Journal Information
Vol. 98. Issue 10.
Pages 702-706 (December 2007)
Vol. 98. Issue 10.
Pages 702-706 (December 2007)
Case report
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Multiple Eruptive Dermatofibromas in 2 Patients Infected With the Human Immunodeficiency Virus
Dermatofibromas Eruptivos Múltiples Asociados al Virus de la Inmunodeficiencia humana. Presentación de dos Casos
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C. García-Millána,
Corresponding author
cgmillan@gmail.com

Correspondence: Cristina García-Millán, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Carretera de Colmenar km. 9,100, 28034 Madrid, Spain.
, I. Aldanondoa, M. Fernández-Lorentea, R. Carrillob, P. Jaéna
a Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Abstract

Multiple eruptive dermatofibromas are an uncommonclinical entity in which several lesions appear in a short period of time. Baraf and Shapiro defined them in 1970 as the appearance of at least 15 dermatofibromas in a few months. Given that incipient cases might be omitted, appearance of 5 to 8 dermatofibromas in 4 months has been proposed as sufficient to establish diagnosis. Although this entity has been reported in healthy subjects, it usually appears with underlying autoimmune diseases (lupus erythematosus), human immunodeficiency virus (HIV) infection, or treatment with certain drugs. We report 2 cases of multiple eruptive dermatofibromas associated with HIV infection. One of these patients was unaware of being infected with HI V, and so we believe that the appearance of these skin lesions could help early diagnosis of autoimmune diseases or patients with immunodepression.

Key words:
multiple dermatofibromas
HIV infection
immunodepression
Resumen

Los dermatofibromas eruptivos múltiples (DFEM) constituyen una entidad clínica infrecuente que consiste en la aparición de varias lesiones en un corto espacio de tiempo. Baraf y Shapiro los definen en 1970 como la aparición de al menos 15 dermatofibromas en pocos meses. Dado que esta cifra podría pasar por alto casos incipientes, se ha propuesto que el hallazgo de 5 a 8 dermatofibromas en 4 meses sea suficiente. Este hallazgo clínico suele aparecer en el contexto de enfe rmedades autoinmunes (lupus eritematoso) así como en enfe rmos positivos para el virus de la inmunodeficiencia humana (VIH) o en tratamiento con ciertos fármacos, pero también se han descrito DFEM en pacientes sanos. Presentamos dos casos de dermatofibromas eruptivos múltiples asociados a infección por el VIH, siendo esta condición desconocida previamente en uno de los pacientes, por lo que creemos que la aparición de estas lesiones cutáneas podría ay udar al diagnóstico precoz de enfe rmedades autoinmunes o situaciones de inmunosupresión.

Palabras clave:
dermatofibromas múltiples
infección VIH
inmunosupresión
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Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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