Ustekinumab. Otros usos. Otras formas de psoriasis. Otras patologías cutáneas
Ustekinumab. Other uses. Other forms of psoriasis. Other skin conditions
M. Sánchez-Regaña
Unidad de Psoriasis y Fototerapia. Servicio de Dermatología. Hospital Universitari Sagrat Cor. Barcelona. España
Read
4338
Timeswas read the article
2274
Total PDF
2064
Total HTML
Share statistics
array:23 [ "pii" => "S0001731012700108" "issn" => "00017310" "doi" => "10.1016/S0001-7310(12)70010-8" "estado" => "S300" "fechaPublicacion" => "2012-10-01" "aid" => "70010" "copyright" => "Academia Española de Dermatología y Venereología" "copyrightAnyo" => "2012" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:59-64" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1559 "formatos" => array:2 [ "HTML" => 778 "PDF" => 781 ] ] "itemSiguiente" => array:18 [ "pii" => "S000173101270011X" "issn" => "00017310" "doi" => "10.1016/S0001-7310(12)70011-X" "estado" => "S300" "fechaPublicacion" => "2012-10-01" "aid" => "70011" "copyright" => "Academia Española de Dermatología y Venereología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:65-72" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1874 "formatos" => array:2 [ "HTML" => 1211 "PDF" => 663 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Ustekinumab en la artritis psoriásica y la enfermedad de Crohn" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "65" "paginaFinal" => "72" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab in Psoriatic Arthritis and Crohn Disease" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Queiro, D. Ginard" "autores" => array:2 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Queiro" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Ginard" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101270011X?idApp=UINPBA000044" "url" => "/00017310/00000103000000S2/v1_201304241722/S000173101270011X/v1_201304241722/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731012700091" "issn" => "00017310" "doi" => "10.1016/S0001-7310(12)70009-1" "estado" => "S300" "fechaPublicacion" => "2012-10-01" "aid" => "70009" "copyright" => "Academia Española de Dermatología y Venereología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:52-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1337 "formatos" => array:2 [ "HTML" => 710 "PDF" => 627 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Manejo práctico de ustekinumab en la psoriasis moderada-grave" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "52" "paginaFinal" => "58" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Practical management of ustekinumab in moderate-severe psoriasis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Notario, X. Bordas" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Notario" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Bordas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700091?idApp=UINPBA000044" "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700091/v1_201304241722/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Ustekinumab. Otros usos. Otras formas de psoriasis. Otras patologías cutáneas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "59" "paginaFinal" => "64" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Sánchez-Regaña" "autores" => array:1 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Sánchez-Regaña" "email" => array:1 [ 0 => "msanchezreg@hotmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Psoriasis y Fototerapia. Servicio de Dermatología. Hospital Universitari Sagrat Cor. Barcelona. España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab. Other uses. Other forms of psoriasis. Other skin conditions" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85101" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Psoriasis" 2 => "Psoriasis ungueal" 3 => "Pitiriasis rubra pilaris" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85102" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Psoriasis" 2 => "Nail psoriasis" 3 => "Pityriasis rubra pilaris" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ustekinumab es un anticuerpo monoclonal humano anti interleucina 12 y 23. En los ensayos clínicos pivotales quedó probada su eficacia y seguridad a nivel de la psoriasis en placas moderada-severa. Asimismo, cabe destacar que en dichos ensayos se utilizó también el índice de severidad de psoriasis ungueal para evaluar su efectividad en la psoriasis ungueal. Los pacientes tratados en el ensayo PHOENIX 1 (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>545) mostraron que las lesiones ungueales mejoraron de forma progresiva hasta la semana 52, si bien en la semana 12, después de dos dosis de ustekinumab, la mediana de la mejoría de las puntuaciones NASPI respecto al valor basal fue del 25%, llegando al 50% en la semana 24. Por otro lado, desde su reciente incorporación, ustekinumab también se ha empleado en otras formas de psoriasis (pustulosa, palmo-plantar, eritrodérmica) y también en otras enfermedades (pitiriasis rubra pilaris, hidradenitis supurativa y dermatitis atópica).</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ustekinumab is a human monoclonal antibody directed against IL-12 and IL-23. Pivotal clinical trials have proven its efficacy and safety in the treatment of moderate to severe plaque psoriasis. The same trials have also evaluated the efficacy of this drug in nail psoriasis using the Nail Psoriasis Severity Index (NAPSI). Patients treated in the PHOENIX 1 trial (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>545) showed progressive improvement in NAPSI scores up to week 52. At week 12, after 2 doses of ustekinumab, the median improvement from baseline was 25% and at week 24, it was 50%. Since its recent approval for the treatment of moderate to severe plaque psoriasis, ustekinumab has been used to treat other forms of psoriasis (pustular, palmoplantar, and erythrodermic psoriasis) and other diseases (pityriasis rubra pilaris, hidradenitis suppurativa, and atopic dermatitis).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aspectos diagnósticos y terapéuticos de la psoriasis ungueal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Sánchez-Regaña" 1 => "P. Umbert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "34" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206085" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis ungueal: estudio en 661 pacientes con psoriasis vulgar" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Armesto" 1 => "A. Esteve" 2 => "P. Coto-Segura" 3 => "M. Drake" 4 => "C. Galache" 5 => "J. Martínez-Borra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.02.007" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "365" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21514549" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nail psoriasis: a retrospective study on the effectiveness of systemic treatments (classical and biological therapy)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Sánchez-Regaña" 1 => "J. Sola-Ortigosa" 2 => "M. Alsina-Gibert" 3 => "M. Vidal-Fernández" 4 => "P. Umbert-Millet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2010.03938.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "579" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21198950" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nail psoriasis in Germany: epidemiology and burden of disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Augustin" 1 => "K. Reich" 2 => "C. Blome" 3 => "I. Schäfer" 4 => "A. Laass" 5 => "M.A. Radtke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09831.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "163" "paginaInicial" => "580" "paginaFinal" => "585" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20456340" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nail as a musculoskeletal appendage-implications for an improved understanding of the link between psoriasis and arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. McGonagle" 1 => "A.L. Tan" 2 => "M. Benjamin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000182250" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2009" "volumen" => "218" "paginaInicial" => "97" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19060455" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1.728 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.M. De Jong" 1 => "B.A. Seegers" 2 => "M.K. Gulinck" 3 => "J.B. Boezeman" 4 => "P.C. Van de Kerkhof" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1996" "volumen" => "193" "paginaInicial" => "300" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8993953" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment and management of psoriasis with nail involvement: a focus on biologic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Langley" 1 => "E. Daudén" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000316179" "Revista" => array:7 [ "tituloSerie" => "Dermatology" "fecha" => "2010" "volumen" => "221" "numero" => "Suppl 1" "paginaInicial" => "29" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20733313" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of fungal involvement in a series of patients with nail psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Sánchez-Regaña" 1 => "S. Videla" 2 => "J. Villoria" 3 => "H. Domingo" 4 => "A. Macaya" 5 => "E. Ortiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2007.02568.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2008" "volumen" => "33" "paginaInicial" => "194" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17983448" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the efficacy of acitretin therapy for nail psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Tosti" 1 => "C. Ricotti" 2 => "P. Romanelli" 3 => "N. Cameli" 4 => "B.M. Piraccini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archdermatol.2008.600" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2009" "volumen" => "145" "paginaInicial" => "269" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19289755" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of psoriatic nails with low-dose cyclosporine administration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Syuto" 1 => "M. Abe" 2 => "H. Ishibuchi" 3 => "O. Ishikawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2007.0162" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2007" "volumen" => "17" "paginaInicial" => "248" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17478393" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Rich" 1 => "C.E. Griffiths" 2 => "K. Reich" 3 => "F.O. Nestle" 4 => "R.K. Scher" 5 => "S. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.07.042" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2008" "volumen" => "58" "paginaInicial" => "224" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18083272" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PHOENIX 1 study investigators. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 1)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.L. Leonardi" 1 => "A.B. Kimball" 2 => "K.A. Papp" 3 => "N. Yeilding" 4 => "C. Guzzo" 5 => "Y. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(08)60725-4" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2008" "volumen" => "371" "paginaInicial" => "1665" "paginaFinal" => "1674" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18486739" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Van den Bosch" 1 => "B. Manger" 2 => "P. Goupille" 3 => "N. McHugh" 4 => "E. Rødevand" 5 => "P. Holck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2009.111856" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2010" "volumen" => "69" "paginaInicial" => "394" "paginaFinal" => "399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19815494" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sustained improvement in joint pain and nail symptoms with etanercept therapy in patients with moderate-to-severe psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.A. Luger" 1 => "J. Barker" 2 => "J. Lambert" 3 => "S. Yang" 4 => "D. Robertson" 5 => "J. Foehl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2009.03211.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2009" "volumen" => "23" "paginaInicial" => "896" "paginaFinal" => "904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19453794" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of ustekinumab in palmoplantar psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Budai Livideanu" 1 => "M. Lahfa" 2 => "J. Mazereeuw-Hautier" 3 => "C. Paul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000320961" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2010" "volumen" => "221" "paginaInicial" => "321" "paginaFinal" => "323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20980724" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ustekinumab induces rapid clearing of erythrodermic psoriasis after failure of antitumor necrosis factor therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Santos-Juanes" 1 => "P. Coto-Segura" 2 => "A. Mas-Vidal" 3 => "C. Galache-Osuna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09669.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "162" "paginaInicial" => "1144" "paginaFinal" => "1146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20222926" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ustekinumab: effective in a patient with severe recalcitrant generalized pustular psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Daudén" 1 => "D. Santiago-et-Sánchez-Mateos" 2 => "E. Sotomayor-López" 3 => "A. García-Díez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09995.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "163" "paginaInicial" => "1346" "paginaFinal" => "1347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20716216" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resolución de un brote de psoriasis pustulosa con ustekinumab en una paciente de difícil control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Merino de Paz" 1 => "M. Rodríguez" 2 => "P. Contreras" 3 => "M. Pestaña" 4 => "A. Noda" 5 => "M. García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Piel (Barc)" "fecha" => "2011" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flare of pustular psoriasis after initiating ustekinumab therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.S. Wenk" 1 => "J.M. Claros" 2 => "A. Ehrlich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Dermatolog Treat" "fecha" => "2011" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pustular psoriasis development after initial ustekinumab administration in chronic plaque psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Gregoriou" 1 => "C. Kazakos" 2 => "E. Christofidou" 3 => "G. Kontochristopoulos" 4 => "G. Vakis" 5 => "D. Rigopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2011.1164" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "104" "paginaFinal" => "105" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21233062" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Ko" 1 => "A.B. Gottlieb" 2 => "J.F. Kerbleski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/09546630802441234" "Revista" => array:6 [ "tituloSerie" => "J Dermatolog Treat" "fecha" => "2009" "volumen" => "20" "paginaInicial" => "100" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18923992" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ustekinumab in the treatment of palmoplantar pustulosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Gerdes" 1 => "J. Franke" 2 => "S. Domm" 3 => "U. Mrowietz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09897.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "163" "paginaInicial" => "1116" "paginaFinal" => "1118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20545680" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento de la pustulosis palmo-plantar con ustekinumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. De Unamuno-Bustos" 1 => "R. Ballester-Sánchez" 2 => "V. Oliver-Martínez" 3 => "V. Alegre de Miguel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.03.026" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "833" "paginaFinal" => "835" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21798490" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of acrodermatitis continua of Hallopeau with ustekinumab" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Allegue" 1 => "J. Pardo" 2 => "J. Ruffin" 3 => "E. Abbad" 4 => "A. López" 5 => "J. Pereda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol" "fecha" => "2010" "volumen" => "24" "paginaInicial" => "30" "paginaFinal" => "31" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of type 1 pityriasis rubra pilaris with ustekinumab therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Ruiz-Villaverde" 1 => "D. Sánchez-Cano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2010.1004" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2010" "volumen" => "20" "paginaInicial" => "630" "paginaFinal" => "631" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20605773" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of pityriasis rubra pilaris with ustekinumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Wohlrab" 1 => "B. Kreft" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09855.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "163" "paginaInicial" => "655" "paginaFinal" => "656" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20491761" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebocontrolled crossover trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Grant" 1 => "T. González" 2 => "M.O. Montgomery" 3 => "V. Cárdenas" 4 => "F.A. Kerdel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2009.06.050" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2010" "volumen" => "62" "paginaInicial" => "205" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20115947" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term successful adalimumab therapy in severe hidradenitis suppurativa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Blanco" 1 => "V.M. Martínez-Taboada" 2 => "I. Villa" 3 => "M.C. González-Vela" 4 => "H. Fernández-Llaca" 5 => "M. Agudo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archdermatol.2009.49" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2009" "volumen" => "145" "paginaInicial" => "580" "paginaFinal" => "584" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19451504" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experience with ustekinumab for the treatment of moderate to severe hidradenitis suppurativa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.P. Gulliver" 1 => "G.B. Jemec" 2 => "K.A. Baker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2011" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of recalcitrant hidradenitis suppurativa with ustekinumab" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V.R. Sharon" 1 => "M.S. García" 2 => "S. Bagheri" 3 => "H. Goodarzi" 4 => "C. Yang" 5 => "Y. Ono" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2011" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Fernández-Antón MC, Mendoza MD, Cieza D, Longo MI, Suárez R. Ustekinumb en el tratamiento de la dermatitis atópica severa. Nuestra experiencia en 4 pacientes. Proceedings of the 39 Congreso Nacional de la Academia Española de Dermatología y Venereología. Santiago de Compostela, 8–11 Jun 2011." ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of severe refractory adult atopic dermatitis with ustekinumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Puya" 1 => "Alvarez-López" 2 => "A. Velez" 3 => "E. Casas Asunción" 4 => "J.C. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2011.05195.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2012" "volumen" => "51" "paginaInicial" => "115" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22182388" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700108/v1_201304241722/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00017310/00000103000000S2/v1_201304241722/S0001731012700108/v1_201304241722/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700108?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 7 | 9 |
| 2024 October | 44 | 46 | 90 |
| 2024 September | 30 | 21 | 51 |
| 2024 August | 59 | 44 | 103 |
| 2024 July | 44 | 23 | 67 |
| 2024 June | 40 | 27 | 67 |
| 2024 May | 38 | 28 | 66 |
| 2024 April | 34 | 32 | 66 |
| 2024 March | 31 | 25 | 56 |
| 2024 February | 28 | 28 | 56 |
| 2024 January | 18 | 24 | 42 |
| 2023 December | 20 | 13 | 33 |
| 2023 November | 21 | 28 | 49 |
| 2023 October | 23 | 16 | 39 |
| 2023 September | 28 | 24 | 52 |
| 2023 August | 20 | 19 | 39 |
| 2023 July | 21 | 29 | 50 |
| 2023 June | 12 | 24 | 36 |
| 2023 May | 9 | 8 | 17 |
| 2023 April | 15 | 15 | 30 |
| 2023 March | 23 | 24 | 47 |
| 2023 February | 20 | 15 | 35 |
| 2023 January | 16 | 26 | 42 |
| 2022 December | 14 | 22 | 36 |
| 2022 November | 22 | 31 | 53 |
| 2022 October | 21 | 21 | 42 |
| 2022 September | 21 | 23 | 44 |
| 2022 August | 28 | 31 | 59 |
| 2022 July | 25 | 37 | 62 |
| 2022 June | 16 | 17 | 33 |
| 2022 May | 17 | 25 | 42 |
| 2022 April | 23 | 35 | 58 |
| 2022 March | 22 | 49 | 71 |
| 2022 February | 15 | 23 | 38 |
| 2022 January | 22 | 38 | 60 |
| 2021 December | 19 | 49 | 68 |
| 2021 November | 20 | 30 | 50 |
| 2021 October | 25 | 40 | 65 |
| 2021 September | 17 | 50 | 67 |
| 2021 August | 23 | 30 | 53 |
| 2021 July | 35 | 40 | 75 |
| 2021 June | 20 | 37 | 57 |
| 2021 May | 19 | 33 | 52 |
| 2021 April | 44 | 51 | 95 |
| 2021 March | 27 | 32 | 59 |
| 2021 February | 23 | 25 | 48 |
| 2021 January | 30 | 18 | 48 |
| 2020 December | 16 | 26 | 42 |
| 2020 November | 13 | 15 | 28 |
| 2020 October | 11 | 10 | 21 |
| 2020 September | 5 | 7 | 12 |
| 2020 August | 10 | 16 | 26 |
| 2020 July | 10 | 10 | 20 |
| 2020 June | 18 | 17 | 35 |
| 2020 May | 27 | 30 | 57 |
| 2020 April | 15 | 15 | 30 |
| 2020 March | 17 | 14 | 31 |
| 2020 February | 0 | 1 | 1 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 2 | 2 |
| 2019 November | 0 | 5 | 5 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 2 | 2 |
| 2019 July | 0 | 20 | 20 |
| 2019 June | 0 | 27 | 27 |
| 2019 May | 0 | 29 | 29 |
| 2019 April | 0 | 33 | 33 |
| 2019 March | 0 | 7 | 7 |
| 2019 February | 0 | 7 | 7 |
| 2019 January | 0 | 8 | 8 |
| 2018 December | 2 | 6 | 8 |
| 2018 November | 0 | 5 | 5 |
| 2018 October | 0 | 2 | 2 |
| 2018 September | 0 | 4 | 4 |
| 2018 August | 0 | 16 | 16 |
| 2018 July | 0 | 9 | 9 |
| 2018 June | 0 | 7 | 7 |
| 2018 May | 0 | 9 | 9 |
| 2018 April | 0 | 9 | 9 |
| 2018 March | 0 | 15 | 15 |
| 2018 February | 14 | 6 | 20 |
| 2018 January | 9 | 7 | 16 |
| 2017 December | 21 | 13 | 34 |
| 2017 November | 14 | 16 | 30 |
| 2017 October | 10 | 11 | 21 |
| 2017 September | 5 | 14 | 19 |
| 2017 August | 11 | 14 | 25 |
| 2017 July | 9 | 11 | 20 |
| 2017 June | 13 | 17 | 30 |
| 2017 May | 12 | 17 | 29 |
| 2017 April | 20 | 19 | 39 |
| 2017 March | 20 | 37 | 57 |
| 2017 February | 12 | 15 | 27 |
| 2017 January | 15 | 17 | 32 |
| 2016 December | 33 | 8 | 41 |
| 2016 November | 22 | 12 | 34 |
| 2016 October | 23 | 9 | 32 |
| 2016 September | 29 | 23 | 52 |
| 2016 August | 31 | 9 | 40 |
| 2016 July | 20 | 7 | 27 |
| 2016 June | 0 | 6 | 6 |
| 2016 May | 0 | 11 | 11 |
| 2016 April | 0 | 2 | 2 |
| 2016 March | 0 | 3 | 3 |
| 2016 February | 0 | 4 | 4 |
| 2016 January | 0 | 15 | 15 |
| 2015 December | 2 | 20 | 22 |
| 2015 November | 5 | 20 | 25 |
| 2015 October | 7 | 9 | 16 |
| 2015 September | 1 | 12 | 13 |
| 2015 August | 3 | 7 | 10 |
| 2015 July | 25 | 2 | 27 |
| 2015 June | 45 | 14 | 59 |
| 2015 May | 61 | 23 | 84 |
| 2015 April | 39 | 13 | 52 |
| 2015 March | 49 | 13 | 62 |
| 2015 February | 39 | 12 | 51 |
| 2015 January | 31 | 18 | 49 |
| 2014 December | 39 | 11 | 50 |
| 2014 November | 34 | 18 | 52 |
| 2014 October | 39 | 22 | 61 |
| 2014 September | 0 | 1 | 1 |
| 2014 August | 1 | 1 | 2 |
| 2014 July | 0 | 1 | 1 |
| 2014 June | 1 | 0 | 1 |
| 2014 May | 1 | 0 | 1 |
| 2014 April | 2 | 0 | 2 |
| 2014 February | 1 | 0 | 1 |
| 2014 January | 1 | 2 | 3 |
| 2013 December | 1 | 0 | 1 |
| 2013 September | 2 | 3 | 5 |
| 2013 July | 1 | 1 | 2 |
| 2013 June | 1 | 1 | 2 |
| 2013 April | 1 | 3 | 4 |
| 2013 March | 1 | 1 | 2 |
| 2013 February | 0 | 1 | 1 |
| 2013 January | 0 | 1 | 1 |
Show all
