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Journal Information
Vol. 105. Issue S1.
IL-17: a new therapeutic target for the regulations of inflammatory responses
Pages 9-20 (October 2014)
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Vol. 105. Issue S1.
IL-17: a new therapeutic target for the regulations of inflammatory responses
Pages 9-20 (October 2014)
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Pathogenic role of IL-17 in psoriasis and psoriatic arthritis
Papel patógeno de la IL-17 en la psoriasis y en la artritis psoriásica
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5215
A. Chiricozzi
Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA
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Article information
Abstract

Psoriasis is a chronic inflammatory skin disorder resulting from a complex network of cytokines and chemokines produced by various immune cell types and tissue cells. Emerging evidence suggests a central role of IL-17 and IL-23/T17 axis in the pathogenesis of psoriasis, giving a rationale for using IL-17-blocking agents as therapeutics.

Three agents targeting IL-17 signaling are being studied in Phase III clinical trials: secukinumab and ixekizumab (IL-17 neutralizing agents), and brodalumab (IL-17 receptor antagonist). Preliminary results are highly promising for all anti-IL17 agents, creating fair expectations on this class of agents as the new effective therapeutic approach for the treatment of psoriasis.

Keywords:
IL-17
Psoriasis
Arthritis
Secukinumab
Ixekizumab
Brodalumab
Atherosclerosis
Obesity
Resumen

La psoriasis es un trastorno crónico inflamatorio de la piel resultante de un complejo sistema de citocinas y quimiocinas producidas por varios tipos de células inmunes y células tisulares. La evidencia incipiente sugiere un papel central de la IL-17 y el eje IL-23/T17 en la patogénesis de la psoriasis, lo que ofrece una base para el uso de agentes bloqueadores de la IL-17 como tratamiento.

Están siendo estudiados en estudios clínicos en fase III tres agentes enfocados en la señalización de la IL-17: secukinumab e ixekizumab (agentes neutralizantes de la IL-17), y brodalumab (antagonista del receptor de la IL-17). Los resultados preliminares son altamente prometedores para todos los agentes anti-IL17, lo que crea claras expectativas para esta clase de agentes como un nuevo planteamiento terapéutico eficaz para el tratamiento de la psoriasis.

Palabras clave:
IL-17
Psoriasis
Artritis
Secukinumab
Ixekizumab
Brodalumab
Aterosclerosis
Obesidad
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