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Vol. 100. Issue 9.
Pages 804-807 (November 2009)
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Vol. 100. Issue 9.
Pages 804-807 (November 2009)
Case reports
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Multiple Painful, Treatment-Resistant Leg Ulcers Associated With Dermatomyositis-Like Lesions Over the Interphalangeal Joints Induced by Hydroxyurea
Úlceras Dolorosas Múltiples en la Pierna Resistentes al Tratamiento Asociadas a Lesiones Dermatomiositis-like en las Articulaciones Interfalángicas de las Manos: Hidroxiurea Como Agente Causal
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A. Martorell-Calatayud
Corresponding author
antmarto@hotmail.com

Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain.
, C. Requena, E. Nagore-Enguídanos, C. Guillén-Barona
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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Abstract

The onset of a dermatomyositis-like rash and persistent skin ulcers during long-term treatment with hydroxyurea is a very rare event that has not been fully described in the literature.

The fact that these lesions have a typical clinical presentation and course, and that complete resolution can only be achieved by immediate withdrawal of the drug, means that dermatologists should be aware of this condition in order to avoid a delay in diagnosis.

We present the case of a 76-year-old woman who developed a dermatomyositis-like eruption associated with chronic ulcers on the lower limbs during long-term treatment with hydroxyurea.

Key words:
hydroxyurea
leg ulcer
dermatomyositis
Resumen

El desarrollo de una erupción dermatomiositis-like y de úlceras cutáneas de evolución tórpida, en el contexto de un tratamiento mantenido a largo plazo con hidroxiurea, es un fenómeno muy infrecuente y parcialmente descrito en la literatura.

El hecho de que las características clínicas y evolutivas de este tipo de lesiones son típicas y que su resolución completa sólo se alcanza mediante la suspensión inmediata del tratamiento, hace necesario que el dermatólogo conozca este cuadro, con el fin de evitar el retraso diagnóstico.

Presentamos el caso de una paciente de 76 años que desarrolló una erupción dermatomiositis-like junto a un proceso ulcerativo crónico en los miembros inferiores en el contexto de un tratamiento con hidroxiurea mantenido a largo plazo.

Palabras clave:
hidroxiurea
úlcera en pierna
dermatomiositis
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Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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