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"apellidos" => "Toribio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731010002358?idApp=UINPBA000044" "url" => "/00017310/0000010100000006/v1_201304241250/S0001731010002358/v1_201304241250/es/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731010002218" "issn" => "00017310" "doi" => "10.1016/j.ad.2010.03.001" "estado" => "S300" "fechaPublicacion" => "2010-07-01" "aid" => "122" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2010;101:573" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2411 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1772 "PDF" => 606 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">LETTER TO THE EDITOR</span>" "titulo" => "Transverse-section histology for parallel-ridge pattern: reply" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "573" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sección histológica horizontal para el patrón de la cresta: réplica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N. Blázquez, I. Fernández-Canedo, R. Fúnez, M. de Troya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Blázquez" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Fernández-Canedo" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Fúnez" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "de Troya" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731010002218?idApp=UINPBA000044" "url" => "/00017310/0000010100000006/v1_201304241250/S0001731010002218/v1_201304241250/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Transverse-section Histology for Parallel-Ridge Pattern" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "572" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "D. Torchia" "autores" => array:1 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Torchia" "email" => array:1 [ 0 => "dtorchia@med.miami.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Experimental Pathology & Oncology, University of Florence, Florence, Italy" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sección histological horizontal para el patron de la cresta" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p class="elsevierStylePara elsevierViewall">In a recent issue of <span class="elsevierStyleItalic">Actas Dermo-Sifiliográficas</span> Blázquez et al raise the issue on the opportunity to analyse skin biopsies of acral pigmented lesions featuring a parallel-ridge pattern (PRP) after cutting them perpendicularly to the skin markings so that cristae profundae intermediae are included for sure in the tissue section.<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> The Authors conclude that “diagnosis of some suspect pigmented lesions is rendered impossible by the low cellularity of the sample. In such cases, the use of molecular biology techniques would be advisable to detect chromosomal abnormalities associated with acrolentiginous melanoma (…)”.<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a></p><p class="elsevierStylePara elsevierViewall">I wish to point out that transverse-section histology is a cheap and reliable tool to perform dermatoscopic-histologic correlations of acral pigmented lesions as plans of tissue sectioning are parallel to the skin surface and therefore to dermatoscopic visualization of lesions.<a class="elsevierStyleCrossRefs" href="#bib2"><span class="elsevierStyleSup">2,3</span></a> First, transverse-section histology allows a quick, low-magnification scan of the whole excised specimen. Then, higher magnification and analysis of deeper sections of key or “suspicious” dermatoscopic areas achieve and accurate and unambiguous localization of microanatomical structures. Namely, eccrine ducts are cut perpendicularly to their major axis and therefore appear as round or ovalar sections. Epidermal areas containing rows of epidermal ducts are the cristae profundae intermediae, which can be searched thoroughly for atypical/malignant cells and other features (for example melanin columns as a key of benignity) from the overlying corneum till the underlying dermoepidermal junction and dermis. The apparent issue of calculating tumor thickness can be overcome by summing the thickness of all sections overlying the deepest one at which malignant cells are still detected.</p><p class="elsevierStylePara elsevierViewall">In view of these considerations, I propose the following diagnostic iter for acral pigmented lesions featuring a PRP: a) physical examination (possibly with the “furrow-ink test”.<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>); b) dermatoscopy; c) wide excisional biopsy; d) split of the specimen into two halves obtained with a cut which is parallel to the skin markings; e) histological examination of half-lesion with sections cut perpendicularly to the skin markings. If no findings of melanoma are present, then f) the remaining half of the specimen should be analyzed after transverse sectioning.</p><p class="elsevierStylePara elsevierViewall">It is worth reaffirming here, though, that the specificity of PRP as a marker of acral lentiginous melanoma is very high<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a> and that only a handful of PRP-featuring, benign lesions (either pigmented or nonpigmented) have been reported.<a class="elsevierStyleCrossRefs" href="#bib5"><span class="elsevierStyleSup">5–8</span></a> Therefore every lesion showing a PRP should be managed as a melanoma unless top-qualified professionals decide otherwise.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patrón paralelo de la cresta en melanoma acral: importancia del procesamiento de la pieza para el diagnóstico histológico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. 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2015 Julio | 32 | 1 | 33 |
2015 Junio | 25 | 5 | 30 |
2015 Mayo | 39 | 8 | 47 |
2015 Abril | 43 | 5 | 48 |
2015 Marzo | 31 | 2 | 33 |
2015 Febrero | 36 | 0 | 36 |
2015 Enero | 34 | 0 | 34 |
2014 Diciembre | 29 | 1 | 30 |
2014 Noviembre | 25 | 0 | 25 |
2014 Octubre | 37 | 1 | 38 |
2014 Septiembre | 34 | 1 | 35 |
2014 Agosto | 39 | 0 | 39 |
2014 Julio | 43 | 3 | 46 |
2014 Junio | 41 | 1 | 42 |
2014 Mayo | 50 | 1 | 51 |
2014 Abril | 36 | 0 | 36 |
2014 Marzo | 61 | 20 | 81 |
2014 Febrero | 55 | 19 | 74 |
2014 Enero | 37 | 21 | 58 |
2013 Diciembre | 41 | 20 | 61 |
2013 Noviembre | 42 | 18 | 60 |
2013 Octubre | 50 | 18 | 68 |
2013 Septiembre | 57 | 17 | 74 |
2013 Agosto | 40 | 18 | 58 |
2013 Julio | 53 | 39 | 92 |
2013 Junio | 36 | 22 | 58 |
2013 Mayo | 38 | 19 | 57 |
2013 Abril | 30 | 24 | 54 |
2013 Marzo | 43 | 15 | 58 |
2013 Febrero | 25 | 16 | 41 |
2013 Enero | 33 | 9 | 42 |
2012 Diciembre | 21 | 12 | 33 |
2012 Noviembre | 11 | 12 | 23 |
2012 Octubre | 7 | 5 | 12 |
2012 Agosto | 2 | 1 | 3 |
2011 Mayo | 1 | 0 | 1 |
2011 Abril | 3 | 0 | 3 |
2011 Marzo | 9 | 0 | 9 |
2011 Febrero | 8 | 0 | 8 |
2011 Enero | 6 | 0 | 6 |
2010 Diciembre | 4 | 0 | 4 |
2010 Noviembre | 6 | 0 | 6 |
2010 Octubre | 5 | 0 | 5 |
2010 Septiembre | 15 | 0 | 15 |
2010 Agosto | 14 | 0 | 14 |