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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This chapter opens with a brief introduction to the content of this supplement summarizing our current knowledge of ustekinumab with a particular focus on psoriasis but also including other indications&#46; In addition to describing the chemical structure and the process used to produce this biologic agent&#44; the chapter analyzes the drug&#39;s pharmacokinetic profile &#40;absorption&#44; distribution&#44; metabolism&#44; and excretion&#41; and interactions with other drugs&#46; A review of the information relating to the immunogenicity of the molecule is also included&#46;</p>"
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                      "titulo" => "Repeated subcutaneous injections of IL12&#47;23 p40 neutralising antibody&#44; ustekinumab&#44; in patients with relapsing-remitting multiple sclerosis&#58; a phase II&#44; double-blind&#44; placebo-controlled&#44; randomized&#44; dose-ranging study"
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                      "titulo" => "Development of the IL-12&#47;23 antagonist ustekinumab in psoriasis&#58; past&#44; present&#44; and future perspectives"
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Journal Information
Vol. 103. Issue S2.
Actualización del uso de ustekinumab: un ava nce en el tratamiento de la psoriasis
Pages 1-6 (October 2012)
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Vol. 103. Issue S2.
Actualización del uso de ustekinumab: un ava nce en el tratamiento de la psoriasis
Pages 1-6 (October 2012)
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Ustekinumab. Introducción. Estructura química. Farmacocinética e inmunogenicidad
Ustekinumab. Introduction. Chemical Structure. Pharmacokinetics and immunogenicity
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5288
E. Daudén
Servicio de Dermatología. Hospital Universitario de la Princesa. Madrid. España
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Resumen

Se presenta el contenido de esta monografía sobre el conocimiento actual del ustekinumab, especialmente en relación con la psoriasis pero también en otras indicaciones. Se describe su estructura química, el proceso de obtención, se analizan los datos farmacocinéticos (absorción, distribución, metabolismo, eliminación), sus interacciones y se revisa la información relativa a la inmunogenicidad de la molécula.

Palabras clave:
Ustekinumab
Interleucina 12
Interleucina 23
Terapia biológica
Psoriasis
Enfermedad de Crohn
Farmacocinética
Abstract

This chapter opens with a brief introduction to the content of this supplement summarizing our current knowledge of ustekinumab with a particular focus on psoriasis but also including other indications. In addition to describing the chemical structure and the process used to produce this biologic agent, the chapter analyzes the drug's pharmacokinetic profile (absorption, distribution, metabolism, and excretion) and interactions with other drugs. A review of the information relating to the immunogenicity of the molecule is also included.

Keywords:
Ustekinumab
Interleukin 12
Interleukin 23
Biologic therapy
Psoriasis
Crohn disease
Pharmacokinetics
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