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Vol. 103. Issue S2.
Actualización del uso de ustekinumab: un ava nce en el tratamiento de la psoriasis
Pages 59-64 (October 2012)
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Vol. 103. Issue S2.
Actualización del uso de ustekinumab: un ava nce en el tratamiento de la psoriasis
Pages 59-64 (October 2012)
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Ustekinumab. Otros usos. Otras formas de psoriasis. Otras patologías cutáneas
Ustekinumab. Other uses. Other forms of psoriasis. Other skin conditions
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M. Sánchez-Regaña
Unidad de Psoriasis y Fototerapia. Servicio de Dermatología. Hospital Universitari Sagrat Cor. Barcelona. España
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Resumen

Ustekinumab es un anticuerpo monoclonal humano anti interleucina 12 y 23. En los ensayos clínicos pivotales quedó probada su eficacia y seguridad a nivel de la psoriasis en placas moderada-severa. Asimismo, cabe destacar que en dichos ensayos se utilizó también el índice de severidad de psoriasis ungueal para evaluar su efectividad en la psoriasis ungueal. Los pacientes tratados en el ensayo PHOENIX 1 (n=545) mostraron que las lesiones ungueales mejoraron de forma progresiva hasta la semana 52, si bien en la semana 12, después de dos dosis de ustekinumab, la mediana de la mejoría de las puntuaciones NASPI respecto al valor basal fue del 25%, llegando al 50% en la semana 24. Por otro lado, desde su reciente incorporación, ustekinumab también se ha empleado en otras formas de psoriasis (pustulosa, palmo-plantar, eritrodérmica) y también en otras enfermedades (pitiriasis rubra pilaris, hidradenitis supurativa y dermatitis atópica).

Palabras clave:
Ustekinumab
Psoriasis
Psoriasis ungueal
Pitiriasis rubra pilaris
Abstract

Ustekinumab is a human monoclonal antibody directed against IL-12 and IL-23. Pivotal clinical trials have proven its efficacy and safety in the treatment of moderate to severe plaque psoriasis. The same trials have also evaluated the efficacy of this drug in nail psoriasis using the Nail Psoriasis Severity Index (NAPSI). Patients treated in the PHOENIX 1 trial (n=545) showed progressive improvement in NAPSI scores up to week 52. At week 12, after 2 doses of ustekinumab, the median improvement from baseline was 25% and at week 24, it was 50%. Since its recent approval for the treatment of moderate to severe plaque psoriasis, ustekinumab has been used to treat other forms of psoriasis (pustular, palmoplantar, and erythrodermic psoriasis) and other diseases (pityriasis rubra pilaris, hidradenitis suppurativa, and atopic dermatitis).

Keywords:
Ustekinumab
Psoriasis
Nail psoriasis
Pityriasis rubra pilaris
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Copyright © 2012. Academia Española de Dermatología y Venereología
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