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      "titulo" => "IL-17 and IL-17R: an auspicious therapeutic target for psoriatic disease"
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          "titulo" => "IL-17 e IL-17R: una diana terapéutica favorable para la enfermedad psoriásica"
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    "pii" => "S0001731014700134"
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    "doi" => "10.1016/S0001-7310(14)70013-4"
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      "titulo" => "IL-17 in psoriasis. The final frontier or just another brick in the wall?"
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    "titulo" => "Pathogenic role of IL-17 in psoriasis and psoriatic arthritis"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is a chronic inflammatory skin disorder resulting from a complex network of cytokines and chemokines produced by various immune cell types and tissue cells&#46; Emerging evidence suggests a central role of IL-17 and IL-23&#47;T17 axis in the pathogenesis of psoriasis&#44; giving a rationale for using IL-17-blocking agents as therapeutics&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Three agents targeting IL-17 signaling are being studied in Phase III clinical trials&#58; secukinumab and ixekizumab &#40;IL-17 neutralizing agents&#41;&#44; and brodalumab &#40;IL-17 receptor antagonist&#41;&#46; Preliminary results are highly promising for all anti-IL17 agents&#44; creating fair expectations on this class of agents as the new effective therapeutic approach for the treatment of psoriasis&#46;</p>"
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      "es" => array:2 [
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        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La psoriasis es un trastorno cr&#243;nico inflamatorio de la piel resultante de un complejo sistema de citocinas y quimiocinas producidas por varios tipos de c&#233;lulas inmunes y c&#233;lulas tisulares&#46; La evidencia incipiente sugiere un papel central de la IL-17 y el eje IL-23&#47;T17 en la patog&#233;nesis de la psoriasis&#44; lo que ofrece una base para el uso de agentes bloqueadores de la IL-17 como tratamiento&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Est&#225;n siendo estudiados en estudios cl&#237;nicos en fase III tres agentes enfocados en la se&#241;alizaci&#243;n de la IL-17&#58; secukinumab e ixekizumab &#40;agentes neutralizantes de la IL-17&#41;&#44; y brodalumab &#40;antagonista del receptor de la IL-17&#41;&#46; Los resultados preliminares son altamente prometedores para todos los agentes anti-IL17&#44; lo que crea claras expectativas para esta clase de agentes como un nuevo planteamiento terap&#233;utico eficaz para el tratamiento de la psoriasis&#46;</p>"
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