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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El liquen plano oral &#40;LPO&#41; es una enfermedad inflamatoria relativamente frecuente que se presenta con un amplio abanico de formas cl&#237;nicas&#46; Todav&#237;a no se ha determinado completamente su patogenia&#44; aunque se sabe que los linfocitos act&#250;an de mediadores con la participaci&#243;n de citoquinas y otras c&#233;lulas inflamatorias&#44; entre ellas los dendrocitos d&#233;rmicos &#40;DD&#41; tipo I y tipo II &#40;DD positivos para el factor XIIIA y CD34&#44; respectivamente&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Describir la presencia y distribuci&#243;n de estas c&#233;lulas en el tejido&#44; mediante t&#233;cnicas inmunohistoqu&#237;micas&#44; en 23 muestras procedentes de pacientes que reun&#237;an los criterios cl&#237;nicos e histopatol&#243;gicos de LPO&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD factor XIII&#43; estaban localizados principalmente en la dermis superficial &#40;p &#60; 0&#44;0001&#41; y no en la submucosa profunda&#46; Dichas c&#233;lulas se encontraban en abundancia en toda la uni&#243;n dermoepid&#233;rmica y se relacionaban estrechamente con la infiltraci&#243;n linfocitaria&#46; Los DD factor XIIIa&#43; se encontraban adem&#225;s en el epitelio y la dermis profunda&#46; En cambio&#44; los DD CD34&#43; se distribuyeron principalmente en la dermis profunda&#44; directamente por debajo del infiltrado linfocitario&#44; con pocas c&#233;lulas en la zona subepitelial&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD estaban presentes en el LPO&#44; con diferentes distribuciones en los tejidos&#46; As&#237;&#44; los DD factor XIIIa&#43; predominaban en la dermis superficial&#44; mientras que los DD CD34&#43; se encontraban principalmente en la dermis profunda&#46; Esto apunta a que los DD&#44; y sobre todo los DD factor XIIIa&#43; debido a su capacidad para expresar mol&#233;culas de adhesi&#243;n intercelulares-1 &#40;ICAM-1&#41; y el factor de necrosis tumoral alfa &#40;TNF-&#945;&#41;&#44; pueden desempe&#241;ar una funci&#243;n destacada en la patog&#233;nesis del LPO&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Oral lichen planus &#40;OLP&#41; is a relatively common inflammatory disease with a wide range of clinical forms&#46; Its pathogenesis has not been fully elucidated although it is known to be mediated by lymphocytes with the participation of cytokines and other inflammatory cells&#44; including type I and type II dermal dendrocytes &#40;DD&#41; &#40;factor XIIIa&#43; DD and CD34&#43; DD&#44; respectively&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To describe the presence and tissue distribution of these cells&#44; through immunohistochemistry&#44; in 23 specimens from patients with clinical and histopathological criteria of OLP&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Factor XIIIa&#43; DD were mainly located in the superficial dermis &#40;p &#60; 0&#46;0001&#41; as opposed to the deep submucosa&#46; These cells were abundant throughout the dermal-epidermal junction and closely related to lymphocyte infiltration&#46; Moreover&#44; factor XIIIa&#43; DD were also found in the epithelium and deep dermis&#46; CD34&#43; DD were distributed mostly to the deep dermis directly below the lymphocyte infiltrate with few cells in the subepithelial region&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">DD were present in OLP&#44; with distinct tissue distributions&#46; Factor XIIIa&#43; DD were predominant in the superficial dermis while CD34&#43; DD could be found mostly in the deep dermis&#46; These findings suggest that DD&#44;and those positive for factor XIIIa&#43; in particular in view of their ability to express intercellular adhesion molecule-1 &#40;ICAM-1&#41; and tumor necrosis factor &#945; &#40;TNF-&#945;&#41;&#44; may play an important role in pathogenesis of OLP&#46;</p>"
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Vol. 100. Issue 1.
Pages 46-52 (January - February 2009)
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Vol. 100. Issue 1.
Pages 46-52 (January - February 2009)
Original articles
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Oral lichen Planus and Dermal Dendrocytes
Oral lichen Planus and Dermal Dendrocytes
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5834
A.L. Cardozoa, C. Moura-Castroa, M. Figueiredob, T. Cuzzic, M. Ramos-e-Silvaa,
Corresponding author
ramos.e.silva@dermato.med.br

Correspondence: Rua Dona Mariana 143/C-32. 22280-020 Rio de Janeiro. Brazil.
a Sector of Dermatology and Post Graduation Course. HUCFF/UFRJ and School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro
b School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro
c Sector of Pathology. HUCFF/UFRJ and School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro. Brazil
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Resumen
Introducción

El liquen plano oral (LPO) es una enfermedad inflamatoria relativamente frecuente que se presenta con un amplio abanico de formas clínicas. Todavía no se ha determinado completamente su patogenia, aunque se sabe que los linfocitos actúan de mediadores con la participación de citoquinas y otras células inflamatorias, entre ellas los dendrocitos dérmicos (DD) tipo I y tipo II (DD positivos para el factor XIIIA y CD34, respectivamente).

Objetivos

Describir la presencia y distribución de estas células en el tejido, mediante técnicas inmunohistoquímicas, en 23 muestras procedentes de pacientes que reunían los criterios clínicos e histopatológicos de LPO.

Resultados

Los DD factor XIII+ estaban localizados principalmente en la dermis superficial (p < 0,0001) y no en la submucosa profunda. Dichas células se encontraban en abundancia en toda la unión dermoepidérmica y se relacionaban estrechamente con la infiltración linfocitaria. Los DD factor XIIIa+ se encontraban además en el epitelio y la dermis profunda. En cambio, los DD CD34+ se distribuyeron principalmente en la dermis profunda, directamente por debajo del infiltrado linfocitario, con pocas células en la zona subepitelial.

Conclusiones

Los DD estaban presentes en el LPO, con diferentes distribuciones en los tejidos. Así, los DD factor XIIIa+ predominaban en la dermis superficial, mientras que los DD CD34+ se encontraban principalmente en la dermis profunda. Esto apunta a que los DD, y sobre todo los DD factor XIIIa+ debido a su capacidad para expresar moléculas de adhesión intercelulares-1 (ICAM-1) y el factor de necrosis tumoral alfa (TNF-α), pueden desempeñar una función destacada en la patogénesis del LPO.

Palabras clave:
liquen plano
célula dendrítica dérmica
dendrocitos
oral
Abstract
Introduction

Oral lichen planus (OLP) is a relatively common inflammatory disease with a wide range of clinical forms. Its pathogenesis has not been fully elucidated although it is known to be mediated by lymphocytes with the participation of cytokines and other inflammatory cells, including type I and type II dermal dendrocytes (DD) (factor XIIIa+ DD and CD34+ DD, respectively).

Objectives

To describe the presence and tissue distribution of these cells, through immunohistochemistry, in 23 specimens from patients with clinical and histopathological criteria of OLP.

Results

Factor XIIIa+ DD were mainly located in the superficial dermis (p < 0.0001) as opposed to the deep submucosa. These cells were abundant throughout the dermal-epidermal junction and closely related to lymphocyte infiltration. Moreover, factor XIIIa+ DD were also found in the epithelium and deep dermis. CD34+ DD were distributed mostly to the deep dermis directly below the lymphocyte infiltrate with few cells in the subepithelial region.

Conclusions

DD were present in OLP, with distinct tissue distributions. Factor XIIIa+ DD were predominant in the superficial dermis while CD34+ DD could be found mostly in the deep dermis. These findings suggest that DD,and those positive for factor XIIIa+ in particular in view of their ability to express intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor α (TNF-α), may play an important role in pathogenesis of OLP.

Key words:
lichen planus
dermal dendritic cell
dendrocytes
mouth
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Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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