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      "titulo" => "Mecanismo de acción de ustekinumab y su relevancia en la patogénesis de la psoriasis. Impacto en el sistema inmune"
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        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta el contenido de esta monograf&#237;a sobre el conocimiento actual del ustekinumab&#44; especialmente en relaci&#243;n con la psoriasis pero tambi&#233;n en otras indicaciones&#46; Se describe su estructura qu&#237;mica&#44; el proceso de obtenci&#243;n&#44; se analizan los datos farmacocin&#233;ticos &#40;absorci&#243;n&#44; distribuci&#243;n&#44; metabolismo&#44; eliminaci&#243;n&#41;&#44; sus interacciones y se revisa la informaci&#243;n relativa a la inmunogenicidad de la mol&#233;cula&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This chapter opens with a brief introduction to the content of this supplement summarizing our current knowledge of ustekinumab with a particular focus on psoriasis but also including other indications&#46; In addition to describing the chemical structure and the process used to produce this biologic agent&#44; the chapter analyzes the drug&#39;s pharmacokinetic profile &#40;absorption&#44; distribution&#44; metabolism&#44; and excretion&#41; and interactions with other drugs&#46; A review of the information relating to the immunogenicity of the molecule is also included&#46;</p>"
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                            0 => "F&#46;O&#46; Nestle"
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                      "doi" => "10.1056/NEJMra0804595"
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                    0 => array:2 [
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                  "referenciaCompleta" => "Ustekinumab SPC&#46; &#40;Acceso en Ago 2011&#41;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.emea.europe.eu/humandocs/PDFs/EPAR/stelara/H-958-PI-en.pdf">http&#58;&#47;&#47;www&#46;emea&#46;europe&#46;eu&#47;humandocs&#47;PDFs&#47;EPAR&#47;stelara&#47;H-958-PI-en&#46;pdf</a>&#41;&#46;"
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                      "titulo" => "A randomized trial of ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; in patients with moderate-to-severe Crohn&#39;s disease"
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                        0 => array:3 [
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                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2008.07.014"
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                      "titulo" => "Ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; for psoriatic arthritis&#58; randomized&#44; double-blind&#44; placebo-controlled&#44; crossover trial"
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                            0 => "A&#46; Gottlieb"
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                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(09)60140-9"
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                            0 => "L&#46;H&#46; Kasper"
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                    0 => array:2 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeated subcutaneous injections of IL12&#47;23 p40 neutralising antibody&#44; ustekinumab&#44; in patients with relapsing-remitting multiple sclerosis&#58; a phase II&#44; double-blind&#44; placebo-controlled&#44; randomized&#44; dose-ranging study"
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                        0 => array:3 [
                          "colaboracion" => "Ustekinumab MS Investigators"
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                            0 => "B&#46;M&#46; Segal"
                            1 => "C&#46;S&#46; Constantinescu"
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                    0 => array:2 [
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                      "titulo" => "High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice"
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                            1 => "S&#46;L&#46; O&#8217;Donnell"
                            2 => "T&#46; Bengoechea"
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                    0 => array:2 [
                      "titulo" => "Development of the IL-12&#47;23 antagonist ustekinumab in psoriasis&#58; past&#44; present&#44; and future perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Yeilding"
                            1 => "P&#46; Szapary"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Benson"
                            1 => "C&#46;W&#46; Sachs"
                            2 => "G&#46; Treacy"
                            3 => "H&#46; Zhou"
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                      ]
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              ]
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                    0 => array:2 [
                      "titulo" => "Population pharmacokinetic modeling of ustekinumab&#44; a human monoclonal antibody targeting IL-12&#47;23p40&#44; in patients with moderate to severe plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhu"
                            1 => "C&#46; Hu"
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                            4 => "J&#46;C&#46; Marini"
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                  ]
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                      "doi" => "10.1177/0091270008329556"
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                          ]
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                ]
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