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but heterozygous carriers may show mild to moderate clinical manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> We describe the findings in a Spanish family with XLHED with a novel pathogenic mutation in the <span class="elsevierStyleItalic">EDA</span> gene&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patients and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The proband &#40;III-5&#41; was a 4-year old girl who had pointed teeth&#44; sparse thin hair&#44; and a congenital scarring lesion on the bridge of the nose&#44; which was thought to be a Blaschko line at that site &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1A&#44; 1B</a>&#41;&#46; The tail of the eyebrows was absent bilaterally&#44; her skin was dry&#44; and sweating was reduced&#46; She also presented a prominent lower lip and hyperpigmentation and dryness around the eyes&#46; Her nails were normal&#46; The results of routine laboratory analyses were within the normal range&#46; Her family stated that she had suffered from febrile convulsions soon after birth&#44; although medical advice had not been sought&#46; Her mother &#40;II-3&#41;&#44; who was 35 years of age&#44; presented similar clinical features to the proband &#40;III-5&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">figs&#46; 1C&#44; 1D</a>&#41;&#44; although her skin was not so dry and her sweating could be described as being about normal&#46; Her hyperpigmented lesions were more prominent and she also exhibited some eczematous plaques&#46; In addition&#44; she had never developed her adult dentition&#46; The grandmother &#40;I-2&#41; and the grandfather &#40;I-1&#41; of the proband did not display phenotypic features&#44; nor did the proband&#39;s father &#40;II-4&#41;&#46; Genetic analysis of the grandfather could not be performed as he had died&#46; The pedigree is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After giving their informed consent&#44; genomic DNA was obtained from peripheral blood from the proband and from her family members&#46; PCR amplification of the <span class="elsevierStyleItalic">EDA</span> gene obtained from the DNA samples was performed&#46; The PCR conditions and primers used to amplify the <span class="elsevierStyleItalic">EDA</span> gene have been described previously&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The reaction was conducted in a 2720 Thermal Cycler &#40;Applied Biosystems<span class="elsevierStyleSup">&#174;</span>&#41;&#46; Analyses were performed in duplicate to ensure reliability of the results&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results and discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">Direct sequencing revealed a novel heterozygous c&#46;734&#95;735insGA mutation in the <span class="elsevierStyleItalic">EDA</span> gene in the proband and in her mother &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>B&#41;&#46; The grandmother and the father of the proband did not carry the mutation&#46; One hundred alleles from healthy people were tested and failed to reveal that mutation&#44; which was located in exon 5 and consisted of a frame-shift mutation at codon 245&#46; This gave rise to an abnormal protein with a premature stop codon after 35 residues &#40;Asn280Ter&#41;&#44; generating a protein lacking the TNF homology domain&#46; The different mutations identified in the <span class="elsevierStyleItalic">EDA</span> gene are located particularly in 3 functional clusters&#58; the furin protease recognition site&#44; whose codon 156 is the one most frequently affected&#59; the collagen-like domain&#59; and the TNF homology domain itself&#44; as seen in this family&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One hundred sixty-one pathogenic mutations have been recognized in XLHED &#40;Human Gene Mutation Database&#44; 25th March 2011&#41;&#46; To our knowledge&#44; the mutation we describe has never been reported&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The impact of this mutation can be appreciated by means of a brief review of protein structure and function&#46; In general&#44; the <span class="elsevierStyleItalic">EDA</span> gene gives rise to several different transcripts through alternative splicing&#46; The longest transcripts&#44; EDA-A1 and EDA-A2&#44; are the most relevant ones from the biological point of view&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> These transcripts are produced as trimeric type II transmembrane proteins that are released from the cell surface by furin-mediated proteolytic cleavage&#46; TNF domains are of great relevance for this protein&#44; and their absence&#44; as seen in our patients&#44; leads to protein dysfunction due to an inability to bind the receptor&#46; For further information about the role of <span class="elsevierStyleItalic">EDA</span> in the development of skin appendages and in NF-kB signalling pathway activation&#44; readers are referred to reference&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The proband exhibited a more severe phenotype than her mother&#44; explained by the X inactivation process&#46; Because of this mechanism&#44; some XLHED female carriers may exhibit a very mild phenotype and the probability of detection by clinical examination alone has been estimated to be of 60 to 70&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The XLHED carrier status can only be unequivocally determined by molecular analysis&#46; A female carrier &#40;the proband and her mother&#41; has a 50&#37; probability of having a male child with clinically severe XLHED&#46; This observation is of particular value in the context of genetic counseling&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">This report expands our knowledge of mutations in the <span class="elsevierStyleItalic">EDA</span> gene&#46; Mutation analysis in families with XLHED enables carrier status to be determined and genetic counseling and prenatal diagnosis to be performed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">X-linked hypohidrotic ectodermal dysplasia &#40;XLHED&#41; is characterized by abnormal development of the hair&#44; teeth&#44; and sweat glands&#46; It is caused by mutations in the <span class="elsevierStyleItalic">EDA</span> gene&#44; which maps to the X chromosome and encodes a protein called ectodysplasin-A&#44; a member of the tumor necrosis factor-related ligand family&#46; Affected males typically exhibit all the typical features of HED&#44; but heterozygous carriers may show mild to moderate clinical manifestations&#46; We describe the case of a Spanish family in which a novel heterozygous c&#46;733&#95;734insGA mutation at the <span class="elsevierStyleItalic">EDA</span> gene was identified&#46; It was located in exon 5 and consisted of a frame-shift mutation at codon 245&#44; which gave rise to an abnormal protein with a premature stop codon after 35 residues&#46; Genetic analyses in families with XLHED are useful for checking carrier status&#44; but they also provide information for genetic counseling and prenatal diagnosis&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La displasia ectod&#233;rmica hipohidr&#243;tica ligada al cromosoma X &#40;XLHED&#41; se caracteriza por un desarrollo anormal del pelo&#44; los dientes y las gl&#225;ndulas sudor&#237;paras&#46; Est&#225; producida por mutaciones en el gen <span class="elsevierStyleItalic">EDA</span>&#44; que se localiza en el cromosoma X y codifica para la prote&#237;na Ecdodisplasina A&#44; miembro de la familia de ligandos relacionados con el factor de necrosis tumoral&#46; Los varones afectados normalmente exhiben todas las caracter&#237;sticas de la enfermedad&#44; pero los portadores heterocigotos pueden mostrar manifestaciones de leves a moderadas&#46; Aqu&#237; se describe una familia espa&#241;ola en la que hemos identificado una mutaci&#243;n c&#46;733&#95;734insGA&#44; previamente no descrita&#44; en el gen <span class="elsevierStyleItalic">EDA</span>&#46; Se localizaba en el ex&#243;n 5 y produc&#237;a un cambio en la fase de lectura en el cod&#243;n 245 de la prote&#237;na&#44; lo que daba lugar a un cod&#243;n de parada prematuro tras 35 residuos&#46; El an&#225;lisis gen&#233;tico en familias con XLHED es fundamental para la identificaci&#243;n de las portadoras&#44; para el diagn&#243;stico prenatal y en general para proporcionar un asesoramiento gen&#233;tico correcto&#46;</p>"
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Caso clínico
A novel EDA gene mutation in a Spanish family with X-linked hypohidrotic ectodermal dysplasia
Una nueva mutación en el gen EDA en una familia española con displasia ectodérmica hipohidrótica ligada al cromosoma X
J. Cañuetoa,
Autor para correspondencia
jcanueto@yahoo.es

Corresponding author.
, M.I. Zafra-Coboa, S. Ciriab, P. Unamunoa, R. González-Sarmientob,c
a Servicio de Dermatología, Hospital Universitario de Salamanca, Salamanca, Spain
b Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
c IBMCC, Universidad de Salamanca-CSIC, Campus Miguel de Unamuno, Salamanca, Spain
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but heterozygous carriers may show mild to moderate clinical manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> We describe the findings in a Spanish family with XLHED with a novel pathogenic mutation in the <span class="elsevierStyleItalic">EDA</span> gene&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patients and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The proband &#40;III-5&#41; was a 4-year old girl who had pointed teeth&#44; sparse thin hair&#44; and a congenital scarring lesion on the bridge of the nose&#44; which was thought to be a Blaschko line at that site &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1A&#44; 1B</a>&#41;&#46; The tail of the eyebrows was absent bilaterally&#44; her skin was dry&#44; and sweating was reduced&#46; She also presented a prominent lower lip and hyperpigmentation and dryness around the eyes&#46; Her nails were normal&#46; The results of routine laboratory analyses were within the normal range&#46; Her family stated that she had suffered from febrile convulsions soon after birth&#44; although medical advice had not been sought&#46; Her mother &#40;II-3&#41;&#44; who was 35 years of age&#44; presented similar clinical features to the proband &#40;III-5&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">figs&#46; 1C&#44; 1D</a>&#41;&#44; although her skin was not so dry and her sweating could be described as being about normal&#46; Her hyperpigmented lesions were more prominent and she also exhibited some eczematous plaques&#46; In addition&#44; she had never developed her adult dentition&#46; The grandmother &#40;I-2&#41; and the grandfather &#40;I-1&#41; of the proband did not display phenotypic features&#44; nor did the proband&#39;s father &#40;II-4&#41;&#46; Genetic analysis of the grandfather could not be performed as he had died&#46; The pedigree is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After giving their informed consent&#44; genomic DNA was obtained from peripheral blood from the proband and from her family members&#46; PCR amplification of the <span class="elsevierStyleItalic">EDA</span> gene obtained from the DNA samples was performed&#46; The PCR conditions and primers used to amplify the <span class="elsevierStyleItalic">EDA</span> gene have been described previously&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The reaction was conducted in a 2720 Thermal Cycler &#40;Applied Biosystems<span class="elsevierStyleSup">&#174;</span>&#41;&#46; Analyses were performed in duplicate to ensure reliability of the results&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results and discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">Direct sequencing revealed a novel heterozygous c&#46;734&#95;735insGA mutation in the <span class="elsevierStyleItalic">EDA</span> gene in the proband and in her mother &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>B&#41;&#46; The grandmother and the father of the proband did not carry the mutation&#46; One hundred alleles from healthy people were tested and failed to reveal that mutation&#44; which was located in exon 5 and consisted of a frame-shift mutation at codon 245&#46; This gave rise to an abnormal protein with a premature stop codon after 35 residues &#40;Asn280Ter&#41;&#44; generating a protein lacking the TNF homology domain&#46; The different mutations identified in the <span class="elsevierStyleItalic">EDA</span> gene are located particularly in 3 functional clusters&#58; the furin protease recognition site&#44; whose codon 156 is the one most frequently affected&#59; the collagen-like domain&#59; and the TNF homology domain itself&#44; as seen in this family&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One hundred sixty-one pathogenic mutations have been recognized in XLHED &#40;Human Gene Mutation Database&#44; 25th March 2011&#41;&#46; To our knowledge&#44; the mutation we describe has never been reported&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The impact of this mutation can be appreciated by means of a brief review of protein structure and function&#46; In general&#44; the <span class="elsevierStyleItalic">EDA</span> gene gives rise to several different transcripts through alternative splicing&#46; The longest transcripts&#44; EDA-A1 and EDA-A2&#44; are the most relevant ones from the biological point of view&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> These transcripts are produced as trimeric type II transmembrane proteins that are released from the cell surface by furin-mediated proteolytic cleavage&#46; TNF domains are of great relevance for this protein&#44; and their absence&#44; as seen in our patients&#44; leads to protein dysfunction due to an inability to bind the receptor&#46; For further information about the role of <span class="elsevierStyleItalic">EDA</span> in the development of skin appendages and in NF-kB signalling pathway activation&#44; readers are referred to reference&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The proband exhibited a more severe phenotype than her mother&#44; explained by the X inactivation process&#46; Because of this mechanism&#44; some XLHED female carriers may exhibit a very mild phenotype and the probability of detection by clinical examination alone has been estimated to be of 60 to 70&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The XLHED carrier status can only be unequivocally determined by molecular analysis&#46; A female carrier &#40;the proband and her mother&#41; has a 50&#37; probability of having a male child with clinically severe XLHED&#46; This observation is of particular value in the context of genetic counseling&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">This report expands our knowledge of mutations in the <span class="elsevierStyleItalic">EDA</span> gene&#46; Mutation analysis in families with XLHED enables carrier status to be determined and genetic counseling and prenatal diagnosis to be performed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">X-linked hypohidrotic ectodermal dysplasia &#40;XLHED&#41; is characterized by abnormal development of the hair&#44; teeth&#44; and sweat glands&#46; It is caused by mutations in the <span class="elsevierStyleItalic">EDA</span> gene&#44; which maps to the X chromosome and encodes a protein called ectodysplasin-A&#44; a member of the tumor necrosis factor-related ligand family&#46; Affected males typically exhibit all the typical features of HED&#44; but heterozygous carriers may show mild to moderate clinical manifestations&#46; We describe the case of a Spanish family in which a novel heterozygous c&#46;733&#95;734insGA mutation at the <span class="elsevierStyleItalic">EDA</span> gene was identified&#46; It was located in exon 5 and consisted of a frame-shift mutation at codon 245&#44; which gave rise to an abnormal protein with a premature stop codon after 35 residues&#46; Genetic analyses in families with XLHED are useful for checking carrier status&#44; but they also provide information for genetic counseling and prenatal diagnosis&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La displasia ectod&#233;rmica hipohidr&#243;tica ligada al cromosoma X &#40;XLHED&#41; se caracteriza por un desarrollo anormal del pelo&#44; los dientes y las gl&#225;ndulas sudor&#237;paras&#46; Est&#225; producida por mutaciones en el gen <span class="elsevierStyleItalic">EDA</span>&#44; que se localiza en el cromosoma X y codifica para la prote&#237;na Ecdodisplasina A&#44; miembro de la familia de ligandos relacionados con el factor de necrosis tumoral&#46; Los varones afectados normalmente exhiben todas las caracter&#237;sticas de la enfermedad&#44; pero los portadores heterocigotos pueden mostrar manifestaciones de leves a moderadas&#46; Aqu&#237; se describe una familia espa&#241;ola en la que hemos identificado una mutaci&#243;n c&#46;733&#95;734insGA&#44; previamente no descrita&#44; en el gen <span class="elsevierStyleItalic">EDA</span>&#46; Se localizaba en el ex&#243;n 5 y produc&#237;a un cambio en la fase de lectura en el cod&#243;n 245 de la prote&#237;na&#44; lo que daba lugar a un cod&#243;n de parada prematuro tras 35 residuos&#46; El an&#225;lisis gen&#233;tico en familias con XLHED es fundamental para la identificaci&#243;n de las portadoras&#44; para el diagn&#243;stico prenatal y en general para proporcionar un asesoramiento gen&#233;tico correcto&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A and B&#46; Clinical features of the proband&#46; C and D&#46; Clinical features of the proband&#39;s mother&#46; The proband has pointed teeth&#44; absence of the tails of the eyebrows&#44; a congenital scaring lesion on her nose &#40;A&#41;&#44; and sparse thin hair &#40;B&#41;&#46; Her mother exhibits similar clinical signs &#40;C and D&#41;&#46; She never developed her adult dentition&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#46; Pedigree of the family analyzed&#46; The proband &#40;III-5&#41; is marked with an arrow&#46; Half-filled symbols represent affected heterozygous carriers&#46; A quotation mark indicates the members that were not analyzed genetically&#46; B&#46; The <span class="elsevierStyleItalic">EDA</span> mutation is shown&#58; &#40;1&#41; the normal sequence&#59; &#40;2&#41; the picture of the heterozygous&#59; c&#46; 734&#95;735insGA mutation in the <span class="elsevierStyleItalic">EDA</span> gene&#46; The black triangle indicates the site of mutation&#46;</p>"
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ISSN: 00017310
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2023 Julio 78 37 115
2023 Junio 43 21 64
2023 Mayo 18 22 40
2023 Abril 39 15 54
2023 Marzo 53 24 77
2023 Febrero 53 22 75
2023 Enero 41 33 74
2022 Diciembre 60 43 103
2022 Noviembre 70 34 104
2022 Octubre 62 34 96
2022 Septiembre 47 50 97
2022 Agosto 69 50 119
2022 Julio 56 49 105
2022 Junio 91 31 122
2022 Mayo 89 29 118
2022 Abril 62 43 105
2022 Marzo 49 55 104
2022 Febrero 54 30 84
2022 Enero 55 50 105
2021 Diciembre 48 44 92
2021 Noviembre 65 49 114
2021 Octubre 54 55 109
2021 Septiembre 42 44 86
2021 Agosto 38 37 75
2021 Julio 38 30 68
2021 Junio 57 43 100
2021 Mayo 51 49 100
2021 Abril 123 63 186
2021 Marzo 61 25 86
2021 Febrero 80 25 105
2021 Enero 44 25 69
2020 Diciembre 39 14 53
2020 Noviembre 15 13 28
2020 Octubre 19 10 29
2020 Septiembre 22 14 36
2020 Agosto 23 15 38
2020 Julio 20 15 35
2020 Junio 31 26 57
2020 Mayo 29 18 47
2020 Abril 24 25 49
2020 Marzo 23 19 42
2020 Febrero 4 2 6
2019 Diciembre 0 5 5
2019 Septiembre 0 1 1
2019 Julio 0 2 2
2019 Mayo 0 7 7
2019 Abril 2 8 10
2019 Marzo 0 9 9
2019 Febrero 0 2 2
2018 Diciembre 2 1 3
2018 Noviembre 3 0 3
2018 Octubre 2 2 4
2018 Septiembre 4 0 4
2018 Marzo 3 0 3
2018 Febrero 86 3 89
2018 Enero 100 8 108
2017 Diciembre 118 10 128
2017 Noviembre 58 6 64
2017 Octubre 62 6 68
2017 Septiembre 55 15 70
2017 Agosto 73 12 85
2017 Julio 77 7 84
2017 Junio 94 9 103
2017 Mayo 50 8 58
2017 Abril 61 9 70
2017 Marzo 76 17 93
2017 Febrero 58 7 65
2017 Enero 59 5 64
2016 Diciembre 72 7 79
2016 Noviembre 106 7 113
2016 Octubre 124 14 138
2016 Septiembre 196 19 215
2016 Agosto 91 7 98
2016 Julio 55 8 63
2016 Junio 25 0 25
2016 Mayo 13 22 35
2016 Abril 22 0 22
2016 Marzo 26 0 26
2016 Febrero 12 4 16
2016 Enero 6 40 46
2015 Diciembre 11 20 31
2015 Noviembre 10 16 26
2015 Octubre 25 17 42
2015 Septiembre 14 0 14
2015 Agosto 24 5 29
2015 Julio 201 3 204
2015 Junio 127 7 134
2015 Mayo 177 14 191
2015 Abril 136 7 143
2015 Marzo 131 2 133
2015 Febrero 102 1 103
2015 Enero 85 0 85
2014 Diciembre 224 0 224
2014 Noviembre 87 0 87
2014 Octubre 102 0 102
2014 Septiembre 102 0 102
2014 Agosto 102 0 102
2014 Julio 103 0 103
2014 Junio 116 0 116
2014 Mayo 145 0 145
2014 Abril 141 0 141
2014 Marzo 154 21 175
2014 Febrero 117 21 138
2014 Enero 123 25 148
2013 Diciembre 98 39 137
2013 Noviembre 49 31 80
2013 Octubre 32 27 59
2013 Septiembre 25 28 53
2013 Agosto 32 35 67
2013 Julio 29 23 52
2013 Junio 36 32 68
2013 Mayo 44 25 69
2013 Abril 28 22 50
2013 Marzo 21 13 34
2013 Febrero 39 8 47
2013 Enero 26 10 36
2012 Diciembre 21 7 28
2012 Noviembre 0 1 1
2012 Octubre 2 2 4
2012 Agosto 1 0 1
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