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FR- Risk of Nonmelanoma Skin Cancer in Patients on Hemodialysis
FR- Riesgo de cáncer cutáneo no melanoma en pacientes hemodializados
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Red arrows, hairs with Pohl-Pinkus or monilethrix-like constrictions; green arrows, exclamation-mark hairs with a thickened distal end; yellow arrows, yellow dots; orange arrows, short vellus hairs; blue arrow, angulated hair.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Lobato-Berezo, F. Olmos-Alpiste, R.M. Pujol, D. Saceda-Corralo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Lobato-Berezo" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Olmos-Alpiste" ] 2 => array:2 [ "nombre" => "R.M." "apellidos" => "Pujol" ] 3 => array:2 [ "nombre" => "D." 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B, Hematoxylin-eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>65.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.I. Martínez-González, S. Goula-Fernández, R. González-Pérez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.I." "apellidos" => "Martínez-González" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Goula-Fernández" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "González-Pérez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018304307" "doi" => "10.1016/j.ad.2017.11.023" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018304307?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300940?idApp=UINPBA000044" "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019300940/v1_201905070820/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident's Forum</span>" "titulo" => "FR- Risk of Nonmelanoma Skin Cancer in Patients on Hemodialysis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "313" "paginaFinal" => "314" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Aguayo Carreras, J. Tercedor Sánchez, R. Ruiz Villaverde" "autores" => array:3 [ 0 => array:4 [ "nombre" => "P. Aguayo" "apellidos" => "Carreras" "email" => array:1 [ 0 => "paula872190@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J. Tercedor" "apellidos" => "Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "R. Ruiz" "apellidos" => "Villaverde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Campus de la Salud, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR- Riesgo de cáncer cutáneo no melanoma en pacientes hemodializados" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Wang et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> recently published an interesting article in the <span class="elsevierStyleItalic">British Journal of Dermatology</span> on the risk of skin cancer in patients on chronic hemodialysis. That study found an increased risk of skin cancer in patients undergoing chronic hemodialysis of 1.58 compared to that of the general population. The authors mainly attribute this increased risk to the increase in inflammatory biomarkers caused by the uremic pruritis suffered by these patients. This situation is analogous to the association between inflammatory bowel disease and colorectal cancer. It was also found that uremia can lead to the impairment of DNA repair,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> a finding that had been published 4 years earlier on an initial review of their database. In their database, this risk is higher in patients aged between 20 and 39 years and falls gradually with age.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We would like to report the experience of our research group, which, in 1995, published a multivariate analysis of aging markers in patients on hemodialysis.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> In this study, we were able to show that hemodialysis is a technique that accelerated skin aging in our patients with chronic kidney disease. In our patients, we found reduced hydration of the stratum corneum, increased Favré-Racouchot senile elastosis with cysts and comedones, and increased actinic keratosis independent of age. The sample size did not allow us to establish a statistically significant link with basal cell carcinoma. Nevertheless, all signs of photoaging found in our patients presented a link with the duration of hemodialysis. Renal failure thus produces accelerated pathologic aging. The prognosis for patients with chronic kidney disease continues to be extremely poor and remains so despite improvements in treatment options. We therefore hypothesize that immunosuppression is age-related and therefore affected by hemodialysis.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">White et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> recently corroborated the similarity between the physiological aging process and hemodialysis in patients with chronic kidney disease. The principal molecular mechanisms affected in both processes and which lead us to believe that there is a crossover between them include impaired proteostasis, mitochondrial dysfunction, post-translational protein modification, and senescence and telomere shortening. We agree that uremia is the key process in the pathophysiology of this accelerated aging process and induces increased apoptosis, necroptosis, and autophagy, and that dialysis may even accelerate the processes of apoptosis per se.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In light of these arguments, we believe that skin cancer in patients on hemodialysis must also be considered as an aging marker and the increased incidence due to the inflammatory cascade caused by the uremia should not be considered as the sole causal factor. It is part of a multifactor process that is more complex and similar to the physiological aging process, where oxidative stress is one more factor to take into account.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1107578" "palabras" => array:4 [ 0 => "Skin cancer" 1 => "Hemodialysis" 2 => "Skin aging" 3 => "Chronic kidney disease" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Carreras PA, Sánchez JT, Villaverde RR. FR- Riesgo de cáncer cutáneo no melanoma en pacientes hemodializados. Actas Dermosifiliogr. 2019;110:313–314.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of skin cancer in patients on chronic haemodialysis: A nationwide, population-based study in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.C. Wang" 1 => "C.H. Tang" 2 => "C.Y. Wang" 3 => "S.Y. Huang" 4 => "Y.M. 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"autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.E. White" 1 => "M.M. Yaqoob" 2 => "S.M. Harwood" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5527/wjn.v4.i1.19" "Revista" => array:6 [ "tituloSerie" => "World J Nephrol" "fecha" => "2015" "volumen" => "4" "paginaInicial" => "19" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25664244" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019301076/v1_201905070820/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000004/v1_201905070820/S1578219019301076/v1_201905070820/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301076?idApp=UINPBA000044" ]
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