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con Australia y Nueva Zelanda&#46; En estos pa&#237;ses el melanoma es el cuarto c&#225;ncer m&#225;s frecuente en los hombres y el tercero en las mujeres&#46; El segundo lugar lo ocupa Am&#233;rica del Norte&#59; Europa est&#225; en tercer lugar<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">En Europa se diagnostican aproximadamente 60&#46;000 nuevos casos al a&#241;o &#40;26&#46;100 en varones y 33&#46;300 en mujeres&#41;&#44; lo que representa el 1&#37; de todos los c&#225;nceres diagnosticados en un a&#241;o&#46; Las cifras de incidencia en Europa son ligeramente superiores en mujeres que en varones&#44; 7 y 6 casos por 100&#46;000 personas y a&#241;o respectivamente&#44; tendencia contraria a la del resto del mundo &#40;en los pa&#237;ses con mayores tasas de incidencia&#44; Australia&#44; Nueva Zelanda y Estados Unidos&#44; las cifras son mayores en hombres que en mujeres&#41;&#46; Adem&#225;s&#44; las cifras siguen un gradiente Norte-Sur&#44; de forma que las mayores tasas de incidencia corresponden a los pa&#237;ses n&#243;rdicos&#44; con 15 casos por 100&#46;000 habitantes y a&#241;o aproximadamente<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a>&#46; Por el contrario&#44; son los pa&#237;ses de la cuenca mediterr&#225;nea&#44; entre ellos Espa&#241;a&#44; los que presentan tasas m&#225;s bajas&#44; entre 5&#8211;7 casos por 100&#46;000 habitantes y a&#241;o concretamente<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a>&#44; aunque tambi&#233;n en estos pa&#237;ses se ha producido un aumento importante en los &#250;ltimos a&#241;os<a class="elsevierStyleCrossRef" href="#bib7"><span class="elsevierStyleSup">7</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Paralelo al incremento en la incidencia de melanoma se ha producido en las &#250;ltimas d&#233;cadas un aumento de las l&#237;neas de investigaci&#243;n en torno a este agresivo tumor&#46; El comportamiento biol&#243;gico del melanoma maligno &#40;MM&#41; est&#225; determinado por la interacci&#243;n de una serie de factores que marcar&#225;n el pron&#243;stico del paciente y&#44; en consecuencia&#44; su manejo terap&#233;utico&#46; Mucho se ha avanzado en la gen&#233;tica del tumor para intentar determinar sus bases moleculares<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a>&#44; aunque en la actualidad todav&#237;a no existe ning&#250;n marcador molecular&#44; cromos&#243;mico&#44; inmunohistoqu&#237;mico o histopatol&#243;gico conocido en el tumor primario que pueda predecir c&#243;mo va a comportarse<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">En lo que todos los expertos se ponen de acuerdo es en afirmar que el pron&#243;stico de un paciente diagnosticado de melanoma maligno depender&#225; fundamentalmente de dos factores&#58; el espesor del tumor primario &#40;medido a trav&#233;s del grosor microm&#233;trico de Breslow&#41; y la presencia o ausencia de met&#225;stasis en los ganglios linf&#225;ticos regionales<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Para determinar el estado histol&#243;gico de los ganglios linf&#225;ticos regionales la realizaci&#243;n de la biopsia del ganglio centinela &#40;BGC&#41; se ha convertido en el procedimiento diagn&#243;stico m&#225;s preciso que existe&#46; Se trata de una t&#233;cnica diagn&#243;stica introducida recientemente que persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas con una morbilidad m&#237;nima<a class="elsevierStyleCrossRef" href="#bib11"><span class="elsevierStyleSup">11</span></a>&#46; Esta t&#233;cnica ha superando a otras no invasivas convencionales&#44; como la ecograf&#237;a ganglionar o la tomograf&#237;a por emisi&#243;n de positrones &#40;PET&#41;&#44; que requieren mayor volumen tumoral para detectar met&#225;stasis y&#44; 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como analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Poblaci&#243;n de estudio</span><p class="elsevierStylePara elsevierViewall">Incluimos en el estudio descriptivo a los pacientes atendidos en el Servicio de Dermatolog&#237;a del Hospital Universitario Dr&#46; Peset de Valencia&#44; diagnosticados con informe histopatol&#243;gico de melanoma&#44; a los que se realiz&#243; BGC entre 1998 y 2008 &#40;144 pacientes&#41;&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metodolog&#237;a</span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Biopsia del ganglio centinela</span><p class="elsevierStylePara elsevierViewall">Se realiz&#243; BGC a todos aquellos pacientes a los que se les hab&#237;an extirpado melanomas con espesor tumoral &#40;Breslow&#41; 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se detectaron los GC mediante marcaje con is&#243;topos radiactivos&#59; se determinaron y marcaron los ganglios linf&#225;ticos regionales mediante una linfograf&#237;a isot&#243;pica din&#225;mica tras la inyecci&#243;n intrad&#233;rmica perilesional de contraste &#40;0&#44;5&#8211;1<span class="elsevierStyleHsp" style=""></span>mCi de sulfuro de antimonio coloidal marcado con <span class="elsevierStyleSup">99m</span>Tc&#41;&#44; con la dosis fragmentada en 2&#8211;4 inyecciones&#46; Posteriormente se localizaron y biopsiaron los GC&#46;</p><p class="elsevierStylePara elsevierViewall">Se realiz&#243; un estudio anatomopatol&#243;gico para determinar la existencia de c&#233;lulas tumorales&#46; Para ello los ganglios fueron fijados con formaldeh&#237;do al 5&#37; y embebidos posteriormente en parafina para ser analizados mediante un estudio histopatol&#243;gico rutinario con hematoxilina-eosina&#44; e inmunohistoqu&#237;mico con S100 y HMB45&#44; y realizaci&#243;n de cortes seriados hasta agotar la pieza&#46;</p><p class="elsevierStylePara elsevierViewall">Los pacientes con BGC positiva para c&#233;lulas tumorales fueron sometidos a una segunda intervenci&#243;n quir&#250;rgica para la realizaci&#243;n de una linfadenectom&#237;a de la cadena ganglionar afecta&#46;</p><p class="elsevierStylePara elsevierViewall">El seguimiento posterior de los pacientes se realiz&#243; de acuerdo con los protocolos establecidos para el melanoma en funci&#243;n del estadio TNM del tumor<a class="elsevierStyleCrossRef" href="#bib17"><span class="elsevierStyleSup">17</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Paralelamente a las BGC de los pacientes se realiz&#243; un estudio retrospectivo recogiendo de forma protocolizada informaci&#243;n a partir de la revisi&#243;n de sus historias cl&#237;nicas&#46; Se recogi&#243; el sexo &#40;hombre&#47;mujer&#41;&#44; edad en el momento del diagn&#243;stico &#40;&#8804;25&#44; 26&#8211;45&#44; 46&#8211;65&#44; &#62;65 a&#241;os&#41;&#44; fototipo &#40;I&#44; II&#44; III&#41;&#44; localizaci&#243;n del melanoma &#40;cabeza&#44; tronco&#44; miembro superior&#44; miembro inferior&#44; mucosa&#41;&#44; tipo histol&#243;gico del melanoma &#40;melanoma de extensi&#243;n superficial &#91;MES&#93;&#44; nodular&#44; lentigo maligno melanoma &#91;LMM&#93;&#44; melanoma lentiginoso acral &#91;MLA&#93;&#44; polipoide&#44; amelan&#243;tico&#41;&#44; nivel Breslow &#40;mm&#41; &#40;&#8804;1&#44;0&#59; 1&#44;1&#8211;2&#44;0&#59; 2&#44;1&#8211;4&#44;0&#59; &#62;4&#44;0&#41;&#44; nivel de Clark &#40;I&#44; II&#44; III&#44; IV&#44; V&#41;&#44; ulceraci&#243;n histol&#243;gica &#40;s&#237;&#44; no&#41;&#44; regresi&#243;n histol&#243;gica &#40;s&#237;&#47;no&#41;&#44; estadio inicial &#40;IA&#44; IB&#44; IIA&#44; IIB&#44; IIC&#44; III&#41;&#44; TNM &#40;T1&#44; T2&#44; T3&#44; T4&#41;&#44; cambio de estadio &#40;s&#237;&#47;no&#41; y fallecimiento por melanoma &#40;s&#237;&#47;no&#41;&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis estad&#237;stico</span><p class="elsevierStylePara elsevierViewall">Las variables cuantitativas se estudiaron en funci&#243;n de las medidas de distribuci&#243;n y dispersi&#243;n &#40;media&#44; desviaci&#243;n est&#225;ndar&#41; y las cualitativas mediante su frecuencia absoluta y relativa&#46; Las variables estudiadas se compararon aplicando una prueba de homogeneidad utilizando el estad&#237;stico Chi-cuadrado de Pearson para variables cualitativas y la t de Student para variables cuantitativas&#46; En caso de existir celdas con n&#60;5 se aplic&#243; una prueba exacta por m&#233;todos condicionados &#40;Fisher&#41;&#44; con un nivel de significaci&#243;n bilateral alfa de 0&#44;05&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStylePara elsevierViewall">Un total de 144 pacientes diagnosticados de melanoma entre 1998 y 2008 fueron sometidos a la realizaci&#243;n BGC e incluidos en el estudio&#46; El seguimiento medio de estos pacientes fue de 58&#44;45 meses&#46;</p><p class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl1">tabla 1</a> muestra las caracter&#237;sticas generales de estos pacientes&#46; En ella observamos que el 58&#44;33&#37; son varones y que existe un predominio de pacientes mayores de 45 a&#241;os &#40;edad media 55&#44;10&#177;15&#44;89 a&#241;os&#41;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p class="elsevierStylePara elsevierViewall">El fototipo de piel predominante fue el II&#44; no encontr&#225;ndose en nuestra serie ning&#250;n paciente con fototipo IV&#46;</p><p class="elsevierStylePara elsevierViewall">La localizaci&#243;n anat&#243;mica mayoritaria del melanoma fue el tronco &#40;54&#44;17&#37;&#41;&#44; seguido del miembro inferior &#40;29&#44;86&#37;&#41; y del superior &#40;13&#44;89&#37;&#41;&#46; Tan solo encontramos dos casos en la cabeza y uno en la mucosa genital vulvar&#46;</p><p class="elsevierStylePara elsevierViewall">Respecto a las caracter&#237;sticas histol&#243;gicas destacamos que el melanoma nodular &#40;45&#44;14&#37;&#37;&#41; y el MES &#40;45&#44;14&#37;&#41; supusieron m&#225;s del 90&#37; de los tipos histol&#243;gicos encontrados&#46;</p><p class="elsevierStylePara elsevierViewall">El espesor tumoral de Breslow predominante fue de 1&#44;1 a 2&#44;0<span class="elsevierStyleHsp" style=""></span>mm &#40;nivel medio&#44; 2&#44;16&#177;1&#44;66<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">En la mayor&#237;a de los melanomas encontramos un nivel de Clark de III &#40;54&#44;86&#37;&#41; o IV &#40;26&#44;39&#37;&#41;&#46; La ulceraci&#243;n estuvo presente en el 60&#44;42&#37; de los melanomas estudiados&#46;</p><p class="elsevierStylePara elsevierViewall">En 119 de los 144 casos no constaba la existencia de regresi&#243;n en la historia cl&#237;nica &#40;119 de 144&#41;&#59; en 15 de los 25 pacientes en que constaba este dato hubo regresi&#243;n histol&#243;gica&#44; lo que supone el 60&#37;&#46;</p><p class="elsevierStylePara elsevierViewall">El estadio inicial predominante fue el IB &#40;31&#44;25&#37;&#41; y el T de la estadificaci&#243;n TNM predominante el T2 &#40;38&#44;89&#37;&#41;&#46; Durante el periodo de seguimiento la estadificaci&#243;n inicial no se modific&#243; en la mayor&#237;a de los pacientes &#40;90&#44;28&#37;&#41;&#59; tan solo ocurri&#243; en 14 sujetos &#40;9&#44;72&#37;&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Finalmente fallecieron a causa del melanoma 9 de los 144 pacientes &#40;6&#44;25&#37;&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">El GC se encontr&#243; en 142 pacientes de los 144 sometidos a la t&#233;cnica &#40;98&#44;61&#37;&#41;&#46; En los dos pacientes restantes &#40;1&#44;39&#37;&#41; el contraste no migr&#243; y no se pudo identificar la localizaci&#243;n del GC&#46; En la <a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a> podemos observar las caracter&#237;sticas de los GC encontrados en los 142 pacientes&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p class="elsevierStylePara elsevierViewall">El 84&#44;03&#37; de los pacientes ten&#237;a localizado el GC en una &#250;nica cadena ganglionar&#46; El 13&#44;192&#37; presentaba GC en dos cadenas ganglionares distintas y solamente en el 1&#44;39&#37; de los pacientes se detect&#243; GC en tres cadenas ganglionares&#46;</p><p class="elsevierStylePara elsevierViewall">En cuanto al n&#250;mero de GC encontrados observamos que en la mayor&#237;a de los pacientes &#40;72&#44;92&#37;&#41; se localiz&#243; un &#250;nico ganglio&#46;</p><p class="elsevierStylePara elsevierViewall">Se observaron micromet&#225;stasis &#40;detectadas mediante estudio histopatol&#243;gico e inmunohistoqu&#237;mico&#41; en 28 de los 142 pacientes &#40;19&#44;44&#37;&#41;&#44; que afectaba en el 85&#44;71&#37; de ellos a un solo ganglio&#46; Estos 28 pacientes con micromet&#225;stasis de melanoma fueron sometidos a linfadenectom&#237;a electiva en el territorio ganglionar afecto&#44; y en 5 de estos 28 pacientes &#40;17&#44;86&#37;&#41; la linfadenectom&#237;a electiva detect&#243; m&#225;s ganglios afectos por met&#225;stasis de melanoma&#46;</p><p class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl3">tabla 3</a> muestra las caracter&#237;sticas de los pacientes con ganglios positivos &#40;28&#41; y sin ganglios positivos &#40;114&#41;&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia><p class="elsevierStylePara elsevierViewall">No encontramos asociaci&#243;n estad&#237;sticamente significativa entre el sexo&#44; la edad&#44; el fototipo de piel ni la localizaci&#243;n del melanoma con la presencia de ganglios positivos&#46; Sin embargo&#44; encontramos asociaci&#243;n entre la presencia de ganglios positivos y el tipo histol&#243;gico de melanoma&#44; concretamente se observa una asociaci&#243;n entre el melanoma nodular y la presencia de ganglios positivos &#40;<span class="elsevierStyleItalic">odds ratio</span> cruda &#91;ORc&#93;&#58; 3&#44;44&#59; IC 95&#37;&#58; 1&#44;33&#8211;8&#44;90&#44; con respecto al MES&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Tambi&#233;n encontramos asociaci&#243;n entre el espesor tumoral y la presencia de ganglios positivos&#59; observamos una asociaci&#243;n entre un nivel de Breslow superior a 2&#44;0 y la presencia de ganglios positivos &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#59; nivel &#62;4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Asimismo&#44; en relaci&#243;n con el &#237;ndice de Clark observamos una asociaci&#243;n entre los niveles m&#225;s altos del melanoma &#40;IV concretamente&#41; y la presencia de ganglios positivos &#40;ORc&#58; 8&#44;73&#59; IC 95&#37;&#58; 1&#44;03&#8211;74&#44;12&#41;&#46; La asociaci&#243;n con el nivel V no se pudo valorar debido a que tan solo hab&#237;a un paciente con este nivel&#46;</p><p class="elsevierStylePara elsevierViewall">La ulceraci&#243;n tambi&#233;n se asoci&#243; con la positividad del ganglio centinela&#44; de forma que la posibilidad de tener un ganglio centinela positivo era 4 veces superior si el melanoma estaba ulcerado &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">La regresi&#243;n histol&#243;gica se pudo consignar tan solo en 25 pacientes&#44; todos ellos sin ganglios positivos&#44; por lo que su asociaci&#243;n con la positividad del GC no se pudo valorar&#46;</p><p class="elsevierStylePara elsevierViewall">En cuanto al estadio inicial del melanoma no pudimos encontrar una asociaci&#243;n estad&#237;sticamente significativa con la presencia de ganglios positivos&#44; pero observamos que los 28 pacientes con ganglios positivos presentaban melanomas en estadio III&#44; mientras que los 114 sin ganglios positivos presentaban melanomas en estadios I o II&#46;</p><p class="elsevierStylePara elsevierViewall">El T de la estadificaci&#243;n TNM tambi&#233;n aparece asociado a la presencia de ganglios positivos&#44; concretamente los estadios T3 y T4 se asocian con una mayor positividad &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37;&#58; 1&#44;27&#8211;17&#44;15&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Los pacientes con GC presentaron mayor tendencia a la progresi&#243;n de la enfermedad a lo largo del tiempo de seguimiento&#44; y por tanto un cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Por &#250;ltimo se observa una asociaci&#243;n entre el fallecimiento por melanoma y la positividad del ganglio centinela &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;9&#41;&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p class="elsevierStylePara elsevierViewall">El presente estudio retrospectivo abarca una experiencia de 10 a&#241;os&#46; Debemos tener en cuenta que la BGC es una pr&#225;ctica introducida para el c&#225;ncer cut&#225;neo melanoma en 1992<a class="elsevierStyleCrossRef" href="#bib18"><span class="elsevierStyleSup">18</span></a>&#44; y que por tanto la mayor parte de los estudios retrospectivos abarcan una experiencia de menor tiempo&#46; Por ejemplo&#44; Avil&#233;s-Izquierdo et al analizaron los resultados obtenidos durante 7 a&#241;os recopilando una serie de 155 pacientes<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">En nuestra serie recogimos 144 pacientes que cumpl&#237;an como principal premisa un diagn&#243;stico de melanoma con un espesor tumoral de Breslow &#8805;1<span class="elsevierStyleHsp" style=""></span>mm&#59; en 33 de estos pacientes &#40;22&#44;92&#37;&#41; los criterios fueron la ulceraci&#243;n o el nivel de Clark &#8805;IV con Breslow menor de 1<span class="elsevierStyleHsp" style=""></span>mm&#46; Aunque a lo largo de estos a&#241;os se ha modificado alg&#250;n criterio de inclusi&#243;n para la realizaci&#243;n de la BGC&#44; siguen sin estar perfectamente definidos&#46; Si consideramos los nuevos criterios del <span class="elsevierStyleItalic">National Comprehensive Cancer Network</span> &#40;NCCN&#41;<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a> para el manejo del melanoma &#40;espesor tumoral &#8805;1<span class="elsevierStyleHsp" style=""></span>mm&#44; alto &#237;ndice mit&#243;tico o espesor tumoral de Breslow &#8805;0&#44;75<span class="elsevierStyleHsp" style=""></span>mm con Clark IV&#47;V&#41;<a class="elsevierStyleCrossRefs" href="#bib20"><span class="elsevierStyleSup">20&#44;21</span></a>&#44; todos nuestros pacientes seguir&#237;an teniendo indicaci&#243;n para la realizaci&#243;n la BGC&#46;</p><p class="elsevierStylePara elsevierViewall">Las tasas estandarizadas para la poblaci&#243;n mundial por 100&#46;000 habitantes conceden una incidencia de melanoma discretamente superior para mujeres que para hombres &#40;5&#44;50 y 5&#44;30&#44; respectivamente&#41;<a class="elsevierStyleCrossRef" href="#bib22"><span class="elsevierStyleSup">22</span></a>&#46; En nuestro estudio encontramos un predominio de hombres&#46; En cualquier caso debemos tener presente que estamos trabajando con un subgrupo de pacientes con diagn&#243;stico de melanoma que estar&#225; sesgado&#44; al excluir s&#243;lo los melanomas de mayor grado&#44; que son los que con menor frecuencia se detectan en mujeres<a class="elsevierStyleCrossRef" href="#bib23"><span class="elsevierStyleSup">23</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">La localizaci&#243;n anat&#243;mica fundamental del melanoma primario fue el tronco&#44; lo que coincide con el notable incremento de melanomas en el tronco observado en otros estudios&#44; sobre todo los realizados en pa&#237;ses con alta incidencia de melanoma<a class="elsevierStyleCrossRef" href="#bib23"><span class="elsevierStyleSup">23</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">El tipo histol&#243;gico nodular aparece en la misma frecuencia que el MES&#44; lo cual difiere con los datos obtenidos de otros estudios&#46; Por ejemplo&#44; Avil&#233;s-Izquierdo et al<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a> encontraron una frecuencia muy superior de MES &#40;44&#44;70&#37;&#41; respecto del melanoma nodular &#40;18&#44;80&#37;&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">El espesor tumoral medio de Breslow en los pacientes estudiados fue de 2&#44;160&#177;1&#44;6593<span class="elsevierStyleHsp" style=""></span>mm&#44; similar al detectado por otros autores<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">De los 144 pacientes a los que se les realiz&#243; la biopsia selectiva del ganglio centinela&#44; en 28 &#40;19&#44;44&#37;&#41; se detectaron micromet&#225;stasis de melanoma&#44; porcentaje similar a los encontrados por Morton et al<a class="elsevierStyleCrossRef" href="#bib20"><span class="elsevierStyleSup">20</span></a> &#40;16&#37;&#41; y por Avil&#233;s-Izquierdo et al<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a> &#40;21&#44;30&#37;&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Al analizar las variables histol&#243;gicas del melanoma primario en relaci&#243;n con la positividad del GC encontramos un predominio del melanoma nodular y polipoide en pacientes con ganglios positivos&#46; Por el contrario&#44; no se encontr&#243; ning&#250;n ganglio positivo en casos de LMM ni de MLA&#46; Este hallazgo contrasta en parte con los resultados obtenidos por Avil&#233;s-Izquierdo et al<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a>&#44; que detectaron&#44; adem&#225;s de los melanomas nodulares&#44; los acrolentiginosos como los tipos histol&#243;gicos m&#225;s frecuentes en pacientes con ganglios positivos&#46; Esta diferencia podr&#237;a deberse al bajo n&#250;mero de pacientes con melanomas lentiginosos acrales en nuestro estudio &#40;tan solo 4 de los 144 pacientes estudiados&#41;&#46;</p><p class="elsevierStylePara elsevierViewall">Tambi&#233;n encontramos asociaci&#243;n entre un espesor tumoral de Breslow elevado &#40;&#62;2&#44;0&#41; y una biopsia selectiva del GC positiva&#46; Tan solo un paciente con espesor tumoral &#8804;1<span class="elsevierStyleHsp" style=""></span>mm present&#243; ganglios positivos&#44; coincidiendo con los resultados obtenidos por Cu&#233;llar et al<a class="elsevierStyleCrossRef" href="#bib13"><span class="elsevierStyleSup">13</span></a>&#46; Esto confirma la poca utilidad de la t&#233;cnica en melanomas de espesor inferior a 1<span class="elsevierStyleHsp" style=""></span>mm&#46;</p><p class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; debemos tener en cuenta que la asociaci&#243;n entre BGC positiva y melanomas nodulares podr&#237;a estar sesgada en parte por el mayor espesor tumoral de Breslow que suelen tener estos tumores en el momento del diagn&#243;stico&#46;</p><p class="elsevierStylePara elsevierViewall">Tambi&#233;n detectamos que la proporci&#243;n de melanomas con GC positivos aumenta en funci&#243;n del nivel histol&#243;gico de Clark para II&#44; III y IV&#59; el &#250;nico paciente de nuestra serie con un Clark V tuvo un resultado del GC negativo&#59; este resultado podr&#237;a deberse a un fallo en la t&#233;cnica&#44; o cabe considerar que la v&#237;a de diseminaci&#243;n de este tumor no fuera linf&#225;tica&#44; ya que el paciente presentaba m&#250;ltiples met&#225;stasis cut&#225;neas en tr&#225;nsito sin adenopat&#237;as 12 meses despu&#233;s del diagn&#243;stico&#46;</p><p class="elsevierStylePara elsevierViewall">La presencia de ulceraci&#243;n en pacientes con BGC positiva fue significativamente superior que en aquellos con BGC negativa&#44; de forma que un melanoma ulcerado presentaba un riesgo 4&#44;86 veces superior de tener una BGC positiva que uno no ulcerado&#46;</p><p class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; los estadios T3 y T4 de la clasificaci&#243;n TNM para el melanoma &#40;que engloba el espesor tumoral de Breslow y la ulceraci&#243;n&#41; se asociaron tambi&#233;n con la positividad del GC&#46;</p><p class="elsevierStylePara elsevierViewall">Si hablamos en t&#233;rminos de supervivencia y estado vital de los pacientes al final del estudio&#44; comprobamos que existe una asociaci&#243;n entre la presencia de GC positivo y el cambio de estadio del melanoma&#46; Adem&#225;s&#44; se confirma la asociaci&#243;n entre la positividad del GC y el fallecimiento por melanoma ya detectada por otros autores<a class="elsevierStyleCrossRef" href="#bib14"><span class="elsevierStyleSup">14</span></a>&#46; En nuestro trabajo se confirma la importancia pron&#243;stica que otorga la BGC respecto a la esperanza de no fallecer por melanoma&#46; Por todo lo anteriormente expuesto podemos considerar que un resultado positivo en la BGC permite identificar&#44; en pacientes con espesor tumoral de Breslow &#62;1<span class="elsevierStyleHsp" style=""></span>mm&#44; a aquellos que van a presentar mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por esta causa&#44; lo que otorga a la t&#233;cnica una utilidad pron&#243;stica clara&#44; como otros estudios ya hab&#237;an apuntado<a class="elsevierStyleCrossRef" href="#bib14"><span class="elsevierStyleSup">14</span></a>&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un aumento mundial de la incidencia de melanoma&#46; Su pron&#243;stico depende entre otros factores de la existencia de met&#225;stasis en los ganglios linf&#225;ticos regionales&#46; La realizaci&#243;n de la biopsia del ganglio centinela persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas como factor pron&#243;stico de la enfermedad&#46; El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma&#44; positivos y negativos a la biopsia del ganglio centinela&#44; y analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow &#8805;1<span class="elsevierStyleHsp" style=""></span>mm o con Breslow &#60;1<span class="elsevierStyleHsp" style=""></span>mm y ulceraci&#243;n&#44; nivel de Clark IV&#8211;V o regresi&#243;n&#46; Aquellos con biopsia positiva fueron sometidos a linfadenectom&#237;a&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Adem&#225;s&#44; se recogieron las siguientes variables&#58; sexo&#44; edad&#44; fototipo&#44; localizaci&#243;n y tipo de melanoma&#44; niveles Breslow y Clark&#44; ulceraci&#243;n&#44; regresi&#243;n&#44; estadio inicial&#44; TNM&#44; cambio de estadio y fallecimiento por melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 19&#44;44&#37; de los pacientes present&#243; ganglios positivos&#46; Esta positividad se present&#243; asociada con el melanoma nodular &#40;<span class="elsevierStyleItalic">odds ratio</span> cruda &#91;ORc&#93;&#58; 3&#44;44&#59; intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#58; 1&#44;33&#8211;8&#44;90&#41; con respecto al melanoma de extensi&#243;n superficial Breslow superior a 2&#44;0 &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#44; nivel &#62;4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#44; nivel Clark IV &#40;ORc&#58; 8&#44;73&#59; IC 95&#37; 1&#44;03&#8211;74&#44;12&#41;&#44; ulceraci&#243;n &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#44; estadios T3 y T4 &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37; 1&#44;27&#8211;17&#44;15&#41;&#44; cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41; y fallecimiento por melanoma &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;96&#44;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados confirman la importancia pron&#243;stica de la biopsia del ganglio centinela&#44; que permite identificar a los pacientes con mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por melanoma&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The incidence of melanoma is currently increasing worldwide&#46; One of the factors influencing disease prognosis is the presence of regional lymph node metastases&#46; Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease&#46; The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics&#58; Breslow thickness &#8805;1<span class="elsevierStyleHsp" style=""></span>mm&#44; Breslow thickness &#60;1<span class="elsevierStyleHsp" style=""></span>mm with ulceration&#44; Clark level IV&#8211;V&#44; or regression&#46; Lymphadenectomy was performed in patients with positive sentinel node biopsy&#46; Data were also collected on the following variables&#58; sex&#44; age&#44; skin phototype&#44; site and type of melanoma&#44; Breslow depth&#44; Clark level&#44; ulceration&#44; regression&#44; cancer stage at diagnosis&#44; TNM classification&#44; change in cancer stage during follow-up&#44; and death due to melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Positive sentinel node biopsies were recorded in 19&#46;44&#37; of patients&#46; Positive results were associated with the following variables&#58; nodular melanoma &#40;crude <span class="elsevierStyleItalic">odds ratio</span> &#91;ORc&#93; compared with superficial spreading melanoma&#44; 3&#46;44&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;33&#8211;8&#46;90&#41;&#59; Breslow thickness &#62;2&#46;0&#44; for a thickness of 2&#46;1&#8211;4&#46;0 &#40;ORc&#44; 21&#46;12&#59; 95&#37; CI&#44; 2&#46;60&#8211;172&#46;03&#41; and for a thickness &#62;4&#46;0 &#40;ORc&#44; 23&#46;25&#59; 95&#37; CI&#44; 2&#46;44&#8211;221&#46;73&#41;&#59; Clark level IV &#40;ORc&#44; 8&#46;73&#59; 95&#37; CI&#44; 1&#46;03&#8211;74&#46;12&#41;&#59; ulceration &#40;ORc&#44; 4&#46;86&#59; 95&#37; CI&#44; 1&#46;58&#8211;14&#46;90&#41;&#59; T3 &#40;ORc&#44; 4&#46;20&#59; 95&#37; CI&#44; 1&#46;52&#8211;11&#46;63&#41; and T4 &#40;ORc&#44; 4&#46;67&#59; 95&#37; CI&#44; 1&#46;27&#8211;17&#46;15&#41; in the TNM classification&#59; change in cancer stage during follow-up &#40;ORc&#44; 7&#46;20&#59; 95&#37; CI&#44; 2&#46;25&#8211;22&#46;99&#41;&#59; and death due to melanoma &#40;ORc&#44; 8&#46;67&#59; 95&#37; CI&#44; 3&#46;62&#8211;96&#46;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">These results confirm the prognostic importance of sentinel lymph node biopsy&#44; which facilitates identification of patients with a greater tendency towards disease progression and death due to melanoma&#46;</p>"
      ]
    ]
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        "tabla" => array:3 [
          "leyenda" => "<p class="elsevierStyleSimplePara elsevierViewall">Valor de p&#58; prueba de Chi cuadrado &#40;p&#60;0&#44;05&#41;&#46; LMM&#58; lentigo maligno melanoma&#59; MES&#58; melanoma de extensi&#243;n superficial&#59; MLA&#58; melanoma lentiginoso acral&#59; TNM&#58; tumor&#44; adenopat&#237;a&#44; met&#225;stasis&#46;</p>"
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                  \t\t\t\t">20&#44;83 &#40;14&#44;79&#8211;28&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>46&#8211;65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">60&#44;42 &#40;52&#44;26&#8211;68&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;64 &#40;25&#44;36&#8211;40&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;39 &#40;0&#44;23&#8211;4&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="5" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tronco&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">54&#44;17 &#40;45&#44;98&#8211;62&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Miembro superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;89 &#40;8&#44;94&#8211;20&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Miembro inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;86 &#40;22&#44;81&#8211;37&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mucosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;69 &#40;0&#44;003&#8211;3&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo histol&#243;gico del melanoma</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MES&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;14 &#40;37&#44;15&#8211;53&#44;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="6" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;14 &#40;37&#44;15&#8211;53&#44;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LMM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;78 &#40;0&#44;89&#8211;6&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MLA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;78 &#40;0&#44;89&#8211;6&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polipoide&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;78 &#40;0&#44;89&#8211;6&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Amelan&#243;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;39 &#40;0&#44;23&#8211;4&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nivel de Breslow &#40;mm&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8804; 1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;92 &#40;16&#44;60&#8211;30&#44;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#44;1&#8211;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;89 &#40;31&#44;18&#8211;47&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&#44;1&#8211;4&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;39 &#40;19&#44;68&#8211;34&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;72 &#40;5&#44;64&#8211;15&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nivel de Clark</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="5" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;03 &#40;5&#44;11&#8211;14&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;86 &#40;46&#44;68&#8211;62&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;39 &#40;19&#44;68&#8211;34&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;69 &#40;0&#44;003&#8211;3&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ulceraci&#243;n histol&#243;gica</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;58 &#40;31&#44;84&#8211;47&#44;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;42 &#40;52&#44;26&#8211;68&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regresi&#243;n histol&#243;gica<a class="elsevierStyleCrossRef" href="#tblfn1hashx0002A"><span class="elsevierStyleSup">&#42;</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;00 &#40;22&#44;41&#8211;59&#44;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">0&#44;157</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;00 &#40;40&#44;21&#8211;77&#44;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estadio inicial</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;72 &#40;5&#44;64&#8211;15&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="6" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;25 &#40;24&#44;08&#8211;39&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IIA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;44 &#40;13&#44;59&#8211;26&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IIB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;67 &#40;11&#44;24&#8211;23&#44;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IIC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;47 &#40;1&#44;28&#8211;7&#44;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;44 &#40;13&#44;59&#8211;26&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clasificaci&#243;n TNM</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;22 &#40;15&#44;99&#8211;29&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;89 &#40;31&#44;18&#8211;47&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;47 &#40;21&#44;55&#8211;36&#44;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;42 &#40;6&#44;18&#8211;16&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cambio de estadio</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;28 &#40;84&#44;59&#8211;94&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;72 &#40;5&#44;64&#8211;15&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fallecimiento por melanoma</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;75 &#40;88&#44;84&#8211;96&#44;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;25 &#40;3&#44;09&#8211;11&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas generales y cl&#237;nicas de la poblaci&#243;n objeto de estudio &#40;n&#61;144&#41;</p>"
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          "leyenda" => "<p class="elsevierStyleSimplePara elsevierViewall">Valor de p&#58; prueba de Chi cuadrado &#40;p&#60;0&#44;05&#41;&#46;</p>"
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            0 => array:2 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Porcentaje &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localizaci&#243;n</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1 territorio ganglionar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;03 &#40;77&#44;35&#8211;89&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2 territorio ganglionar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;19 &#40;8&#44;38&#8211;19&#44;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3 territorio ganglionar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;39 &#40;0&#44;23&#8211;4&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; de ganglios centinela encontrados</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;92 &#40;65&#44;22&#8211;79&#44;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;36 &#40;11&#44;82&#8211;24&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;64 &#40;4&#44;08&#8211;12&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;69 &#40;0&#44;03&#8211;3&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Micromet&#225;stasis</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;17 &#40;71&#44;96&#8211;85&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;44 &#40;13&#44;59&#8211;26&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; de ganglios centinela con micromet&#225;stasis</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;17 &#40;71&#44;96&#8211;85&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;67 &#40;11&#44;24&#8211;23&#44;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;08 &#40;0&#44;53&#8211;5&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;69 &#40;0&#44;03&#8211;3&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linfadenectom&#237;a</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;17 &#40;71&#44;96&#8211;85&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;44 &#40;13&#44;59&#8211;26&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#44;14 &#40;64&#44;76&#8211;93&#44;15&#41;<a class="elsevierStyleCrossRef" href="#tblfn2hashx0002A"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">&#60;0&#44;001</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Positiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;86 &#40;6&#44;85&#8211;35&#44;24&#41;<a class="elsevierStyleCrossRef" href="#tblfn2hashx0002A"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara">Calculados sobre el total de linfadenectom&#237;as practicadas &#40;n&#61;28&#41;&#46;</p>"
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        "descripcion" => array:1 [
          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas de los ganglios centinela &#40;n&#61;142&#41;</p>"
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          "leyenda" => "<p class="elsevierStyleSimplePara elsevierViewall">Valor de p&#58; prueba de Chi cuadrado &#40;p&#60;0&#44;05&#41;&#46; LMM&#58; lentigo maligno melanoma&#59; MES&#58; melanoma de extensi&#243;n superficial&#59; MLA&#58; melanoma lentiginoso acral&#59; Ref&#46;&#58; nivel de referencia&#59; TNM&#58; tumor&#44; adenopat&#237;a&#44; met&#225;stasis&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Sin ganglios positivos &#40;n&#61;114&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Con ganglios positivos &#40;n&#61;28&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Valor de p</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Porcentaje &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Porcentaje &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">ORc &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hombre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#44;72 &#40;71&#44;18&#8211;88&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;28 &#40;11&#44;85&#8211;28&#44;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="char" valign="middle">0&#44;875</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;66 &#40;67&#44;98&#8211;88&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;34 &#40;11&#44;51&#8211;32&#44;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;07 &#40;0&#44;46&#8211;2&#44;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8804;25 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#44;00 &#40;71&#44;69&#8211;100&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00 &#40;0&#44;00&#8211;28&#44;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="char" valign="middle">0&#44;237</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>26&#8211;45 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#44;21 &#40;70&#44;00&#8211;95&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;79 &#40;4&#44;54&#8211;30&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;Ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>46&#8211;65 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;66 &#40;67&#44;98&#8211;88&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;34 &#40;11&#44;51&#8211;32&#44;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;60 &#40;0&#44;47&#8211;5&#44;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;65 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;33 &#40;59&#44;07&#8211;84&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;67 &#40;15&#44;32&#8211;40&#44;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;27 &#40;0&#44;65&#8211;7&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fototipo</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#44;61 &#40;69&#44;64&#8211;91&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;39 &#40;8&#44;42&#8211;30&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="char" valign="middle">0&#44;244</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;39 &#40;72&#44;13&#8211;88&#44;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;09 &#40;0&#44;43&#8211;2&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">60&#44;00 &#40;29&#44;11&#8211;85&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">40&#44;00 &#40;14&#44;23&#8211;70&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">3&#44;17 &#40;0&#44;72&#8211;13&#44;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localizaci&#243;n del melanoma</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cabeza&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#44;00 &#40;22&#44;36&#8211;100&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;00 &#40;0&#44;00&#8211;77&#44;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="5" align="char" valign="middle">0&#44;691</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mucosa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">100&#44;00 &#40;5&#44;00&#8211;100&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Miembro superior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#44;00 &#40;64&#44;39&#8211;96&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15&#44;00 &#40;3&#44;96&#8211;35&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tronco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;82 &#40;72&#44;02&#8211;89&#44;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;18 &#40;10&#44;74&#8211;27&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;26 &#40;0&#44;2&#8211;4&#44;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Miembro inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;81 &#40;59&#44;04&#8211;85&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;19 &#40;14&#44;61&#8211;40&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;01 &#40;0&#44;49&#8211;8&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo histol&#243;gico del melanoma</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LMM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#44;00 &#40;47&#44;29&#8211;100&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00 &#40;0&#44;00&#8211;52&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="5" align="char" valign="middle">0&#44;036</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MLA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">100&#44;00 &#40;47&#44;29&#8211;100&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;00 &#40;0&#44;00&#8211;52&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Amelan&#243;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MES&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nodular&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">70&#44;31 &#40;58&#44;30&#8211;80&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;69 &#40;19&#44;48&#8211;41&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">3&#44;44 &#40;1&#44;33&#8211;8&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polipoide&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">50&#44;00 &#40;9&#44;43&#8211;90&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">50&#44;00 &#40;9&#44;43&#8211;90&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">8&#44;14 &#40;0&#44;99&#8211;67&#44;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Regresi&#243;n histol&#243;gica<a class="elsevierStyleCrossRef" href="#tblfn3hashx0002A"><span class="elsevierStyleSup">&#42;</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  "referenciaCompleta" => "National Comprehensive Cancer Network&#44; Clinical Practice Guidelines in Oncology 2009&#46; &#91;consultado&#58; 5&#47;5&#47;2009&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.nccn.org/index.asp">http&#58;&#47;&#47;www&#46;nccn&#46;org&#47;index&#46;asp</a>"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micrometastasis of sentinel lymph node in cutaneous melanoma is a significant prognostic factor for disease-free survival&#44; distant-metastasis-free survival&#44; and overall survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Moehite"
                            1 => "W&#46; Schippert"
                            2 => "G&#46; Rassner"
                            3 => "C&#46; Garbe"
                            4 => "H&#46; Breuninger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2004.30376.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2004"
                        "volumen" => "30"
                        "paginaInicial" => "1319"
                        "paginaFinal" => "1328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15458529"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An evidence-based staging system for cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Balch"
                            1 => "S&#46; Soong"
                            2 => "M&#46;B&#46; Atkins"
                            3 => "A&#46;C&#46; Buzaid"
                            4 => "N&#46; Cascinelli"
                            5 => "D&#46;G&#46; Coit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2004"
                        "volumen" => "54"
                        "paginaInicial" => "131"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15195788"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Small cell melanoma and ulceration as predictors of positive sentinel lymph node in malignant melanoma patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;A&#46; Cu&#233;llar"
                            1 => "A&#46; Vilalta"
                            2 => "R&#46; Rull"
                            3 => "S&#46; Vidal-Sicart"
                            4 => "J&#46; Palou"
                            5 => "P&#46;J&#46; Ventura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2004"
                        "volumen" => "14"
                        "paginaInicial" => "277"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15305158"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sentinel lymph node biopsy in melanoma patients with clinically negative regional lymph nodes- one institution&#39;s experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Z&#46;I&#46; Nowecki"
                            1 => "P&#46; Rutkowski"
                            2 => "A&#46; Nasierowska-Guttmejer"
                            3 => "W&#46; Ruka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.cmr.0000056207.78713.8b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "35"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12569283"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Bedrosian"
                            1 => "M&#46;B&#46; Faries"
                            2 => "D&#46;T&#46; Guerry"
                            3 => "R&#46; Elenitsas"
                            4 => "L&#46; Schuchter"
                            5 => "R&#46; Mick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg Oncol"
                        "fecha" => "2000"
                        "volumen" => "7"
                        "paginaInicial" => "262"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10819365"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Gu&#237;a de prevenci&#243;n y tratamiento del melanoma&#46; Generalitat Valenciana&#46; Conselleria de Sanitat&#46; &#91;consultado&#58; 7&#47;9&#47;2009&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://publicaciones.san.gva.es/publicaciones/documentos/V.5234-2006.pdf">http&#58;&#47;&#47;publicaciones&#46;san&#46;gva&#46;es&#47;publicaciones&#47;documentos&#47;V&#46;5234-2006&#46;pdf</a>"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Balch"
                            1 => "A&#46;C&#46; Buzaid"
                            2 => "S&#46;J&#46; Soong"
                            3 => "M&#46;B&#46; Atkins"
                            4 => "N&#46; Cascinelli"
                            5 => "D&#46;G&#46; Coit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.2001.19.16.3635"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2001"
                        "volumen" => "19"
                        "paginaInicial" => "3635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11504745"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Technical details of intraoperative lymphatic mapping for early stage melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;L&#46; Morton"
                            1 => "D&#46;r&#46; Wen"
                            2 => "J&#46;H&#46; Wong"
                            3 => "J&#46;S&#46; Economou"
                            4 => "L&#46;A&#46; Cagle"
                            5 => "F&#46;K&#46; Storm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "1992"
                        "volumen" => "127"
                        "paginaInicial" => "392"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1558490"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biopsia del ganglio centinela en pacientes con melanoma&#46; Resultados de 7 a&#241;os de experiencia &#40;1997&#8211;2003&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Avil&#233;s-Izquierdo"
                            1 => "P&#46; L&#225;zaro-Ochaita"
                            2 => "M&#46; Lecona-Echeverr&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2006"
                        "volumen" => "2"
                        "paginaInicial" => "281"
                        "paginaFinal" => "288"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sentinel-node biopsy or nodal observation in melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;L&#46; Morton"
                            1 => "J&#46;F&#46; Thompson"
                            2 => "A&#46;J&#46; Cochran"
                            3 => "N&#46; Mozzillo"
                            4 => "R&#46; Elashoff"
                            5 => "R&#46; Essner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa060992"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2006"
                        "volumen" => "355"
                        "paginaInicial" => "1307"
                        "paginaFinal" => "1317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17005948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "NCCN Clinical Practice Guidelines in Oncology&#58; Melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;G&#46; Coit"
                            1 => "R&#46; Andtbacka"
                            2 => "C&#46;K&#46; Bichakjian"
                            3 => "R&#46;A&#46; Dilawari"
                            4 => "D&#46; Dimaio"
                            5 => "V&#46; Guild"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Compr Canc Netw"
                        "fecha" => "2009"
                        "volumen" => "7"
                        "paginaInicial" => "250"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19401060"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "IARC- International Agency for Research on Cancer&#46; &#91;consultado&#58; 11&#47;9&#47;2009&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www-dep.iarc.fr/globocan">http&#58;&#47;&#47;www-dep&#46;iarc&#46;fr&#47;globocan</a>&#59; 2002&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "EUROCARE-3&#58; survival of cancer patients diagnosed 1990&#8211;94&#46; Results and commentary"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "and the EUROCARE Working Group"
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Sant"
                            1 => "T&#46; Aareleid"
                            2 => "F&#46; Berrino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "61"
                        "paginaFinal" => "118"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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