Journal Information
Vol. 100. Issue S2.
Mirando hacia el futuro en Dermatología Extraordinario del Centenario. Parte II
Pages 22-27 (December 2009)
Vol. 100. Issue S2.
Mirando hacia el futuro en Dermatología Extraordinario del Centenario. Parte II
Pages 22-27 (December 2009)
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Managing Comorbidities in Psoriasis
Tratamiento de enfermedades concomitantes en la psoriasis
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W.H. Boehnckea,
Corresponding author
Boehncke@em.uni-frankfurt.de

Correspondence: Department of Dermatology. Theodor-Stern-Kai 7. D – 60590 Frankfurt.
, S. Boehnckeb
a Department of Dermatology. Clinic of the Johann Wolfgang Goethe-University. Frankfurt am Main. Germany
b Department of Internal Medicine. Section of Endocrinology, Diabetes and Metabolism. Clinic of the Johann Wolfgang Goethe-University. Frankfurt am Main. Germany
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Abstract

Psoriasis is a common inflammatory skin condition, often associated with other diseases. Around 25% of patients develop joint involvement in the form of psoriatic arthritis as well. Recent epidemiologic studies demonstrated an increased cardiovascular morbidity among psoriasis patients, which contributes to their reduced life expectancy. High prevalence of the metabolic syndrome as well as adverse effects of systemic anti-psoriatic therapies may contribute to the observed association. The consequences for the management of psoriasis at this point are three-fold: As comorbidity goes along with comedication, potential drug interactions need to be kept in mind when choosing a systemic anti-psoriatic therapy. Moreover, as psoriasis itself is a risk factor for cardiovascular morbidity, patients must avoid other known risk factors such as obesity or smoking. Dermatologists need to communicate this additional risk to their patients and support them accordingly. Finally, dermatologists serve as sentinels when it comes to the early diagnosis of developing comorbidities in general and psoriatic arthritis in particular, thus opening the door to early intervention.

Key words:
psoriasis
comorbidities
cardiovascular morbidity
Resumen

La psoriasis es una enfermedad inflamatoria cutánea frecuente, que se asocia a menudo con otros procesos. Aproximadamente el 25% de los pacientes desarrolla afectación articular en forma de artritis psoriásica. Estudios epidemiológicos recientes demuestran un aumento de la morbilidad cardiovascular en los pacientes con psoriasis, lo que contribuye a su menor esperanza de vida. La elevada prevalencia del síndrome metabólico, así como los efectos adversos de las terapias sistémicas para la psoriasis, pueden contribuir a la asociación observada. Las consecuencias para el tratamiento de la psoriasis son triples: hay que tener en cuenta las potenciales interacciones farmacológicas a la hora de elegir una terapia sistémica, ya que la patología asociada requiere medicación concomitante; además, como la psoriasis es un factor de riesgo en sí misma para la morbilidad cardiovascular, los pacientes deben evitar otros factores de riesgo conocidos como la obesidad o el tabaquismo. Los dermatólogos deben informar sobre este riesgo añadido y apoyar a sus pacientes. Por último, los dermatólogos sirven como centinelas cuando se trata de realizar un diagnóstico precoz de las enfermedades concomitantes en general y de la artritis psoriásica en particular, facilitando un tratamiento precoz.

Palabras clave:
psoriasis
enfermedades concomitantes
morbilidad cardiovascular
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