array:23 [
  "pii" => "S1578219008702713"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(08)70271-3"
  "estado" => "S300"
  "fechaPublicacion" => "2008-06-01"
  "aid" => "70271"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2008;99:380-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2931
    "formatos" => array:3 [
      "EPUB" => 38
      "HTML" => 1657
      "PDF" => 1236
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219008702725"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70272-5"
    "estado" => "S300"
    "fechaPublicacion" => "2008-06-01"
    "aid" => "70272"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:390-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5187
      "formatos" => array:3 [
        "EPUB" => 36
        "HTML" => 1469
        "PDF" => 3682
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Superficial Migratory Thrombophlebitis&#58; A Clinical and Histologic Review of 8 Cases"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "390"
          "paginaFinal" => "395"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tromboflebitis Superficial Migratoria&#58; Revisi&#243;n Cl&#237;nica e Histol&#243;gica de 8 Casos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Laguna, V&#46; Alegre, A&#46; P&#233;rez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Laguna"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Alegre"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702725?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000005/v1_201304241433/S1578219008702725/v1_201304241433/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219008702701"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70270-1"
    "estado" => "S300"
    "fechaPublicacion" => "2008-06-01"
    "aid" => "70270"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:373-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2183
      "formatos" => array:3 [
        "EPUB" => 36
        "HTML" => 1479
        "PDF" => 668
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Scientific Output of Spanish Dermatology Departments in International Journals&#44; 1997-2006"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "373"
          "paginaFinal" => "379"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Producci&#243;n Cient&#237;fica de los Servicios de Dermatolog&#237;a Espa&#241;oles en Revistas Internacionales&#58; 1997-2006"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Belinch&#243;n, J&#46;M&#46; Ramos"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n"
            ]
            1 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Ramos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702701?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000005/v1_201304241433/S1578219008702701/v1_201304241433/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
    "titulo" => "Correlation Between Clinical&#44; Dermatoscopic&#44; and Histopathologic Variables in Atypical Melanocytic Nevi"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "380"
        "paginaFinal" => "389"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46;M&#46; Morales-Callaghan, J&#46; Castrodeza-Sanz, G&#46; Mart&#237;nez-Garc&#237;a, I&#46; Peral-Mart&#237;nez, A&#46; Miranda-Romero"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Morales-Callaghan"
            "email" => array:1 [
              0 => "acallaghan&#64;aedv&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Castrodeza-Sanz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Mart&#237;nez-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "Peral-Mart&#237;nez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Miranda-Romero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Preventiva&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Ana Mar&#237;a Morales-Callaghan&#44; C&#47; Barcelona&#44; 67&#44; 1<span class="elsevierStyleSup">a</span>&#44; 50017 Zaragoza&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Estudio de Correlaci&#243;n Cl&#237;nica&#44; Dermatosc&#243;pica e Histopatol&#243;gica de Nevus Melanoc&#237;ticos At&#237;picos"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2007-09-14"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84198"
          "palabras" => array:3 [
            0 => "atypical melanocytic nevus"
            1 => "dermatoscopy"
            2 => "correlation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84197"
          "palabras" => array:3 [
            0 => "nevus melanoc&#237;tico at&#237;pico"
            1 => "dermatoscopia"
            2 => "correlaci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Atypical melanocytic nevi are acquired melanocytic lesions that were described for the first time by Clark in studies of melanocytic nevi in patients with melanomas&#46; Today&#44; the use of dermatoscopy has made identification of this type of nevus much easier&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Our aim was to study the correlation between the clinical&#44; dermatoscopic&#44; and histopathologic findings of melanocytic nevi and compare our findings with those of previous studies&#46; We also aimed to investigate the value of dermatoscopy for identifying atypical melanocytic nevi&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this cross-sectional&#44; observational study&#44; 200 melanocytic lesions were analyzed in 166 patients examined between January 1&#44; 2005 and December 31&#44; 2005&#46; We recorded the clinical&#44; dermatoscopic&#44; and histopathologic characteristics of each lesion and established the correlation between the different findings on a case-by-case basis&#46; We then determined the agreement between diagnoses and assessed the value of dermatoscopy for identifying atypical melanocytic melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The clinical characteristics associated with atypical histology were a macular component &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; irregular borders&#44; and presence of 3 or more colors&#46; Asymmetry&#44; diameter greater than 5 or 6 mm&#44; and progression were not associated with atypical histopathologic characteristics &#40;<span class="elsevierStyleItalic">P</span>&#62;&#46;05&#41;&#46; Agreement between clinical and histologic diagnosis was weak &#40;&#954;&#61;0&#46;38&#41;&#44; whereas the agreement between dermatoscopic and histologic diagnosis was moderate &#40;&#954;&#61;0&#46;52&#41;&#46; The area under the receiver operating characteristic curve for the model that included dermatoscopy was larger than that for the model that only included clinical data&#44; and this difference was statistically significant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Atypical clinical features were not found to correspond to atypical histology&#46; Dermatoscopy improved the accuracy of clinical diagnosis of atypical melanocytic nevus&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Los nevus melanoc&#237;ticos at&#237;picos &#40;NMA&#41; son lesiones melanoc&#237;ticas adquiridas descritas por primera vez por Clark en estudios de nevus melanoc&#237;ticos &#40;NM&#41; en pacientes con melanomas&#46; Actualmente&#44; el uso de la dermatoscopia ha facilitado en gran medida la identificaci&#243;n de esta variante de nevus&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar la correlaci&#243;n entre los hallazgos cl&#237;nicos&#44; dermatosc&#243;picos e histopatol&#243;gicos de los NM a estudio y comparar nuestros resultados con trabajos previos&#46; Establecer el valor de la dermatoscopia para la identificaci&#243;n de NMA&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; transversal de 200 lesiones melanoc&#237;ticas correspondientes a 166 pacientes&#44; llevado a cabo desde el 1 de enero de 2005 hasta el 31 de diciembre de 2005&#46; Describimos las caracter&#237;sticas cl&#237;nicas&#44; dermatosc&#243;picas e histopatol&#243;gicas de cada lesi&#243;n y establecimos la correlaci&#243;n entre los diferentes hallazgos obtenidos&#44; caso por caso&#46; Posteriormente determinamos la concordancia entre diagn&#243;sticos y establecimos el valor de la dermatoscopia para la identificaci&#243;n de NMA&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Las caracter&#237;sticas cl&#237;nicas que se asociaron a atipia histol&#243;gica fueron componente macular &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; bordes irregulares y presencia de tres o m&#225;s colores&#46; La asimetr&#237;a&#44; di&#225;metro mayor de 5 o 6<span class="elsevierStyleHsp" style=""></span>mm o la evoluci&#243;n no se correspondieron con atipia desde el punto de vista histopatol&#243;gico &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La concordancia entre diagn&#243;stico cl&#237;nico e histol&#243;gico fue baja &#40;&#237;ndice kappa ponderado &#91;Kp&#93;&#58; 0&#44;38&#41;&#44; mientras que entre diagn&#243;stico dermatosc&#243;pico e histol&#243;gico fue moderada &#40;&#237;ndice Kp&#58; 0&#44;52&#41;&#46; Mediante curvas ROC &#40;receiver operating characteristic&#41; comprobamos que el modelo que conten&#237;a la dermatoscopia presentaba un incremento bajo la curva estad&#237;sticamente significativo respecto al modelo que s&#243;lo inclu&#237;a los datos cl&#237;nicos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La atipia cl&#237;nica no es equivalente a atipia histol&#243;gica&#46; La dermatoscopia mejora la precisi&#243;n del diagn&#243;stico cl&#237;nico de NMA&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:34 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Origin of familial malignant melanomas from heritable melanocytic lesions&#58; the B-K mole syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46;HJ&#46; Clark"
                            1 => "R&#46;R&#46; Reimer"
                            2 => "M&#46; Greene"
                            3 => "A&#46;M&#46; Ainsworth"
                            4 => "M&#46;J&#46; Mastrangelo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1978"
                        "volumen" => "114"
                        "paginaInicial" => "732"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/646394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;K&#46; Koh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199107183250306"
                      "Revista" => array:7 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1991"
                        "volumen" => "325"
                        "paginaInicial" => "171"
                        "paginaFinal" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1805813"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508508018581"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A natural history of melanomas and dysplastic nevi&#58; an atlas of lesions in melanoma-prone families"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Tucker"
                            1 => "M&#46; Fraser"
                            2 => "A&#46; Goldstein"
                            3 => "J&#46; Struewing"
                            4 => "M&#46; King"
                            5 => "J&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.10605"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2002"
                        "volumen" => "94"
                        "paginaInicial" => "3192"
                        "paginaFinal" => "3209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12115352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Number of melanocytic nevi as a major risk for malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Holly"
                            1 => "J&#46;W&#46; Kelly"
                            2 => "S&#46;N&#46; Shpall"
                            3 => "S&#46;H&#46; Chiu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1987"
                        "volumen" => "17"
                        "paginaInicial" => "459"
                        "paginaFinal" => "468"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3655025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinically recognized dysplastic nevi&#58; a central risk factor for cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Tucker"
                            1 => "A&#46; Halpern"
                            2 => "A&#46;E&#46; Holly"
                            3 => "P&#46; Hartge"
                            4 => "D&#46;E&#46; Elder"
                            5 => "R&#46;W&#46; Sagebiel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1997"
                        "volumen" => "227"
                        "paginaInicial" => "1439"
                        "paginaFinal" => "1444"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysplastic naevi with moderate to severe histological dysplasia&#58; a risk factor for melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Shors"
                            1 => "S&#46; Kim"
                            2 => "E&#46; White"
                            3 => "Z&#46; Argenyi"
                            4 => "R&#46;L&#46; Barnhill"
                            5 => "P&#46; Duray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07466.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "155"
                        "paginaInicial" => "988"
                        "paginaFinal" => "993"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17034530"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S001651070802628X"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation of clinical and histopathologic features in clinically atypical melanocytic nevi"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Barnhill"
                            1 => "G&#46; Roush"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1991"
                        "volumen" => "67"
                        "paginaInicial" => "3157"
                        "paginaFinal" => "3164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2044059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Annessi"
                            1 => "M&#46;S&#46; Cattaruzza"
                            2 => "D&#46; Abeni"
                            3 => "G&#46; Baliva"
                            4 => "M&#46; Laurenza"
                            5 => "V&#46; Macchini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2001.114580"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "45"
                        "paginaInicial" => "77"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11423839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopic classification of atypical nevi &#40;Clark nevi&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:5 [
                            0 => "R&#46; Hoffman-Wellenhof"
                            1 => "A&#46; Blum"
                            2 => "H&#46; Wolf"
                            3 => "D&#46;&#44; K&#46;erlH&#46; Piccolo"
                            4 => "C&#46; arbe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2001"
                        "volumen" => "137"
                        "paginaInicial" => "1575"
                        "paginaFinal" => "1580"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11735707"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathologic correlation in dermoscopy&#46; A micropunch technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;P&#46; Braun"
                            1 => "G&#46; Kaya"
                            2 => "I&#46; Masouy&#233;"
                            3 => "J&#46; Krischer"
                            4 => "J&#46;H&#46; Saurat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2003"
                        "volumen" => "139"
                        "paginaInicial" => "349"
                        "paginaFinal" => "351"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12622628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surface microscopy&#58; a new approach to the diagnosis of cutaneous pigmented tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;P&#46; Soyer"
                            1 => "J&#46; Smolle"
                            2 => "S&#46; H&#246;dl"
                            3 => "H&#46; Pachernegg"
                            4 => "H&#46; Kerl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1989"
                        "volumen" => "11"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2521782"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic correlates of structures seen on dermoscopy &#40;epiluminescence microscopy&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Yadav"
                            1 => "K&#46;A&#46; Vossaert"
                            2 => "A&#46;W&#46; Kopf"
                            3 => "M&#46; Silverman"
                            4 => "C&#46; Grin-Jorgensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1993"
                        "volumen" => "15"
                        "paginaInicial" => "297"
                        "paginaFinal" => "305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8214386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathological correlation of pigmented skin lesions using dermoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;P&#46; Soyer"
                            1 => "R&#46;O&#46; Kenet"
                            2 => "I&#46;H&#46; Wolf"
                            3 => "B&#46;J&#46; Kenet"
                            4 => "L&#46; Cerroni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2000"
                        "volumen" => "10"
                        "paginaInicial" => "22"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10694293"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The dermoscopic classification of atypical melanocytic naevi &#40;Clark naevi&#41; is useful to discriminate benign from malignant melanocytic lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Blum"
                            1 => "H&#46;P&#46; Soyer"
                            2 => "C&#46; Garbe"
                            3 => "H&#46; Kerl"
                            4 => "G&#46; Rassner"
                            5 => "R&#46; Hoffman-Wellenhof"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "149"
                        "paginaInicial" => "1159"
                        "paginaFinal" => "1164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14674892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation with digital dermoscopic images can help dermatopathologists to diagnose equivocal skin tumours"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Bauer"
                            1 => "B&#46; Leinweber"
                            2 => "G&#46; Metzler"
                            3 => "A&#46; Blum"
                            4 => "R&#46; Hofmann-Wellenhof"
                            5 => "N&#46; Leitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07342.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "155"
                        "paginaInicial" => "546"
                        "paginaFinal" => "551"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16911279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical methods for rates and proportions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;L&#46; Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "2nd ed&#46;"
                        "fecha" => "1981"
                        "editorial" => "Wiley"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Applied Logistic Regression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;W&#46; Hosmer"
                            1 => "S&#46; Lemeshow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2000"
                        "editorial" => "John Wiley &#38; sons"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Digital dermoscopy analysis for the differentiation of atypical nevi and early melanoma&#46; A new quantitative semiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Andreassi"
                            1 => "R&#46; Perotti"
                            2 => "P&#46; Rubegni"
                            3 => "M&#46; Burroni"
                            4 => "G&#46; Cevenini"
                            5 => "M&#46; Biagioli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1999"
                        "volumen" => "135"
                        "paginaInicial" => "1459"
                        "paginaFinal" => "1465"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10606050"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709028879"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical selection of melanocytic lesions for dermoscopy decreases the identification of suspicious lesions in comparison with dermoscopy without clinical preselection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Seidenari"
                            1 => "C&#46; Longo"
                            2 => "F&#46; Giusti"
                            3 => "G&#46; Pellacani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07165.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "154"
                        "paginaInicial" => "873"
                        "paginaFinal" => "879"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16634889"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204509703298"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micro-melanoma detection&#58; a clinical study on 206 consecutive cases of pigmented skin lesions with a diameter &#35;&#60; 3 mm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Bono"
                            1 => "E&#46; Tolomio"
                            2 => "S&#46; Trincone"
                            3 => "C&#46; Bartoli"
                            4 => "S&#46; Tomatis"
                            5 => "A&#46; Carbone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07396.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "155"
                        "paginaInicial" => "570"
                        "paginaFinal" => "573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16911283"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of the dermatoscope to identify early melanoma using the three-colour test"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;M&#46; MacKie"
                            1 => "C&#46; Fleming"
                            2 => "A&#46;D&#46; McMahon"
                            3 => "P&#46; Jarret"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2002"
                        "volumen" => "146"
                        "paginaInicial" => "481"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11952549"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Fikrle"
                            1 => "K&#46; Pizinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.cmr.0000195700.42766.23"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "45"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16432455"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic significance of the blue hue in dermoscopy of melanocytic lesions&#58; a dermoscopic-pathologic study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Massi"
                            1 => "V&#46; de Giorgi"
                            2 => "P&#46; Carli"
                            3 => "M&#46; Santucci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2001"
                        "volumen" => "23"
                        "paginaInicial" => "463"
                        "paginaFinal" => "469"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11801781"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Features of regression in dermoscopic diagnosis&#58; a confounding factor&#63; Two clinical&#44; dermoscopic-pathologic case studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46; De Giorgi"
                            1 => "D&#46; Massi"
                            2 => "C&#46; Salvini"
                            3 => "S&#46; Sestini"
                            4 => "P&#46; Carli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2006"
                        "volumen" => "32"
                        "paginaInicial" => "282"
                        "paginaFinal" => "286"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16442056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinically equivocal melanocytic skin lesions with features of regression&#58; a dermoscopic-pathological study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Zaludek"
                            1 => "G&#46; Argenziano"
                            2 => "G&#46; Ferrara"
                            3 => "H&#46;P&#46; Soyer"
                            4 => "R&#46; Corona"
                            5 => "F&#46; Sera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2004"
                        "volumen" => "150"
                        "paginaInicial" => "64"
                        "paginaFinal" => "71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14746618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Corona"
                            1 => "A&#46; Mele"
                            2 => "M&#46; Amini"
                            3 => "G&#46; de Rosa"
                            4 => "G&#46; Coppola"
                            5 => "P&#46; Piccardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.1996.14.4.1218"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "1996"
                        "volumen" => "14"
                        "paginaInicial" => "1218"
                        "paginaFinal" => "1223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8648377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopic and histopathologic diagnosis of equivocal melanocytic skin lesions&#46; An interdisciplinary study on 107 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Ferrara"
                            1 => "G&#46; Argenziano"
                            2 => "H&#46;P&#46; Soyer"
                            3 => "R&#46; Corona"
                            4 => "F&#46; Sera"
                            5 => "B&#46; Brubetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.10768"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2002"
                        "volumen" => "95"
                        "paginaInicial" => "1094"
                        "paginaFinal" => "1100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12209696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical diagnosis of dysplastic melanocytic nevi&#58; a clinicopathologic correlation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;W&#46; Kelly"
                            1 => "W&#46;A&#46; Crutcher"
                            2 => "R&#46;W&#46; Sagebiel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1986"
                        "volumen" => "14"
                        "paginaInicial" => "1044"
                        "paginaFinal" => "1052"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3722481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic correlations with the clinical diagnosis of dysplastic nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;C&#46; Black"
                            1 => "W&#46;C&#46; Hunt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1990"
                        "volumen" => "14"
                        "paginaInicial" => "44"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2294780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysplastic naevus vs&#46; in situ melanoma&#58; digital dermoscopy analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Burroni"
                            1 => "P&#46; Sbano"
                            2 => "G&#46; Cevenini"
                            3 => "M&#46; Risulo"
                            4 => "G&#46; Dell&#8217;Eva"
                            5 => "P&#46; Barbini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06481.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2005"
                        "volumen" => "152"
                        "paginaInicial" => "679"
                        "paginaFinal" => "684"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840098"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The dermoscopic versus the clinical diagnosis of melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Benelli"
                            1 => "E&#46; Roscetti"
                            2 => "V&#46;D&#46; Pozzo"
                            3 => "G&#46; Gasparini"
                            4 => "S&#46; Cavicchini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "9"
                        "paginaInicial" => "470"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10491506"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508510013223"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vivo epiluminiscence microscopy of pigmented skin lesions II&#46; Diagnosis of small pigmented skin lesions and early detection of melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Steiner"
                            1 => "H&#46; Pehamberger"
                            2 => "K&#46; Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1987"
                        "volumen" => "17"
                        "paginaInicial" => "584"
                        "paginaFinal" => "591"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3668003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic eliability of dermoscopic criteria for detecting malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;P&#46; Soyer"
                            1 => "J&#46; Smolle"
                            2 => "G&#46; Leitinger"
                            3 => "E&#46; Rieger"
                            4 => "H&#46; Keri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "1995"
                        "volumen" => "190"
                        "paginaInicial" => "25"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7894091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic review of the diagnostic accuracy of dermatoscopy in detecting malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Mayer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med J Aust"
                        "fecha" => "1997"
                        "volumen" => "167"
                        "paginaInicial" => "206"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9293268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000009900000005/v1_201304241433/S1578219008702713/v1_201304241433/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000005/v1_201304241433/S1578219008702713/v1_201304241433/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702713?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 99. Núm. 5.
Páginas 380-389 (junio - julio 2008)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 99. Núm. 5.
Páginas 380-389 (junio - julio 2008)
Original articles
Acceso a texto completo
Correlation Between Clinical, Dermatoscopic, and Histopathologic Variables in Atypical Melanocytic Nevi
Estudio de Correlación Clínica, Dermatoscópica e Histopatológica de Nevus Melanocíticos Atípicos
Visitas
6359
A.M. Morales-Callaghana,
Autor para correspondencia
acallaghan@aedv.es

Correspondence: Ana María Morales-Callaghan, C/ Barcelona, 67, 1a, 50017 Zaragoza, Spain.
, J. Castrodeza-Sanzb, G. Martínez-Garcíac, I. Peral-Martínezc, A. Miranda-Romeroa
a Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
b Servicio de Medicina Preventiva, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
c Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
Este artículo ha recibido
Información del artículo
Abstract
Introduction

Atypical melanocytic nevi are acquired melanocytic lesions that were described for the first time by Clark in studies of melanocytic nevi in patients with melanomas. Today, the use of dermatoscopy has made identification of this type of nevus much easier.

Objective

Our aim was to study the correlation between the clinical, dermatoscopic, and histopathologic findings of melanocytic nevi and compare our findings with those of previous studies. We also aimed to investigate the value of dermatoscopy for identifying atypical melanocytic nevi.

Material and methods

In this cross-sectional, observational study, 200 melanocytic lesions were analyzed in 166 patients examined between January 1, 2005 and December 31, 2005. We recorded the clinical, dermatoscopic, and histopathologic characteristics of each lesion and established the correlation between the different findings on a case-by-case basis. We then determined the agreement between diagnoses and assessed the value of dermatoscopy for identifying atypical melanocytic melanoma.

Results

The clinical characteristics associated with atypical histology were a macular component (P<.001), irregular borders, and presence of 3 or more colors. Asymmetry, diameter greater than 5 or 6 mm, and progression were not associated with atypical histopathologic characteristics (P>.05). Agreement between clinical and histologic diagnosis was weak (κ=0.38), whereas the agreement between dermatoscopic and histologic diagnosis was moderate (κ=0.52). The area under the receiver operating characteristic curve for the model that included dermatoscopy was larger than that for the model that only included clinical data, and this difference was statistically significant.

Conclusions

Atypical clinical features were not found to correspond to atypical histology. Dermatoscopy improved the accuracy of clinical diagnosis of atypical melanocytic nevus.

Key words:
atypical melanocytic nevus
dermatoscopy
correlation
Resumen
Introducción

Los nevus melanocíticos atípicos (NMA) son lesiones melanocíticas adquiridas descritas por primera vez por Clark en estudios de nevus melanocíticos (NM) en pacientes con melanomas. Actualmente, el uso de la dermatoscopia ha facilitado en gran medida la identificación de esta variante de nevus.

Objetivo

Estudiar la correlación entre los hallazgos clínicos, dermatoscópicos e histopatológicos de los NM a estudio y comparar nuestros resultados con trabajos previos. Establecer el valor de la dermatoscopia para la identificación de NMA.

Material y métodos

Estudio observacional, transversal de 200 lesiones melanocíticas correspondientes a 166 pacientes, llevado a cabo desde el 1 de enero de 2005 hasta el 31 de diciembre de 2005. Describimos las características clínicas, dermatoscópicas e histopatológicas de cada lesión y establecimos la correlación entre los diferentes hallazgos obtenidos, caso por caso. Posteriormente determinamos la concordancia entre diagnósticos y establecimos el valor de la dermatoscopia para la identificación de NMA.

Resultados

Las características clínicas que se asociaron a atipia histológica fueron componente macular (p<0,001), bordes irregulares y presencia de tres o más colores. La asimetría, diámetro mayor de 5 o 6mm o la evolución no se correspondieron con atipia desde el punto de vista histopatológico (p>0,05). La concordancia entre diagnóstico clínico e histológico fue baja (índice kappa ponderado [Kp]: 0,38), mientras que entre diagnóstico dermatoscópico e histológico fue moderada (índice Kp: 0,52). Mediante curvas ROC (receiver operating characteristic) comprobamos que el modelo que contenía la dermatoscopia presentaba un incremento bajo la curva estadísticamente significativo respecto al modelo que sólo incluía los datos clínicos.

Conclusiones

La atipia clínica no es equivalente a atipia histológica. La dermatoscopia mejora la precisión del diagnóstico clínico de NMA.

Palabras clave:
nevus melanocítico atípico
dermatoscopia
correlación
El Texto completo está disponible en PDF
References
[1]
W.HJ. Clark, R.R. Reimer, M. Greene, A.M. Ainsworth, M.J. Mastrangelo.
Origin of familial malignant melanomas from heritable melanocytic lesions: the B-K mole syndrome.
Arch Dermatol, 114 (1978), pp. 732-738
[2]
H.K. Koh.
Cutaneous melanoma.
N Engl J Med, 325 (1991), pp. 171-182
[3]
M. Tucker, M. Fraser, A. Goldstein, J. Struewing, M. King, J. Crawford.
A natural history of melanomas and dysplastic nevi: an atlas of lesions in melanoma-prone families.
Cancer, 94 (2002), pp. 3192-3209
[4]
E.A. Holly, J.W. Kelly, S.N. Shpall, S.H. Chiu.
Number of melanocytic nevi as a major risk for malignant melanoma.
J Am Acad Dermatol, 17 (1987), pp. 459-468
[5]
M.A. Tucker, A. Halpern, A.E. Holly, P. Hartge, D.E. Elder, R.W. Sagebiel, et al.
Clinically recognized dysplastic nevi: a central risk factor for cutaneous melanoma.
JAMA, 227 (1997), pp. 1439-1444
[6]
A.R. Shors, S. Kim, E. White, Z. Argenyi, R.L. Barnhill, P. Duray, et al.
Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma.
Br J Dermatol, 155 (2006), pp. 988-993
[7]
R. Barnhill, G. Roush.
Correlation of clinical and histopathologic features in clinically atypical melanocytic nevi.
Cancer, 67 (1991), pp. 3157-3164
[8]
G. Annessi, M.S. Cattaruzza, D. Abeni, G. Baliva, M. Laurenza, V. Macchini, et al.
Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi.
J Am Acad Dermatol, 45 (2001), pp. 77-85
[9]
R. Hoffman-Wellenhof, A. Blum, H. Wolf, D., K.erlH. Piccolo, C. arbe, et al.
Dermoscopic classification of atypical nevi (Clark nevi).
Arch Dermatol, 137 (2001), pp. 1575-1580
[10]
R.P. Braun, G. Kaya, I. Masouyé, J. Krischer, J.H. Saurat.
Histopathologic correlation in dermoscopy. A micropunch technique.
Arch Dermatol, 139 (2003), pp. 349-351
[11]
H.P. Soyer, J. Smolle, S. Hödl, H. Pachernegg, H. Kerl.
Surface microscopy: a new approach to the diagnosis of cutaneous pigmented tumors.
Am J Dermatopathol, 11 (1989), pp. 1-10
[12]
S. Yadav, K.A. Vossaert, A.W. Kopf, M. Silverman, C. Grin-Jorgensen.
Histologic correlates of structures seen on dermoscopy (epiluminescence microscopy).
Am J Dermatopathol, 15 (1993), pp. 297-305
[13]
H.P. Soyer, R.O. Kenet, I.H. Wolf, B.J. Kenet, L. Cerroni.
Clinicopathological correlation of pigmented skin lesions using dermoscopy.
Eur J Dermatol, 10 (2000), pp. 22-28
[14]
A. Blum, H.P. Soyer, C. Garbe, H. Kerl, G. Rassner, R. Hoffman-Wellenhof.
The dermoscopic classification of atypical melanocytic naevi (Clark naevi) is useful to discriminate benign from malignant melanocytic lesions.
Br J Dermatol, 149 (2003), pp. 1159-1164
[15]
J. Bauer, B. Leinweber, G. Metzler, A. Blum, R. Hofmann-Wellenhof, N. Leitz, et al.
Correlation with digital dermoscopic images can help dermatopathologists to diagnose equivocal skin tumours.
Br J Dermatol, 155 (2006), pp. 546-551
[16]
J.L. Fleiss.
Statistical methods for rates and proportions.
2nd ed., Wiley, (1981),
[17]
D.W. Hosmer, S. Lemeshow.
Applied Logistic Regression.
John Wiley & sons, (2000),
[18]
L. Andreassi, R. Perotti, P. Rubegni, M. Burroni, G. Cevenini, M. Biagioli, et al.
Digital dermoscopy analysis for the differentiation of atypical nevi and early melanoma. A new quantitative semiology.
Arch Dermatol, 135 (1999), pp. 1459-1465
[19]
S. Seidenari, C. Longo, F. Giusti, G. Pellacani.
Clinical selection of melanocytic lesions for dermoscopy decreases the identification of suspicious lesions in comparison with dermoscopy without clinical preselection.
Br J Dermatol, 154 (2006), pp. 873-879
[20]
A. Bono, E. Tolomio, S. Trincone, C. Bartoli, S. Tomatis, A. Carbone, et al.
Micro-melanoma detection: a clinical study on 206 consecutive cases of pigmented skin lesions with a diameter #< 3 mm.
Br J Dermatol, 155 (2006), pp. 570-573
[21]
R.M. MacKie, C. Fleming, A.D. McMahon, P. Jarret.
The use of the dermatoscope to identify early melanoma using the three-colour test.
Br J Dermatol, 146 (2002), pp. 481-484
[22]
T. Fikrle, K. Pizinger.
Dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas.
[23]
D. Massi, V. de Giorgi, P. Carli, M. Santucci.
Diagnostic significance of the blue hue in dermoscopy of melanocytic lesions: a dermoscopic-pathologic study.
Am J Dermatopathol, 23 (2001), pp. 463-469
[24]
V. De Giorgi, D. Massi, C. Salvini, S. Sestini, P. Carli.
Features of regression in dermoscopic diagnosis: a confounding factor? Two clinical, dermoscopic-pathologic case studies.
Dermatol Surg, 32 (2006), pp. 282-286
[25]
I. Zaludek, G. Argenziano, G. Ferrara, H.P. Soyer, R. Corona, F. Sera, et al.
Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic-pathological study.
Br J Dermatol, 150 (2004), pp. 64-71
[26]
R. Corona, A. Mele, M. Amini, G. de Rosa, G. Coppola, P. Piccardi, et al.
Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions.
J Clin Oncol, 14 (1996), pp. 1218-1223
[27]
G. Ferrara, G. Argenziano, H.P. Soyer, R. Corona, F. Sera, B. Brubetti, et al.
Dermoscopic and histopathologic diagnosis of equivocal melanocytic skin lesions. An interdisciplinary study on 107 cases.
Cancer, 95 (2002), pp. 1094-1100
[28]
J.W. Kelly, W.A. Crutcher, R.W. Sagebiel.
Clinical diagnosis of dysplastic melanocytic nevi: a clinicopathologic correlation.
J Am Acad Dermatol, 14 (1986), pp. 1044-1052
[29]
W.C. Black, W.C. Hunt.
Histologic correlations with the clinical diagnosis of dysplastic nevus.
Am J Surg Pathol, 14 (1990), pp. 44-52
[30]
M. Burroni, P. Sbano, G. Cevenini, M. Risulo, G. Dell’Eva, P. Barbini, et al.
Dysplastic naevus vs. in situ melanoma: digital dermoscopy analysis.
Br J Dermatol, 152 (2005), pp. 679-684
[31]
C. Benelli, E. Roscetti, V.D. Pozzo, G. Gasparini, S. Cavicchini.
The dermoscopic versus the clinical diagnosis of melanoma.
Eur J Dermatol, 9 (1999), pp. 470-476
[32]
A. Steiner, H. Pehamberger, K. Wolf.
In vivo epiluminiscence microscopy of pigmented skin lesions II. Diagnosis of small pigmented skin lesions and early detection of melanoma.
J Am Acad Dermatol, 17 (1987), pp. 584-591
[33]
H.P. Soyer, J. Smolle, G. Leitinger, E. Rieger, H. Keri.
Diagnostic eliability of dermoscopic criteria for detecting malignant melanoma.
Dermatology, 190 (1995), pp. 25-30
[34]
J. Mayer.
Systematic review of the diagnostic accuracy of dermatoscopy in detecting malignant melanoma.
Med J Aust, 167 (1997), pp. 206-210
Copyright © 2008. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?