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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La xerosis o piel seca es un trastorno cut&#225;neo de alta prevalencia en la poblaci&#243;n general que se caracteriza cl&#237;nicamente por una piel &#225;spera&#44; descamativa y habitualmente pruriginosa&#46; Ciertas dermatosis como la dermatitis at&#243;pica cursan con este trastorno&#44; aunque puede presentarse en individuos sanos si coinciden varios factores etiol&#243;gicos&#46; Fisiopatol&#243;gicamente consiste en la modificaci&#243;n estructural del estrato c&#243;rneo&#44; su contenido en agua y un defecto en la diferenciaci&#243;n queratinocitaria&#46; El tratamiento de la xerosis debiera buscar la recomposici&#243;n de los l&#237;pidos fisiol&#243;gicos de la epidermis y el aporte de sustancias que faciliten la diferenciaci&#243;n epid&#233;rmica&#46;</p>"
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November 2008 Xerosis: a Dysfunction of the Epidermal Barrier
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Vol. 99. Issue 9.
Pages 671-682 (November 2008)
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Vol. 99. Issue 9.
Pages 671-682 (November 2008)
Review article
DOI: 10.1016/S1578-2190(08)70343-3
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Xerosis: a Dysfunction of the Epidermal Barrier
Xerosis: una Disfunción de la Barrera Epidérmica
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D. Barcoa, A. Giménez-Arnaub,
Corresponding author
agimenez@imas.imim.es

Correspondence: Servicio de Dermatología, Hospital del Mar, c/ Passeig Maritím, 25-29, 08003 Barcelona.
a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Departamento de Dermatología, Hospital del Mar-IMIM, Barcelona Spain
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Abstract

Xerosis or dry skin is a common skin disorder among the general population. It is characterized clinically by rough, scaly, and often itchy skin. This disorder is present in the course of some dermatoses such as atopic dermatitis, although it can also occur in healthy individuals if a combination of certain etiologic factors is present. It is characterized pathophysiologically by a disrupted stratum corneum, dehydration, and impaired keratinocyte differentiation. Treatment of xerosis should seek to restore physiologic lipids in the epidermis and provide substances that facilitate epidermal differentiation.

Key words:
xerosis
dry skin
stratum corneum
ceramides
lipids
Resumen

La xerosis o piel seca es un trastorno cutáneo de alta prevalencia en la población general que se caracteriza clínicamente por una piel áspera, descamativa y habitualmente pruriginosa. Ciertas dermatosis como la dermatitis atópica cursan con este trastorno, aunque puede presentarse en individuos sanos si coinciden varios factores etiológicos. Fisiopatológicamente consiste en la modificación estructural del estrato córneo, su contenido en agua y un defecto en la diferenciación queratinocitaria. El tratamiento de la xerosis debiera buscar la recomposición de los lípidos fisiológicos de la epidermis y el aporte de sustancias que faciliten la diferenciación epidérmica.

Palabras clave:
xerosis
piel seca
estrato córneo
ceramidas
lípidos
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Copyright © 2008. Academia Española de Dermatología y Venereología and Elsevier España, S.L.

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