Journal Information
Vol. 111. Issue 8.
Pages 696-698 (October 2020)
Vol. 111. Issue 8.
Pages 696-698 (October 2020)
Case and Research Letters
DOI: 10.1016/j.adengl.2020.09.007
Open Access
Moderate to Severe Hidradenitis Suppurativa Successfully Treated With Secukinumab
Hidradenitis supurativa moderada-grave tratada exitosamente con secukinumab
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I. Villegas-Romero
Corresponding author
, C. Collantes-Rodríguez, S. Valenzuela-Ubiña, D. Jiménez-Gallo
Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain
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Table 1. Clinical Characteristics and Evaluation Scores for the 3 Cases.
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To the Editor:

Hidradenitis suppurativa (HS) is a chronic and recurrent inflammatory disease of the follicular infundibulum that principally affects the intertriginous regions. The estimated prevalence is 1%. T-helper (Th)-17 lymphocytes and neutrophils are the main source of the proinflammatory cytokines involved in the pathogenesis of HS.1

We report our experience with 3 patients with moderate to severe HS treated with 300 mg of subcutaneous secukinumab, as per the induction and maintenance regimen indicated in psoriasis. All patients signed an informed consent of off-label use. The patients were evaluated before and after treatment using the Hurley score, the International Hidradenitis Suppurative Severity Scores System, and the Modified Hidradenitis Suppurativa Score (mHSS). Serum levels of C-reactive protein before and after treatment were evaluated as a parameter of systemic inflammation. We evaluated achievement of the Hidradenitis Suppurativa Clinical Response (HiSCR) therapeutic goal. We also performed a quality of life evaluation using the Dermatology Life Quality Index (DLQI). We also recorded data on prior and concomitant treatment, response time, and treatment time with secukinumab. All these data are shown in Table 1 and images of 1 of the patients are shown in Fig. 1.

Table 1.

Clinical Characteristics and Evaluation Scores for the 3 Cases.

Cases  Age, Y and Sex  Previous Treatment  Concomitant Treatment  Response Time  Treatment Time  Hurley Before  Hurley After  DLQIBefore  DLQIAfter  IHS4 Before  IHS4After  mHSSBefore  mHSSAfter  HiSCR  CRP Before  CRPAfter 
Patient 1  46, F  Oral antibioticsisotretinoin, acitretin, corticosteroids, sulfasalazine,methotrexate, infliximab, anakinra, adalimumab.  Intralesional triamcinolone  4 wk  7 mo  28  17  13  59  10  Yes  11 
Patient 2  21, F  Oral antibiotics, nicotinamide, adalimumab  Dapsone, 100 mg/d  8 wk  12 mo  32  11  15  56  12  Yes  31 
Patient 3  45, M  Oral antibiotics, acitretin, adalimumab, infliximab  Abdominal-fold surgery  12 wk  4 mo  10  12  48  Yes  21 

Abbreviations: DLQI indicates Dermatology Life Quality Index; F, female; HiSCR, Hidradenitis Suppurativa Clinical Response; IHS4, International Hidradenitis Suppurativa Severity Scores System; M, male; mHSS, Modified Hidradenitis Suppurativa Score; CRP, C-reactive protein.

Figure 1.

A and B, Left and right axillae with nodules and suppurative fistulas prior to treatment. C and D, Left and right axillae with residual lesions after 4 months of treatment with secukinumab, 300 mg.

(0.15MB).

All 3 patients presented stage 3 on the Hurley scale, a score of 10, 28, and 32 on the DLQI, a score of 12, 13, and 15 on the International Hidradenitis Suppurativa Severity Scores System, and a score of 48, 56, and 59 on the mHSS prior to start of treatment. The response time was 4, 8, and 12 weeks. All the patients achieved a reduction of 53% on the DLQI, 85% on the IHS, 94.7% on the mHSS, and all patients showed improvement on the Hurley scale (Table 1). Levels of C-reactive protein fell by more than 70% in all cases (74%, 81%, and 85%). All patients achieved the HiSCR therapeutic goal. No adverse effects were observed during treatment.

HS is a systemic inflammatory disease, the pathogenesis of which involves principally Th-17 lymphocytes and neutrophils.2 The IL-23 produced by the dendritic cells favors differentiation into Th-17 lymphocytes. Th-17 lymphocytes promote the recruitment of neutrophils implicated in the inflammatory response of HS.2 Secukinumab is a human monoclonal antibody that inhibits both IL-17A and the interaction of cytokines with the IL-17 receptors. IL-17 regulates the expression of the antimicrobial peptides and is overexpressed in HS lesions and in the HS perilesional skin, which may explain the efficacy of anti-IL-17 drugs in HS.2

Treatment of HS poses a challenge for dermatologists and includes a medical and surgical approach. Medical treatment is based on scaled regimens of antibiotics, retinoids, and biological drugs.3 Adalimumab is currently the only biological drug approved by both the US Food and Drug Administration and by the European Medicines Agency.1,3 In recent years, however, studies have been published on the efficacy of secukinumab in moderate to severe HS.4–9

To date, secukinumab has demonstrated its efficacy in 5 case reports4–8 and in just 1 open trial with 9 patients,9 for which it was not possible to establish comparable relationships due to the lack of unanimity in the use of severity scores.

We present our experience with 3 patients with moderate to severe HS treated with secukinumab off label. All 3 patients achieved the HiSCR objective and no adverse effects were observed during treatment. Our results, together with the cases published in the literature, support the need for randomized phase-III trials to evaluate the efficacy and safety of secukinumab in HS.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
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Ł Matusiak, J. Szczęch, A. Bieniek, D. Nowicka-Suszko, J.C. Szepietowski.
Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents.
J Am Acad Dermatol, 76 (2017), pp. 670-675
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Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis.
JAMA Dermatol, 154 (2018), pp. 592-595
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Secukinumab and hidradenitis suppurativa: friends or foes?.
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B.M.RitaA Case of Moderate Hidradenitis Suppurativa and Psoriasis Treated with Secukinumab.
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Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab.
Acta Derm Venereol, 98 (2018), pp. 151-152
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L. Thorlacius, P. Theut Riis, G.B.E. Jemec.
Severe hidradenitis suppurativa responding to treatment with secukinumab: a case report.
Br J Dermatol, 179 (2018), pp. 182-185
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L. Prussick, S. Tonelli, A.B. Gottlieb, D. Joshipura, A. Alomran, P. Zancanaro, et al.
Open-label, Investigator-Initiated, Single Site Exploratory Trial Evaluating Secukinumab, an anti IL17A monoclonal antibody, for Patients with Moderate-to-Severe Hidradenitis Suppurativa.
Br J Dermatol, 30 (2019), pp. 708-713

Please cite this article as: Villegas-Romero I, Collantes-Rodríguez C, Valenzuela-Ubiña S, Jiménez-Gallo D. Hidradenitis supurativa moderada-grave tratada exitosamente con secukinumab. Actas Dermosifiliogr. 2020. https://doi.org/10.1016/j.ad.2019.07.007

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