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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Psoriasis is an immune-mediated disease typically associated with cutaneous neutrophilic infiltration and Munro microabscesses&#46; Interleukin &#40;IL&#41;-8 is one of the main neutrophil-attracting chemokines&#46; Although keratinocytes have traditionally been considered to be the principal source of IL-8 in psoriasis&#44; we present data that suggest that cutaneous lymphocyte associated antigen CLA<span class="elsevierStyleSup">&#43;</span> T lymphocytes synthesize this cytokine&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Six patients with psoriasis and 6 healthy controls were studied&#46; Immunomagnetic separation was used to isolate CLA<span class="elsevierStyleSup">&#43;</span> and CLA<span class="elsevierStyleSup">&#8722;</span> T lymphocytes and IL-8 and interferon &#40;IFN&#41;-&#947; production was quantified for each cell subpopulation using enzyme-linked immunosorbent assay&#46; Finally&#44; gene expression of IL-8 was analyzed by reverse transcriptase-polymerase chain reaction&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">CLA<span class="elsevierStyleSup">&#43;</span> and CLA<span class="elsevierStyleSup">&#8722;</span> T lymphocytes from patients with psoriasis and from controls showed a significantly increased production of IFN-&#947; when activated&#44; whereas only activated CLA<span class="elsevierStyleSup">&#43;</span> T lymphocytes &#40;from patients and controls&#41; synthesized IL-8&#46; The higher level of expression of IL-8 and IFN-&#947; by CLA<span class="elsevierStyleSup">&#43;</span> T lymphocytes in comparison to CLA<span class="elsevierStyleSup">&#8722;</span> cells was confirmed&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStyleSimplePara elsevierViewall">Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates&#44; such as acute generalized exanthematous pustulosis&#44; Beh&#231;et disease&#44; and pustular psoriasis&#46; We have confirmed the role of the subset of T lymphocytes with skin tropism &#40;CLA<span class="elsevierStyleSup">&#43;</span>&#41; in IL-8 production in nonpustular psoriasis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La psoriasis es una enfermedad mediada inmunol&#243;gicamente&#44; de causa desconocida&#44; que caracter&#237;sticamente presenta infiltraci&#243;n cut&#225;nea por polimorfonucleares neutr&#243;filos y microabscesos de Munro&#46; La interleucina &#40;IL&#41;-8 es una de las principales quemocinas atrayentes de los polimorfonucleares neutr&#243;filos&#46; Aunque la producci&#243;n de IL-8 en psoriasis se ha atribuido principalmente al queratinocito&#44; presentamos datos que apoyan la producci&#243;n de esta por los linfocitos T ant&#237;geno de linfocito cut&#225;neo &#40;CLA&#41;&#43;&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 6 pacientes con psoriasis y 6 sanos&#46; Mediante t&#233;cnicas de separaci&#243;n inmunomagn&#233;tica se aislaron los linfocitos T CLA&#43; y CLA-&#46; Se cuantific&#243; la producci&#243;n de IL-8 e IFN&#947; de cada subpoblaci&#243;n celular a trav&#233;s de un ELISA&#46; Finalmente&#44; se analiz&#243; su expresi&#243;n g&#233;nica mediante reacci&#243;n en cadena de la polimerasa a tiempo real&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Tanto los linfocitos T CLA&#43; como CLA-&#44; de controles y pacientes con psoriasis&#44; aumentaban significativamente la producci&#243;n de IFN&#947; cuando eran activados&#44; mientras que s&#243;lo los linfocitos T CLA&#43; activados&#44; tanto de controles como de sujetos con psoriasis&#44; produc&#237;an IL-8&#46; Se confirm&#243; la expresi&#243;n preferente de IL-8 e IFN&#947; en linfocitos T CLA&#43; respecto de CLA-&#46;</p> <span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Estudios previos han demostrado la producci&#243;n de IL-8 por linfocitos T en dermatosis inflamatorias ricas en neutr&#243;filos&#44; tales como la pustulosis exantem&#225;tica aguda generalizada&#44; la enfermedad de Beh&#231;et y la psoriasis pustulosa&#46; Nosotros hemos confirmado el papel del subgrupo de linfocitos T con tropismo cut&#225;neo &#40;CLA&#43;&#41; en la producci&#243;n de IL-8 en la psoriasis no pustulosa&#46;</p>"
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Vol. 101. Issue 2.
Pages 151-155 (March 2010)
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Vol. 101. Issue 2.
Pages 151-155 (March 2010)
Original Article
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Production of Interleukin 8 by Circulating CLA+ T Cells With Skin Tropism in Patients With Psoriasis and in Healthy Controls
Producción preferente de IL-8 por linfocitos T CLA+ circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos
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M. Ferrana,b,
Corresponding author
mferran@imas.imim.es

Corresponding author.
, A.B. Galvána, A. Giménez-Arnaua,b, R.M. Pujola,b, L.F. Santamaría-Babiac
a Servicio de Dermatología, Hospital del Mar-IMIM, Barcelona, Spain
b Universidad Autónoma de Barcelona, Barcelona, Spain
c Instituto de investigación Biomédica, Universidad de Barcelona, Barcelona, Spain
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Article information
Abstract
Background

Psoriasis is an immune-mediated disease typically associated with cutaneous neutrophilic infiltration and Munro microabscesses. Interleukin (IL)-8 is one of the main neutrophil-attracting chemokines. Although keratinocytes have traditionally been considered to be the principal source of IL-8 in psoriasis, we present data that suggest that cutaneous lymphocyte associated antigen CLA+ T lymphocytes synthesize this cytokine.

Material and methods

Six patients with psoriasis and 6 healthy controls were studied. Immunomagnetic separation was used to isolate CLA+ and CLA T lymphocytes and IL-8 and interferon (IFN)-γ production was quantified for each cell subpopulation using enzyme-linked immunosorbent assay. Finally, gene expression of IL-8 was analyzed by reverse transcriptase-polymerase chain reaction.

Results

CLA+ and CLA T lymphocytes from patients with psoriasis and from controls showed a significantly increased production of IFN-γ when activated, whereas only activated CLA+ T lymphocytes (from patients and controls) synthesized IL-8. The higher level of expression of IL-8 and IFN-γ by CLA+ T lymphocytes in comparison to CLA cells was confirmed.

Discussion

Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates, such as acute generalized exanthematous pustulosis, Behçet disease, and pustular psoriasis. We have confirmed the role of the subset of T lymphocytes with skin tropism (CLA+) in IL-8 production in nonpustular psoriasis.

Keywords:
Psoriasis
T lymphocyte
CLA
Neutrophil
IL-8
Resumen
Introducción

La psoriasis es una enfermedad mediada inmunológicamente, de causa desconocida, que característicamente presenta infiltración cutánea por polimorfonucleares neutrófilos y microabscesos de Munro. La interleucina (IL)-8 es una de las principales quemocinas atrayentes de los polimorfonucleares neutrófilos. Aunque la producción de IL-8 en psoriasis se ha atribuido principalmente al queratinocito, presentamos datos que apoyan la producción de esta por los linfocitos T antígeno de linfocito cutáneo (CLA)+.

Material y métodos

Se incluyeron 6 pacientes con psoriasis y 6 sanos. Mediante técnicas de separación inmunomagnética se aislaron los linfocitos T CLA+ y CLA-. Se cuantificó la producción de IL-8 e IFNγ de cada subpoblación celular a través de un ELISA. Finalmente, se analizó su expresión génica mediante reacción en cadena de la polimerasa a tiempo real.

Resultados

Tanto los linfocitos T CLA+ como CLA-, de controles y pacientes con psoriasis, aumentaban significativamente la producción de IFNγ cuando eran activados, mientras que sólo los linfocitos T CLA+ activados, tanto de controles como de sujetos con psoriasis, producían IL-8. Se confirmó la expresión preferente de IL-8 e IFNγ en linfocitos T CLA+ respecto de CLA-.

Discusión

Estudios previos han demostrado la producción de IL-8 por linfocitos T en dermatosis inflamatorias ricas en neutrófilos, tales como la pustulosis exantemática aguda generalizada, la enfermedad de Behçet y la psoriasis pustulosa. Nosotros hemos confirmado el papel del subgrupo de linfocitos T con tropismo cutáneo (CLA+) en la producción de IL-8 en la psoriasis no pustulosa.

Palabras clave:
Psoriasis
Linfocitos T
Antígeno de linfocito cutáneo
Neutrófilos
IL-8
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References
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J.E. Gudjonsson, J.T. Elder.
Psoriasis.
Fitzpatrick's Dermatology in general medicine, 7th ed., pp. 169-193
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Copyright © 2010. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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