Manejo del paciente con hidradenitis supurativa

Martorell, A.; Caballero, A.; González Lama, Y.; Jiménez-Gallo, D.; Lázaro Serrano, M.; Miranda, J.; Pascual, J.C.; Salgado-Boquete, L.; Marín-Jiménez, I.

doi:10.1016/S0001-7310(17)30007-8

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Su tratamiento comprende un abordaje médico y quirúrgico. El tratamiento médico se basa en el uso de antibióticos, retinoides y fármacos antiinflamatorios, donde la terapia biológica anti-TNFα (infliximab y adalimumab) ocupa el papel central en el tratamiento de la hidradenitis supurativa moderada-grave con el mayor grado de evidencia científica. Actualmente, adalimumab es el único fármaco indicado en ficha técnica para el tratamiento de esta patología. Debido a los pocos ensayos clínicos terapéuticos en hidradenitis supurativa, todavía no existe una guía terapéutica con evidencia sólida, y la mayoría de fármacos tienen un nivel de evidencia bajo. Sin embargo, el tratamiento precoz en pacientes con hidradenitis supurativa, probablemente pueda disminuir las complicaciones derivadas de esta. 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Actas Dermo-Sifiliográficas

ISSN: 0001-7310

The Official publication of the Spanish Academy of Dermatology and Venereology (AEDV). Actas Dermo-Sifiliográficas, founded in 1909, is the oldest monthly medical journals published in Spain. In the year 2006 has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern. All articles are subjected to a rigorous process of revision in pairs, and careful editing for literary and scientific style. Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews. Dermo-Sifiliográficas is an essential publication for anyone who needs to be current on all aspects of Spanish and world dermatology.

Con su JCI 2023, Actas Dermo-Sifiliográficas es Q1 y se posiciona la revista nº 15 de 94 en Dermatología

With JCI 2023, Actas Dermo-Sifiliográficas is Q1 and is ranked number 15 of 94 in Dermatology

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La hidradenitis supurativa es una enfermedad inflamatoria crónica con una alta prevalencia en la población. Su tratamiento comprende un abordaje médico y quirúrgico. El tratamiento médico se basa en el uso de antibióticos, retinoides y fármacos antiinflamatorios, donde la terapia biológica anti-TNFα (infliximab y adalimumab) ocupa el papel central en el tratamiento de la hidradenitis supurativa moderada-grave con el mayor grado de evidencia científica. Actualmente, adalimumab es el único fármaco indicado en ficha técnica para el tratamiento de esta patología. Debido a los pocos ensayos clínicos terapéuticos en hidradenitis supurativa, todavía no existe una guía terapéutica con evidencia sólida, y la mayoría de fármacos tienen un nivel de evidencia bajo. Sin embargo, el tratamiento precoz en pacientes con hidradenitis supurativa, probablemente pueda disminuir las complicaciones derivadas de esta. En esta revisión se analizan los diferentes tratamientos utilizados en esta enfermedad dermatológica y se aporta un algoritmo terapéutico con diferentes opciones de tratamiento.

Palabras clave:

Hidradenitis supurativa

Tratamiento

Infliximab

Adalimumab

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a high prevalence in the population. Treatment options are both medical and surgical. Medical treatment is based on the use of antibiotics, retinoids, and anti-inflammatory drugs, in which anti-TNFα agents (infliximab y adalimumab) play a central role in the treatment of moderate-to-severe HS and enjoy the highest level of scientific support. Currently, adalimumab is the only drug approved in the summary of product characteristics for the treatment of this disease. Due to the scarcity of clinical trials in HS, there is still no therapeutic guideline backed by solid evidence and the evidence for most drugs is low. However, early treatment in patients with HS would probably reduce the complications of this disease. This review analyses the distinct treatments used in this dermatological disease and provides a therapeutic algorithm with different treatment options.

Keywords:

Hidradenitis suppurativa

Treatment

Infliximab

Adalimumab

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