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who presented with a lesion that was vascular in appearance&#46; She reported onset some 9 years earlier&#46; Initially the lesion had been asymptomatic&#44; but in the 6 months before the consultation it had grown and become painful&#46; The clinical presentation was a mottled&#44; erythematous lesion on the front and right side of the neck&#44; characterized by superficial telangiectasias&#46; The slightly indurated lesion was about 7<span class="elsevierStyleHsp" style=""></span>cm wide and we detected no thrill or increase in temperature &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Dermoscopy revealed an erythematous reticular pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Histologic examination showed a proliferation of vessels grouped into lobules distributed throughout the reticular dermis in a cannonball pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; These findings led to a diagnosis of tufted angioma&#46; As the lesion was painful&#44; treatment with rapamycin 0&#46;4&#37; was started using a topical preparation comprising rapamycin powder in a cream base&#46; After 5 months of treatment&#44; the lesion was no longer palpable&#44; the coloration had diminished &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#44; and the patient reported no pain&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The second patient was a 24-year-old woman with a history of familial Mediterranean fever&#44; who presented with an erythematous-violaceous macular lesion 2<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; which had first appeared 11 years earlier &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figs&#46; 2</a>A and B&#41;&#46; The asymptomatic lesion was located on the left breast&#46; Histologic examination showed clusters of endothelial cells in the reticular dermis&#44; forming lobules that protruded into dilated&#44; thin-walled vascular channels&#44; forming slit-like spaces &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; These findings confirmed the diagnosis of tufted angioma&#46; Given the absence of symptoms&#44; no treatment was prescribed&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The third patient was a 66-year-old man who presented 17 years ago with a verrucous lesion measuring approximately 2<span class="elsevierStyleHsp" style=""></span>cm in diameter on the anterior face of his right hand&#46; The lesion had appeared some months earlier and bled frequently&#46; Complete surgical excision of the tumor was performed&#46; The diagnosis of tufted angioma was reached on the basis of the symptoms and the histologic findings&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cases of tufted angioma in adults are very rare&#44; with fewer than 50 cases reported in the literature&#44; of which only one was associated with Kassabach-Merritt phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> In general&#44; these tumors are characterized by slow and gradual growth followed by stabilization&#46; Spontaneous regression has also been reported&#46; No differences have been reported between adults and children in the presentation&#46; The morbidity of these lesions is mainly related to the pain caused by the tumor&#44; as was the case in our first patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Tufted angioma and kaposiform hemangioendothelioma share certain clinical and histopathologic features and it is thought that the two entities may represent the opposite poles of a spectrum of vascular lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They also share a common complication known as Kasabach-Merritt syndrome&#58; consumptive coagulopathy with severe thrombocytopenia&#46; This syndrome is rare in adults&#46; The characteristic histologic feature of tufted angioma is the presence of lobular clusters of capillaries forming tufts within the dermis&#46; The differential diagnosis includes several other vascular anomalies&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Complicated tufted angioma in childhood is treated systemically with vincristine&#44; ticlopidine&#44; and acetylsalicylic acid<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a>&#59; recently&#44; rapamycin has emerged as a very effective alternative&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#44;7</span></a> In uncomplicated cases&#44; Javvaji et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> report good results with low dose aspirin&#46; Clinical management in adults is not well established&#44; and the evidence does not support any definite conclusions as to what the first-line therapy should be&#46; The treatment options described in the literature&#44; with variable results&#44; include pulsed dye laser&#44; topical corticosteroids&#44; intralesional interferon-alfa&#44; surgery&#44; and a watch-and-wait approach&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Of our 3 cases&#44; one was resolved with surgery&#44; another is being followed up&#44; and the third&#8212;a painful neck lesion&#8212;improved after topical treatment with 0&#46;4&#37; rapamycin ointment&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Oral rapamycin has become the treatment of choice for complicated tufted angioma in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#44;7</span></a> There has been no experience to date of the use of topical rapamycin in the treatment of this type of tumor&#46; However&#44; in view of the demonstrated efficacy of rapamycin in the treatment of facial angiofibromas in tuberous sclerosis&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> and in isolated cases of lymphatic malformation&#44; we suggest that topical rapamycin may be another option for the treatment of symptomatic tufted hemangioma not associated with coagulopathy&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Topical Rapamycin: An Additional Therapeutic Option for Tufted Angioma in Adults
Rapamicina tópica: otra opción terapéutica del angioma en penacho en el adulto
M.M. Escudero-Góngoraa,
Corresponding author
mmarescudero88@gmail.com

Corresponding author.
, O. Corral-Magañaa, C. Gómezb, A. Martín-Santiagoa
a Servicio de Dermatología, Hospital Universitario Son Espases, Palma de Mallorca, Spain
b Anatomía Patológica, Hospital Universitario Son Espases, Palma de Mallorca, Spain
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    "titulo" => "Topical Rapamycin&#58; An Additional Therapeutic Option for Tufted Angioma in Adults"
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        "titulo" => "Rapamicina t&#243;pica&#58; otra opci&#243;n terap&#233;utica del angioma en penacho en el adulto"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Erythematous-violaceous macular lesion on the left breast&#46; B&#44; Dermoscopic image showing a pattern of white lines on a pink background&#46; C&#44; Histological image showing endothelial cells grouped into several lobules&#44; which protrude into dilated&#44; thin-walled channels forming slit-like spaces &#40;hematoxylin-eosin&#44; original magnification &#215;10&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tufted angiomas are relatively rare benign vascular proliferations&#44; which were previously referred to as <span class="elsevierStyleItalic">progressive capilliary hemangiomas</span> or <span class="elsevierStyleItalic">angioblastomas</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> They appear mainly in patients under 5 years of age&#44; although adult-onset cases have been reported&#46; They present as erythematous-violaceous plaques or nodules affecting the upper trunk and limbs or the neck&#46; Histologic examination is necessary to establish a definitive diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> We report the cases of 3 adults with tufted angiomas diagnosed in our hospital in the past 20 years&#44; highlighting the usefulness of topical rapamycin in one case&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Reports</span><p id="par0010" class="elsevierStylePara elsevierViewall">The first patient was a 51-year-old woman with no past medical history of interest&#44; who presented with a lesion that was vascular in appearance&#46; She reported onset some 9 years earlier&#46; Initially the lesion had been asymptomatic&#44; but in the 6 months before the consultation it had grown and become painful&#46; The clinical presentation was a mottled&#44; erythematous lesion on the front and right side of the neck&#44; characterized by superficial telangiectasias&#46; The slightly indurated lesion was about 7<span class="elsevierStyleHsp" style=""></span>cm wide and we detected no thrill or increase in temperature &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Dermoscopy revealed an erythematous reticular pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Histologic examination showed a proliferation of vessels grouped into lobules distributed throughout the reticular dermis in a cannonball pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; These findings led to a diagnosis of tufted angioma&#46; As the lesion was painful&#44; treatment with rapamycin 0&#46;4&#37; was started using a topical preparation comprising rapamycin powder in a cream base&#46; After 5 months of treatment&#44; the lesion was no longer palpable&#44; the coloration had diminished &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#44; and the patient reported no pain&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The second patient was a 24-year-old woman with a history of familial Mediterranean fever&#44; who presented with an erythematous-violaceous macular lesion 2<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; which had first appeared 11 years earlier &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figs&#46; 2</a>A and B&#41;&#46; The asymptomatic lesion was located on the left breast&#46; Histologic examination showed clusters of endothelial cells in the reticular dermis&#44; forming lobules that protruded into dilated&#44; thin-walled vascular channels&#44; forming slit-like spaces &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; These findings confirmed the diagnosis of tufted angioma&#46; Given the absence of symptoms&#44; no treatment was prescribed&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The third patient was a 66-year-old man who presented 17 years ago with a verrucous lesion measuring approximately 2<span class="elsevierStyleHsp" style=""></span>cm in diameter on the anterior face of his right hand&#46; The lesion had appeared some months earlier and bled frequently&#46; Complete surgical excision of the tumor was performed&#46; The diagnosis of tufted angioma was reached on the basis of the symptoms and the histologic findings&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cases of tufted angioma in adults are very rare&#44; with fewer than 50 cases reported in the literature&#44; of which only one was associated with Kassabach-Merritt phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> In general&#44; these tumors are characterized by slow and gradual growth followed by stabilization&#46; Spontaneous regression has also been reported&#46; No differences have been reported between adults and children in the presentation&#46; The morbidity of these lesions is mainly related to the pain caused by the tumor&#44; as was the case in our first patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Tufted angioma and kaposiform hemangioendothelioma share certain clinical and histopathologic features and it is thought that the two entities may represent the opposite poles of a spectrum of vascular lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They also share a common complication known as Kasabach-Merritt syndrome&#58; consumptive coagulopathy with severe thrombocytopenia&#46; This syndrome is rare in adults&#46; The characteristic histologic feature of tufted angioma is the presence of lobular clusters of capillaries forming tufts within the dermis&#46; The differential diagnosis includes several other vascular anomalies&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Complicated tufted angioma in childhood is treated systemically with vincristine&#44; ticlopidine&#44; and acetylsalicylic acid<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a>&#59; recently&#44; rapamycin has emerged as a very effective alternative&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#44;7</span></a> In uncomplicated cases&#44; Javvaji et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> report good results with low dose aspirin&#46; Clinical management in adults is not well established&#44; and the evidence does not support any definite conclusions as to what the first-line therapy should be&#46; The treatment options described in the literature&#44; with variable results&#44; include pulsed dye laser&#44; topical corticosteroids&#44; intralesional interferon-alfa&#44; surgery&#44; and a watch-and-wait approach&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Of our 3 cases&#44; one was resolved with surgery&#44; another is being followed up&#44; and the third&#8212;a painful neck lesion&#8212;improved after topical treatment with 0&#46;4&#37; rapamycin ointment&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Oral rapamycin has become the treatment of choice for complicated tufted angioma in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#44;7</span></a> There has been no experience to date of the use of topical rapamycin in the treatment of this type of tumor&#46; However&#44; in view of the demonstrated efficacy of rapamycin in the treatment of facial angiofibromas in tuberous sclerosis&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> and in isolated cases of lymphatic malformation&#44; we suggest that topical rapamycin may be another option for the treatment of symptomatic tufted hemangioma not associated with coagulopathy&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Escudero-G&#243;ngora MM&#44; Corral-Maga&#241;a O&#44; G&#243;mez C&#44; Mart&#237;n-Santiago A&#46; Rapamicina t&#243;pica&#58; otra opci&#243;n terap&#233;utica del angioma en penacho en el adulto&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;192&#8211;194&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
Actas Dermo-Sifiliográficas
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