIV&#46; On the contrary&#44; by the time older patients are infected with HIV&#44; they have developed better immune mechanisms against HPV infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The skin lesions appear years after HIV diagnosis following a long period of immunosuppression&#44; and tend to be chronic and refractory to the different therapies available&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> The mucosal membranes are usually unaffected&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Typical histological findings are acanthosis&#44; a prominent granular layer&#44; vacuolated keratinocytes with perinuclear halos and blue-gray pallor cytoplasm&#44; and rare koilocytotic keratinocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">According to the literature&#44; the progression of cutaneous lesions is not influenced by the immunological status of the patient and response to treatment is poor&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequent HPV strains implicated in skin eruptions are HPV subtypes 5 and 8&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5&#44;6&#44;8&#44;9</span></a> Co-infection with other HPV types has also been documented in several publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When oncogenic HPV subtypes are involved&#44; cutaneous lesions can progress to invasive nonmelanoma skin cancer &#40;mostly Bowen disease and invasive squamous cell carcinomas<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#41; after several years of cellular immunodeficiency and sun exposure&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">While this is not the first report of EV-like eruption in a patient with congenital HIV&#44; we believe that it is of educational value and would like to stress the importance of determining the type of HPV involved in the development of disease in order to estimate the degree of oncogenic potential&#46; We also believe it is important to closely follow all patients with EV-like eruptions&#44; with periodic complete skin examinations&#44; skin biopsy of suspicious lesions&#44; avoidance of radiation therapies&#44; improvement of immunological status&#44; and strong recommendations to avoid sun exposure&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1221
            "Ancho" => 1584
            "Tamanyo" => 176373
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pityriasis versicolor-like macules on the chest and arms&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1667
            "Ancho" => 1252
            "Tamanyo" => 259960
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hundreds of flat warts on the back of the trunk and on the shoulders and arms &#40;Koebner phenomenon&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 449936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Large keratinocytes with voluminous nuclei&#44; basophilic cytoplasm&#44; and perinuclear halos in the epidermis &#40;hematoxylin and eosin&#44; original magnification 40&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in human immunodeficiency virus-infected patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Jacobelli"
                            1 => "H&#46; Laude"
                            2 => "A&#46; Carlotti"
                            3 => "F&#46; Rozenberg"
                            4 => "J&#46; Deleuza"
                            5 => "J&#46;P&#46; Morini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2010.399"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2011"
                        "volumen" => "147"
                        "paginaInicial" => "590"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21242344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Generalized verrucosis&#58; a review of the associated diseases&#44; evaluation&#44; and treatments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Sri"
                            1 => "M&#46;I&#46; Dubina"
                            2 => "G&#46;F&#46; Kao"
                            3 => "P&#46;L&#46; Rady"
                            4 => "S&#46;K&#46; Tyring"
                            5 => "A&#46;A&#46; Gaspari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2010.12.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2012"
                        "volumen" => "66"
                        "paginaInicial" => "292"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21571393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;M&#46; Paternoster"
                            1 => "M&#46; Cester"
                            2 => "C&#46; Resente"
                            3 => "I&#46; Pascoli"
                            4 => "K&#46; Nanhorngue"
                            5 => "F&#46; Manchini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2008.05.074"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "1877"
                        "paginaFinal" => "1880"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18675077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis in a renal transplant recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Gomez-Bernal"
                            1 => "L&#46; Rodr&#237;guez-Pazos"
                            2 => "M&#46;M&#46; Pereiro-Ferreir&#243;s"
                            3 => "J&#46; Toribio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Dermosifilogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "159"
                        "paginaFinal" => "161"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Morrison"
                            1 => "Y&#46; Eliezri"
                            2 => "C&#46; Magro"
                            3 => "G&#46;J&#46; Nuovo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "480"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12207742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermodysplasia verruciformis in a patient with HIV infection&#58; no response to highly active antiretroviral therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Carr&#233;"
                            1 => "A&#46; Dompmartin"
                            2 => "L&#46; Verneuil"
                            3 => "R&#46; Verdon"
                            4 => "F&#46; Comoz"
                            5 => "E&#46; Le Brun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12694498"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis due to multiple and unusual HPV infection among vertically infected&#44; HIV-positive adolescents in Zimbabwe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Lowe"
                            1 => "L&#46; Katsidzira"
                            2 => "R&#46; Meys"
                            3 => "J&#46;C&#46; Sterling"
                            4 => "M&#46; de Koning"
                            5 => "W&#46; Quint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Infec Dis"
                        "fecha" => "2012"
                        "volumen" => "54"
                        "paginaInicial" => "e119"
                        "paginaFinal" => "e123"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired epidermodysplasia verruciformis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;D&#46; Rogers"
                            1 => "J&#46;L&#46; MacGregor"
                            2 => "K&#46;M&#46; Nord"
                            3 => "S&#46; Tyring"
                            4 => "P&#46; Rady"
                            5 => "D&#46;E&#46; Engler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Am Acad Deramtol"
                        "fecha" => "2009"
                        "paginaInicial" => "315"
                        "paginaFinal" => "320"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of antibodies against virus-like particlules of epidermodysplasia verruciformis-associated HPV8 in patients at risk of skin cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Stark"
                            1 => "A&#46;K&#46; Petridis"
                            2 => "S&#46;J&#46; Ghim"
                            3 => "A&#46;B&#46; Jenson"
                            4 => "J&#46;N&#46; Bowes Bavinck"
                            5 => "G&#46; Gross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00360.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "111"
                        "paginaInicial" => "696"
                        "paginaFinal" => "701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764856"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "identificador" => "xack63548"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">We would like to thank Dr&#46; Alejandra Picconi and Ms&#46; Mariel Correa of the Department of Virology &#40;Oncogenic Viruses Unit&#41; at the National Institute of Infectious Diseases Dr&#46; Carlos Malbran for their diagnostic help&#46;</p>"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000010400000008/v1_201309240051/S0001731012005571/v1_201309240051/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6160"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010400000008/v1_201309240051/S0001731012005571/v1_201309240051/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012005571?idApp=UINPBA000044"
]
Información del artículo
ISSN: 00017310
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 7 9 16
2024 Octubre 58 55 113
2024 Septiembre 81 26 107
2024 Agosto 103 55 158
2024 Julio 77 35 112
2024 Junio 68 31 99
2024 Mayo 65 31 96
2024 Abril 78 23 101
2024 Marzo 63 30 93
2024 Febrero 91 27 118
2024 Enero 74 30 104
2023 Diciembre 79 13 92
2023 Noviembre 66 25 91
2023 Octubre 34 15 49
2023 Septiembre 46 25 71
2023 Agosto 47 15 62
2023 Julio 117 34 151
2023 Junio 58 22 80
2023 Mayo 75 27 102
2023 Abril 58 16 74
2023 Marzo 64 21 85
2023 Febrero 123 21 144
2023 Enero 74 23 97
2022 Diciembre 93 43 136
2022 Noviembre 101 40 141
2022 Octubre 100 35 135
2022 Septiembre 103 38 141
2022 Agosto 71 56 127
2022 Julio 84 52 136
2022 Junio 134 54 188
2022 Mayo 117 24 141
2022 Abril 108 47 155
2022 Marzo 82 62 144
2022 Febrero 85 25 110
2022 Enero 92 39 131
2021 Diciembre 91 33 124
2021 Noviembre 96 53 149
2021 Octubre 79 50 129
2021 Septiembre 75 35 110
2021 Agosto 63 24 87
2021 Julio 68 31 99
2021 Junio 47 33 80
2021 Mayo 39 47 86
2021 Abril 146 88 234
2021 Marzo 72 36 108
2021 Febrero 57 43 100
2021 Enero 47 22 69
2020 Diciembre 37 13 50
2020 Noviembre 33 20 53
2020 Octubre 35 11 46
2020 Septiembre 40 15 55
2020 Agosto 35 19 54
2020 Julio 30 13 43
2020 Junio 22 25 47
2020 Mayo 28 12 40
2020 Abril 26 24 50
2020 Marzo 37 21 58
2020 Febrero 7 3 10
2020 Enero 2 3 5
2019 Diciembre 8 3 11
2019 Noviembre 2 0 2
2019 Septiembre 10 1 11
2019 Agosto 4 5 9
2019 Julio 4 5 9
2019 Junio 4 6 10
2019 Mayo 7 7 14
2019 Abril 3 5 8
2019 Marzo 0 8 8
2019 Febrero 7 1 8
2019 Enero 2 0 2
2018 Diciembre 2 4 6
2018 Noviembre 3 3 6
2018 Octubre 2 1 3
2018 Septiembre 6 1 7
2018 Julio 0 3 3
2018 Mayo 0 1 1
2018 Abril 0 1 1
2018 Marzo 0 3 3
2018 Febrero 91 2 93
2018 Enero 103 5 108
2017 Diciembre 105 6 111
2017 Noviembre 84 4 88
2017 Octubre 88 7 95
2017 Septiembre 111 9 120
2017 Agosto 124 8 132
2017 Julio 126 5 131
2017 Junio 116 13 129
2017 Mayo 81 9 90
2017 Abril 42 8 50
2017 Marzo 39 43 82
2017 Febrero 124 10 134
2017 Enero 70 7 77
2016 Diciembre 73 12 85
2016 Noviembre 156 12 168
2016 Octubre 172 25 197
2016 Septiembre 165 7 172
2016 Agosto 50 7 57
2016 Julio 42 6 48
2016 Junio 10 11 21
2016 Mayo 6 0 6
2016 Abril 6 0 6
2016 Marzo 4 0 4
2016 Febrero 11 4 15
2016 Enero 12 0 12
2015 Diciembre 18 8 26
2015 Noviembre 6 0 6
2015 Octubre 7 0 7
2015 Septiembre 4 1 5
2015 Agosto 8 3 11
2015 Julio 179 0 179
2015 Junio 127 0 127
2015 Mayo 111 0 111
2015 Abril 115 1 116
2015 Marzo 174 1 175
2015 Febrero 154 1 155
2015 Enero 115 0 115
2014 Diciembre 139 0 139
2014 Noviembre 90 0 90
2014 Octubre 119 0 119
2014 Septiembre 119 0 119
2014 Agosto 93 0 93
2014 Julio 87 0 87
2014 Junio 92 0 92
2014 Mayo 91 0 91
2014 Abril 66 0 66
2014 Marzo 122 8 130
2014 Febrero 98 19 117
2014 Enero 99 12 111
2013 Diciembre 58 5 63
2013 Noviembre 55 10 65
2013 Octubre 22 26 48
2013 Septiembre 5 4 9
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?