Case reports
Multiple Painful, Treatment-Resistant Leg Ulcers Associated With Dermatomyositis-Like Lesions Over the Interphalangeal Joints Induced by Hydroxyurea
Úlceras Dolorosas Múltiples en la Pierna Resistentes al Tratamiento Asociadas a Lesiones Dermatomiositis-like en las Articulaciones Interfalángicas de las Manos: Hidroxiurea Como Agente Causal
A. Martorell-Calatayud
, C. Requena, E. Nagore-Enguídanos, C. Guillén-Barona
Corresponding author
antmarto@hotmail.com
Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain.
Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain.
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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"apellidos" => "Liso" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701751?idApp=UINPBA000044" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701751/v1_201304241507/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Multiple Painful, Treatment-Resistant Leg Ulcers Associated With Dermatomyositis-Like Lesions Over the Interphalangeal Joints Induced by Hydroxyurea" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "804" "paginaFinal" => "807" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martorell-Calatayud, C. Requena, E. Nagore-Enguídanos, C. Guillén-Barona" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martorell-Calatayud" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Requena" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Nagore-Enguídanos" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Guillén-Barona" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Úlceras Dolorosas Múltiples en la Pierna Resistentes al Tratamiento Asociadas a Lesiones Dermatomiositis-like en las Articulaciones Interfalángicas de las Manos: Hidroxiurea Como Agente Causal" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-03-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84583" "palabras" => array:3 [ 0 => "hydroxyurea" 1 => "leg ulcer" 2 => "dermatomyositis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84584" "palabras" => array:3 [ 0 => "hidroxiurea" 1 => "úlcera en pierna" 2 => "dermatomiositis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The onset of a dermatomyositis-like rash and persistent skin ulcers during long-term treatment with hydroxyurea is a very rare event that has not been fully described in the literature.</p><p class="elsevierStyleSimplePara elsevierViewall">The fact that these lesions have a typical clinical presentation and course, and that complete resolution can only be achieved by immediate withdrawal of the drug, means that dermatologists should be aware of this condition in order to avoid a delay in diagnosis.</p><p class="elsevierStyleSimplePara elsevierViewall">We present the case of a 76-year-old woman who developed a dermatomyositis-like eruption associated with chronic ulcers on the lower limbs during long-term treatment with hydroxyurea.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El desarrollo de una erupción dermatomiositis-like y de úlceras cutáneas de evolución tórpida, en el contexto de un tratamiento mantenido a largo plazo con hidroxiurea, es un fenómeno muy infrecuente y parcialmente descrito en la literatura.</p><p class="elsevierStyleSimplePara elsevierViewall">El hecho de que las características clínicas y evolutivas de este tipo de lesiones son típicas y que su resolución completa sólo se alcanza mediante la suspensión inmediata del tratamiento, hace necesario que el dermatólogo conozca este cuadro, con el fin de evitar el retraso diagnóstico.</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una paciente de 76 años que desarrolló una erupción dermatomiositis-like junto a un proceso ulcerativo crónico en los miembros inferiores en el contexto de un tratamiento con hidroxiurea mantenido a largo plazo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2022 June | 17 | 42 | 59 |
| 2022 May | 22 | 50 | 72 |
| 2022 April | 33 | 34 | 67 |
| 2022 March | 22 | 54 | 76 |
| 2022 February | 17 | 36 | 53 |
| 2022 January | 32 | 63 | 95 |
| 2021 December | 19 | 54 | 73 |
| 2021 November | 30 | 65 | 95 |
| 2021 October | 32 | 53 | 85 |
| 2021 September | 12 | 36 | 48 |
| 2021 August | 14 | 31 | 45 |
| 2021 July | 22 | 40 | 62 |
| 2021 June | 16 | 28 | 44 |
| 2021 May | 16 | 29 | 45 |
| 2021 April | 36 | 71 | 107 |
| 2021 March | 32 | 12 | 44 |
| 2021 February | 48 | 31 | 79 |
| 2021 January | 29 | 17 | 46 |
| 2020 December | 30 | 13 | 43 |
| 2020 November | 35 | 21 | 56 |
| 2020 October | 17 | 10 | 27 |
| 2020 September | 24 | 16 | 40 |
| 2020 August | 26 | 11 | 37 |
| 2020 July | 10 | 12 | 22 |
| 2020 June | 28 | 21 | 49 |
| 2020 May | 15 | 26 | 41 |
| 2020 April | 18 | 12 | 30 |
| 2020 March | 34 | 18 | 52 |
| 2020 February | 4 | 2 | 6 |
| 2020 January | 0 | 6 | 6 |
| 2019 December | 0 | 6 | 6 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 3 | 3 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 4 | 4 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 1 | 63 | 64 |
| 2019 March | 0 | 6 | 6 |
| 2019 February | 0 | 3 | 3 |
| 2018 February | 14 | 4 | 18 |
| 2018 January | 15 | 3 | 18 |
| 2017 December | 11 | 11 | 22 |
| 2017 November | 18 | 4 | 22 |
| 2017 October | 12 | 3 | 15 |
| 2017 September | 12 | 3 | 15 |
| 2017 August | 21 | 5 | 26 |
| 2017 July | 20 | 3 | 23 |
| 2017 June | 22 | 12 | 34 |
| 2017 May | 10 | 8 | 18 |
| 2017 April | 23 | 13 | 36 |
| 2017 March | 20 | 3 | 23 |
| 2017 February | 12 | 6 | 18 |
| 2017 January | 9 | 7 | 16 |
| 2016 December | 26 | 10 | 36 |
| 2016 November | 21 | 4 | 25 |
| 2016 October | 26 | 11 | 37 |
| 2016 September | 30 | 9 | 39 |
| 2016 August | 29 | 1 | 30 |
| 2016 July | 28 | 4 | 32 |
| 2016 June | 14 | 4 | 18 |
| 2016 May | 6 | 5 | 11 |
| 2016 April | 7 | 4 | 11 |
| 2016 March | 6 | 7 | 13 |
| 2016 February | 10 | 3 | 13 |
| 2016 January | 3 | 0 | 3 |
| 2015 December | 7 | 1 | 8 |
| 2015 November | 14 | 1 | 15 |
| 2015 October | 2 | 3 | 5 |
| 2015 September | 6 | 3 | 9 |
| 2015 August | 10 | 5 | 15 |
| 2015 July | 37 | 11 | 48 |
| 2015 June | 20 | 2 | 22 |
| 2015 May | 70 | 22 | 92 |
| 2015 April | 31 | 9 | 40 |
| 2015 March | 40 | 13 | 53 |
| 2015 February | 36 | 16 | 52 |
| 2015 January | 27 | 28 | 55 |
| 2014 December | 21 | 19 | 40 |
| 2014 November | 23 | 16 | 39 |
| 2014 October | 25 | 24 | 49 |
| 2014 September | 18 | 26 | 44 |
| 2014 August | 29 | 13 | 42 |
| 2014 July | 43 | 28 | 71 |
| 2014 June | 49 | 9 | 58 |
| 2014 May | 53 | 9 | 62 |
| 2014 April | 29 | 13 | 42 |
| 2014 March | 46 | 22 | 68 |
| 2014 February | 28 | 22 | 50 |
| 2014 January | 42 | 13 | 55 |
| 2013 December | 36 | 14 | 50 |
| 2013 November | 32 | 23 | 55 |
| 2013 October | 33 | 22 | 55 |
| 2013 September | 36 | 25 | 61 |
| 2013 August | 16 | 26 | 42 |
| 2013 July | 30 | 52 | 82 |
| 2013 June | 29 | 27 | 56 |
| 2013 May | 28 | 25 | 53 |
| 2013 April | 32 | 31 | 63 |
| 2013 March | 37 | 21 | 58 |
| 2013 February | 27 | 17 | 44 |
| 2013 January | 8 | 3 | 11 |
Show all
