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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El liquen plano oral &#40;LPO&#41; es una enfermedad inflamatoria relativamente frecuente que se presenta con un amplio abanico de formas cl&#237;nicas&#46; Todav&#237;a no se ha determinado completamente su patogenia&#44; aunque se sabe que los linfocitos act&#250;an de mediadores con la participaci&#243;n de citoquinas y otras c&#233;lulas inflamatorias&#44; entre ellas los dendrocitos d&#233;rmicos &#40;DD&#41; tipo I y tipo II &#40;DD positivos para el factor XIIIA y CD34&#44; respectivamente&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Describir la presencia y distribuci&#243;n de estas c&#233;lulas en el tejido&#44; mediante t&#233;cnicas inmunohistoqu&#237;micas&#44; en 23 muestras procedentes de pacientes que reun&#237;an los criterios cl&#237;nicos e histopatol&#243;gicos de LPO&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD factor XIII&#43; estaban localizados principalmente en la dermis superficial &#40;p &#60; 0&#44;0001&#41; y no en la submucosa profunda&#46; Dichas c&#233;lulas se encontraban en abundancia en toda la uni&#243;n dermoepid&#233;rmica y se relacionaban estrechamente con la infiltraci&#243;n linfocitaria&#46; Los DD factor XIIIa&#43; se encontraban adem&#225;s en el epitelio y la dermis profunda&#46; En cambio&#44; los DD CD34&#43; se distribuyeron principalmente en la dermis profunda&#44; directamente por debajo del infiltrado linfocitario&#44; con pocas c&#233;lulas en la zona subepitelial&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD estaban presentes en el LPO&#44; con diferentes distribuciones en los tejidos&#46; As&#237;&#44; los DD factor XIIIa&#43; predominaban en la dermis superficial&#44; mientras que los DD CD34&#43; se encontraban principalmente en la dermis profunda&#46; Esto apunta a que los DD&#44; y sobre todo los DD factor XIIIa&#43; debido a su capacidad para expresar mol&#233;culas de adhesi&#243;n intercelulares-1 &#40;ICAM-1&#41; y el factor de necrosis tumoral alfa &#40;TNF-&#945;&#41;&#44; pueden desempe&#241;ar una funci&#243;n destacada en la patog&#233;nesis del LPO&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Oral lichen planus &#40;OLP&#41; is a relatively common inflammatory disease with a wide range of clinical forms&#46; Its pathogenesis has not been fully elucidated although it is known to be mediated by lymphocytes with the participation of cytokines and other inflammatory cells&#44; including type I and type II dermal dendrocytes &#40;DD&#41; &#40;factor XIIIa&#43; DD and CD34&#43; DD&#44; respectively&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To describe the presence and tissue distribution of these cells&#44; through immunohistochemistry&#44; in 23 specimens from patients with clinical and histopathological criteria of OLP&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Factor XIIIa&#43; DD were mainly located in the superficial dermis &#40;p &#60; 0&#46;0001&#41; as opposed to the deep submucosa&#46; These cells were abundant throughout the dermal-epidermal junction and closely related to lymphocyte infiltration&#46; Moreover&#44; factor XIIIa&#43; DD were also found in the epithelium and deep dermis&#46; CD34&#43; DD were distributed mostly to the deep dermis directly below the lymphocyte infiltrate with few cells in the subepithelial region&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">DD were present in OLP&#44; with distinct tissue distributions&#46; Factor XIIIa&#43; DD were predominant in the superficial dermis while CD34&#43; DD could be found mostly in the deep dermis&#46; These findings suggest that DD&#44;and those positive for factor XIIIa&#43; in particular in view of their ability to express intercellular adhesion molecule-1 &#40;ICAM-1&#41; and tumor necrosis factor &#945; &#40;TNF-&#945;&#41;&#44; may play an important role in pathogenesis of OLP&#46;</p>"
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Original articles
Oral lichen Planus and Dermal Dendrocytes
Oral lichen Planus and Dermal Dendrocytes
A.L. Cardozoa, C. Moura-Castroa, M. Figueiredob, T. Cuzzic, M. Ramos-e-Silvaa,
Corresponding author
ramos.e.silva@dermato.med.br

Correspondence: Rua Dona Mariana 143/C-32. 22280-020 Rio de Janeiro. Brazil.
a Sector of Dermatology and Post Graduation Course. HUCFF/UFRJ and School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro
b School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro
c Sector of Pathology. HUCFF/UFRJ and School of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro. Brazil
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El liquen plano oral &#40;LPO&#41; es una enfermedad inflamatoria relativamente frecuente que se presenta con un amplio abanico de formas cl&#237;nicas&#46; Todav&#237;a no se ha determinado completamente su patogenia&#44; aunque se sabe que los linfocitos act&#250;an de mediadores con la participaci&#243;n de citoquinas y otras c&#233;lulas inflamatorias&#44; entre ellas los dendrocitos d&#233;rmicos &#40;DD&#41; tipo I y tipo II &#40;DD positivos para el factor XIIIA y CD34&#44; respectivamente&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Describir la presencia y distribuci&#243;n de estas c&#233;lulas en el tejido&#44; mediante t&#233;cnicas inmunohistoqu&#237;micas&#44; en 23 muestras procedentes de pacientes que reun&#237;an los criterios cl&#237;nicos e histopatol&#243;gicos de LPO&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD factor XIII&#43; estaban localizados principalmente en la dermis superficial &#40;p &#60; 0&#44;0001&#41; y no en la submucosa profunda&#46; Dichas c&#233;lulas se encontraban en abundancia en toda la uni&#243;n dermoepid&#233;rmica y se relacionaban estrechamente con la infiltraci&#243;n linfocitaria&#46; Los DD factor XIIIa&#43; se encontraban adem&#225;s en el epitelio y la dermis profunda&#46; En cambio&#44; los DD CD34&#43; se distribuyeron principalmente en la dermis profunda&#44; directamente por debajo del infiltrado linfocitario&#44; con pocas c&#233;lulas en la zona subepitelial&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los DD estaban presentes en el LPO&#44; con diferentes distribuciones en los tejidos&#46; As&#237;&#44; los DD factor XIIIa&#43; predominaban en la dermis superficial&#44; mientras que los DD CD34&#43; se encontraban principalmente en la dermis profunda&#46; Esto apunta a que los DD&#44; y sobre todo los DD factor XIIIa&#43; debido a su capacidad para expresar mol&#233;culas de adhesi&#243;n intercelulares-1 &#40;ICAM-1&#41; y el factor de necrosis tumoral alfa &#40;TNF-&#945;&#41;&#44; pueden desempe&#241;ar una funci&#243;n destacada en la patog&#233;nesis del LPO&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Oral lichen planus &#40;OLP&#41; is a relatively common inflammatory disease with a wide range of clinical forms&#46; Its pathogenesis has not been fully elucidated although it is known to be mediated by lymphocytes with the participation of cytokines and other inflammatory cells&#44; including type I and type II dermal dendrocytes &#40;DD&#41; &#40;factor XIIIa&#43; DD and CD34&#43; DD&#44; respectively&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To describe the presence and tissue distribution of these cells&#44; through immunohistochemistry&#44; in 23 specimens from patients with clinical and histopathological criteria of OLP&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Factor XIIIa&#43; DD were mainly located in the superficial dermis &#40;p &#60; 0&#46;0001&#41; as opposed to the deep submucosa&#46; These cells were abundant throughout the dermal-epidermal junction and closely related to lymphocyte infiltration&#46; Moreover&#44; factor XIIIa&#43; DD were also found in the epithelium and deep dermis&#46; CD34&#43; DD were distributed mostly to the deep dermis directly below the lymphocyte infiltrate with few cells in the subepithelial region&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">DD were present in OLP&#44; with distinct tissue distributions&#46; Factor XIIIa&#43; DD were predominant in the superficial dermis while CD34&#43; DD could be found mostly in the deep dermis&#46; These findings suggest that DD&#44;and those positive for factor XIIIa&#43; in particular in view of their ability to express intercellular adhesion molecule-1 &#40;ICAM-1&#41; and tumor necrosis factor &#945; &#40;TNF-&#945;&#41;&#44; may play an important role in pathogenesis of OLP&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
Actas Dermo-Sifiliográficas
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