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Production of Interleukin 8 by Circulating CLA+ T Cells With Skin Tropism in Patients With Psoriasis and in Healthy Controls
Producción preferente de IL-8 por linfocitos T CLA+ circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos
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"apellidos" => "Ferran" "email" => array:1 [ 0 => "mferran@imas.imim.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A.B." "apellidos" => "Galván" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Giménez-Arnau" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." 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"apellidos" => "Santamaría-Babia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar-IMIM, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Universidad Autónoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Instituto de investigación Biomédica, Universidad de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Producción preferente de IL-8 por linfocitos T CLA<span class="elsevierStyleSup">+</span> circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-17" "fechaAceptado" => "2009-07-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84688" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "T lymphocyte" 2 => "CLA" 3 => "Neutrophil" 4 => "IL-8" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84689" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Linfocitos T" 2 => "Antígeno de linfocito cutáneo" 3 => "Neutrófilos" 4 => "IL-8" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Psoriasis is an immune-mediated disease typically associated with cutaneous neutrophilic infiltration and Munro microabscesses. Interleukin (IL)-8 is one of the main neutrophil-attracting chemokines. Although keratinocytes have traditionally been considered to be the principal source of IL-8 in psoriasis, we present data that suggest that cutaneous lymphocyte associated antigen CLA<span class="elsevierStyleSup">+</span> T lymphocytes synthesize this cytokine.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Six patients with psoriasis and 6 healthy controls were studied. Immunomagnetic separation was used to isolate CLA<span class="elsevierStyleSup">+</span> and CLA<span class="elsevierStyleSup">−</span> T lymphocytes and IL-8 and interferon (IFN)-γ production was quantified for each cell subpopulation using enzyme-linked immunosorbent assay. Finally, gene expression of IL-8 was analyzed by reverse transcriptase-polymerase chain reaction.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">CLA<span class="elsevierStyleSup">+</span> and CLA<span class="elsevierStyleSup">−</span> T lymphocytes from patients with psoriasis and from controls showed a significantly increased production of IFN-γ when activated, whereas only activated CLA<span class="elsevierStyleSup">+</span> T lymphocytes (from patients and controls) synthesized IL-8. The higher level of expression of IL-8 and IFN-γ by CLA<span class="elsevierStyleSup">+</span> T lymphocytes in comparison to CLA<span class="elsevierStyleSup">−</span> cells was confirmed.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStyleSimplePara elsevierViewall">Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates, such as acute generalized exanthematous pustulosis, Behçet disease, and pustular psoriasis. We have confirmed the role of the subset of T lymphocytes with skin tropism (CLA<span class="elsevierStyleSup">+</span>) in IL-8 production in nonpustular psoriasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La psoriasis es una enfermedad mediada inmunológicamente, de causa desconocida, que característicamente presenta infiltración cutánea por polimorfonucleares neutrófilos y microabscesos de Munro. La interleucina (IL)-8 es una de las principales quemocinas atrayentes de los polimorfonucleares neutrófilos. Aunque la producción de IL-8 en psoriasis se ha atribuido principalmente al queratinocito, presentamos datos que apoyan la producción de esta por los linfocitos T antígeno de linfocito cutáneo (CLA)+.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 6 pacientes con psoriasis y 6 sanos. Mediante técnicas de separación inmunomagnética se aislaron los linfocitos T CLA+ y CLA-. Se cuantificó la producción de IL-8 e IFNγ de cada subpoblación celular a través de un ELISA. Finalmente, se analizó su expresión génica mediante reacción en cadena de la polimerasa a tiempo real.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Tanto los linfocitos T CLA+ como CLA-, de controles y pacientes con psoriasis, aumentaban significativamente la producción de IFNγ cuando eran activados, mientras que sólo los linfocitos T CLA+ activados, tanto de controles como de sujetos con psoriasis, producían IL-8. Se confirmó la expresión preferente de IL-8 e IFNγ en linfocitos T CLA+ respecto de CLA-.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">Estudios previos han demostrado la producción de IL-8 por linfocitos T en dermatosis inflamatorias ricas en neutrófilos, tales como la pustulosis exantemática aguda generalizada, la enfermedad de Behçet y la psoriasis pustulosa. Nosotros hemos confirmado el papel del subgrupo de linfocitos T con tropismo cutáneo (CLA+) en la producción de IL-8 en la psoriasis no pustulosa.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Gudjonsson" 1 => "J.T. Elder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Fitzpatrick's Dermatology in general medicine" "paginaInicial" => "169" "paginaFinal" => "193" "edicion" => "7th ed." "serieFecha" => "2008" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 8 | 12 |
| 2024 October | 58 | 37 | 95 |
| 2024 September | 71 | 37 | 108 |
| 2024 August | 92 | 66 | 158 |
| 2024 July | 60 | 34 | 94 |
| 2024 June | 44 | 20 | 64 |
| 2024 May | 41 | 25 | 66 |
| 2024 April | 48 | 30 | 78 |
| 2024 March | 44 | 33 | 77 |
| 2024 February | 39 | 35 | 74 |
| 2024 January | 39 | 37 | 76 |
| 2023 December | 42 | 26 | 68 |
| 2023 November | 37 | 25 | 62 |
| 2023 October | 35 | 34 | 69 |
| 2023 September | 36 | 35 | 71 |
| 2023 August | 24 | 17 | 41 |
| 2023 July | 26 | 48 | 74 |
| 2023 June | 35 | 28 | 63 |
| 2023 May | 23 | 20 | 43 |
| 2023 April | 25 | 29 | 54 |
| 2023 March | 17 | 37 | 54 |
| 2023 February | 24 | 19 | 43 |
| 2023 January | 30 | 26 | 56 |
| 2022 December | 32 | 48 | 80 |
| 2022 November | 15 | 24 | 39 |
| 2022 October | 18 | 23 | 41 |
| 2022 September | 22 | 39 | 61 |
| 2022 August | 15 | 47 | 62 |
| 2022 July | 18 | 26 | 44 |
| 2022 June | 14 | 21 | 35 |
| 2022 May | 21 | 27 | 48 |
| 2022 April | 19 | 46 | 65 |
| 2022 March | 21 | 63 | 84 |
| 2022 February | 20 | 28 | 48 |
| 2022 January | 18 | 33 | 51 |
| 2021 December | 20 | 45 | 65 |
| 2021 November | 25 | 52 | 77 |
| 2021 October | 22 | 52 | 74 |
| 2021 September | 18 | 46 | 64 |
| 2021 August | 11 | 32 | 43 |
| 2021 July | 15 | 31 | 46 |
| 2021 June | 23 | 36 | 59 |
| 2021 May | 18 | 27 | 45 |
| 2021 April | 34 | 46 | 80 |
| 2021 March | 45 | 25 | 70 |
| 2021 February | 37 | 33 | 70 |
| 2021 January | 23 | 26 | 49 |
| 2020 December | 30 | 20 | 50 |
| 2020 November | 11 | 10 | 21 |
| 2020 October | 16 | 6 | 22 |
| 2020 September | 23 | 7 | 30 |
| 2020 August | 27 | 20 | 47 |
| 2020 July | 29 | 12 | 41 |
| 2020 June | 26 | 19 | 45 |
| 2020 May | 13 | 13 | 26 |
| 2020 April | 19 | 17 | 36 |
| 2020 March | 22 | 20 | 42 |
| 2020 February | 0 | 2 | 2 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 16 | 16 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 1 | 1 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 2 | 49 | 51 |
| 2019 April | 0 | 9 | 9 |
| 2019 March | 0 | 9 | 9 |
| 2019 February | 0 | 6 | 6 |
| 2018 December | 0 | 2 | 2 |
| 2018 November | 0 | 6 | 6 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 9 | 3 | 12 |
| 2018 January | 19 | 6 | 25 |
| 2017 December | 16 | 7 | 23 |
| 2017 November | 13 | 4 | 17 |
| 2017 October | 21 | 4 | 25 |
| 2017 September | 18 | 1 | 19 |
| 2017 August | 27 | 10 | 37 |
| 2017 July | 25 | 3 | 28 |
| 2017 June | 20 | 7 | 27 |
| 2017 May | 30 | 5 | 35 |
| 2017 April | 24 | 21 | 45 |
| 2017 March | 12 | 12 | 24 |
| 2017 February | 25 | 5 | 30 |
| 2017 January | 16 | 4 | 20 |
| 2016 December | 30 | 7 | 37 |
| 2016 November | 25 | 19 | 44 |
| 2016 October | 19 | 26 | 45 |
| 2016 September | 23 | 4 | 27 |
| 2016 August | 31 | 5 | 36 |
| 2016 July | 13 | 5 | 18 |
| 2016 June | 8 | 8 | 16 |
| 2016 May | 5 | 6 | 11 |
| 2016 April | 4 | 6 | 10 |
| 2016 March | 3 | 0 | 3 |
| 2016 February | 10 | 1 | 11 |
| 2016 January | 11 | 1 | 12 |
| 2015 December | 6 | 0 | 6 |
| 2015 November | 14 | 5 | 19 |
| 2015 October | 4 | 6 | 10 |
| 2015 September | 7 | 1 | 8 |
| 2015 August | 12 | 5 | 17 |
| 2015 July | 31 | 6 | 37 |
| 2015 June | 34 | 4 | 38 |
| 2015 May | 53 | 8 | 61 |
| 2015 April | 34 | 4 | 38 |
| 2015 March | 35 | 13 | 48 |
| 2015 February | 20 | 7 | 27 |
| 2015 January | 13 | 4 | 17 |
| 2014 December | 20 | 9 | 29 |
| 2014 November | 15 | 14 | 29 |
| 2014 October | 31 | 14 | 45 |
| 2014 September | 17 | 14 | 31 |
| 2014 August | 26 | 10 | 36 |
| 2014 July | 32 | 18 | 50 |
| 2014 June | 27 | 11 | 38 |
| 2014 May | 26 | 16 | 42 |
| 2014 April | 37 | 11 | 48 |
| 2014 March | 33 | 13 | 46 |
| 2014 February | 24 | 11 | 35 |
| 2014 January | 18 | 14 | 32 |
| 2013 December | 28 | 10 | 38 |
| 2013 November | 23 | 14 | 37 |
| 2013 October | 24 | 13 | 37 |
| 2013 September | 31 | 17 | 48 |
| 2013 August | 24 | 13 | 37 |
| 2013 July | 30 | 22 | 52 |
| 2013 June | 27 | 13 | 40 |
| 2013 May | 25 | 10 | 35 |
| 2013 April | 20 | 19 | 39 |
| 2013 March | 28 | 19 | 47 |
| 2013 February | 18 | 13 | 31 |
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