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measurement tools aim to objectively evaluate how a certain disease affects the life of an individual&#46; These questionnaires offer insights into the impact of the disease on overall quality of life or specific areas&#44; such as functionality&#44; emotions&#44; etc&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">HRQoL measurement can be done in 2 ways&#58; using generic instruments that assess quality of life globally&#44; such as the SF-12 questionnaire&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">5</span></a> and specific instruments to deal with problems associated with particular disorders&#44; patient types&#44; or functional areas&#44;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">6&#44;7</span></a> such as the Dermatology Life Quality Index &#91;DLQI&#93;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">8</span></a> or the SKINDEX-29&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">9</span></a> both validated in Spanish language&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The SF-12 scale&#44; widely used in research&#44; has been associated with specific scales such as the DLQI in atopic dermatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">10</span></a> However&#44; these generic scales may not adequately capture the impact of certain diseases like rosacea&#46; The Rosacea Quality of Life &#40;RosaQoL&#41; scale&#8212;which is specific to rosacea&#8212;is available in English and measures the impact of its symptoms on quality of life&#44; being more precise than generalist scales&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">11</span></a> Having a validated tool in Spanish will allow for assessing the impact on the patient&#39;s quality of life&#44; and individualizing treatment effectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The objectives of this study are&#58; 1&#41; 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scale15 &#40;cases&#41; and 50 healthy participants &#40;controls&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">RosaQoL questionnaire</span><p id="par0060" class="elsevierStylePara elsevierViewall">The RosaQoL questionnaire is available in English and measures the impact of the disorder and its symptoms on quality of life&#44; being more precise than generalist scales as it is specific to rosacea-related quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">11</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">It is a self-administered tool developed from the SKINDEX-29 questionnaire consisting of 21 items categorized into 3 dimensions or domains&#58; symptoms &#40;7 items&#41;&#44; functionality &#40;3 items&#41;&#44; and emotional state &#40;11 items&#41;&#46; Each item has a response scale with 5 possible options&#44; being 0&#58; never&#59; 1&#58; rarely&#59; 2&#58; sometimes&#59; 3&#59; often&#59; and 4&#58; always&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">SF-12 questionnaire</span><p id="par0070" class="elsevierStylePara elsevierViewall">The SF-12 health questionnaire is available in Spanish and measures 8 different aspects of HRQoL&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">16&#44;17</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The SF-12 scale is a self-administered tool developed from the SF-36 scale consisting of 12 items categorized into 8 different dimensions or domains&#58; physical function &#40;2 items&#41;&#44; physical role &#40;2 items&#41;&#44; bodily pain &#40;1 item&#41;&#44; general health &#40;1 item&#41;&#44; vitality &#40;1 item&#41;&#44; emotional role &#40;2 items&#41;&#44; social function &#40;1 item&#41;&#44; and mental health &#40;2 items&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">16</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">IGA scale</span><p id="par0080" class="elsevierStylePara elsevierViewall">The IGA scale is an ordinal scale with 5 categories that evaluate the severity of lesions&#46; Classification goes from 0 &#40;no inflammatory lesions or erythema&#41; up to 4 &#40;intense erythema and&#47;or numerous papules and pustules&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0085" class="elsevierStylePara elsevierViewall">Data analysis was performed using the SAS System version 9&#46;4 statistical package &#40;SAS Institute Inc&#46;&#44; Cary&#44; North Carolina&#44; United States&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The questionnaire will be considered discriminative the closer the area under the ROC &#40;Receiver Operating Characteristic&#41; curve is to a value of 1&#46;00&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">18</span></a> Both the sensitivity and specificity rates of the questionnaire were evaluated using Youden&#39;s criterion&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">19</span></a> and the internal consistency reliability of the questionnaire was measured using Cronbach&#39;s alpha coefficient&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> Following the criterion recommended by George and Mallery&#44;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">21</span></a> a Cronbach&#39;s alpha coefficient &#8805; 0&#46;90 indicates excellent internal consistency&#46; To evaluate test-retest reliability&#44; the method proposed by Bland and Altman<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">22</span></a> and the intraclass correlation coefficient proposed by Shrout and Fleiss<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">23</span></a> were used&#46; An intraclass correlation coefficient &#62; 0&#46;90 indicates high reliability of the questionnaire&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">24</span></a> Convergence analysis between the RosaQoL scale and the more general SF-12 scale was obtained using Pearson correlation coefficient &#40;results between 0&#46;4 and 0&#46;7 were considered satisfactory&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">25</span></a></p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">The translated RosaQoL questionnaire</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; was submitted to 531 participants with a mean age of 47 years &#40;SD&#44; 13&#46;4 &#91;95&#37;CI&#44; 45&#46;8-48&#46;1&#93;&#41;&#44; 71 of whom &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>369&#41; were women and 29&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>151&#41;&#44; men&#46; Among those with rosacea&#44; the papulopustular type was the most common&#44; representing 65&#46;9&#37; of the cases&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">According to the IGA scale&#44; IGA grade 2 was the most common one found in 44&#46;4&#37; of the cases &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Statistically significant differences were reported between men and women in the overall score of the RosaQoL questionnaire&#44; as well as in each of the 3 dimensions of the scale &#40;symptoms&#44; functionality&#44; and emotional state&#59; p &#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#44; although these differences were non statistically significant when analyzed by age &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">No significant differences were found in the RosaQoL score between the control group &#40;healthy patients &#91;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&#93;&#44; mean overall score&#44; 43&#46;5 &#91;SD&#44; 13&#46;7&#93;&#41; and the patient group &#40;&#91;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>468&#93;&#44; mean overall score&#44; 47&#46;3 &#91;SD&#44; 13&#46;3&#93;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;052&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Similarly&#44; the score obtained in RosaQoL was higher in more severe grades of rosacea&#44; with a greater impact being reported in the symptomatology dimension &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">The internal consistency method&#44; based on Cronbach&#39;s alpha&#44; estimates the reliability of a measurement instrument through a set of items expected to measure the same construct or theoretical dimension&#46; Cronbach&#39;s alpha value evaluated across all questionnaires was 0&#46;96&#44; which is consistent with the general criterion recommended by George and Mallery21&#44; where values <span class="elsevierStyleUnderline">&#62;</span> 0&#46;9 are indicative of high internal consistency&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">When each item was individually removed from the scale&#44; no improvement in Cronbach&#39;s alpha was obtained&#46; Therefore&#44; it is established that no item is prone to elimination&#46; The questionnaire statistical power to discriminate cases using the ROC curve yielded an area under the curve &#40;AUC&#41; of 0&#46;96 &#40;95&#37;CI&#44; 0&#46;92-0&#46;99&#41;&#46; Considering that values &#62; 0&#46;9 indicate high discriminative power&#44; we can say that the questionnaire has a high capacity to detect cases&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The evaluation of sensitivity and specificity using Youden&#39;s criterion yielded a cutoff in the RosaQoL score &#62; 1&#46;476&#44; thusproviding the questionnaire with high sensitivity&#44; with a value of 0&#46;99&#44; and a specificity to detect cases of 0&#46;85&#46; For this cutoff&#44; 425 true positives&#44; 43 true negatives&#44; 7 false positives&#44; and 3 false negatives were reported&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The Varimax rotated component matrix for 3 factors contributes to the validation of the scale construct&#44; showing that items tend to group into the functional&#44; emotional&#44; and symptomatic factors proposed in the original scale<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">26</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">All the items of the questionnaire are categorized as in the original questionnaire&#44; except for slight discrepancies in 4 of them&#46; Item &#35;11 &#8220;I am bothered by the look of my skin &#40;redness&#44; spots&#41;&#8221; and item &#35;14 &#8220;I am bothered by the persistence&#47;recurrence of my rosacea&#44;&#8221; which in the original scale are grouped in the emotional dimension and seem to have a slightly more specific weight in the symptomatic dimension in the Spanish version&#46; Although item &#35;16 &#8220;My skin looks bumpy &#40;uneven&#44; not smooth&#44; irregular&#41;&#8221; should be represented in the symptomatic dimension&#44; it is somehow better represented in the emotional one&#46; Finally&#44; although item &#35;19 &#8220;My eyes bother me &#40;I can feel how dry or gritty they are&#41;&#44;&#8221; should be better represented in the symptomatic dimension&#44; it was better represented in the functional one&#46; Since the specific weight difference of these 4 items was minimal&#44; we decided to maintain the original dimension classification for comparative evaluation purposes with other versions of the scale&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">When analyzing the correlation between the RosaQoL scale and the more generalist SF-12 scale&#44; most studied correlations were statistically significant and entirely negative&#46; A higher score on the RosaQoL scale in any dimension &#40;whether functional&#44; emotional&#44; or symptomatic&#41; is associated with a worse quality of life in all dimensions of the SF-12 scale &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">The temporal reliability of the questionnaire was confirmed through the test-retest method&#44; as no discrepancies were detected over time between patients&#8217; responses&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">To evaluate sensitivity to change&#44; a follow-up visit was conducted 3 months after the start of the study&#44; when rosacea patients were asked to complete both the RosaQoL and SF-12 questionnaires again&#46; In most calculated correlations&#44; a statistically significant negative correlation was reported&#46; A greater increase in the RosaQoL scale and all its dimensions &#40;functional&#44; emotional&#44; and symptomatic&#41; was associated with a worse progression of quality of life in all dimensions of the SF-12 scale&#46; This same correlation was also seen when analyzed by age group and disease severity&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">To consider a scale valid as an instrument for measuring HRQoL&#44; a simple translation is not sufficient&#59; rather&#44; a series of structured and guided steps are necessary&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">13</span></a> To make sure that the reliability and validity requirements of such tools are met&#44; the measurement properties of the translated version in a population need to be evaluated with similar characteristics and then submitted to a validation process&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">25</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">The study of measurement properties demonstrates that the Spanish-translated and culturally adapted version of the RosaQoL questionnaire allows us&#44; like the original version&#44; to obtain statistically significant differences between the healthy population and the population with rosacea&#46; The level of impact on the RosaQoL scale in all dimensions was directly proportional to the severity of rosacea&#44; with the highest degree of impact being reported in the symptomatology dimension&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Nicholson et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">11</span></a> highlighted the validity of RosaQoL in discriminating rosacea patients vs the SKINDEX-29&#46; In its original version&#44; the specific RosaQoL scale showed a higher response level at 4-6 months vs the SKINDEX-29 for the total score in patients reporting improvement in their rosacea&#44; showing greater specificity&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The reliability study of the RosaQoL questionnaire demonstrates that the tool has a high degree of internal consistency&#44; obtaining a Cronbach&#39;s alpha value of 0&#46;96&#44; and that its discriminative power to detect cases is extremely high&#44; obtaining a ROC AUC score of 0&#46;96&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Reproducibility is one of the important points we should consider when evaluating a tool for measuring HRQoL&#46; To assess reproducibility&#44; it is checked whether similar scores can be obtained when applied in 2 different points in time to the same population by the same evaluators using the exact same method&#46; Since it is important to avoid the &#8220;learning effect&#44;&#8221; the time between the initial test and the retest should not be too long&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">27</span></a> In our study&#44; the score obtained with the RosaQoL questionnaire does not vary significantly between the test and retest results of the same patient &#40;interval of 1 to 2 days&#41;&#46; Our test-retest results show a very high correlation between both tests in the 3 dimensions of the questionnaire&#44; indicating a high degree of reliability&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The construct validity study through factor analysis showed that the items of the RosaQoL scale tend to group based on the functional&#44; emotional&#44; and symptomatic dimensions&#44; as in the original version of the scale&#44; and that the items that make up each one of them tend to group consistently in each dimension&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Our study also analyzed the convergence &#40;&#8220;correlation&#8221;&#41; between the RosaQoL scale and the more generalist SF-12 scale and found that it was positive&#44; evidencing that the scales are conceptually congruent or similar&#58;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">25</span></a> higher increases in the RosaQoL scale and all its sub-dimensions &#40;functional&#44; emotional&#44; and symptomatic&#41; were associated with worse quality of life in all dimensions of the SF-12 scale&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusions</span><p id="par0195" class="elsevierStylePara elsevierViewall">The RosaQoL scale&#44; adapted to Spanish&#44; has proven to be a valid&#44; sensitive&#44; and reliable tool for measuring quality of life&#44; in all its dimensions &#40;symptoms&#44; functionality&#44; and emotional state&#41; among the Spanish population with rosacea&#46; Results indicate that the greater the severity of rosacea&#44; the greater the impact on quality of life&#44; with the dimensions of symptomatology and emotional state being the most affected ones&#44; especially in women&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0200" class="elsevierStylePara elsevierViewall">This project has received funding and support from Laboratorios Galderma S&#46;A&#46;U&#46; Dr&#46; Salleras and Dr&#46; Pozo declared no conflicts of interest whatsoever&#46; Dr&#46; Ribera received grants and fees related to research&#44; consulting&#44; and training from the following companies&#58; AbbVie&#44; Almirall&#44; Amgen&#44; Boehringer Ingelheim&#44; Bristol Myers Squibb&#44; Galderma&#44; Gebro Pharma&#44; Janssen&#44; LEO Pharma&#44; Eli Lilly&#44; Novartis&#44; Pfizer&#44; Pierre-Fabre&#44; Sandoz&#44; SKB&#44; and UCB&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rosacea is a chronic disease negatively impacting the patients&#8217; quality of life and mental health&#46; The Rosacea Quality of Life &#40;RosaQoL&#41; scale could be a useful tool to monitor patients while on therapy vs rosacea&#44; as it measures the impact on quality of life and helps individualize treatment to meet the patients&#8217; needs&#46; RosaQoL is a validated scale that can be completed within a few minutes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The original scale was translated and back translated by 2 native translators&#44; with input from an expert committee when necessary&#46; This version was tested on 21 patients to ensure proper understanding&#46; Psychometric characteristics and validity were determined using various measures &#40;sensitivity and specificity via ROC curve and internal consistency via Cronbach&#39;s alpha&#41;&#46; The correlation between RosaQoL and SF-12 scales was assessed using Pearson correlation coefficients&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 531 participants responded to the scale &#40;481 with rosacea and 50 controls&#41;&#46; The scale demonstrated excellent sensitivity and specificity &#40;ROC curve&#44; 0&#46;96&#59; 95&#37;<span class="elsevierStyleSmallCaps">C</span>I&#44; 0&#46;92-0&#46;99&#41; and high internal consistency &#40;Cronbach&#39;s alpha&#44; 0&#46;96&#41;&#46; RosaQoL correlated with SF-12&#46; A higher score on the RosaQoL scale was associated with worse quality of life in all dimensions of the SF-12 scale&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The Spanish version of the RosaQoL scale exhibits psychometric characteristics&#44; which are similar to the original scale&#46; Also&#44; the RosaQoL scale is useful to assess the quality of life of patients with rosacea&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La ros&#225;cea es una enfermedad cr&#243;nica que afecta negativamente a la calidad de vida y la salud mental de los pacientes&#46; La escala <span class="elsevierStyleItalic">Rosacea Quality of Life</span> &#40;RosaQoL&#41; podr&#237;a ser una herramienta &#250;til para seguir a los pacientes durante el tratamiento de la ros&#225;cea&#44; ya que mide el impacto en la calidad de vida y ayuda a adaptar el tratamiento a las necesidades del paciente&#46; Es una escala validada&#44; que se cumplimenta en pocos minutos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; la traducci&#243;n y retrotraducci&#243;n de la escala original&#44; por parte de dos traductores nativos&#44; con el consejo de un comit&#233; de expertos cuando fue necesario&#46; Esta versi&#243;n fue testada en 21 pacientes para comprobar la correcta comprensi&#243;n&#46; Las caracter&#237;sticas psicom&#233;tricas y su validez se determinaron utilizando varias medidas &#40;sensibilidad y especificidad mediante curva ROC y consistencia interna por alfa de Cronbach&#41;&#46; La correlaci&#243;n entre escalas RosaQoL y SF-12 se realiz&#243; mediante coeficientes de correlaci&#243;n de Pearson&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Un total de 531 participantes respondieron a la escala &#40;481 con ros&#225;cea y 50 controles&#41;&#46; La escala present&#243; una excelente sensibilidad y especificidad &#40;curva ROC&#58; 0&#44;96&#59; IC 95&#37;&#58; 0&#44;92-0&#44;99&#41; y una elevada correlaci&#243;n interna &#40;alfa de Cronbach&#58; 0&#44;96&#41;&#46; La escala RosaQoL se correlacion&#243; con la SF-12&#46; Una mayor puntuaci&#243;n en la escala RosaQoL se asoci&#243; con una peor calidad de vida en todas las dimensiones de la escala SF-12&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La versi&#243;n espa&#241;ola de la escala RosaQoL presenta caracter&#237;sticas psicom&#233;tricas similares a la escala original&#44; y es &#250;til para evaluar la calidad de vida en los pacientes con ros&#225;cea&#46;</p></span>"
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        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1995
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            "Tamanyo" => 345103
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Impact of various RosaQoL dimensions based on the severity of rosacea measured by IGA&#46; Significant p-values for all dimensions &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0000 for all dimensions except for the functional dimension where p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;00631&#41;&#46; V0&#58; initial visit&#46;</p>"
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      1 => array:8 [
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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            "identificador" => "at1"
            "detalle" => "Table "
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">How often have you identified yourself with any of these statements over the past 4 weeks&#63;</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry that my rosacea could be severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea burns or itches&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry about scarring from my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry that my rosacea might get worse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry about the side effects associated with rosacea drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea is irritated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea embarrasses me&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am frustrated with my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea makes my skin sensitive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am annoyed by my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am bothered by the look of my skin &#40;redness&#44; spots&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea makes me feel self-conscious&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I try to cover my rosacea &#40;with makeup&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am bothered by the persistence&#47;recurrence of my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I avoid certain foods and drinks due to my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin looks bumpy &#40;uneven&#44; not smooth&#44; irregular&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin gets red&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin gets easily irritated &#40;cosmetics&#44; aftershave lotions&#44; makeup removers&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My eyes bother me &#40;they feel dry or gritty&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I think about my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I avoid certain environments &#40;heat&#44; humidity&#44; cold&#41; due to my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Items of the RosaQoL Questionnaire&#46;</p>"
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      2 => array:8 [
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        "etiqueta" => "Table 2"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Severity of rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; Valid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IGA 0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IGA 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IGA 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IGA 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IGA 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;64 &#40;1&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">332&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;14 &#40;0&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;00000<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Missing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;43 &#40;0&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">478&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;00 &#40;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3689671.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Statistically significant difference&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Differences in the RosaQoLquestionnaire scores at initial visit by gender&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">p-value not significant for all age groups&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean score &#40;SD&#41;</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Emotional dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Symptomatology dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Functional dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 to 35 years &#40;n <span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span> 97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;92 &#40;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;93 &#40;1&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;03 &#40;0&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;64 &#40;1&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 to 60 years &#40;n <span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span> 297&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;04 &#40;0&#46;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;08 &#40;1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;14 &#40;0&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;69 &#40;1&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 60 years &#40;n <span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span> 71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;84 &#40;1&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;86 &#40;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;94 &#40;1&#46;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;52 &#40;1&#46;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Missing &#40;n <span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span> 13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;51 &#40;0&#46;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;50 &#40;0&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;67 &#40;0&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;13 &#40;1&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total &#40;n <span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span> 478&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;00 &#40;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;03 &#40;1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;10 &#40;0&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;67 &#40;1&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3689674.png"
              ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Results of the RosaQoL Questionnaire scores by age groups &#40;cases only&#41;&#46;</p>"
        ]
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      5 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at5"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Figures in bold show the results of the factor analysis in the dimension in which it is categorized within the Spanish scale&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Figures in italics show the results of the factor analysis in the dimension it occupied in the original scale&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Questionnaire item&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Question&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Emotional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Symptomatic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Functional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry that my rosacea could be severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry about scarring from my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry that my rosacea might get worse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I worry about the side effects associated with rosacea drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea embarrasses me&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am frustrated with my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am annoyed by my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;11<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am bothered by the look of my skin &#40;redness&#44; spots&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">0&#46;58</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;64</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea makes me feel self-conscious&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;14<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I am bothered by the persistence&#47;recurrence of my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">0&#46;58</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;63</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I think about my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea burns or itches&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea is irritated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My rosacea makes my skin sensitive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;16<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin looks bumpy &#40;uneven&#44; not smooth&#44; irregular&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">0&#46;42</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin gets red&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My skin gets easily irritated &#40;cosmetics&#44; aftershave lotions&#44; makeup removers&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;19<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">My eyes bother me &#40;they feel dry or gritty&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">0&#46;26</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;54</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I try to cover my rosacea &#40;with makeup&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I avoid certain foods and drinks due to my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Item &#35;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I avoid certain environments &#40;heat&#44; humidity&#44; cold&#41; due to my rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="11" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pearson correlation coefficients</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Physical health SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mental health SF-12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Physical function SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Physical role SF-12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bodily pain SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">General health SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vitality SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Emotional role SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Social function SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mental health SF-12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="11" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Emotional Dimension &#40;RosaQoL&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pearson correlation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;03553&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;33318&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;11879&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;04632&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;19839&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;17693&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;12947&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;2349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;28287&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;36157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sig&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;471</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0146&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;3425</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0077&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">414&nbsp;\t\t\t\t\t\t\n
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                0 => array:2 [
                  "contribucion" => array:1 [
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                            0 => "F&#46; Moustafa"
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                      "doi" => "10.1016/j.jaad.2014.05.036"
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
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                        "paginaInicial" => "973"
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                          "etal" => false
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                        "paginaInicial" => "143"
                        "paginaFinal" => "148"
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                    0 => array:2 [
                      "titulo" => "&#91;The Spanish version of Skindex-29 An instrument for measuring quality of life in patients with cutaneous diseases&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Jones-Caballero"
                            1 => "P&#46;F&#46; Pe&#241;as"
                            2 => "A&#46; Garc&#237;a-D&#237;ez"
                            3 => "M&#46;M&#46; Chren"
                            4 => "X&#46; Bad&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2002"
                        "volumen" => "118"
                        "paginaInicial" => "5"
                        "paginaFinal" => "9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation and Interpretation of Short Form 12 and Comparison with Dermatology Life Quality Index in Atopic Dermatitis in Adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;I&#46; Silverberg"
                            1 => "J&#46;M&#46; Gelfand"
                            2 => "D&#46;J&#46; Margolis"
                            3 => "M&#46; Boguniewicz"
                            4 => "L&#46; Fonacier"
                            5 => "M&#46;H&#46; Grayson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jid.2019.03.1152"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2019"
                        "volumen" => "139"
                        "paginaInicial" => "2090"
                        "paginaFinal" => "2097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31009616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A pilot quality-of-life instrument for acne rosacea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Nicholson"
                            1 => "L&#46; Abramova"
                            2 => "M&#46;M&#46; Chren"
                            3 => "J&#46; Yeung"
                            4 => "S&#46;Y&#46; Chon"
                            5 => "S&#46;C&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.01.048"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "213"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17445948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross Cultural Adaptation &#38; Psychometric Validation of Instruments&#58; Step-wise Description"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;M&#46;Y&#46; Arafat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Psychiatry&#46;"
                        "fecha" => "2016"
                        "volumen" => "1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14252250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the process of cross- cultural adaptation of self-report measures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;E&#46; Beaton"
                            1 => "C&#46; Bombardier"
                            2 => "F&#46; Guillemin"
                            3 => "M&#46;B&#46; Ferraz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00007632-200012150-00014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Spine &#40;Phila Pa 1976&#41;&#46;"
                        "fecha" => "2000"
                        "volumen" => "25"
                        "paginaInicial" => "3186"
                        "paginaFinal" => "3191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11124735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adaptaci&#243;n cultural y validaci&#243;n de cuestionarios de salud&#58; Revisi&#243;n y recomendaciones metodol&#243;gicas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Ramada-Rodilla"
                            1 => "C&#46; Serra-Pujadas"
                            2 => "G&#46;L&#46; Delcl&#243;s-Clanchet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0036-36342013000100009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Salud Publica Mex&#46;"
                        "fecha" => "2013"
                        "volumen" => "55"
                        "paginaInicial" => "57"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23370259"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining treatment success in rosacea as &#8216;clear&#8217; may provide multiple patient benefits&#58; results of a pooled analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Webster"
                            1 => "M&#46; Schaller"
                            2 => "J&#46; Tan"
                            3 => "J&#46;M&#46; Jackson"
                            4 => "N&#46; Kerrouche"
                            5 => "G&#46; Sch&#228;fer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546634.2017.1343435"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2017"
                        "volumen" => "28"
                        "paginaInicial" => "469"
                        "paginaFinal" => "474"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28617145"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross- validation of item selection and scoring for the SF-12 Health Survey in nine countries&#58; results from the IQOLA Project International Quality of Life Assessment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Gandek"
                            1 => "J&#46;E&#46; Ware"
                            2 => "N&#46;K&#46; Aaronson"
                            3 => "G&#46; Apolone"
                            4 => "J&#46;B&#46; Bjorner"
                            5 => "J&#46;E&#46; Brazier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0895-4356(98)00109-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol&#46;"
                        "fecha" => "1998"
                        "volumen" => "51"
                        "paginaInicial" => "1171"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9817135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normas de referencia para el Cuestionario de Salud SF-12 versi&#243;n 2 basadas en poblaci&#243;n general de Catalu&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Schmidt"
                            1 => "G&#46; Vilagut"
                            2 => "O&#46; Garin"
                            3 => "O&#46; Cunillera"
                            4 => "R&#46; Tresserras"
                            5 => "P&#46; Brugulat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medcli.2011.10.024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2012"
                        "volumen" => "139"
                        "paginaInicial" => "613"
                        "paginaFinal" => "625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22244683"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Using ROC curves in clinical investigation&#58; theoretical and practical issues&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Cerda"
                            1 => "L&#46; Cifuentes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182012000200003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol&#46;"
                        "fecha" => "2012"
                        "volumen" => "29"
                        "paginaInicial" => "138"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22689026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Youden Index and optimal cut- point estimated from observations affected by a lower limit of detection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;D&#46; Ruopp"
                            1 => "N&#46;J&#46; Perkins"
                            2 => "B&#46;W&#46; Whitcomb"
                            3 => "E&#46;F&#46; Schisterman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/bimj.200710415"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biom J&#46;"
                        "fecha" => "2008"
                        "volumen" => "50"
                        "paginaInicial" => "419"
                        "paginaFinal" => "430"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18435502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coefficient alpha and the internal structure of tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;J&#46; Cronbach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Psychometrika&#46;"
                        "fecha" => "1951"
                        "volumen" => "16"
                        "paginaInicial" => "297"
                        "paginaFinal" => "334"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SPSS for Windows step by step&#58; A simple guide and reference 11&#46; 0 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;M&#46; George"
                            1 => "P&#46; Mallery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2003"
                        "editorial" => "Allyn &#38; Bacon"
                        "editorialLocalizacion" => "Boston"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measuring agreement in method comparison studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Bland"
                            1 => "D&#46;G&#46; Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/096228029900800204"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Methods Med Res&#46;"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "135"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10501650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraclass correlations&#58; Uses in assessing rater reliability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;E&#46; Shrout"
                            1 => "J&#46;L&#46; Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1037//0033-2909.86.2.420"
                      "Revista" => array:6 [
                        "tituloSerie" => "Psychol Bull&#46;"
                        "fecha" => "1979"
                        "volumen" => "86"
                        "paginaInicial" => "420"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18839484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;K&#46; Koo"
                            1 => "M&#46;Y&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Chiropr Med&#46;"
                        "fecha" => "2016"
                        "volumen" => "15"
                        "paginaInicial" => "155"
                        "paginaFinal" => "163"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Construcci&#243;n y validaci&#243;n de escalas de medici&#243;n en salud&#58; Revisi&#243;n de propiedades psicom&#233;tricas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Luj&#225;n-Tangarife"
                            1 => "J&#46;A&#46; Cardona-Arias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "11"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El An&#225;lisis Factorial en la construcci&#243;n e interpretaci&#243;n de tests&#44; escalas y cuestionarios"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;M&#46; Vallejo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2011"
                        "editorial" => "Universidad Pontificia de Comillas"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of questionnaires"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Garc&#237;a de Y&#233;benes Prous"
                            1 => "F&#46; Rodr&#237;guez Salvan&#233;s"
                            2 => "L&#46; Carmona Ortells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2008.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin&#46;"
                        "fecha" => "2009"
                        "volumen" => "5"
                        "paginaInicial" => "171"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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Vol. 115. Issue 9.
Pages T858-T866 (October 2024)
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Vol. 115. Issue 9.
Pages T858-T866 (October 2024)
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Cross-Cultural Validation of the RosaQoL Scale in Spanish Language
Validación transcultural al idioma español de la escala RosaQoL
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M. Salleras Redonneta,
Corresponding author
salleras_m@yahoo.es

Corresponding author.
, J. del Pozo Losadab, M. Ribera Pibernatc
a Servicio de Dermatología, Hospital Universitario Sagrat Cor, Barcelona, Spain
b Servicio de Dermatología, Hospital Universitario, A Coruña, Spain
c Servicio de Dermatología, Parc Taulí Hospital Universitari. Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain
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Actas Dermosifiliogr. 2024;115:858-6610.1016/j.ad.2024.02.014
M. Salleras Redonnet, J. del Pozo Losada, M. Ribera Pibernat
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Figures (1)
Tables (6)
Table 1. Items of the RosaQoL Questionnaire.
Table 2. Severity of rosacea based on the IGA scale at initial visit (cases).
Table 3. Differences in the RosaQoLquestionnaire scores at initial visit by gender.
Table 4. Results of the RosaQoL Questionnaire scores by age groups (cases only).
Table 5. Rotated component matrix of the varimax factor model for the RosaQoL questionnaire (cases only).
Table 6. Correlation between the RosaQoL and SF-12 scales.
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Abstract
Introduction

Rosacea is a chronic disease negatively impacting the patients’ quality of life and mental health. The Rosacea Quality of Life (RosaQoL) scale could be a useful tool to monitor patients while on therapy vs rosacea, as it measures the impact on quality of life and helps individualize treatment to meet the patients’ needs. RosaQoL is a validated scale that can be completed within a few minutes.

Materials and methods

The original scale was translated and back translated by 2 native translators, with input from an expert committee when necessary. This version was tested on 21 patients to ensure proper understanding. Psychometric characteristics and validity were determined using various measures (sensitivity and specificity via ROC curve and internal consistency via Cronbach's alpha). The correlation between RosaQoL and SF-12 scales was assessed using Pearson correlation coefficients.

Results

A total of 531 participants responded to the scale (481 with rosacea and 50 controls). The scale demonstrated excellent sensitivity and specificity (ROC curve, 0.96; 95%CI, 0.92-0.99) and high internal consistency (Cronbach's alpha, 0.96). RosaQoL correlated with SF-12. A higher score on the RosaQoL scale was associated with worse quality of life in all dimensions of the SF-12 scale.

Conclusions

The Spanish version of the RosaQoL scale exhibits psychometric characteristics, which are similar to the original scale. Also, the RosaQoL scale is useful to assess the quality of life of patients with rosacea.

Keywords:
Quality of life
Rosacea
Scale
Questionnaire
Validation and cross-cultural adaptation
Resumen
Introducción

La rosácea es una enfermedad crónica que afecta negativamente a la calidad de vida y la salud mental de los pacientes. La escala Rosacea Quality of Life (RosaQoL) podría ser una herramienta útil para seguir a los pacientes durante el tratamiento de la rosácea, ya que mide el impacto en la calidad de vida y ayuda a adaptar el tratamiento a las necesidades del paciente. Es una escala validada, que se cumplimenta en pocos minutos.

Materiales y métodos

Se realizó la traducción y retrotraducción de la escala original, por parte de dos traductores nativos, con el consejo de un comité de expertos cuando fue necesario. Esta versión fue testada en 21 pacientes para comprobar la correcta comprensión. Las características psicométricas y su validez se determinaron utilizando varias medidas (sensibilidad y especificidad mediante curva ROC y consistencia interna por alfa de Cronbach). La correlación entre escalas RosaQoL y SF-12 se realizó mediante coeficientes de correlación de Pearson.

Resultados

Un total de 531 participantes respondieron a la escala (481 con rosácea y 50 controles). La escala presentó una excelente sensibilidad y especificidad (curva ROC: 0,96; IC 95%: 0,92-0,99) y una elevada correlación interna (alfa de Cronbach: 0,96). La escala RosaQoL se correlacionó con la SF-12. Una mayor puntuación en la escala RosaQoL se asoció con una peor calidad de vida en todas las dimensiones de la escala SF-12.

Conclusiones

La versión española de la escala RosaQoL presenta características psicométricas similares a la escala original, y es útil para evaluar la calidad de vida en los pacientes con rosácea.

Palabras clave:
Calidad de vida
Rosácea
Escala
Cuestionario
Validación y adaptación transcultural
Full Text
Introduction

Rosacea is a chronic skin disease that can also damage the eyes. It typically occurs in middle-aged and older adults with fair skin, especially women. Symptoms include redness, papules, and pustules, and in some patients, thickening and fibrosis of the skin, known as phyma.1

Rosacea negatively impacts the patients’ quality of life and mental health due to the presence of erythema and facial lesions that severely alter self-image and self-esteem.2,3

Health-related quality of life (HRQoL) measurement tools aim to objectively evaluate how a certain disease affects the life of an individual. These questionnaires offer insights into the impact of the disease on overall quality of life or specific areas, such as functionality, emotions, etc.4.

HRQoL measurement can be done in 2 ways: using generic instruments that assess quality of life globally, such as the SF-12 questionnaire,5 and specific instruments to deal with problems associated with particular disorders, patient types, or functional areas,6,7 such as the Dermatology Life Quality Index [DLQI]8 or the SKINDEX-29,9 both validated in Spanish language).

The SF-12 scale, widely used in research, has been associated with specific scales such as the DLQI in atopic dermatitis.10 However, these generic scales may not adequately capture the impact of certain diseases like rosacea. The Rosacea Quality of Life (RosaQoL) scale—which is specific to rosacea—is available in English and measures the impact of its symptoms on quality of life, being more precise than generalist scales.11 Having a validated tool in Spanish will allow for assessing the impact on the patient's quality of life, and individualizing treatment effectively.4,5

The objectives of this study are: 1) to validate and culturally adapt the RosaQoL scale into Spanish and 2) to analyze the correlation between the RosaQoL scale and the SF-12 scale.

Materials and methodsStudy design

The study was conducted from August through December 2021 after being approved by Hospital Universitario Sagrat Cor de Barcelona (Barcelona, Spain) Research and Ethics Committee, and consisted of the translation and cultural adaptation of the RosaQoL scale into Spanish, following the 5 stages indicated in international literature12–14: 1) direct translation of the original questionnaire into Spanish by, at least, 2 bilingual translators independently; 2) synthesis and resolution of any discrepancies in the translations; 3) back-translation into the original language by, at least, 2 independent translators who were blinded to the original version; 4) review by an expert committee, consisting of the 3 study coordinators recognized as Key Opinion Leaders in rosacea, to ensure semantic, idiomatic, cultural, and conceptual equivalence; and 5) pilot testing of the translated questionnaire with 21 subjects (7 healthy controls, 2 patients with rosacea, and 12 patients with various dermatological conditions), similar to the target population.

To make sure that the timing associated with response did not influence the result, a test-retest was conducted through which a group of 10 patients completed the scale yet again within 1-2 days of the initial visit. Additionally, to analyze discrimination between cases and controls, a group of 50 subjects without rosacea (controls) completed the scale too. At the end of this phase, a final version of the RosaQoL questionnaire was ready for validation.

In a 2nd phase, a total of 481 patients completed the RosaQoL and SF-12 scales for questionnaire validation purposes.

To assess sensitivity to change, the same patients completed both scales again 3 months later.

Patients

Cultural adaptation to Spanish was performed with 531 adult participants attending 17 dermatology clinics in Spain. The sample consisted of 481 participants with varying severity of rosacea based on the Investigator Global Assessment (IGA) scale15 (cases) and 50 healthy participants (controls).

RosaQoL questionnaire

The RosaQoL questionnaire is available in English and measures the impact of the disorder and its symptoms on quality of life, being more precise than generalist scales as it is specific to rosacea-related quality of life.11

It is a self-administered tool developed from the SKINDEX-29 questionnaire consisting of 21 items categorized into 3 dimensions or domains: symptoms (7 items), functionality (3 items), and emotional state (11 items). Each item has a response scale with 5 possible options, being 0: never; 1: rarely; 2: sometimes; 3; often; and 4: always.11

SF-12 questionnaire

The SF-12 health questionnaire is available in Spanish and measures 8 different aspects of HRQoL.16,17

The SF-12 scale is a self-administered tool developed from the SF-36 scale consisting of 12 items categorized into 8 different dimensions or domains: physical function (2 items), physical role (2 items), bodily pain (1 item), general health (1 item), vitality (1 item), emotional role (2 items), social function (1 item), and mental health (2 items).16

IGA scale

The IGA scale is an ordinal scale with 5 categories that evaluate the severity of lesions. Classification goes from 0 (no inflammatory lesions or erythema) up to 4 (intense erythema and/or numerous papules and pustules).15

Statistical analysis

Data analysis was performed using the SAS System version 9.4 statistical package (SAS Institute Inc., Cary, North Carolina, United States).

The questionnaire will be considered discriminative the closer the area under the ROC (Receiver Operating Characteristic) curve is to a value of 1.00.18 Both the sensitivity and specificity rates of the questionnaire were evaluated using Youden's criterion,19 and the internal consistency reliability of the questionnaire was measured using Cronbach's alpha coefficient.20 Following the criterion recommended by George and Mallery,21 a Cronbach's alpha coefficient ≥ 0.90 indicates excellent internal consistency. To evaluate test-retest reliability, the method proposed by Bland and Altman22 and the intraclass correlation coefficient proposed by Shrout and Fleiss23 were used. An intraclass correlation coefficient > 0.90 indicates high reliability of the questionnaire.24 Convergence analysis between the RosaQoL scale and the more general SF-12 scale was obtained using Pearson correlation coefficient (results between 0.4 and 0.7 were considered satisfactory).25

Results

The translated RosaQoL questionnaire (Table 1) was submitted to 531 participants with a mean age of 47 years (SD, 13.4 [95%CI, 45.8-48.1]), 71 of whom (n=369) were women and 29% (n=151), men. Among those with rosacea, the papulopustular type was the most common, representing 65.9% of the cases.

Table 1.

Items of the RosaQoL Questionnaire.

How often have you identified yourself with any of these statements over the past 4 weeks?
I worry that my rosacea could be severe 
My rosacea burns or itches 
I worry about scarring from my rosacea 
I worry that my rosacea might get worse 
I worry about the side effects associated with rosacea drugs 
My rosacea is irritated 
My rosacea embarrasses me 
I am frustrated with my rosacea 
My rosacea makes my skin sensitive 
10  I am annoyed by my rosacea 
11  I am bothered by the look of my skin (redness, spots) 
12  My rosacea makes me feel self-conscious 
13  I try to cover my rosacea (with makeup) 
14  I am bothered by the persistence/recurrence of my rosacea 
15  I avoid certain foods and drinks due to my rosacea 
16  My skin looks bumpy (uneven, not smooth, irregular) 
17  My skin gets red 
18  My skin gets easily irritated (cosmetics, aftershave lotions, makeup removers) 
19  My eyes bother me (they feel dry or gritty) 
20  I think about my rosacea 
21  I avoid certain environments (heat, humidity, cold) due to my rosacea 

According to the IGA scale, IGA grade 2 was the most common one found in 44.4% of the cases (Table 2).

Table 2.

Severity of rosacea based on the IGA scale at initial visit (cases).

Severity of rosacea  % Valid 
IGA 0  2.16 
IGA 1  110  26.38 
IGA 2  185  44.36 
IGA 3  97  23.26 
IGA 4  16  3.84 
Missing  64  0.00 
Total  481  100.00 

Statistically significant differences were reported between men and women in the overall score of the RosaQoL questionnaire, as well as in each of the 3 dimensions of the scale (symptoms, functionality, and emotional state; p <0.001) (Table 3), although these differences were non statistically significant when analyzed by age (Table 4).

Table 3.

Differences in the RosaQoLquestionnaire scores at initial visit by gender.

  Mean (SD)  p-value 
Emotional dimension
Men  137  2.73 (1.16)   
Women  332  3.14 (0.98)  0.00010* 
Missing  3.41 (0.77)   
Overall  478  3.03 (1.05)   
Symptomatology dimension
Men  137  2.75 (1.00)   
Women  332  3.23 (0.88)  0.00000* 
Missing  3.54 (0.46)   
Overall  478  3.10 (0.94)   
Functional dimension
Men  137  2.04 (1.04)   
Women  332  2.91 (1.09)  0.00000* 
Missing  3.26 (1.08)   
Overall  478  2.67 (1.15)   
Overall RosaQoL score
Men  137  2.64 (1.02)   
Women  332  3.14 (0.89)  0.00000* 
Missing  3.43 (0.63)   
Overall  478  3.00 (0.95)   
*

Statistically significant difference.

Table 4.

Results of the RosaQoL Questionnaire scores by age groups (cases only).

Mean score (SD)
  Overall  Emotional dimension  Symptomatology dimension  Functional dimension 
18 to 35 years (n = 97)  2.92 (0.99)  2.93 (1.09)  3.03 (0.97)  2.64 (1.14) 
36 to 60 years (n = 297)  3.04 (0.93)  3.08 (1.03)  3.14 (0.91)  2.69 (1.14) 
> 60 years (n = 71)  2.84 (1.00)  2.86 (1.07)  2.94 (1.04)  2.52 (1.20) 
Missing (n = 13)  3.51 (0.64)  3.50 (0.72)  3.67 (0.58)  3.13 (1.06) 
Total (n = 478)  3.00 (0.95)  3.03 (1.05)  3.10 (0.94)  2.67 (1.15) 

p-value not significant for all age groups.

No significant differences were found in the RosaQoL score between the control group (healthy patients [n=50], mean overall score, 43.5 [SD, 13.7]) and the patient group ([n=468], mean overall score, 47.3 [SD, 13.3]; p=0.052).

Similarly, the score obtained in RosaQoL was higher in more severe grades of rosacea, with a greater impact being reported in the symptomatology dimension (Figure 1).

Figure 1.

Impact of various RosaQoL dimensions based on the severity of rosacea measured by IGA. Significant p-values for all dimensions (p=0.0000 for all dimensions except for the functional dimension where p=0.00631). V0: initial visit.

(0.33MB).

The internal consistency method, based on Cronbach's alpha, estimates the reliability of a measurement instrument through a set of items expected to measure the same construct or theoretical dimension. Cronbach's alpha value evaluated across all questionnaires was 0.96, which is consistent with the general criterion recommended by George and Mallery21, where values > 0.9 are indicative of high internal consistency.

When each item was individually removed from the scale, no improvement in Cronbach's alpha was obtained. Therefore, it is established that no item is prone to elimination. The questionnaire statistical power to discriminate cases using the ROC curve yielded an area under the curve (AUC) of 0.96 (95%CI, 0.92-0.99). Considering that values > 0.9 indicate high discriminative power, we can say that the questionnaire has a high capacity to detect cases.

The evaluation of sensitivity and specificity using Youden's criterion yielded a cutoff in the RosaQoL score > 1.476, thusproviding the questionnaire with high sensitivity, with a value of 0.99, and a specificity to detect cases of 0.85. For this cutoff, 425 true positives, 43 true negatives, 7 false positives, and 3 false negatives were reported.

The Varimax rotated component matrix for 3 factors contributes to the validation of the scale construct, showing that items tend to group into the functional, emotional, and symptomatic factors proposed in the original scale26 (Table 5).

Table 5.

Rotated component matrix of the varimax factor model for the RosaQoL questionnaire (cases only).

Questionnaire item  Question  Emotional  Symptomatic  Functional 
Item #1  I worry that my rosacea could be severe  0.73     
Item #3  I worry about scarring from my rosacea  0.76     
Item #4  I worry that my rosacea might get worse  0.65     
Item #5  I worry about the side effects associated with rosacea drugs  0.67     
Item #7  My rosacea embarrasses me  0.72     
Item #8  I am frustrated with my rosacea  0.74     
Item #10  I am annoyed by my rosacea  0.65     
Item #11a  I am bothered by the look of my skin (redness, spots)  0.58  0.64   
Item #12  My rosacea makes me feel self-conscious  0.66     
Item #14a  I am bothered by the persistence/recurrence of my rosacea  0.58  0.63   
Item #20  I think about my rosacea  0.62     
Item #2  My rosacea burns or itches    0.47   
Item #6  My rosacea is irritated    0.71   
Item #9  My rosacea makes my skin sensitive    0.74   
Item #16a  My skin looks bumpy (uneven, not smooth, irregular)  0.48  0.42   
Item #17  My skin gets red    0.82   
Item #18  My skin gets easily irritated (cosmetics, aftershave lotions, makeup removers)    0.73   
Item #19a  My eyes bother me (they feel dry or gritty)    0.26  0.54 
Item #13  I try to cover my rosacea (with makeup)      0.53 
Item #15  I avoid certain foods and drinks due to my rosacea      0.79 
Item #21  I avoid certain environments (heat, humidity, cold) due to my rosacea      0.77 

Figures in bold show the results of the factor analysis in the dimension in which it is categorized within the Spanish scale.

Figures in italics show the results of the factor analysis in the dimension it occupied in the original scale.

a

Item with discrepancy in dimension classification vs the original scale.

All the items of the questionnaire are categorized as in the original questionnaire, except for slight discrepancies in 4 of them. Item #11 “I am bothered by the look of my skin (redness, spots)” and item #14 “I am bothered by the persistence/recurrence of my rosacea,” which in the original scale are grouped in the emotional dimension and seem to have a slightly more specific weight in the symptomatic dimension in the Spanish version. Although item #16 “My skin looks bumpy (uneven, not smooth, irregular)” should be represented in the symptomatic dimension, it is somehow better represented in the emotional one. Finally, although item #19 “My eyes bother me (I can feel how dry or gritty they are),” should be better represented in the symptomatic dimension, it was better represented in the functional one. Since the specific weight difference of these 4 items was minimal, we decided to maintain the original dimension classification for comparative evaluation purposes with other versions of the scale.

When analyzing the correlation between the RosaQoL scale and the more generalist SF-12 scale, most studied correlations were statistically significant and entirely negative. A higher score on the RosaQoL scale in any dimension (whether functional, emotional, or symptomatic) is associated with a worse quality of life in all dimensions of the SF-12 scale (Table 6).

Table 6.

Correlation between the RosaQoL and SF-12 scales.

Pearson correlation coefficients
  Physical health SF-12  Mental health SF-12  Physical function SF-12  Physical role SF-12  Bodily pain SF-12  General health SF-12  Vitality SF-12  Emotional role SF-12  Social function SF-12  Mental health SF-12 
Emotional Dimension (RosaQoL)
Pearson correlation  −0.03553  −0.33318  −0.11879  −0.04632  −0.19839  −0.17693  −0.12947  −0.2349  −0.28287  −0.36157 
Sig.  0.471  < 0.0001  0.0146  0.3425  < 0.0001  0.0003  0.0077  < 0.0001  < 0.0001  < 0.0001 
414  414  422  422  418  423  423  422  422  423 
Symptomatology Dimension (RosaQoL)
Pearson correlation  −0.07726  −0.29001  −0.13782  −0.08834  −0.19843  −0.17091  −0.13874  −0.20142  −0.2995  −0.30055 
Sig.  0.1165  < 0.0001  0.0046  0.0699  < 0.0001  0.0004  0.0043  < 0.0001  < 0.0001  < 0.0001 
414  414  422  422  418  423  423  422  422  423 
Functional Dimension (RosaQoL)
Pearson correlation  −0.04349  −0.32742  −0.10016  −0.16885  −0.21872  −0.08485  −0.16456  −0.26691  −0.31037  −0.30137 
Sig.  0.3774  < 0.0001  0.0397  0.0005  < 0.0001  0.0813  0.0007  < 0.0001  < 0.0001  < 0.0001 
414  414  422  422  418  423  423  422  422  423 
Overall RosaQoL score
Pearson correlation  −0.05504  −0.3571  −0.13555  −0.08981  −0.22579  −0.17785  −0.15483  −0.25805  −0.32736  −0.37258 
Sig.  0.2639  < 0.0001  0.0053  0.0653  < 0.0001  0.0002  0.0014  < 0.0001  < 0.0001  < 0.0001 
414  414  422  422  418  423  423  422  422  423 

Figures in bold show statistically non-significant correlations.

The temporal reliability of the questionnaire was confirmed through the test-retest method, as no discrepancies were detected over time between patients’ responses.

To evaluate sensitivity to change, a follow-up visit was conducted 3 months after the start of the study, when rosacea patients were asked to complete both the RosaQoL and SF-12 questionnaires again. In most calculated correlations, a statistically significant negative correlation was reported. A greater increase in the RosaQoL scale and all its dimensions (functional, emotional, and symptomatic) was associated with a worse progression of quality of life in all dimensions of the SF-12 scale. This same correlation was also seen when analyzed by age group and disease severity.

Discussion

To consider a scale valid as an instrument for measuring HRQoL, a simple translation is not sufficient; rather, a series of structured and guided steps are necessary.13 To make sure that the reliability and validity requirements of such tools are met, the measurement properties of the translated version in a population need to be evaluated with similar characteristics and then submitted to a validation process.25

The study of measurement properties demonstrates that the Spanish-translated and culturally adapted version of the RosaQoL questionnaire allows us, like the original version, to obtain statistically significant differences between the healthy population and the population with rosacea. The level of impact on the RosaQoL scale in all dimensions was directly proportional to the severity of rosacea, with the highest degree of impact being reported in the symptomatology dimension.

Nicholson et al.11 highlighted the validity of RosaQoL in discriminating rosacea patients vs the SKINDEX-29. In its original version, the specific RosaQoL scale showed a higher response level at 4-6 months vs the SKINDEX-29 for the total score in patients reporting improvement in their rosacea, showing greater specificity.

The reliability study of the RosaQoL questionnaire demonstrates that the tool has a high degree of internal consistency, obtaining a Cronbach's alpha value of 0.96, and that its discriminative power to detect cases is extremely high, obtaining a ROC AUC score of 0.96.

Reproducibility is one of the important points we should consider when evaluating a tool for measuring HRQoL. To assess reproducibility, it is checked whether similar scores can be obtained when applied in 2 different points in time to the same population by the same evaluators using the exact same method. Since it is important to avoid the “learning effect,” the time between the initial test and the retest should not be too long.27 In our study, the score obtained with the RosaQoL questionnaire does not vary significantly between the test and retest results of the same patient (interval of 1 to 2 days). Our test-retest results show a very high correlation between both tests in the 3 dimensions of the questionnaire, indicating a high degree of reliability.

The construct validity study through factor analysis showed that the items of the RosaQoL scale tend to group based on the functional, emotional, and symptomatic dimensions, as in the original version of the scale, and that the items that make up each one of them tend to group consistently in each dimension.

Our study also analyzed the convergence (“correlation”) between the RosaQoL scale and the more generalist SF-12 scale and found that it was positive, evidencing that the scales are conceptually congruent or similar:25 higher increases in the RosaQoL scale and all its sub-dimensions (functional, emotional, and symptomatic) were associated with worse quality of life in all dimensions of the SF-12 scale.

Conclusions

The RosaQoL scale, adapted to Spanish, has proven to be a valid, sensitive, and reliable tool for measuring quality of life, in all its dimensions (symptoms, functionality, and emotional state) among the Spanish population with rosacea. Results indicate that the greater the severity of rosacea, the greater the impact on quality of life, with the dimensions of symptomatology and emotional state being the most affected ones, especially in women.

Conflicts of interest

This project has received funding and support from Laboratorios Galderma S.A.U. Dr. Salleras and Dr. Pozo declared no conflicts of interest whatsoever. Dr. Ribera received grants and fees related to research, consulting, and training from the following companies: AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Galderma, Gebro Pharma, Janssen, LEO Pharma, Eli Lilly, Novartis, Pfizer, Pierre-Fabre, Sandoz, SKB, and UCB.

Acknowledgements

We wish to thank all group participants for their collaboration while working on this manuscript, Laboratorios Galderma S.A.U. for funding the project, and CRO Crossdata for their advice while working on the project and writing this article.

References
[1]
R.L. Gallo, R.D. Granstein, S. Kang, M. Mannis, M. Steinhoff, J. Tan, et al.
Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.
J Am Acad Dermatol., 78 (2018), pp. 148-155
[2]
F. Moustafa, R.S. Lewallen, S.R. Feldman.
The psychological impact of rosacea and the influence of current management options.
J Am Acad Dermatol., 71 (2014), pp. 973-980
[3]
B. Aksoy, A. Altaykan-Hapa, D. Egemen, F. Karagöz, N. Atakan.
The impact of rosacea on quality of life: Effects of demographic and clinical characteristics and various treatment modalities.
Br J Dermatol., 163 (2010), pp. 719-725
[4]
A.Y. Finlay.
Quality of life indices.
Indian J Dermatol Venereol Leprol., 70 (2004), pp. 143-148
[5]
J.J. Ware, M. Kosinski, S.D. Keller.
A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.
Med Care., 34 (1996), pp. 220-233
[6]
G.A. Wells, A.S. Russell, B. Haraoui, R. Bissonnette, C.F. Ware.
Validity of quality of life measurement tools--from generic to disease-specific.
J Rheumatol Suppl., 88 (2011), pp. 2-6
[7]
M. Jones-caballero, P.F. Peñas.
Calidad de vida (II). Calidad de vida en Dermatología.
Actas Dermosifiliogr., 93 (2002), pp. 481-489
[8]
A. García de Tiedra, J. Mercadal, X. Badía, J.M. Mascaró, M. Herdman.
LR. Adaptación transcultural al español del cuestionario Dermatology Life Quality Index (DLQI): el índice de calidad de vida en Dermatología.
Actas Dermosifiliogr., 89 (1998), pp. 692-700
[9]
M. Jones-Caballero, P.F. Peñas, A. García-Díez, M.M. Chren, X. Badía.
[The Spanish version of Skindex-29 An instrument for measuring quality of life in patients with cutaneous diseases].
Med Clin (Barc)., 118 (2002), pp. 5-9
[10]
J.I. Silverberg, J.M. Gelfand, D.J. Margolis, M. Boguniewicz, L. Fonacier, M.H. Grayson, et al.
Validation and Interpretation of Short Form 12 and Comparison with Dermatology Life Quality Index in Atopic Dermatitis in Adults.
J Invest Dermatol, 139 (2019), pp. 2090-2097
[11]
K. Nicholson, L. Abramova, M.M. Chren, J. Yeung, S.Y. Chon, S.C. Chen.
A pilot quality-of-life instrument for acne rosacea.
J Am Acad Dermatol., 57 (2007), pp. 213-221
[12]
S.M.Y. Arafat.
Cross Cultural Adaptation & Psychometric Validation of Instruments: Step-wise Description.
Int J Psychiatry., 1 (2016), pp. 1-4
[13]
D.E. Beaton, C. Bombardier, F. Guillemin, M.B. Ferraz.
Guidelines for the process of cross- cultural adaptation of self-report measures.
Spine (Phila Pa 1976)., 25 (2000), pp. 3186-3191
[14]
J.M. Ramada-Rodilla, C. Serra-Pujadas, G.L. Delclós-Clanchet.
Adaptación cultural y validación de cuestionarios de salud: Revisión y recomendaciones metodológicas.
Salud Publica Mex., 55 (2013), pp. 57-66
[15]
G. Webster, M. Schaller, J. Tan, J.M. Jackson, N. Kerrouche, G. Schäfer.
Defining treatment success in rosacea as ‘clear’ may provide multiple patient benefits: results of a pooled analysis.
J Dermatolog Treat., 28 (2017), pp. 469-474
[16]
B. Gandek, J.E. Ware, N.K. Aaronson, G. Apolone, J.B. Bjorner, J.E. Brazier, et al.
Cross- validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project International Quality of Life Assessment.
J Clin Epidemiol., 51 (1998), pp. 1171-1178
[17]
S. Schmidt, G. Vilagut, O. Garin, O. Cunillera, R. Tresserras, P. Brugulat, et al.
Normas de referencia para el Cuestionario de Salud SF-12 versión 2 basadas en población general de Cataluña.
Med Clin (Barc)., 139 (2012), pp. 613-625
[18]
J. Cerda, L. Cifuentes.
[Using ROC curves in clinical investigation: theoretical and practical issues].
Rev Chilena Infectol., 29 (2012), pp. 138-141
[19]
M.D. Ruopp, N.J. Perkins, B.W. Whitcomb, E.F. Schisterman.
Youden Index and optimal cut- point estimated from observations affected by a lower limit of detection.
Biom J., 50 (2008), pp. 419-430
[20]
L.J. Cronbach.
Coefficient alpha and the internal structure of tests.
Psychometrika., 16 (1951), pp. 297-334
[21]
D.M. George, P. Mallery.
SPSS for Windows step by step: A simple guide and reference 11. 0 update.
Allyn & Bacon, (2003),
[22]
J.M. Bland, D.G. Altman.
Measuring agreement in method comparison studies.
Stat Methods Med Res., 8 (1999), pp. 135-160
[23]
P.E. Shrout, J.L. Fleiss.
Intraclass correlations: Uses in assessing rater reliability.
Psychol Bull., 86 (1979), pp. 420-428
[24]
T.K. Koo, M.Y. Li.
A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.
J Chiropr Med., 15 (2016), pp. 155-163
[25]
J.A. Luján-Tangarife, J.A. Cardona-Arias.
Construcción y validación de escalas de medición en salud: Revisión de propiedades psicométricas.
Arch Med., 11 (2015), pp. 1-10
[26]
P.M. Vallejo.
El Análisis Factorial en la construcción e interpretación de tests, escalas y cuestionarios.
Universidad Pontificia de Comillas, (2011),
[27]
M.J. García de Yébenes Prous, F. Rodríguez Salvanés, L. Carmona Ortells.
Validation of questionnaires.
Reumatol Clin., 5 (2009), pp. 171-177
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