Journal Information
Vol. 98. Issue 6.
Pages 415-419 (August 2007)
Vol. 98. Issue 6.
Pages 415-419 (August 2007)
Original articles
Full text access
Pulsed Dye Laser Treatment of Acne. Study of Clinical Efficacy and Mechanism of Action
Láser de Colorante Pulsado en el Tratamiento del Acné. Estudio de la Eficacia Clínica y Mecanismo de Acción
Visits
8055
A. Harto
Corresponding author
antonlonarto@notmail.com
renegmorales@gmall.com

Correspondence: Departamento de Dermatología. Hospital Ramón y Cajal. Ctra. de Colmenar Viejo, km 9,100. 28034 Madrid. Spain.
, I. García-Morales, P. Beldar, P. Jaén
Unidad de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
This item has received
Article information
Abstract
Introduction

Acne vulgaris is a multifactorial disease of the pilosebaceous unit characterized by the development of inflammatory (papules, pustules, cysts) and/or non inflammatory lesions (open and closed comedones) that may progress to scars. The increase of bacterial resistances, adverse effects and teratogenicity of retinoids and lack of response to usual therapies have led to investigate new therapeutic alternatives for acne.

Material and method

We studied 36 patients with mild to moderate acne vulgaris. We performed treatment every 4 weeks using pulsed dye laser therapy with a wavelength of 585 nm and pulse duration of 350 microseconds.

Results

At twelve weeks of treatment a decrease of 27% of non inflammatory lesions and of 57% of active lesions was observed. Treatment was well tolerated and considered positive, in terms of healing, in 25 patients.

Conclusions

Pulse dye laser therapy mainly improves inflammatory lesions of acne with few adverse effects.

Key words:
acne vulgaris
phototherapy
laser
Resumen
Introducción

El acné vulgar es una enfermedad multifactorial de la unidad pilosebácea caracterizada por la aparición de lesiones inflamatorias (pápulas, pústulas, quistes) y/o no inflamatorias (comedones cerrados y abiertos) que pueden evolucionar al desarrollo de cicatrices. El aumento de las resistencias bacterianas, los efectos adversos y teratogenicidad de los retinoides y la falta de respuesta a tratamientos habituales llevan a la necesidad de investigar nuevas opciones terapéuticas para el acné.

Material y métodos

Estudiamos a 36 pacientes con acné vulgar de grado leve a moderado. Realizamos tratamiento cada 4 semanas utilizando un láser de colorante pulsado de 585 nm de longitud de onda y 350 microseg de duración de pulso.

Resultados

A las doce semanas de tratamiento se observa descenso del 27% de lesiones no inflamatorias y de un 57% de lesiones activas. El tratamiento fue bien tolerado y considerado como positivo, en cuanto a curación, en 25 pacientes.

Conclusiones

El láser de colorante pulsado mejora principalmente las lesiones inflamatorias del acné con pocos efectos adversos.

Palabras clave:
acné vulgar
fototerapia
láser
Full text is only aviable in PDF
References
[1.]
M. Parrar, E. Ingham.
Acne: Inflammation.
Clin Dermatol, 22 (2004), pp. 380-384
[2.]
R. Bojard, K. Holland.
Acne and Propionibacterium acnes.
Clin Dermatol, 22 (2004), pp. 375-379
[3.]
S. Bhardwaj, T. Rohrer, K. Arndt.
Lasers and light therapy for acne vulgaris.
Semin Cutan Med Surg, 24 (2005), pp. 107-112
[4.]
V. Ross.
Optical treatments for acne.
Dermatol Ther, 18 (2005), pp. 253-266
[5.]
K. Mariwalla, T. Rohrer.
Use of lasers and light-based therapies for treatment of acne vulgaris.
Lasers Surg Med, 37 (2005), pp. 333-342
[6.]
M. Elman, J. Lebzelter.
Light therapy in the treatment of acne vulgaris.
Dermatol Surg, 30 (2004), pp. 139-146
[7.]
A. Charakida, E. Seaton, M. Charakida.
Phototherapy in the treatment of acne vulgaris. What is its role?.
Am J Clin Dermatol, 5 (2004), pp. 211-216
[8.]
E. Ross, M. Blair, B. Saleh.
Laser treatment of acne through selective dermal heating.
Lasers Surg Med, 14 (2002), pp. 23
[9.]
P. Friedman, M. Jih, A. Kimyai-Asadi.
Treatment of inflammatory facial acne vulgaris with the 1450-nm diode laser: a pilot study.
Dermatol Surg, 30 (2004), pp. 147-151
[10.]
D. Boineau, S. Angel, N. Auffret.
Treatment of active acne with an erbium glass (1.54 micron) laser.
Lasers Surg Med, 16 (2004), pp. 55
[11.]
S. Wiegell, H. Wulf.
Photodynamic therapy of acne vulgaris using 5-aminolevulnic acid versus methyl aminolevulinate.
J Am Acad Dermatol, 54 (2006), pp. 647-651
[12.]
A. Ortiz, M. van Vliet, G. lask.
A review of lasers and light sources in the treatment of acne vulgaris.
J Cosmet Laser Ther, 7 (2005), pp. 69-75
[13.]
E.D. Seaton, A. Charakida, P.E. Mouser.
Pulsed-dye laser treament for inflammatory acne vulgaris: randomised controlled trial.
Lancet, 362 (2003), pp. 1347-1352
[14.]
E.D. Seaton, P.E. Mouser, A. Charakida.
Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris.
Br J Dermatol, 155 (2006), pp. 748-755
Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?